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Select item 69868731.

TRF1 averts chromatin remodelling, recombination and replication dependent-break induced replication at mouse telomeres

Rosa Maria Porreca, Emilia Herrera-Moyano, Eleni Skourti, Pui Pik Law, Roser Gonzalez Franco, Alex Montoya, Peter Faull, Holger Kramer, Jean-Baptiste Vannier

eLife. 2020; 9: e49817. Published online 2020 Jan 14. doi: 10.7554/eLife.49817

PMCID:: PMC6986873

Abstract Article PDF–5.8M

Select item 59886952.

Dual roles of TRF1 in tethering telomeres to the nuclear envelope and protecting them from fusion during meiosis

Lina Wang, Zhaowei Tu, Chao Liu, Hongbin Liu, Philipp Kaldis, Zijiang Chen, Wei Li

Cell Death Differ. 2018 Jun; 25(6): 1174–1188. Published online 2018 Jan 8. doi: 10.1038/s41418-017-0037-8

PMCID:: PMC5988695

Abstract Article PDF–5.3M

Select item 50768493.

Molecular Architecture of Full-length TRF1 Favors Its Interaction with DNA

Jasminka Boskovic, Jaime Martinez-Gago, Marinela Mendez-Pertuz, Alberto Buscato, Jorge Luis Martinez-Torrecuadrada, Maria A. Blasco

J Biol Chem. 2016 Oct 7; 291(41): 21829–21835. Published online 2016 Aug 25. doi: 10.1074/jbc.M116.744896

PMCID:: PMC5076849

Abstract Article PDF–1.2M

Select item 46139874.

Genome-wide analysis of in vivo TRF1 binding to chromatin restricts its location exclusively to telomeric repeats

Ianire Garrobo, Rosa M Marión, Orlando Domínguez, David G Pisano, Maria A Blasco

Cell Cycle. 2014 Dec 1; 13(23): 3742–3749. Published online 2014 Oct 29. doi: 10.4161/15384101.2014.965044

PMCID:: PMC4613987

Abstract Article PDF–286K

Select item 40725705.

Resolution of telomere associations by TRF1 cleavage in mouse embryonic stem cells

Kathleen Lisaingo, Evert-Jan Uringa, Peter M. Lansdorp

Mol Biol Cell. 2014 Jul 1; 25(13): 1958–1968. doi: 10.1091/mbc.E13-10-0564

PMCID:: PMC4072570

Abstract Article PDF–1.7M

Select item 39186646.

Conditional TRF1 knockout in the hematopoietic compartment leads to bone marrow failure and recapitulates clinical features of dyskeratosis congenita

Fabian Beier, Miguel Foronda, Paula Martinez, Maria A. Blasco

Blood. Author manuscript; available in PMC 2014 Feb 10.

Published in final edited form as: Blood. 2012 Oct 11; 120(15): 2990–3000. Published online 2012 Aug 29. doi: 10.1182/blood-2012-03-418038

PMCID:: PMC3918664

Abstract Article PDF–3.6M

Select item 31746567.

Different telomere-length dynamics at the inner cell mass versus established embryonic stem (ES) cells

Elisa Varela, Ralph P. Schneider, Sagrario Ortega, Maria A. Blasco

Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37): 15207–15212. Published online 2011 Aug 24. doi: 10.1073/pnas.1105414108

PMCID:: PMC3174656

Abstract Article PDF–1.2M

Select item 85848528.

Molecular Consequences of Depression Treatment: A Potential In Vitro Mechanism for Antidepressants-Induced Reprotoxic Side Effects

Przemysław Sołek, Jennifer Mytych, Anna Tabęcka-Łonczyńska, Marek Koziorowski

Int J Mol Sci. 2021 Nov; 22(21): 11855. Published online 2021 Nov 1. doi: 10.3390/ijms222111855

PMCID:: PMC8584852

Abstract Article PDF–21M

Select item 67019279.

TERRA regulate the transcriptional landscape of pluripotent cells through TRF1-dependent recruitment of PRC2

Rosa María Marión, Juan J Montero, Isabel López de Silanes, Osvaldo Graña-Castro, Paula Martínez, Stefan Schoeftner, José Alejandro Palacios-Fábrega, Maria A Blasco

eLife. 2019; 8: e44656. Published online 2019 Aug 20. doi: 10.7554/eLife.44656

PMCID:: PMC6701927

Abstract Article PDF–3.4M

Select item 571609610.

