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Select item 73763851.

The E3 ubiquitin ligase SPOP controls resolution of systemic inflammation by triggering MYD88 degradation

Maria Guillamot, Dahmane Ouazia, Igor Dolgalev, Stephen T. Yeung, Nikos Kourtis, Yuling Dai, Kate Corrigan, Luna Zea-Redondo, Anita Saraf, Laurence Florens, Michael P. Washburn, Anastasia N. Tikhonova, Marina Malumbres, Yixiao Gong, Aristotelis Tsirigos, Christopher Park, Christopher Barbieri, Kamal M. Khanna, Luca Busino, Iannis Aifantis

Nat Immunol. Author manuscript; available in PMC 2020 Jul 23.

Published in final edited form as: Nat Immunol. 2019 Sep; 20(9): 1196–1207. Published online 2019 Aug 12. doi: 10.1038/s41590-019-0454-6

PMCID:: PMC7376385

Abstract Article PDF–3.1M

Select item 71369092.

SPOP and cancer: a systematic review

Alison Clark, Marieke Burleson

Am J Cancer Res. 2020; 10(3): 704–726. Published online 2020 Mar 1.

PMCID:: PMC7136909

Abstract Article PDF–944K

Select item 69423843.

The emerging role of SPOP protein in tumorigenesis and cancer therapy

Yizuo Song, Yichi Xu, Chunyu Pan, Linzhi Yan, Zhi-wei Wang, Xueqiong Zhu

Mol Cancer. 2020; 19: 2. Published online 2020 Jan 4. doi: 10.1186/s12943-019-1124-x

PMCID:: PMC6942384

Abstract Article PDF–1.2M

Select item 68030474.

The ubiquitin ligase adaptor SPOP in cancer

Matthew J. Cuneo, Tanja Mittag

FEBS J. Author manuscript; available in PMC 2020 Oct 1.

Published in final edited form as: FEBS J. 2019 Oct; 286(20): 3946–3958. Published online 2019 Sep 18. doi: 10.1111/febs.15056

PMCID:: PMC6803047

Abstract Article PDF–1.5M

Select item 61057345.

Uterine function in the mouse requires speckle-type poz protein

Lan Hai, Maria M Szwarc, Bin He, David M Lonard, Ramakrishna Kommagani, Francesco J DeMayo, John P Lydon

Biol Reprod. 2018 Jun; 98(6): 856–869. Published online 2018 Mar 13. doi: 10.1093/biolre/ioy060

PMCID:: PMC6105734

Abstract Article PDF–29M

Select item 92698856.

A phospho-tyrosine–based signaling module using SPOP, CSK, and LYN controls TLR-induced IRF activity

Kazuki Tawaratsumida, Vanessa Redecke, Ruiqiong Wu, Jeeba Kuriakose, Jill J. Bouchard, Tanja Mittag, Brian K. Lohman, Ashutosh Mishra, Anthony A. High, Hans Häcker

Sci Adv. 2022 Jul; 8(27): eabq0084. Published online 2022 Jul 8. doi: 10.1126/sciadv.abq0084

PMCID:: PMC9269885

Abstract Article PDF–6.3M

Select item 58871637.

SPOP regulates prostate epithelial cell proliferation and promotes ubiquitination and turnover of cMYC oncoprotein

Chuandong Geng, Salma Kaochar, Min Li, Kimal Rajapakshe, Warren Fiskus, Jianrong Dong, Christopher Foley, Boming Dong, Li Zhang, Oh-Joon Kwon, Shrijal S. Shah, Menaka Bolaki, Li Xin, Michael Ittmann, Bert W. O’Malley, Cristian Coarfa, Nicholas Mitsiades

Oncogene. Author manuscript; available in PMC 2018 Apr 6.

Published in final edited form as: Oncogene. 2017 Aug 17; 36(33): 4767–4777. Published online 2017 Apr 17. doi: 10.1038/onc.2017.80

PMCID:: PMC5887163

Abstract Article PDF–3.8M

Select item 29297258.

Serine protease activity contributes to control of Mycobacterium tuberculosis in hypoxic lung granulomas in mice

Stephen T. Reece, Christoph Loddenkemper, David J. Askew, Ulrike Zedler, Sandra Schommer-Leitner, Maik Stein, Fayaz Ahmad Mir, Anca Dorhoi, Hans-Joachim Mollenkopf, Gary A. Silverman, Stefan H.E. Kaufmann

J Clin Invest. 2010 Sep 1; 120(9): 3365–3376. Published online 2010 Aug 2. doi: 10.1172/JCI42796

PMCID:: PMC2929725

Abstract Article PDF–4.7M

Select item 99923479.

Higher-order SPOP assembly reveals a basis for cancer mutant dysregulation

Matthew J. Cuneo, Brian G. O’Flynn, Yu-Hua Lo, Nafiseh Sabri, Tanja Mittag

Mol Cell. Author manuscript; available in PMC 2024 Mar 2.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 731–745.e4. Published online 2023 Jan 23. doi: 10.1016/j.molcel.2022.12.033

PMCID:: PMC9992347

Abstract Article PDF–4.6M

Select item 785473210.

