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Select item 99071261.

Gut flora disequilibrium promotes the initiation of liver cancer by modulating tryptophan metabolism and up-regulating SREBP2

Wen Chen, Liang Wen, Yingying Bao, Zengwei Tang, Jianhui Zhao, Xiaozhen Zhang, Tao Wei, Jian Zhang, Tao Ma, Qi Zhang, Xiao Zhi, Jin Li, Cheng Zhang, Lei Ni, Muchun Li, Tingbo Liang

Proc Natl Acad Sci U S A. 2022 Dec 27; 119(52): e2203894119. Published online 2022 Dec 19. doi: 10.1073/pnas.2203894119

PMCID:: PMC9907126

Abstract Article PDF–37M

Select item 56251222.

Cholesterol auxotrophy and intolerance to ezetimibe in mice with SREBP-2 deficiency in the intestine

Shunxing Rong, Jeffrey G. McDonald, Luke J. Engelking

J Lipid Res. 2017 Oct; 58(10): 1988–1998. Published online 2017 Jun 19. doi: 10.1194/jlr.M077610

PMCID:: PMC5625122

Abstract Article PDF–2.1M

Select item 38963313.

Overactivation of Intestinal SREBP2 in Mice Increases Serum Cholesterol

Ke Ma, Pooja Malhotra, Vinay Soni, Omar Hedroug, Fadi Annaba, Amish Dudeja, Le Shen, Jerrold R. Turner, Ekaterina A. Khramtsova, Seema Saksena, Pradeep K. Dudeja, Ravinder K. Gill, Waddah A. Alrefai

PLoS One. 2014; 9(1): e84221. Published online 2014 Jan 20. doi: 10.1371/journal.pone.0084221

PMCID:: PMC3896331

Abstract Article PDF–4.2M

Select item 33669414.

Early Dengue Virus Protein Synthesis Induces Extensive Rearrangement of the Endoplasmic Reticulum Independent of the UPR and SREBP-2 Pathway

José Peña, Eva Harris

PLoS One. 2012; 7(6): e38202. Published online 2012 Jun 4. doi: 10.1371/journal.pone.0038202

PMCID:: PMC3366941

Abstract Article PDF–921K

Select item 32519045.

A spontaneous mutation in Srebf2 leads to cataracts and persistent skin wounds in the lens opacity 13 (lop13) mouse

Kate M. Merath, Bo Chang, Richard Dubielzig, Richard Jeannotte, Duska J. Sidjanin

Mamm Genome. Author manuscript; available in PMC 2012 Jan 5.

Published in final edited form as: Mamm Genome. 2011 Dec; 22(11-12): 661–673. Published online 2011 Aug 21. doi: 10.1007/s00335-011-9354-2

PMCID:: PMC3251904

Abstract Article PDF–1.9M

Select item 30862646.

Genome-wide Localization of SREBP-2 in Hepatic Chromatin Predicts a Role in Autophagy

Young Kyo Seo, Tae-Il Jeon, Hansook Kim Chong, Jacob Beisinger, Xiaohui Xie, Timothy F. Osborne

Cell Metab. Author manuscript; available in PMC 2012 Apr 6.

Published in final edited form as: Cell Metab. 2011 Apr 6; 13(4): 367–375. doi: 10.1016/j.cmet.2011.03.005

PMCID:: PMC3086264

Abstract Article PDF–1.6M

Select item 25646137.

SREBP-2 regulates gut peptide secretion through intestinal bitter taste receptor signaling in mice

Tae-Il Jeon, Bing Zhu, Jarrod L. Larson, Timothy F. Osborne

J Clin Invest. 2008 Nov 3; 118(11): 3693–3700. Published online 2008 Oct 9. doi: 10.1172/JCI36461

PMCID:: PMC2564613

Abstract Article PDF–990K

Select item 5339818.

Novel Role for a Sterol Response Element Binding Protein in Directing Spermatogenic Cell-Specific Gene Expression

Hang Wang, Jovenal T. San Agustin, George B. Witman, Daniel L. Kilpatrick

Mol Cell Biol. 2004 Dec; 24(24): 10681–10688. doi: 10.1128/MCB.24.24.10681-10688.2004

PMCID:: PMC533981

Abstract Article PDF–525K

Select item 50733159.

SREBP-2/PNPLA8 axis improves non-alcoholic fatty liver disease through activation of autophagy

Kwang-Youn Kim, Hyun-Jun Jang, Yong Ryul Yang, Kwang-Il Park, JeongKon Seo, Il-Woo Shin, Tae-Il Jeon, Soon-cheol Ahn, Pann-Ghill Suh, Timothy F. Osborne, Young-Kyo Seo

Sci Rep. 2016; 6: 35732. Published online 2016 Oct 21. doi: 10.1038/srep35732

Correction in:: Sci Rep. 2016; 6: 37794.

