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Select item 111597701.

TEL/ETV6 accelerates erythroid differentiation and inhibits megakaryocytic maturation in a human leukemia cell line UT‐7/GM

Wataru Takahashi, Ko Sasaki, Norio Komatsu, Kinuko Mitani

Cancer Sci. 2005 Jun; 96(6): 340–348. Published online 2005 Jun 15. doi: 10.1111/j.1349-7006.2005.00052.x

PMCID:: PMC11159770

Abstract Article PDF–505K

Select item 106909102.

ETV6 fusions from insertions of exons 3-5 in pediatric hematologic malignancies

Sarah B. Mueller, Yana Pikman, Sarah K. Tasian, Lewis B. Silverman, Marian H. Harris, Harrison K. Tsai

Haematologica. 2023 Dec 1; 108(12): 3471–3476. Published online 2023 Jun 29. doi: 10.3324/haematol.2022.282498

PMCID:: PMC10690910

Article PDF–733K

Select item 106142213.

Description of an Institutional Cohort of Myeloid Neoplasms Carrying ETV6-Locus Deletions or ETV6 Rearrangements

Vasiliki Papadopoulou, Jacqueline Schoumans, Ilaria Scarpelli, Sabine Blum

Acta Haematol. 2023 Feb 27; 146(5): 401–407. Published online 2023 Feb 27. doi: 10.1159/000529844

PMCID:: PMC10614221

Abstract Article

Select item 96569464.

Elevated ETV6 Expression in Glioma Promotes an Aggressive In Vitro Phenotype Associated with Shorter Patient Survival

Zhang Xiong, Shuai Wu, Feng-jiao Li, Chen Luo, Qiu-yan Jin, Ian David Connolly, Melanie Hayden Gephart, Linya You

Genes (Basel) 2022 Oct; 13(10): 1882. Published online 2022 Oct 17. doi: 10.3390/genes13101882

PMCID:: PMC9656946

Abstract Article PDF–2.4M

Select item 79490255.

Biophysical characterization of the ETV6 PNT domain polymerization interfaces

Chloe A.N. Gerak, Sophia Y. Cho, Maxim Kolesnikov, Mark Okon, Michael E.P. Murphy, Richard B. Sessions, Michel Roberge, Lawrence P. McIntosh

J Biol Chem. 2021 Jan-Jun; 296: 100284. Published online 2021 Jan 13. doi: 10.1016/j.jbc.2021.100284

PMCID:: PMC7949025

Abstract Article PDF–2.5M

Select item 78197606.

Molecular basis of ETV6-mediated predisposition to childhood acute lymphoblastic leukemia

Rina Nishii, Rebekah Baskin-Doerfler, Wentao Yang, Ninad Oak, Xujie Zhao, Wenjian Yang, Keito Hoshitsuki, Mackenzie Bloom, Katherine Verbist, Melissa Burns, Zhenhua Li, Ting-Nien Lin, Maoxiang Qian, Takaya Moriyama, Julie M. Gastier-Foster, Karen R. Rabin, Elizabeth Raetz, Charles Mullighan, Ching-Hon Pui, Allen Eng-Juh Yeoh, Jinghui Zhang, Monika L. Metzger, Jeffery M. Klco, Stephen P. Hunger, Scott Newman, Gang Wu, Mignon L. Loh, Kim E. Nichols, Jun J. Yang

Blood. 2021 Jan 21; 137(3): 364–373. Prepublished online 2020 Jul 21. doi: 10.1182/blood.2020006164

PMCID:: PMC7819760

Abstract Article

Select item 75265377.

ETV6 germline mutations cause HDAC3/NCOR2 mislocalization and upregulation of interferon response genes

Marlie H. Fisher, Gregory D. Kirkpatrick, Brett Stevens, Courtney Jones, Michael Callaghan, Madhvi Rajpurkar, Joy Fulbright, Megan A. Cooper, Jesse Rowley, Christopher C. Porter, Arthur Gutierrez-Hartmann, Kenneth Jones, Craig Jordan, Eric M. Pietras, Jorge Di Paola

JCI Insight. 2020 Sep 17; 5(18): e140332. Published online 2020 Sep 17. doi: 10.1172/jci.insight.140332

PMCID:: PMC7526537

Abstract Article PDF–6.6M

Select item 69943568.

Pan-Trk immunohistochemistry is a sensitive and specific ancillary tool in diagnosing secretory carcinoma of salivary gland and detecting ETV6-NTRK3 fusion

Bin Xu, Mohamed Rizwan Haroon Al Rasheed, Cristina R. Antonescu, Deepu Alex, Denise Frosina, Ronald Ghossein, Achim A. Jungbluth, Nora Katabi

Histopathology. Author manuscript; available in PMC 2021 Feb 1.

Published in final edited form as: Histopathology. 2020 Feb; 76(3): 375–382. Published online 2019 Dec 11. doi: 10.1111/his.13981

PMCID:: PMC6994356

Abstract Article PDF–426K

Select item 67068119.

