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Select item 93386661.

Reducing VEGFB accelerates NAFLD and insulin resistance in mice via inhibiting AMPK signaling pathway

Rongrong Li, Yuqi Li, Xueling Yang, Yaorui Hu, Haining Yu, Yana Li

J Transl Med. 2022; 20: 341. Published online 2022 Jul 30. doi: 10.1186/s12967-022-03540-2

PMCID:: PMC9338666

Abstract Article PDF–12M

Select item 73357172.

Susceptibility to Cardiac Arrhythmias and Sympathetic Nerve Growth in VEGF-B Overexpressing Myocardium

Johanna Lähteenvuo, Olli-Pekka Hätinen, Antti Kuivanen, Jenni Huusko, Jussi Paananen, Markku Lähteenvuo, Jussi Nurro, Marja Hedman, Juha Hartikainen, Nihay Laham-Karam, Petri Mäkinen, Markus Räsänen, Kari Alitalo, Anthony Rosenzweig, Seppo Ylä-Herttuala

Mol Ther. 2020 Jul 8; 28(7): 1731–1740. Published online 2020 Mar 19. doi: 10.1016/j.ymthe.2020.03.011

PMCID:: PMC7335717

Abstract Article PDF–2.2M

Select item 69766473.

VEGF-B ablation in pancreatic β-cells upregulates insulin expression without affecting glucose homeostasis or islet lipid uptake

Frank Chenfei Ning, Nina Jensen, Jiarui Mi, William Lindström, Mirela Balan, Lars Muhl, Ulf Eriksson, Ingrid Nilsson, Daniel Nyqvist

Sci Rep. 2020; 10: 923. Published online 2020 Jan 22. doi: 10.1038/s41598-020-57599-2

PMCID:: PMC6976647

Abstract Article PDF–6.5M

Select item 52384154.

VEGF-B promotes recovery of corneal innervations and trophic functions in diabetic mice

Guohu Di, Xiaowen Zhao, Xia Qi, Songmei Zhang, Lu Feng, Weiyun Shi, Qingjun Zhou

Sci Rep. 2017; 7: 40582. Published online 2017 Jan 16. doi: 10.1038/srep40582

PMCID:: PMC5238415

Abstract Article PDF–2.6M

Select item 44604385.

VEGF-B promotes cancer metastasis through a VEGF-A–independent mechanism and serves as a marker of poor prognosis for cancer patients

Xiaojuan Yang, Yin Zhang, Kayoko Hosaka, Patrik Andersson, Jian Wang, Fredrik Tholander, Ziquan Cao, Hiromasa Morikawa, Jesper Tegnér, Yunlong Yang, Hideki Iwamoto, Sharon Lim, Yihai Cao

Proc Natl Acad Sci U S A. 2015 Jun 2; 112(22): E2900–E2909. Published online 2015 May 19. doi: 10.1073/pnas.1503500112

PMCID:: PMC4460438

Abstract Article PDF–3.1M

Select item 42605606.

VEGF-B selectively regenerates injured peripheral neurons and restores sensory and trophic functions

Victor H. Guaiquil, Zan Pan, Natalia Karagianni, Shima Fukuoka, Gemstonn Alegre, Mark I. Rosenblatt

Proc Natl Acad Sci U S A. 2014 Dec 2; 111(48): 17272–17277. Published online 2014 Nov 17. doi: 10.1073/pnas.1407227111

PMCID:: PMC4260560

Abstract Article PDF–1.3M

Select item 41486487.

Lack of cardiac and high-fat diet induced metabolic phenotypes in two independent strains of Vegf-b knockout mice

M. H. Dijkstra, E. Pirinen, J. Huusko, R. Kivelä, D. Schenkwein, K. Alitalo, S. Ylä-Herttuala

Sci Rep. 2014; 4: 6238. Published online 2014 Aug 29. doi: 10.1038/srep06238

PMCID:: PMC4148648

Abstract Article PDF–807K

Select item 39583068.