Aurora Kinase B, a novel regulator of TERF1 binding and telomeric integrity

Foong Lyn Chan, Benjamin Vinod, Karel Novy, Ralf B. Schittenhelm, Cheng Huang, Maheshi Udugama, Juan Nunez-Iglesias, Jane I. Lin, Linda Hii, Julie Chan, Hilda A. Pickett, Roger J. Daly, Lee H. Wong

Nucleic Acids Res. 2017 Dec 1; 45(21): 12340–12353. Published online 2017 Oct 10. doi: 10.1093/nar/gkx904

PMCID:: PMC5716096

Abstract Article PDF–5.1M

Select item 503390611.

Telomere dysfunction in alveolar epithelial cells causes lung remodeling and fibrosis

Ram P. Naikawadi, Supparerk Disayabutr, Benat Mallavia, Matthew L. Donne, Gary Green, Janet L. La, Jason R. Rock, Mark R. Looney, Paul J. Wolters

JCI Insight. 2016 Sep 8; 1(14): e86704. Published online 2016 Sep 8. doi: 10.1172/jci.insight.86704

PMCID:: PMC5033906

Abstract Article PDF–1.2M

Select item 477777612.

Gene dosage reductions of Trf1 and/or Tin2 induce telomere DNA damage and lymphoma formation in aging mice

K Hartmann, A Illing, F Leithäuser, A Baisantry, L Quintanilla-Martinez, K L Rudolph

Leukemia. 2016 Mar; 30(3): 749–753. Prepublished online 2015 Jul 2. Published online 2015 Jul 31. doi: 10.1038/leu.2015.173

Correction in:: Leukemia. 2017; 31(12): 2853.

PMCID:: PMC4777776

Article PDF–463K

Select item 373355113.

A two-step mechanism for TRF2-mediated chromosome end protection

Keiji Okamoto, Cristina Bartocci, Iliana Ouzounov, Jolene K. Diedrich, John R. Yates, III, Eros Lazzerini Denchi

Nature. Author manuscript; available in PMC 2013 Aug 28.

Published in final edited form as: Nature. 2013 Feb 28; 494(7438): 502–505. Published online 2013 Feb 6. doi: 10.1038/nature11873

PMCID:: PMC3733551

Abstract Article PDF–757K

Select item 325977414.

Distinct Roles of TRF1 in the Regulation of Telomere Structure and Lengthening

Keiji Okamoto, Tomohiko Iwano, Makoto Tachibana, Yoichi Shinkai

J Biol Chem. 2008 Aug 29; 283(35): 23981–23988. doi: 10.1074/jbc.M802395200

PMCID:: PMC3259774

Abstract Article PDF–541K

Select item 269994215.

Essential role of Pin1 in regulation of TRF1 stability and telomere maintenance

Tae Ho Lee, Adrian Tun-Kyi, Rong Shi, Jormay Lim, Christina Soohoo, Greg Finn, Martin Balastik, Lucia Pastorino, Gerburg Wulf, Xiao Zhen Zhou, Kun Ping Lu

Nat Cell Biol. Author manuscript; available in PMC 2009 Jun 22.

Published in final edited form as: Nat Cell Biol. 2009 Jan; 11(1): 97–105. Published online 2008 Dec 7. doi: 10.1038/ncb1818

PMCID:: PMC2699942

Abstract Article PDF–2.0M

Select item 953729316.

Consequences of telomere dysfunction in fibroblasts, club and basal cells for lung fibrosis development

Sergio Piñeiro-Hermida, Paula Martínez, Giuseppe Bosso, Juana María Flores, Sarita Saraswati, Jane Connor, Raphael Lemaire, Maria A. Blasco

Nat Commun. 2022; 13: 5656. Published online 2022 Oct 6. doi: 10.1038/s41467-022-32771-6

PMCID:: PMC9537293

Abstract Article PDF–20M

Select item 433174717.

In vivo role of checkpoint kinase 2 in signaling telomere dysfunction

María García-Beccaria, Paula Martínez, Juana M Flores, Maria A Blasco

Aging Cell. 2014 Oct; 13(5): 810–816. Published online 2014 Jun 12. doi: 10.1111/acel.12237

PMCID:: PMC4331747

Abstract Article PDF–949K

Select item 275197018.

Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice

Paula Martínez, Maria Thanasoula, Purificación Muñoz, Chunyan Liao, Agueda Tejera, Carolyn McNees, Juana M. Flores, Oscar Fernández-Capetillo, Madalena Tarsounas, Maria A. Blasco

Genes Dev. 2009 Sep 1; 23(17): 2060–2075. doi: 10.1101/gad.543509