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Select item 112359981.

Association of the neonatal Fc receptor promoter variable number of tandem repeat polymorphism with immunoglobulin response in patients with chronic inflammatory demyelinating polyneuropathy

Anna Lena Fisse, Emelie Schäfer, Alina Hieke, Maximilian Schröder, Rafael Klimas, Jil Brünger, Sophie Huckemann, Thomas Grüter, Melissa Sgodzai, Christiane Schneider‐Gold, Ralf Gold, Huu Phuc Nguyen, Kalliopi Pitarokoili, Jeremias Motte, Larissa Arning

Eur J Neurol. 2024 Apr; 31(4): e16205. Published online 2024 Jan 11. doi: 10.1111/ene.16205

PMCID:: PMC11235998

Abstract Article PDF–470K

Select item 98917662.

The therapeutic age of the neonatal Fc receptor

Michal Pyzik, Lisa K. Kozicky, Amit K. Gandhi, Richard S. Blumberg

Nat Rev Immunol. 2023 Feb 1 : 1–18. doi: 10.1038/s41577-022-00821-1 [Epub ahead of print]

PMCID:: PMC9891766

Abstract Article PDF–4.9M

Select item 94265093.

Human FcRn Is a Two-in-One Attachment-Uncoating Receptor for Echovirus 18

Xiangpeng Chen, Xiao Qu, Congcong Liu, Yong Zhang, Guigen Zhang, Pu Han, Yali Duan, Qi Li, Liang Wang, Wenjing Ruan, Peiyi Wang, Wensheng Wei, George F. Gao, Xin Zhao, Zhengde Xie

mBio. 2022 Jul-Aug; 13(4): e01166-22. Published online 2022 Jul 5. doi: 10.1128/mbio.01166-22

PMCID:: PMC9426509

Abstract Article PDF–3.5M

Select item 87419204.

Human IgE does not bind to human FcRn

Maximilian Brinkhaus, Elvera J. van der Kooi, Arthur E. H. Bentlage, Pleuni Ooijevaar-de Heer, Ninotska I. L. Derksen, Theo Rispens, Gestur Vidarsson

Sci Rep. 2022; 12: 62. Published online 2022 Jan 7. doi: 10.1038/s41598-021-03852-1

PMCID:: PMC8741920

Abstract Article PDF–2.1M

Select item 87144785.

新生儿 Fc受体基础研究和临床应用进展

Mangsha HU, Shuli WEI, Wuyuan ZHOU, Pingli WANG

Zhejiang Da Xue Xue Bao Yi Xue Ban. 2021 Aug; 50(4): 537–544. Chinese. doi: 10.3724/zdxbyxb-2021-0252

PMCID:: PMC8714478

Abstract Article PDF–2.7M

Select item 75373876.

FcRn is a CD32a coreceptor that determines susceptibility to IgG immune complex–driven autoimmunity

Jonathan J. Hubbard, Michal Pyzik, Timo Rath, Lisa K. Kozicky, Kine M.K. Sand, Amit K. Gandhi, Algirdas Grevys, Stian Foss, Susan C. Menzies, Jonathan N. Glickman, Edda Fiebiger, Derry C. Roopenian, Inger Sandlie, Jan Terje Andersen, Laura M. Sly, Kristi Baker, Richard S. Blumberg

J Exp Med. 2020 Oct 5; 217(10): e20200359. Published online 2020 Jul 13. doi: 10.1084/jem.20200359

PMCID:: PMC7537387

Abstract Article PDF–3.4M

Select item 65175917.

Reduced FcRn-mediated transcytosis of IgG2 due to a missing Glycine in its lower hinge

Nigel M. Stapleton, Maximilian Brinkhaus, Kathryn L. Armour, Arthur E. H. Bentlage, Steven W. de Taeye, A. Robin Temming, Juk Yee Mok, Giso Brasser, Marielle Maas, Wim J. E. van Esch, Mike R. Clark, Lorna M. Williamson, C. Ellen van der Schoot, Gestur Vidarsson

Sci Rep. 2019; 9: 7363. Published online 2019 May 14. doi: 10.1038/s41598-019-40731-2

PMCID:: PMC6517591

Abstract Article PDF–1.5M

Select item 64705708.