VEGF-B-induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart

Riikka Kivelä, Maija Bry, Marius R Robciuc, Markus Räsänen, Miia Taavitsainen, Johanna MU Silvola, Antti Saraste, Juha J Hulmi, Andrey Anisimov, Mikko I Mäyränpää, Jan H Lindeman, Lauri Eklund, Sanna Hellberg, Ruslan Hlushchuk, Zhen W Zhuang, Michael Simons, Valentin Djonov, Juhani Knuuti, Eero Mervaala, Kari Alitalo

EMBO Mol Med. 2014 Mar; 6(3): 307–321. Published online 2014 Jan 21. doi: 10.1002/emmm.201303147

PMCID:: PMC3958306

Abstract Article PDF–2.3M

Select item 29913389.

Suppressive Effects of Vascular Endothelial Growth Factor-B on Tumor Growth in a Mouse Model of Pancreatic Neuroendocrine Tumorigenesis

Imke Albrecht, Lucie Kopfstein, Karin Strittmatter, Tibor Schomber, Annelie Falkevall, Carolina E. Hagberg, Pascal Lorentz, Michael Jeltsch, Kari Alitalo, Ulf Eriksson, Gerhard Christofori, Kristian Pietras

PLoS One. 2010; 5(11): e14109. Published online 2010 Nov 24. doi: 10.1371/journal.pone.0014109

PMCID:: PMC2991338

Abstract Article PDF–3.3M

Select item 936615410.

Reducing VEGFB expression regulates the balance of glucose and lipid metabolism in mice via VEGFR1

Xu Luo, Rong-Rong Li, Yu-Qi Li, Han-Pu Yu, Hai-Ning Yu, Wen-Guo Jiang, Ya-Na Li

Mol Med Rep. 2022 Sep; 26(3): 285. Published online 2022 Jul 26. doi: 10.3892/mmr.2022.12801

PMCID:: PMC9366154

Abstract Article PDF–7.2M

Select item 931560911.

Knockdown of VEGFB/VEGFR1 Signaling Promotes White Adipose Tissue Browning and Skeletal Muscle Development

Mingfa Ling, Xumin Lai, Lulu Quan, Fan Li, Limin Lang, Yiming Fu, Shengchun Feng, Xin Yi, Canjun Zhu, Ping Gao, Xiaotong Zhu, Lina Wang, Gang Shu, Qingyan Jiang, Songbo Wang

Int J Mol Sci. 2022 Jul; 23(14): 7524. Published online 2022 Jul 7. doi: 10.3390/ijms23147524

PMCID:: PMC9315609

Abstract Article PDF–2.6M

Select item 733297612.

VEGF‐B signaling impairs endothelial glucose transcytosis by decreasing membrane cholesterol content

Christine Moessinger, Ingrid Nilsson, Lars Muhl, Manuel Zeitelhofer, Benjamin Heller Sahlgren, Josefin Skogsberg, Ulf Eriksson

EMBO Rep. 2020 Jul 3; 21(7): e49343. Published online 2020 May 24. doi: 10.15252/embr.201949343

PMCID:: PMC7332976

Abstract Article PDF–3.0M

Select item 673933413.

CircAnks1a in the spinal cord regulates hypersensitivity in a rodent model of neuropathic pain

Su-Bo Zhang, Su-Yan Lin, Meng Liu, Cui-Cui Liu, Huan-Huan Ding, Yang Sun, Chao Ma, Rui-Xian Guo, You-You Lv, Shao-Ling Wu, Ting Xu, Wen-Jun Xin

Nat Commun. 2019; 10: 4119. Published online 2019 Sep 11. doi: 10.1038/s41467-019-12049-0

PMCID:: PMC6739334

Abstract Article PDF–2.9M

Select item 667132614.

Novel Role for Vascular Endothelial Growth Factor (VEGF) Receptor-1 and Its Ligand VEGF-B in Motor Neuron Degeneration

Koen Poesen, Diether Lambrechts, Philip Van Damme, Joke Dhondt, Florian Bender, Nicolas Frank, Elke Bogaert, Bart Claes, Line Heylen, An Verheyen, Katrien Raes, Marc Tjwa, Ulf Eriksson, Masabumi Shibuya, Rony Nuydens, Ludo Van Den Bosch, Theo Meert, Rudi D'Hooge, Michael Sendtner, Wim Robberecht, Peter Carmeliet

J Neurosci. 2008 Oct 15; 28(42): 10451–10459. doi: 10.1523/JNEUROSCI.1092-08.2008

Correction in:: J Neurosci. 2008 Dec 17; 28(51): np.

