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1.
Upregulation of the serine palmitoyltransferase subunit SPTLC2 by endoplasmic reticulum stress inhibits the hepatic insulin response
Goon-Tae Kim, Shivani Devi, Amitesh Sharma, Kyung-Hee Cho, Su-Jung Kim, Bo-Rahm Kim, Sang-Ho Kwon, Tae-Sik Park
Exp Mol Med. 2022 May; 54(5): 573–584. Published online 2022 May 5. doi: 10.1038/s12276-022-00766-4
PMCID:
PMC9166747
AbstractArticlePDF–1.6M
2.
Endotoxin activates de novo sphingolipid biosynthesis via nuclear factor kappa B-mediated upregulation of Sptlc2
Zhi-Qiang Chang, Su-Yeon Lee, Hye-Jin Kim, Jung Ran Kim, Su-Jung Kim, In-Kyung Hong, Byung-Chul Oh, Cheol-Soo Choi, Ira J. Goldberg, Tae-Sik Park
Prostaglandins Other Lipid Mediat. Author manuscript; available in PMC 2012 Jun 3.
Published in final edited form as: Prostaglandins Other Lipid Mediat. 2011 Feb; 94(0): 44–52. Published online 2010 Dec 15. doi: 10.1016/j.prostaglandins.2010.12.003
PMCID:
PMC3366150
AbstractArticlePDF–1.1M
3.
Cardiomyocyte Specific Deficiency of Serine Palmitoyltransferase Subunit 2 Reduces Ceramide but Leads to Cardiac Dysfunction
Su-Yeon Lee, Jung Ran Kim, Yunying Hu, Raffay Khan, Su-Jung Kim, Kalyani G. Bharadwaj, Mercy M. Davidson, Cheol-Soo Choi, Kyong-Oh Shin, Yong-Moon Lee, Woo-Jin Park, In-Sun Park, Xian-Cheng Jiang, Ira J. Goldberg, Tae-Sik Park
J Biol Chem. 2012 May 25; 287(22): 18429–18439. Published online 2012 Apr 9. doi: 10.1074/jbc.M111.296947
PMCID:
PMC3365730
AbstractArticlePDF–3.4M
4.
Functional characterization of the promoter for the mouse SPTLC2 gene, which encodes subunit 2 of serine palmitoyltransferase
Stephen C. Linn, Lindsay M. Andras, Hee-Sook Kim, Jia Wei, M. Marek Nagiec, Robert C. Dickson, Alfred H. Merrill, Jr.
FEBS Lett. Author manuscript; available in PMC 2007 Nov 13.
Published in final edited form as: FEBS Lett. 2006 Nov 13; 580(26): 6217–6223. Published online 2006 Oct 19. doi: 10.1016/j.febslet.2006.10.025
PMCID:
PMC1698862
AbstractArticlePDF–590K
5.
Adipocyte-Specific Deficiency of De Novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Insulin Resistance
Su-Yeon Lee, Hui-Young Lee, Jae-Hwi Song, Goon-Tae Kim, Suwon Jeon, Yoo-Jeong Song, Jae Sung Lee, Jang-Ho Hur, Hyun Hee Oh, Shi-Young Park, Soon-Mi Shim, Hyun Joo Yoo, Byung Cheon Lee, Xian-Cheng Jiang, Cheol Soo Choi, Tae-Sik Park
Diabetes. 2017 Oct; 66(10): 2596–2609. Published online 2017 Jul 11. doi: 10.2337/db16-1232
PMCID:
PMC7970771
AbstractArticlePDF–2.3M
6.
Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8+ T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness
Jingxia Wu, Sicong Ma, Roger Sandhoff, Yanan Ming, Agnes Hotz-Wagenblatt, Vincent Timmerman, Nathalie Bonello-Palot, Beate Schlotter-Weigel, Michaela Auer-Grumbach, Pavel Seeman, Wolfgang N. Löscher, Markus Reindl, Florian Weiss, Eric Mah, Nina Weisshaar, Alaa Madi, Kerstin Mohr, Tilo Schlimbach, Rubí M.-H. Velasco Cárdenas, Jonas Koeppel, Florian Grünschläger, Lisann Müller, Maren Baumeister, Britta Brügger, Michael Schmitt, Guido Wabnitz, Yvonne Samstag, Guoliang Cui
Immunity. Author manuscript; available in PMC 2020 May 21.