FcRn-Dependent Transcytosis of Monoclonal Antibody in Human Nasal Epithelial Cells In Vitro: A Prerequisite for a New Delivery Route for Therapy?

Emilie Bequignon, Christine Dhommée, Christelle Angely, Lucie Thomas, Mathieu Bottier, Estelle Escudier, Daniel Isabey, André Coste, Bruno Louis, Jean-François Papon, Valérie Gouilleux-Gruart

Int J Mol Sci. 2019 Mar; 20(6): 1379. Published online 2019 Mar 19. doi: 10.3390/ijms20061379

PMCID:: PMC6470570

Abstract Article PDF–5.0M

Select item 61530319.

Expression of FcRn receptor in placental tissue and its relationship with IgG levels in term and pre-term newborns

N.A. Lozano, A. Lozano, V. Marini, R.J. Saranz, R.S. Blumberg, K. Baker, M.F. Agresta, M.F. Ponzio

Am J Reprod Immunol. Author manuscript; available in PMC 2019 Sep 1.

Published in final edited form as: Am J Reprod Immunol. 2018 Sep; 80(3): e12972. Published online 2018 May 10. doi: 10.1111/aji.12972

PMCID:: PMC6153031

Abstract Article PDF–907K

Select item 598386210.

Insight into small molecule binding to the neonatal Fc receptor by X-ray crystallography and 100 kHz magic-angle-spinning NMR

Daniel Stöppler, Alex Macpherson, Susanne Smith-Penzel, Nicolas Basse, Fabien Lecomte, Hervé Deboves, Richard D. Taylor, Tim Norman, John Porter, Lorna C. Waters, Marta Westwood, Ben Cossins, Katharine Cain, James White, Robert Griffin, Christine Prosser, Sebastian Kelm, Amy H. Sullivan, David Fox, III, Mark D. Carr, Alistair Henry, Richard Taylor, Beat H. Meier, Hartmut Oschkinat, Alastair D. Lawson

PLoS Biol. 2018 May; 16(5): e2006192. Published online 2018 May 21. doi: 10.1371/journal.pbio.2006192

PMCID:: PMC5983862

Abstract Article PDF–23M

Select item 592579111.

Half-life–extended recombinant coagulation factor IX–albumin fusion protein is recycled via the FcRn-mediated pathway

Jenny Chia, Jade Louber, Isabelle Glauser, Shirley Taylor, Greg T. Bass, Steve K. Dower, Paul A. Gleeson, Anne M. Verhagen

J Biol Chem. 2018 Apr 27; 293(17): 6363–6373. Published online 2018 Mar 9. doi: 10.1074/jbc.M117.817064

PMCID:: PMC5925791

Abstract Article PDF–2.8M

Select item 580036412.

Changes in complementarity-determining regions significantly alter IgG binding to the neonatal Fc receptor (FcRn) and pharmacokinetics

Nicole M. Piche-Nicholas, Lindsay B. Avery, Amy C. King, Mania Kavosi, Mengmeng Wang, Denise M. O'Hara, Lioudmila Tchistiakova, Madan Katragadda

MAbs. 2018 Jan; 10(1): 81–94. Published online 2017 Nov 3. doi: 10.1080/19420862.2017.1389355

PMCID:: PMC5800364

Abstract Article PDF–1.1M

Select item 565640013.

The neonatal Fc receptor (FcRn) and complement fixation facilitate prophylactic vaccine-mediated humoral protection against viral infection in the ocular mucosa

Derek J. Royer, Meghan M. Carr, Hem R. Gurung, William P. Halford, Daniel J.J. Carr

J Immunol. Author manuscript; available in PMC 2018 Sep 1.

Published in final edited form as: J Immunol. 2017 Sep 1; 199(5): 1898–1911. Published online 2017 Jul 31. doi: 10.4049/jimmunol.1700316

PMCID:: PMC5656400

Abstract Article PDF–4.4M

Select item 563313914.

