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Select item 107960021.

USP22 overexpression fails to augment tumor formation in MMTV-ERBB2 mice but loss of function impacts MMTV promoter activity

Xianghong Kuang, Andrew Salinger, Fernando Benavides, William J. Muller, Sharon Y. R. Dent, Evangelia Koutelou

PLoS One. 2024; 19(1): e0290837. Published online 2024 Jan 18. doi: 10.1371/journal.pone.0290837

PMCID:: PMC10796002

Abstract Article PDF–2.5M

Select item 71734062.

Tumor cell–intrinsic USP22 suppresses antitumor immunity in pancreatic cancer

Jinyang Li, Salina Yuan, Robert J Norgard, Fangxue Yan, Taiji Yamazoe, Andrés Blanco, Ben Z. Stanger

Cancer Immunol Res. Author manuscript; available in PMC 2020 Sep 1.

Published in final edited form as: Cancer Immunol Res. 2020 Mar; 8(3): 282–291. Published online 2019 Dec 23. doi: 10.1158/2326-6066.CIR-19-0661

PMCID:: PMC7173406

Abstract Article PDF–2.2M

Select item 108631693.

USP22 supports the aggressive behavior of basal-like breast cancer by stimulating cellular respiration

Evangelos Prokakis, Husam Bamahmoud, Shaishavi Jansari, Lena Fritsche, Alexander Dietz, Angela Boshnakovska, Peter Rehling, Steven A. Johnsen, Julia Gallwas, Florian Wegwitz

Cell Commun Signal. 2024; 22: 120. Published online 2024 Feb 12. doi: 10.1186/s12964-023-01441-5

PMCID:: PMC10863169

Abstract Article PDF–12M

Select item 83290074.

Histone H2Bub1 deubiquitylation is essential for mouse development, but does not regulate global RNA polymerase II transcription

Fang Wang, Farrah El-Saafin, Tao Ye, Matthieu Stierle, Luc Negroni, Matej Durik, Veronique Fischer, Didier Devys, Stéphane D. Vincent, László Tora

Cell Death Differ. 2021 Aug; 28(8): 2385–2403. Published online 2021 Mar 17. doi: 10.1038/s41418-021-00759-2

PMCID:: PMC8329007

Abstract Article PDF–6.1M

Select item 72019255.

USP22 controls iNKT immunity through MED1 suppression of histone H2A monoubiquitination

Yana Zhang, Yajun Wang, Beixue Gao, Yueqi Sun, Liang Cao, Samantha M. Genardi, Chyung-Ru Wang, HuaBin Li, Zhaolin Sun, Yanjie Yang, Deyu Fang

J Exp Med. 2020 May 4; 217(5): e20182218. Published online 2020 Feb 18. doi: 10.1084/jem.20182218

PMCID:: PMC7201925

Abstract Article PDF–4.7M

Select item 60715636.

USP22 deficiency leads to myeloid leukemia upon oncogenic Kras activation through a PU.1-dependent mechanism

Johanna Melo-Cardenas, Yuanming Xu, Juncheng Wei, Can Tan, Sinyi Kong, Beixue Gao, Elena Montauti, Gina Kirsammer, Jonathan D. Licht, Jindan Yu, Peng Ji, John D. Crispino, Deyu Fang

Blood. 2018 Jul 26; 132(4): 423–434. Prepublished online 2018 May 29. doi: 10.1182/blood-2017-10-811760

PMCID:: PMC6071563

Abstract Article

Select item 37453687.

The Epigenetic Modifier Ubiquitin-specific Protease 22 (USP22) Regulates Embryonic Stem Cell Differentiation via Transcriptional Repression of Sex-determining Region Y-box 2 (SOX2)

Robyn T. Sussman, Timothy J. Stanek, Paul Esteso, John D. Gearhart, Karen E. Knudsen, Steven B. McMahon

J Biol Chem. 2013 Aug 16; 288(33): 24234–24246. Published online 2013 Jun 12. doi: 10.1074/jbc.M113.469783

PMCID:: PMC3745368

Abstract Article PDF–2.0M

Select item 96996838.