PMCID:: PMC6671326

Abstract Article PDF–343K

Select item 618715215.

VEGF-B is a potent antioxidant

Pachiappan Arjunan, Xianchai Lin, Zhongshu Tang, Yuxiang Du, Anil Kumar, Lixian Liu, Xiangke Yin, Lijuan Huang, Wei Chen, Qishan Chen, Zhimin Ye, Shasha Wang, Haiqing Kuang, Linbin Zhou, Kai Xu, Xue Chen, Haitao Zeng, Weisi Lu, Yihai Cao, Yizhi Liu, Chen Zhao, Xuri Li

Proc Natl Acad Sci U S A. 2018 Oct 9; 115(41): 10351–10356. Published online 2018 Sep 24. doi: 10.1073/pnas.1801379115

PMCID:: PMC6187152

Abstract Article PDF–1.9M

Select item 331147616.

Expansion of the fetoplacental vasculature in late gestation is strain dependent in mice

Monique Y. Rennie, Jacqui Detmar, Kathie J. Whiteley, Andrea Jurisicova, S. Lee Adamson, John G. Sled

Am J Physiol Heart Circ Physiol. 2012 Mar 15; 302(6): H1261–H1273. Published online 2012 Jan 20. doi: 10.1152/ajpheart.00776.2011

PMCID:: PMC3311476

Abstract Article

Select item 301352817.

Overexpression of VEGF₁₆₅b in Podocytes Reduces Glomerular Permeability

Yan Qiu, Joanne Ferguson, Sebastian Oltean, Chris R. Neal, Amit Kaura, Heather Bevan, Emma Wood, Leslie M. Sage, Silvia Lanati, Dawid G. Nowak, Andy H.J. Salmon, David Bates, Steve J. Harper

J Am Soc Nephrol. 2010 Sep; 21(9): 1498–1509. doi: 10.1681/ASN.2009060617

PMCID:: PMC3013528

Abstract Article

Select item 266933718.

VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis

Fan Zhang, Zhongshu Tang, Xu Hou, Johan Lennartsson, Yang Li, Alexander W. Koch, Pierre Scotney, Chunsik Lee, Pachiappan Arjunan, Lijin Dong, Anil Kumar, Tuomas T. Rissanen, Bin Wang, Nobuo Nagai, Pierre Fons, Robert Fariss, Yongqing Zhang, Eric Wawrousek, Ginger Tansey, James Raber, Guo-Hua Fong, Hao Ding, David A. Greenberg, Kevin G. Becker, Jean-Marc Herbert, Andrew Nash, Seppo Yla-Herttuala, Yihai Cao, Ryan J. Watts, Xuri Li

Proc Natl Acad Sci U S A. 2009 Apr 14; 106(15): 6152–6157. Published online 2009 Apr 6. doi: 10.1073/pnas.0813061106

PMCID:: PMC2669337

Abstract Article PDF–1.8M

Select item 870786019.

VEGFB Promotes Myoblasts Proliferation and Differentiation through VEGFR1-PI3K/Akt Signaling Pathway

Mingfa Ling, Lulu Quan, Xumin Lai, Limin Lang, Fan Li, Xiaohua Yang, Yiming Fu, Shengchun Feng, Xin Yi, Canjun Zhu, Ping Gao, Xiaotong Zhu, Lina Wang, Gang Shu, Qingyan Jiang, Songbo Wang

Int J Mol Sci. 2021 Dec; 22(24): 13352. Published online 2021 Dec 12. doi: 10.3390/ijms222413352

PMCID:: PMC8707860

Abstract Article PDF–2.7M

Select item 307929620.

Neuronal FLT1 receptor and its selective ligand VEGF-B protect against retrograde degeneration of sensory neurons

Joke Dhondt, Eve Peeraer, An Verheyen, Rony Nuydens, Ian Buysschaert, Koen Poesen, Katie Van Geyte, Manu Beerens, Masabumi Shibuya, Jody J. Haigh, Theo Meert, Peter Carmeliet, Diether Lambrechts

FASEB J. 2011 May; 25(5): 1461–1473. doi: 10.1096/fj.10-170944

PMCID:: PMC3079296

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