PMCID:: PMC5073315

Abstract Article PDF–2.8M

Select item 503585310.

SCAP/SREBP pathway is required for the full steroidogenic response to cyclic AMP

Masami Shimizu-Albergine, Brian Van Yserloo, Martin G. Golkowski, Shao-En Ong, Joseph A. Beavo, Karin E. Bornfeldt

Proc Natl Acad Sci U S A. 2016 Sep 20; 113(38): E5685–E5693. Published online 2016 Sep 6. doi: 10.1073/pnas.1611424113

PMCID:: PMC5035853

Abstract Article PDF–1.8M

Select item 346639411.

Expanding roles for SREBP in metabolism

Wei Shao, Peter J. Espenshade

Cell Metab. Author manuscript; available in PMC 2013 Oct 3.

Published in final edited form as: Cell Metab. 2012 Oct 3; 16(4): 414–419. Published online 2012 Sep 20. doi: 10.1016/j.cmet.2012.09.002

PMCID:: PMC3466394

Abstract Article PDF–650K

Select item 280613012.

Regulation of the ADMA-DDAH system in endothelial cells: a novel mechanism for the sterol response element binding proteins, SREBP1c and -2

Christine Y. Ivashchenko, Benjamin T. Bradley, Zhaohui Ao, James Leiper, Patrick Vallance, Douglas G. Johns

Am J Physiol Heart Circ Physiol. 2010 Jan; 298(1): H251–H258. Published online 2009 Nov 13. doi: 10.1152/ajpheart.00195.2009

PMCID:: PMC2806130

Abstract Article

Select item 278152413.

Prion-induced Activation of Cholesterogenic Gene Expression by Srebp2 in Neuronal Cells

Christian Bach, Sabine Gilch, Romina Rost, Alex D. Greenwood, Marion Horsch, Glaucia N. M. Hajj, Susanne Brodesser, Axel Facius, Sandra Schädler, Konrad Sandhoff, Johannes Beckers, Christine Leib-Mösch, Hermann M. Schätzl, Ina Vorberg

J Biol Chem. 2009 Nov 6; 284(45): 31260–31269. Published online 2009 Sep 11. doi: 10.1074/jbc.M109.004382

PMCID:: PMC2781524

Abstract Article PDF–2.5M

Select item 241428414.

Selective Binding of Sterol Regulatory Element-binding Protein Isoforms and Co-regulatory Proteins to Promoters for Lipid Metabolic Genes in Liver

Mary K. Bennett, Young-Kyo Seo, Shrimati Datta, Dong-Ju Shin, Timothy F. Osborne

J Biol Chem. 2008 Jun 6; 283(23): 15628–15637. doi: 10.1074/jbc.M800391200

PMCID:: PMC2414284

Abstract Article PDF–438K

Select item 1107960515.

Mitochondrial translation failure represses cholesterol gene expression via Pyk2-Gsk3β-Srebp2 axis

Takahiro Toshima, Mikako Yagi, Yura Do, Haruka Hirai, Yuya Kunisaki, Dongchon Kang, Takeshi Uchiumi

Life Sci Alliance. 2024 Jul; 7(7): e202302423. Published online 2024 May 8. doi: 10.26508/lsa.202302423

PMCID:: PMC11079605

Abstract Article PDF–2.6M

Select item 1004062316.

Long Non-Coding RNA TUG1 Attenuates Insulin Resistance in Mice with Gestational Diabetes Mellitus via Regulation of the MicroRNA-328-3p/SREBP-2/ERK Axis

Xuwen Tang, Qingxin Qin, Wenjing Xu, Xuezhen Zhang

Diabetes Metab J. 2023 Mar; 47(2): 267–286. Published online 2023 Jan 19. doi: 10.4093/dmj.2021.0216

PMCID:: PMC10040623

Abstract Article PDF–4.6M

Select item 813983417.

Qki regulates myelinogenesis through Srebp2-dependent cholesterol biosynthesis

Xin Zhou, Seula Shin, Chenxi He, Qiang Zhang, Matthew N Rasband, Jiangong Ren, Congxin Dai, Rocío I Zorrilla-Veloz, Takashi Shingu, Liang Yuan, Yunfei Wang, Yiwen Chen, Fei Lan, Jian Hu

eLife. 2021; 10: e60467. Published online 2021 May 4. doi: 10.7554/eLife.60467