Published in final edited form as: Immunity. 2019 May 21; 50(5): 1218–1231.e5. Published online 2019 Apr 2. doi: 10.1016/j.immuni.2019.03.005
PMCID:
PMC6531359
AbstractArticlePDF–2.8M
7.
Macrophage-specific de Novo Synthesis of Ceramide Is Dispensable for Inflammasome-driven Inflammation and Insulin Resistance in Obesity
Christina D. Camell, Kim Y. Nguyen, Michael J. Jurczak, Brooke E. Christian, Gerald I. Shulman, Gerald S. Shadel, Vishwa Deep Dixit
J Biol Chem. 2015 Dec 4; 290(49): 29402–29413. Published online 2015 Oct 5. doi: 10.1074/jbc.M115.680199
PMCID:
PMC4705943
AbstractArticlePDF–1.2M
8.
Reducing Plasma Membrane Sphingomyelin Increases Insulin Sensitivity
Zhiqiang Li, Hongqi Zhang, Jing Liu, Chien-Ping Liang, Yan Li, Yue Li, Gladys Teitelman, Thomas Beyer, Hai H. Bui, David A. Peake, Youyan Zhang, Phillip E. Sanders, Ming-Shang Kuo, Tae-Sik Park, Guoqing Cao, Xian-Cheng Jiang
Mol Cell Biol. 2011 Oct; 31(20): 4205–4218. doi: 10.1128/MCB.05893-11
PMCID:
PMC3187286
AbstractArticlePDF–2.0M
9.
Liver-specific Deficiency of Serine Palmitoyltransferase Subunit 2 Decreases Plasma Sphingomyelin and Increases Apolipoprotein E Levels
Zhiqiang Li, Yan Li, Mahua Chakraborty, Yifan Fan, Hai H. Bui, David A. Peake, Ming-Shang Kuo, Xiao Xiao, Guoqing Cao, Xian-Cheng Jiang
J Biol Chem. 2009 Sep 25; 284(39): 27010–27019. Published online 2009 Aug 1. doi: 10.1074/jbc.M109.042028
PMCID:
PMC2785386
AbstractArticlePDF–2.3M
10.
Myeloid cell–specific serine palmitoyltransferase subunit 2 haploinsufficiency reduces murine atherosclerosis
Mahua Chakraborty, Caixia Lou, Chongmin Huan, Ming-Shang Kuo, Tae-Sik Park, Guoqing Cao, Xian-Cheng Jiang
J Clin Invest. 2013 Apr 1; 123(4): 1784–1797. Published online 2013 Mar 15. doi: 10.1172/JCI60415
Correction in:
J Clin Invest. 2013 May 1; 123(5): 2332.
Correction in:
J Clin Invest. 2013 May 1; 123(5): 2333.
PMCID:
PMC3613902
AbstractArticlePDF–5.4M
11.
Why we scratch an itch: the molecules, cells and circuits of itch
Diana M Bautista, Sarah R Wilson, Mark A Hoon
Nat Neurosci. Author manuscript; available in PMC 2015 Mar 18.
Published in final edited form as: Nat Neurosci. 2014 Feb; 17(2): 175–182. Published online 2014 Jan 28. doi: 10.1038/nn.3619
PMCID:
PMC4364402
AbstractArticlePDF–577K
12.
Ceramide-Activated Phosphatase Mediates Fatty Acid–Induced Endothelial VEGF Resistance and Impaired Angiogenesis
Vishal C. Mehra, Elias Jackson, Xian M. Zhang, Xian-Cheng Jiang, Lawrence W. Dobrucki, Jun Yu, Pascal Bernatchez, Albert J. Sinusas, Gerald I. Shulman, William C. Sessa, Timur O. Yarovinsky, Jeffrey R. Bender
Am J Pathol. 2014 May; 184(5): 1562–1576. doi: 10.1016/j.ajpath.2014.01.009
PMCID:
PMC4005977
AbstractArticlePDF–2.4M
13.
Multi-system disorders of glycosphingolipid and ganglioside metabolism
You-Hai Xu, Sonya Barnes, Ying Sun, Gregory A. Grabowski
J Lipid Res. 2010 Jul; 51(7): 1643–1675. doi: 10.1194/jlr.R003996
PMCID:
PMC2882741
AbstractArticlePDF–1.5M
14.
