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Select item 82529581.

Thrombopoietin maintains cell numbers of hematopoietic stem and progenitor cells with megakaryopoietic potential

Aled O’Neill, Desmond Chin, Darren Tan, A’Qilah Banu Bte Abdul Majeed, Ayako Nakamura-Ishizu, Toshio Suda

Haematologica. 2021 Jul 1; 106(7): 1883–1891. Published online 2020 Jun 11. doi: 10.3324/haematol.2019.241406

PMCID:: PMC8252958

Abstract Article PDF–1.4M

Select item 59303572.

Hepatic thrombopoietin is required for bone marrow hematopoietic stem cell maintenance

Matthew Decker, Juliana Leslie, Qingxue Liu, Lei Ding

Science. Author manuscript; available in PMC 2019 Apr 6.

Published in final edited form as: Science. 2018 Apr 6; 360(6384): 106–110. doi: 10.1126/science.aap8861

PMCID:: PMC5930357

Abstract Article PDF–1.4M

Select item 42731863.

Thrombopoietin Treatment of One Graft in a Double Cord Blood Transplant Provides Early Platelet Recovery While Contributing to Long-Term Engraftment in NSG Mice

Mark van der Garde, Yvette van Hensbergen, Anneke Brand, Manon C. Slot, Alice de Graaf-Dijkstra, Arend Mulder, Suzanne M. Watt, Jaap Jan Zwaginga

Stem Cells Dev. 2015 Jan 1; 24(1): 67–76. Published online 2014 Aug 19. doi: 10.1089/scd.2014.0294

PMCID:: PMC4273186

Abstract Article PDF–411K

Select item 36774424.

Fundamental differences in endoreplication in mammals and Drosophila revealed by analysis of endocycling and endomitotic cells

Noa Sher, Jessica R. Von Stetina, George W. Bell, Shinobu Matsuura, Katya Ravid, Terry L. Orr-Weaver

Proc Natl Acad Sci U S A. 2013 Jun 4; 110(23): 9368–9373. Published online 2013 Apr 23. doi: 10.1073/pnas.1304889110

PMCID:: PMC3677442

Abstract Article PDF–1.0M

Select item 25176085.

TRANSCRIPTIONAL REGULATION OF BONE MARROW THROMBOPOIETIN BY PLATELET PROTEINS

Bryan McIntosh, Kenneth Kaushansky

Exp Hematol. Author manuscript; available in PMC 2009 Jul 1.

Published in final edited form as: Exp Hematol. 2008 Jul; 36(7): 799–806. Published online 2008 Apr 14. doi: 10.1016/j.exphem.2008.02.012

PMCID:: PMC2517608

Abstract Article PDF–383K

Select item 21924706.

Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin

J Exp Med. 1996 Feb 1; 183(2): 651–656. doi: 10.1084/jem.183.2.651

PMCID:: PMC2192470

Summary PDF–647K

Select item 1510897.

Thrombopoietin expands hematopoietic stem cells after transplantation

Norma Fox, Greg Priestley, Thalia Papayannopoulou, Kenneth Kaushansky

J Clin Invest. 2002 Aug 1; 110(3): 389–394. doi: 10.1172/JCI15430

PMCID:: PMC151089

Abstract Article PDF–122K

Select item 108500858.

Cryo-EM structure of the extracellular domain of murine Thrombopoietin Receptor in complex with Thrombopoietin

Kaiseal T. G. Sarson-Lawrence, Joshua M. Hardy, Josephine Iaria, Dina Stockwell, Kira Behrens, Tamanna Saiyed, Cyrus Tan, Leila Jebeli, Nichollas E. Scott, Toby A. Dite, Nicos A. Nicola, Andrew P. Leis, Jeffrey J. Babon, Nadia J. Kershaw

Nat Commun. 2024; 15: 1135. Published online 2024 Feb 7. doi: 10.1038/s41467-024-45356-2

PMCID:: PMC10850085

Abstract Article PDF–3.2M

Select item 91989069.