A deubiquitination module essential for T_reg fitness in the tumor microenvironment

Elena Montauti, Samuel E. Weinberg, Peng Chu, Shuvam Chaudhuri, Nikita L. Mani, Radhika Iyer, Yuanzhang Zhou, Yusi Zhang, Changhong Liu, Chen Xin, Shana Gregory, Juncheng Wei, Yana Zhang, Wantao Chen, Zhaolin Sun, Ming Yan, Deyu Fang

Sci Adv. 2022 Nov; 8(47): eabo4116. Published online 2022 Nov 25. doi: 10.1126/sciadv.abo4116

PMCID:: PMC9699683

Abstract Article PDF–1.7M

Select item 62646489.

Gα₁₂ ablation exacerbates liver steatosis and obesity by suppressing USP22/SIRT1-regulated mitochondrial respiration

Tae Hyun Kim, Yoon Mee Yang, Chang Yeob Han, Ja Hyun Koo, Hyunhee Oh, Su Sung Kim, Byoung Hoon You, Young Hee Choi, Tae-Sik Park, Chang Ho Lee, Hitoshi Kurose, Mazen Noureddin, Ekihiro Seki, Yu-Jui Yvonne Wan, Cheol Soo Choi, Sang Geon Kim

J Clin Invest. 2018 Dec 3; 128(12): 5587–5602. Published online 2018 Nov 12. doi: 10.1172/JCI97831

PMCID:: PMC6264648

Abstract Article PDF–18M

Select item 982709310.

The ubiquitin-specific peptidase 22 is a deubiquitinase of CD73 in breast cancer cells

Shana Gregory, Yanan Xu, Ping Xie, Jie Fan, Beixue Gao, Nikita Mani, Radhika Iyer, Amy Tang, Juncheng Wei, Shuvam Mohan Chaudhuri, Shengnan Wang, Huiping Liu, Bin Zhang, Deyu Fang

Am J Cancer Res. 2022; 12(12): 5564–5575. Published online 2022 Dec 15.

PMCID:: PMC9827093

Abstract Article PDF–1.4M

Select item 819573811.

USP22 promotes HER2-driven mammary carcinoma aggressiveness by suppressing the unfolded protein response

Evangelos Prokakis, Anna Dyas, Regina Grün, Sonja Fritzsche, Upasana Bedi, Zahra B. Kazerouni, Robyn L. Kosinsky, Steven A. Johnsen, Florian Wegwitz

Oncogene. 2021; 40(23): 4004–4018. Published online 2021 May 18. doi: 10.1038/s41388-021-01814-5

PMCID:: PMC8195738

Abstract Article PDF–5.0M

Select item 781439412.

USP22 functions as an oncogenic driver in prostate cancer by regulating cell proliferation and DNA repair

Jennifer J. McCann, Irina A. Vasilevskaya, Neermala Poudel Neupane, Ayesha A. Shafi, Christopher McNair, Emanuela Dylgjeri, Amy C. Mandigo, Matthew J. Schiewer, Randy S. Schrecengost, Peter Gallagher, Timothy J. Stanek, Steven B. McMahon, Lisa D. Berman-Booty, William F. Ostrander, Jr, Karen E. Knudsen

Cancer Res. Author manuscript; available in PMC 2021 Jan 19.

Published in final edited form as: Cancer Res. 2020 Feb 1; 80(3): 430–443. Published online 2019 Nov 18. doi: 10.1158/0008-5472.CAN-19-1033

PMCID:: PMC7814394

Abstract Article PDF–2.1M

Select item 730598913.

CRISPR Screen in Regulatory T Cells Reveals Modulators of Foxp3

Jessica T. Cortez, Elena Montauti, Eric Shifrut, Jovylyn Gatchalian, Yusi Zhang, Oren Shaked, Yuanming Xu, Theodore L. Roth, Dimitre R. Simeonov, Yana Zhang, Siqi Chen, Zhongmei Li, Jonathan M. Woo, Josephine Ho, Ian A. Vogel, Grace Y. Prator, Bin Zhang, Youjin Lee, Zhaolin Sun, Igal Ifergan, Frédéric Van Gool, Diana C. Hargreaves, Jeffrey A. Bluestone, Alexander Marson, Deyu Fang

Nature. Author manuscript; available in PMC 2020 Oct 29.