Regulation of plasma cholesterol esterification by sphingomyelin: Effect of physiological variations of plasma sphingomyelin on lecithin-cholesterol acyltransferase activity
Papasani Venkata Subbaiah, Xian-Cheng Jiang, Natalia A. Belikova, Buzulagu Aizezi, Zhi Hua Huang, Catherine A. Reardon
Biochim Biophys Acta. Author manuscript; available in PMC 2013 Jun 1.
Published in final edited form as: Biochim Biophys Acta. 2012 Jun; 1821(6): 908–913. Published online 2012 Feb 18. doi: 10.1016/j.bbalip.2012.02.007
PMCID:
PMC3340435
AbstractArticlePDF–2.8M
15.
1-deoxysphingolipids bind to COUP-TF to modulate lymphatic and cardiac cell development
Ting Wang, Zheng Wang, Lauriane de Fabritus, Jinglian Tao, Essa M. Saied, Ho-Joon Lee, Bulat R. Ramazanov, Benjamin Jackson, Daniel Burkhardt, Mikhail Parker, Anne S. Gleinich, Zhirui Wang, Dong Eun Seo, Ting Zhou, Shihao Xu, Irina Alecu, Parastoo Azadi, Christoph Arenz, Thorsten Hornemann, Smita Krishnaswamy, Serge A. van de Pavert, Susan M. Kaech, Natalia B. Ivanova, Fabio R. Santori
Dev Cell. Author manuscript; available in PMC 2022 Nov 22.
Published in final edited form as: Dev Cell. 2021 Nov 22; 56(22): 3128–3145.e15. Published online 2021 Nov 10. doi: 10.1016/j.devcel.2021.10.018
PMCID:
PMC8628544
AbstractArticlePDF–2.9M
16.
Autophagy regulates sphingolipid levels in the liver
Aikaterini Alexaki, Sita D. Gupta, Saurav Majumder, Mari Kono, Galina Tuymetova, Jeffrey M. Harmon, Teresa M. Dunn, Richard L. Proia
J Lipid Res. 2014 Dec; 55(12): 2521–2531. doi: 10.1194/jlr.M051862
PMCID:
PMC4242445
AbstractArticlePDF–1.7M
17.
The Essential Nature of Sphingolipids in Plants as Revealed by the Functional Identification and Characterization of the Arabidopsis LCB1 Subunit of Serine Palmitoyltransferase
Ming Chen, Gongshe Han, Charles R. Dietrich, Teresa M. Dunn, Edgar B. Cahoon
Plant Cell. 2006 Dec; 18(12): 3576–3593. doi: 10.1105/tpc.105.040774
PMCID:
PMC1785403
AbstractArticlePDF–1.5M
18.
Tissue- and sex-specific effects of β-carotene 15,15′ oxygenase (BCO1) on retinoid and lipid metabolism in adult and developing mice
Youn-Kyung Kim, Michael V. Zuccaro, Brianna K. Costabile, Rebeka Rodas, Loredana Quadro
Arch Biochem Biophys. Author manuscript; available in PMC 2016 Apr 15.
Published in final edited form as: Arch Biochem Biophys. 2015 Apr 15; 572: 11–18. Published online 2015 Jan 17. doi: 10.1016/j.abb.2015.01.002
PMCID:
PMC4402122
AbstractArticlePDF–1.1M
19.
ORMDL/serine palmitoyltransferase stoichiometry determines effects of ORMDL3 expression on sphingolipid biosynthesis
Deanna Siow, Manjula Sunkara, Teresa M. Dunn, Andrew J. Morris, Binks Wattenberg
J Lipid Res. 2015 Apr; 56(4): 898–908. doi: 10.1194/jlr.M057539
PMCID:
PMC4373746
AbstractArticlePDF–1.1M
20.
Transcription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development
Zhixing Wang, Jay S. Kirkwood, Alan W. Taylor, Jan F. Stevens, Mark Leid, Gitali Ganguli-Indra, Arup K. Indra
J Invest Dermatol. Author manuscript; available in PMC 2013 Sep 1.
Published in final edited form as: J Invest Dermatol. 2013 Mar; 133(3): 668–676. Published online 2012 Oct 25. doi: 10.1038/jid.2012.358
PMCID:
PMC3556343
AbstractArticlePDF–608K

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