Jorge Di Paola, Christopher C. Porter

Blood. 2019 Aug 22; 134(8): 663–667. Prepublished online 2019 Jun 27. doi: 10.1182/blood.2019852418

PMCID:: PMC6706811

Abstract Article

Select item 645722010.

Germline deletion of ETV6 in familial acute lymphoblastic leukemia

Evadnie Rampersaud, David S. Ziegler, Ilaria Iacobucci, Debbie Payne-Turner, Michelle L. Churchman, Kasmintan A. Schrader, Vijai Joseph, Kenneth Offit, Katherine Tucker, Rosemary Sutton, Meera Warby, Georgia Chenevix-Trench, David G. Huntsman, Maria Tsoli, R. Scott Mead, Chunxu Qu, Vasiliki Leventaki, Gang Wu, Charles G. Mullighan

Blood Adv. 2019 Apr 9; 3(7): 1039–1046. Published online 2019 Apr 2. doi: 10.1182/bloodadvances.2018030635

PMCID:: PMC6457220

Abstract Article PDF–1.3M

Select item 619551411.

Genome wide mapping of ETV6 binding sites in pre-B leukemic cells

Benjamin Neveu, Maxime Caron, Karine Lagacé, Chantal Richer, Daniel Sinnett

Sci Rep. 2018; 8: 15526. Published online 2018 Oct 19. doi: 10.1038/s41598-018-33947-1

PMCID:: PMC6195514

Abstract Article PDF–2.4M

Select item 559466312.

Nasopharyngeal carcinoma super-enhancer–driven ETV6 correlates with prognosis

Liangru Ke, Hufeng Zhou, Chong Wang, Geng Xiong, Yanqun Xiang, Yihong Ling, Abdelmajid Khabir, George S. Tsao, Yixin Zeng, Musheng Zeng, Pierre Busson, Elliott Kieff, Xiang Guo, Bo Zhao

Proc Natl Acad Sci U S A. 2017 Sep 5; 114(36): 9683–9688. Published online 2017 Aug 22. doi: 10.1073/pnas.1705236114

PMCID:: PMC5594663

Abstract Article PDF–1.4M

Select item 555518213.

Electrostatic control of DNA intersegmental translocation by the ETS transcription factor ETV6

Tam Vo, Shuo Wang, Gregory M. K. Poon, W. David Wilson

J Biol Chem. 2017 Aug 11; 292(32): 13187–13196. Published online 2017 Jun 7. doi: 10.1074/jbc.M117.792887

PMCID:: PMC5555182

Abstract Article PDF–1.2M

Select item 542079014.

Clinical utility of gene panel-based testing for hereditary myelodysplastic syndrome/acute leukemia predisposition syndromes

L Guidugli, A K Johnson, G Alkorta-Aranburu, V Nelakuditi, K Arndt, J E Churpek, L A Godley, D Townsley, N S Young, C Fitzpatrick, D del Gaudio, S Das, Z Li

Leukemia. 2017 May; 31(5): 1226–1229. Prepublished online 2017 Jan 20. Published online 2017 Feb 7. doi: 10.1038/leu.2017.28

PMCID:: PMC5420790

Article PDF–139K

Select item 539486515.

Clinical and pathogenic features of ETV6-related thrombocytopenia with predisposition to acute lymphoblastic leukemia

Federica Melazzini, Flavia Palombo, Alessandra Balduini, Daniela De Rocco, Caterina Marconi, Patrizia Noris, Chiara Gnan, Tommaso Pippucci, Valeria Bozzi, Michela Faleschini, Serena Barozzi, Michael Doubek, Christian A. Di Buduo, Katerina Stano Kozubik, Lenka Radova, Giuseppe Loffredo, Sarka Pospisilova, Caterina Alfano, Marco Seri, Carlo L. Balduini, Alessandro Pecci, Anna Savoia

Haematologica. 2016 Nov; 101(11): 1333–1342. doi: 10.3324/haematol.2016.147496

PMCID:: PMC5394865

Abstract Article PDF–1.3M

Select item 485872816.

Common genetic variation in ETV6 is associated with colorectal cancer susceptibility

Meilin Wang, Dongying Gu, Mulong Du, Zhi Xu, Suzhan Zhang, Lingjun Zhu, Jiachun Lu, Rui Zhang, Jinliang Xing, Xiaoping Miao, Haiyan Chu, Zhibin Hu, Lei Yang, Cuiju Tang, Lei Pan, Haina Du, Jian Zhao, Jiangbo Du, Na Tong, Jielin Sun, Hongbing Shen, Jianfeng Xu, Zhengdong Zhang, Jinfei Chen

Nat Commun. 2016; 7: 11478. Published online 2016 May 5. doi: 10.1038/ncomms11478

PMCID:: PMC4858728

Abstract Article PDF–1.3M

Select item 468470917.