Published in final edited form as: Nature. 2020 Jun; 582(7812): 416–420. Published online 2020 Apr 29. doi: 10.1038/s41586-020-2246-4

PMCID:: PMC7305989

Abstract Article PDF–4.2M

Select item 689287514.

USP22-dependent HSP90AB1 expression promotes resistance to HSP90 inhibition in mammary and colorectal cancer

Robyn Laura Kosinsky, Marlena Helms, Maria Zerche, Luisa Wohn, Anna Dyas, Evangelos Prokakis, Zahra Basir Kazerouni, Upasana Bedi, Florian Wegwitz, Steven A. Johnsen

Cell Death Dis. 2019 Dec; 10(12): 911. Published online 2019 Dec 4. doi: 10.1038/s41419-019-2141-9

PMCID:: PMC6892875

Abstract Article PDF–5.5M

Select item 584363415.

The H2B deubiquitinase Usp22 promotes antibody class switch recombination by facilitating non-homologous end joining

Conglei Li, Thergiory Irrazabal, Clare C. So, Maribel Berru, Likun Du, Evelyn Lam, Alexanda K. Ling, Jennifer L. Gommerman, Qiang Pan-Hammarström, Alberto Martin

Nat Commun. 2018; 9: 1006. Published online 2018 Mar 8. doi: 10.1038/s41467-018-03455-x

PMCID:: PMC5843634

Abstract Article PDF–1.8M

Select item 274949216.

Gcn5 and SAGA Regulate Shelterin Protein Turnover and Telomere Maintenance

Boyko S. Atanassov, Yvonne A. Evrard, Asha S. Multani, Zhijing Zhang, László Tora, Didier Devys, Sandy Chang, Sharon Y.R. Dent

Mol Cell. Author manuscript; available in PMC 2010 Aug 14.

Published in final edited form as: Mol Cell. 2009 Aug 14; 35(3): 352–364. doi: 10.1016/j.molcel.2009.06.015

PMCID:: PMC2749492

Abstract Article PDF–3.7M

Select item 817844017.

USP22 deficiency in melanoma mediates resistance to T cells through IFNγ-JAK1-STAT1 signal axis

Min Li, Yanqin Xu, Jie Liang, Hao Lin, Xinyue Qi, Fanlin Li, Ping Han, Yanfeng Gao, Xuanming Yang

Mol Ther. 2021 Jun 2; 29(6): 2108–2120. Published online 2021 Feb 15. doi: 10.1016/j.ymthe.2021.02.018

PMCID:: PMC8178440

Abstract Article PDF–2.6M

Select item 720588018.

USP22 exerts tumor-suppressive functions in colorectal cancer by decreasing mTOR activity

Robyn Laura Kosinsky, Maria Zerche, Dominik Saul, Xin Wang, Luisa Wohn, Florian Wegwitz, Yvonne Begus-Nahrmann, Steven A. Johnsen

Cell Death Differ. 2020 Apr; 27(4): 1328–1340. Published online 2019 Sep 17. doi: 10.1038/s41418-019-0420-8

PMCID:: PMC7205880

Abstract Article PDF–4.9M

Select item 720192319.

USP22 promotes IRF3 nuclear translocation and antiviral responses by deubiquitinating the importin protein KPNA2

Zeng Cai, Meng-Xin Zhang, Zhen Tang, Qiang Zhang, Jing Ye, Tian-Chen Xiong, Zhi-Dong Zhang, Bo Zhong

J Exp Med. 2020 May 4; 217(5): e20191174. Published online 2020 Mar 4. doi: 10.1084/jem.20191174

PMCID:: PMC7201923

Abstract Article PDF–8.0M

Select item 502632720.

Nuclear GSK3ß promotes tumorigenesis by phosphorylating KDM1A and inducing its deubiquitination by USP22

Aidong Zhou, Kangyu Lin, Sicong Zhang, Yaohui Chen, Nu Zhang, Jianfei Xue, Zhongyong Wang, Kenneth D. Aldape, Keping Xie, James R. Woodgett, Suyun Huang

Nat Cell Biol. Author manuscript; available in PMC 2017 Mar 1.

Published in final edited form as: Nat Cell Biol. 2016 Sep; 18(9): 954–966. Published online 2016 Aug 8. doi: 10.1038/ncb3396

PMCID:: PMC5026327

Abstract Article PDF–3.7M

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