Megakaryocyte/platelet-derived TGF-β1 inhibits megakaryopoiesis in bone marrow by regulating thrombopoietin production in liver

Sandra Gostynska, Thamizhiniyan Venkatesan, Kumar Subramani, Brienne Cortez, Amanda Robertson, Sandeep Subrahmanian, Pratibha Dube, Jasimuddin Ahamed

Blood Adv. 2022 Jun 14; 6(11): 3321–3328. Published online 2022 Jun 3. doi: 10.1182/bloodadvances.2021005977

PMCID:: PMC9198906

Abstract Article PDF–2.0M

Select item 892633910.

Hematopoietic stem cells temporally transition to thrombopoietin dependence in the fetal liver

Yeojin Lee, Emily DiMaulo-Milk, Juliana Leslie, Lei Ding

Sci Adv. 2022 Mar; 8(11): eabm7688. Published online 2022 Mar 16. doi: 10.1126/sciadv.abm7688

PMCID:: PMC8926339

Abstract Article PDF–861K

Select item 480194811.

Cytokine‐induced megakaryocytic differentiation is regulated by genome‐wide loss of a uSTAT transcriptional program

Hyun Jung Park, Juan Li, Rebecca Hannah, Simon Biddie, Ana I Leal‐Cervantes, Kristina Kirschner, David Flores Santa Cruz, Veronika Sexl, Berthold Göttgens, Anthony R Green

EMBO J. 2016 Mar 15; 35(6): 580–594. Published online 2015 Dec 23. doi: 10.15252/embj.201592383

PMCID:: PMC4801948

Abstract Article PDF–1.4M

Select item 476672512.

H₂S protects against fatal myelosuppression by promoting the generation of megakaryocytes/platelets

Huan-Di Liu, Ai-Jie Zhang, Jing-Jing Xu, Ying Chen, Yi-Chun Zhu

J Hematol Oncol. 2016; 9: 13. Published online 2016 Feb 24. doi: 10.1186/s13045-016-0244-7

PMCID:: PMC4766725

Abstract Article PDF–2.3M

Select item 189518213.

Tie2 activation contributes to hemangiogenic regeneration after myelosuppression

Hans-Georg Kopp, Scott T. Avecilla, Andrea T. Hooper, Sergey V. Shmelkov, Carlos A. Ramos, Fan Zhang, Shahin Rafii

Blood. 2005 Jul 15; 106(2): 505–513. Prepublished online 2005 Apr 7. doi: 10.1182/blood-2004-11-4269

PMCID:: PMC1895182

Abstract Article

Select item 189298314.

Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction

Jun Seita, Hideo Ema, Jun Ooehara, Satoshi Yamazaki, Yuko Tadokoro, Akiko Yamasaki, Koji Eto, Satoshi Takaki, Kiyoshi Takatsu, Hiromitsu Nakauchi

Proc Natl Acad Sci U S A. 2007 Feb 13; 104(7): 2349–2354. Published online 2007 Feb 6. doi: 10.1073/pnas.0606238104

PMCID:: PMC1892983

Abstract Article PDF–657K

Select item 189082615.

Studies of c-Mpl function distinguish the replication of hematopoietic stem cells from the expansion of differentiating clones

Janis L. Abkowitz, Jing Chen

Blood. 2007 Jun 15; 109(12): 5186–5190. Prepublished online 2007 Mar 8. doi: 10.1182/blood-2006-08-044503

PMCID:: PMC1890826

Abstract Article

Select item 153605316.

Cytokines regulate postnatal hematopoietic stem cell expansion: opposing roles of thrombopoietin and LNK

Natalija Buza-Vidas, Jennifer Antonchuk, Hong Qian, Robert Månsson, Sidinh Luc, Sasan Zandi, Kristina Anderson, Satoshi Takaki, Jens M. Nygren, Christina T. Jensen, Sten Eirik W. Jacobsen

Genes Dev. 2006 Aug 1; 20(15): 2018–2023. doi: 10.1101/gad.385606