Associations between an IgG3 polymorphism in the binding domain for FcRn, transplacental transfer of malaria-specific IgG3, and protection against Plasmodium falciparum malaria during infancy: A birth cohort study in Benin

Celia Dechavanne, Sebastien Dechavanne, Ibrahim Sadissou, Adjimon Gatien Lokossou, Fernanda Alvarado, Magalie Dambrun, Kabirou Moutairou, David Courtin, Gregory Nuel, Andre Garcia, Florence Migot-Nabias, Christopher L. King

PLoS Med. 2017 Oct; 14(10): e1002403. Published online 2017 Oct 9. doi: 10.1371/journal.pmed.1002403

PMCID:: PMC5633139

Abstract Article PDF–4.4M

Select item 535690115.

Loss of expression of the recycling receptor, FcRn, promotes tumor cell growth by increasing albumin consumption

Rafal Swiercz, Min Mo, Priyanka Khare, Zita Schneider, Raimund J Ober, Elizabeth Sally Ward

Oncotarget. 2017 Jan 10; 8(2): 3528–3541. Published online 2016 Dec 10. doi: 10.18632/oncotarget.13869

PMCID:: PMC5356901

Abstract Article PDF–2.2M

Select item 496642916.

The interplay of non-specific binding, target-mediated clearance and FcRn interactions on the pharmacokinetics of humanized antibodies

Amita Datta-Mannan, Jirong Lu, Derrick R Witcher, Donmienne Leung, Ying Tang, Victor J Wroblewski

MAbs. 2015 Nov-Dec; 7(6): 1084–1093. Published online 2015 Sep 4. doi: 10.1080/19420862.2015.1075109

PMCID:: PMC4966429

Abstract Article PDF–385K

Select item 458302917.

Critical Role of the Neonatal Fc Receptor (FcRn) in the Pathogenic Action of Antimitochondrial Autoantibodies Synergizing with Anti-desmoglein Autoantibodies in Pemphigus Vulgaris

Yumay Chen, Alex Chernyavsky, Robert J. Webber, Sergei A. Grando, Ping H. Wang

J Biol Chem. 2015 Sep 25; 290(39): 23826–23837. Published online 2015 Aug 10. doi: 10.1074/jbc.M115.668061

PMCID:: PMC4583029

Abstract Article PDF–2.0M

Select item 452917818.

Analysis of Response Elements Involved in the Regulation of the Human Neonatal Fc Receptor Gene (FCGRT)

Joanna E. Mikulska

PLoS One. 2015; 10(8): e0135141. Published online 2015 Aug 7. doi: 10.1371/journal.pone.0135141

Correction in:: PLoS One. 2015; 10(9): e0139744.

PMCID:: PMC4529178

Abstract Article PDF–6.0M

Select item 443784419.

Evidence that FcRn mediates the transplacental passage of maternal IgE in the form of IgG anti‐IgE/IgE immune complexes

A. Bundhoo, S. Paveglio, E. Rafti, A. Dhongade, R. S. Blumberg, A. P. Matson

Clin Exp Allergy. 2015 Jun; 45(6): 1085–1098. Published online 2015 May 16. doi: 10.1111/cea.12508

PMCID:: PMC4437844

Abstract Article PDF–554K

Select item 405916320.

Dissection of the Neonatal Fc Receptor (FcRn)-Albumin Interface Using Mutagenesis and Anti-FcRn Albumin-blocking Antibodies

Kine Marita Knudsen Sand, Bjørn Dalhus, Gregory J. Christianson, Malin Bern, Stian Foss, Jason Cameron, Darrell Sleep, Magnar Bjørås, Derry C. Roopenian, Inger Sandlie, Jan Terje Andersen

J Biol Chem. 2014 Jun 13; 289(24): 17228–17239. Published online 2014 Apr 24. doi: 10.1074/jbc.M113.522565

PMCID:: PMC4059163

Abstract Article PDF–2.6M

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