Germline Genetic Variation in ETV6 and Risk of Childhood Acute Lymphoblastic Leukemia: a Systematic Genetic Study

Takaya Moriyama, Monika L. Metzger, Gang Wu, Rina Nishii, Maoxiang Qian, Meenakshi Devidas, Prof. Wenjian Yang, Cheng Cheng, Cao, Prof. Quinn Emily, Prof. Susana Raimondi, Prof. Julie M. Gastier-Foster, Elizabeth Raetz, Eric Larsen, Paul L. Martin, Prof. W. Paul Bowman, Prof. Naomi Winick, Yoshihiro Komada, Shuoguo Wang, Michael Edmonson, Prof. Heng Xu, Elaine Mardis, Prof. Robert Fulton, Prof. Pui, Prof. Charles Mullighan, Prof. William E. Evans, Prof. Jinghui Zhang, Prof. Stephen P. Hunger, Prof. Mary V. Relling, Prof. Kim E. Nichols, Mignon L. Loh, Jun J. Yang

Lancet Oncol. Author manuscript; available in PMC 2016 Dec 1.

Published in final edited form as: Lancet Oncol. 2015 Dec; 16(16): 1659–1666. Published online 2015 Oct 28. doi: 10.1016/S1470-2045(15)00369-1

PMCID:: PMC4684709

Abstract Article PDF–411K

Select item 463161318.

Germline mutations in ETV6 are associated with thrombocytopenia, red cell macrocytosis and predisposition to lymphoblastic leukemia

Leila Noetzli, Richard W. Lo, Alisa B. Lee-Sherick, Michael Callaghan, Patrizia Noris, Anna Savoia, Madhvi Rajpurkar, Kenneth Jones, Katherine Gowan, Carlo Balduini, Alessandro Pecci, Chiara Gnan, Daniela De Rocco, Michael Doubek, Ling Li, Lily Lu, Richard Leung, Carolina Landolt-Marticorena, Stephen Hunger, Paula Heller, Arthur Gutierrez-Hartmann, Liang Xiayuan, Fred G. Pluthero, Jesse W. Rowley, Andrew S. Weyrich, Walter H. A. Kahr, Christopher C. Porter, Jorge Di Paola

Nat Genet. Author manuscript; available in PMC 2015 Nov 3.

Published in final edited form as: Nat Genet. 2015 May; 47(5): 535–538. Published online 2015 Mar 25. doi: 10.1038/ng.3253

PMCID:: PMC4631613

Abstract Article PDF–700K

Select item 447787719.

Germline ETV6 Mutations Confer Susceptibility to Acute Lymphoblastic Leukemia and Thrombocytopenia

Sabine Topka, Joseph Vijai, Michael F. Walsh, Lauren Jacobs, Ann Maria, Danylo Villano, Pragna Gaddam, Gang Wu, Rose B. McGee, Emily Quinn, Hiroto Inaba, Christine Hartford, Ching-hon Pui, Alberto Pappo, Michael Edmonson, Michael Y. Zhang, Polina Stepensky, Peter Steinherz, Kasmintan Schrader, Anne Lincoln, James Bussel, Steve M. Lipkin, Yehuda Goldgur, Mira Harit, Zsofia K. Stadler, Charles Mullighan, Michael Weintraub, Akiko Shimamura, Jinghui Zhang, James R. Downing, Kim E. Nichols, Kenneth Offit

PLoS Genet. 2015 Jun; 11(6): e1005262. Published online 2015 Jun 23. doi: 10.1371/journal.pgen.1005262

PMCID:: PMC4477877

Abstract Article PDF–1.9M

Select item 444011120.

Expression of ETV6/TEL is associated with prognosis in non-small cell lung cancer

Jian-Zhong Liang, Yuan-Hua Li, Yu Zhang, Qi-Nian Wu, Qiu-Liang Wu

Int J Clin Exp Pathol. 2015; 8(3): 2937–2945. Published online 2015 Mar 1.

PMCID:: PMC4440111

Abstract Article PDF–1.0M

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PMC Links for Gene (Select 2120) (138)
PMC
NADH dehydrogenase subunit 5, partial (mitochondrion) [Papio cynocephalus]
NADH dehydrogenase subunit 5, partial (mitochondrion) [Papio cynocephalus]
gi|1335008391|gb|AUT19346.1|

Protein
Ipomoea dichroa voucher SB-3860 small subunit ribosomal RNA gene, partial sequen...
Ipomoea dichroa voucher SB-3860 small subunit ribosomal RNA gene, partial sequence; internal transcribed spacer 1, 5.8S ribosomal RNA gene, and internal transcribed spacer 2, complete sequence; and large subunit ribosomal RNA gene, partial sequence
gi|1783629149|gb|MN825189.1|

Nucleotide
RRM2B-related mitochondrial disease
RRM2B-related mitochondrial disease

MedGen
CN187502[conceptid] (1)
MedGen

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