Dual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer

Tiziano Bernasocchi, Geniver El Tekle, Marco Bolis, Azzurra Mutti, Arianna Vallerga, Laura P. Brandt, Filippo Spriano, Tanya Svinkina, Marita Zoma, Valentina Ceserani, Anna Rinaldi, Hana Janouskova, Daniela Bossi, Manuela Cavalli, Simone Mosole, Roger Geiger, Ze Dong, Cai-Guang Yang, Domenico Albino, Andrea Rinaldi, Peter Schraml, Simon Linder, Giuseppina M. Carbone, Andrea Alimonti, Francesco Bertoni, Holger Moch, Steven A. Carr, Wilbert Zwart, Marianna Kruithof-de Julio, Mark A. Rubin, Namrata D. Udeshi, Jean-Philippe P. Theurillat

Nat Commun. 2021; 12: 734. Published online 2021 Feb 2. doi: 10.1038/s41467-020-20820-x

PMCID:: PMC7854732

Abstract Article PDF–4.5M

Select item 722456711.

SPOP promotes ubiquitination and degradation of MyD88 to suppress the innate immune response

Qinghe Li, Fei Wang, Qiao Wang, Na Zhang, Jumei Zheng, Maiqing Zheng, Ranran Liu, Huanxian Cui, Jie Wen, Guiping Zhao

PLoS Pathog. 2020 May; 16(5): e1008188. Published online 2020 May 4. doi: 10.1371/journal.ppat.1008188

PMCID:: PMC7224567

Abstract Article PDF–1.8M

Select item 574953112.

SPOP mutation drives prostate neoplasia without stabilizing oncogenic transcription factor ERG

Jonathan Shoag, Deli Liu, Mirjam Blattner, Andrea Sboner, Kyung Park, Lesa Deonarine, Brian D. Robinson, Juan Miguel Mosquera, Yu Chen, Mark A. Rubin, Christopher E. Barbieri

J Clin Invest. 2018 Jan 2; 128(1): 381–386. Published online 2017 Dec 4. doi: 10.1172/JCI96551

PMCID:: PMC5749531

Abstract Article PDF–9.1M

Select item 279548813.

Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase

Qing Zhang, Qing Shi, Yongbin Chen, Tao Yue, Shuang Li, Bing Wang, Jin Jiang

Proc Natl Acad Sci U S A. 2009 Dec 15; 106(50): 21191–21196. Published online 2009 Dec 2. doi: 10.1073/pnas.0912008106

PMCID:: PMC2795488

Abstract Article PDF–1.6M

Select item 1069646714.

Reduction of oligomer size modulates the competition between cluster formation and phase separation of the tumor suppressor SPOP

Nafiseh Sabri, Matthew J. Cuneo, Melissa R. Marzahn, Jihun Lee, Jill J. Bouchard, Ömer Güllülü, Sivaraja Vaithiyalingam, Madeleine B. Borgia, Jeremy Schmit, Tanja Mittag

J Biol Chem. 2023 Dec; 299(12): 105427. Published online 2023 Nov 4. doi: 10.1016/j.jbc.2023.105427

PMCID:: PMC10696467

Abstract Article PDF–5.1M

Select item 462174515.

SPOP mutation leads to genomic instability in prostate cancer

Gunther Boysen, Christopher E Barbieri, Davide Prandi, Mirjam Blattner, Sung-Suk Chae, Arun Dahija, Srilakshmi Nataraj, Dennis Huang, Clarisse Marotz, Limei Xu, Julie Huang, Paola Lecca, Sagar Chhangawala, Deli Liu, Pengbo Zhou, Andrea Sboner, Johann S de Bono, Francesca Demichelis, Yariv Houvras, Mark A Rubin

eLife. 2015; 4: e09207. Published online 2015 Sep 16. doi: 10.7554/eLife.09207

PMCID:: PMC4621745

Abstract Article PDF–3.0M

Select item 752318816.

AMPK promotes SPOP-mediated NANOG degradation to regulate prostate cancer cell stemness

Xinbo Wang, Jiali Jin, Fangning Wan, Linlin Zhao, Hongshang Chu, Cong Chen, Guanghong Liao, Jian Liu, Yue Yu, Hongqi Teng, Lan Fang, Cong Jiang, Weijuan Pan, Xin Xie, Jia Li, Xiaolin Lu, Xuejun Jiang, Xin Ge, Dingwei Ye, Ping Wang

Dev Cell. Author manuscript; available in PMC 2020 Sep 29.

Published in final edited form as: Dev Cell. 2019 Feb 11; 48(3): 345–360.e7. Published online 2018 Dec 27. doi: 10.1016/j.devcel.2018.11.033