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Select item 68509981.

Impaired glucose tolerance, glucagon, and insulin responses in mice lacking the loop diuretic-sensitive Nkcc2a transporter

Lisa Kelly, Mohammed M. Almutairi, Shams Kursan, Romario Pacheco, Eduardo Dias-Junior, Hayo Castrop, Mauricio Di Fulvio

Am J Physiol Cell Physiol. 2019 Oct 1; 317(4): C843–C856. Published online 2019 Jul 31. doi: 10.1152/ajpcell.00144.2019

PMCID:: PMC6850998

Abstract Article

Select item 60276352.

Renal-specific silencing of TNF unmasks salt-dependent increases in blood pressure via an NKCC2A-dependent mechanism

Shoujin Hao, Mary Hao, Nicholas R. Ferreri

Hypertension. Author manuscript; available in PMC 2019 Jun 1.

Published in final edited form as: Hypertension. 2018 Jun; 71(6): 1117–1125. Published online 2018 May 7. doi: 10.1161/HYPERTENSIONAHA.117.10764

PMCID:: PMC6027635

Abstract Article PDF–1.5M

Select item 42377763.

Standardized, systemic phenotypic analysis of Slc12a1^I299F mutant mice

Elisabeth Kemter, Birgit Rathkolb, Lore Becker, Ines Bolle, Dirk H Busch, Claudia Dalke, Ralf Elvert, Jack Favor, Jochen Graw, Wolfgang Hans, Boris Ivandic, Svetoslav Kalaydjiev, Thomas Klopstock, Ildikó Rácz, Jan Rozman, Anja Schrewe, Holger Schulz, Andreas Zimmer, Helmut Fuchs, Valérie Gailus-Durner, Martin Hrabé de Angelis, Eckhard Wolf, Bernhard Aigner

J Biomed Sci. 2014; 21(1): 68. Published online 2014 Aug 2. doi: 10.1186/s12929-014-0068-0

PMCID:: PMC4237776

Abstract Article PDF–349K

Select item 40005054.

Localization and vasopressin regulation of the Na⁺-K⁺-2Cl^- cotransporter in the distal colonic epithelium

Hong Xue, Zi-Juan Zhang, Xiao-Shuang Li, Hai-Mei Sun, Qian Kang, Bo Wu, Ya-Xi Wang, Wan-Jing Zou, De-Shan Zhou

World J Gastroenterol. 2014 Apr 28; 20(16): 4692–4701. Published online 2014 Apr 28. doi: 10.3748/wjg.v20.i16.4692

PMCID:: PMC4000505

Abstract Article PDF–1.6M

Select item 35222655.

Multiple Evolutionarily Conserved Di-leucine Like Motifs in the Carboxyl Terminus Control the Anterograde Trafficking of NKCC2

Nancy Zaarour, Sylvie Demaretz, Nadia Defontaine, Yingying Zhu, Kamel Laghmani

J Biol Chem. 2012 Dec 14; 287(51): 42642–42653. Published online 2012 Oct 26. doi: 10.1074/jbc.M112.399162

PMCID:: PMC3522265

Abstract Article PDF–2.2M

Select item 27558976.

A Highly Conserved Motif at the COOH Terminus Dictates Endoplasmic Reticulum Exit and Cell Surface Expression of NKCC2

Nancy Zaarour, Sylvie Demaretz, Nadia Defontaine, David Mordasini, Kamel Laghmani

J Biol Chem. 2009 Aug 7; 284(32): 21752–21764. Published online 2009 Jun 17. doi: 10.1074/jbc.M109.000679

PMCID:: PMC2755897

Abstract Article PDF–4.3M

Select item 19252437.

Regulation of the renal-specific Na⁺–K⁺–2Cl⁻ co-transporter NKCC2 by AMP-activated protein kinase (AMPK)

Scott A. Fraser, Ignacio Gimenez, Natasha Cook, Ian Jennings, Marina Katerelos, Frosa Katsis, Vicki Levidiotis, Bruce E. Kemp, David A. Power

Biochem J. 2007 Jul 1; 405(Pt 1): 85–93. Prepublished online 2007 Mar 7. Published online 2007 Jun 13. doi: 10.1042/BJ20061850

PMCID:: PMC1925243

Abstract Article PDF–622K

Select item 258468.

Uncompensated polyuria in a mouse model of Bartter's syndrome

Nobuyuki Takahashi, Daniel R. Chernavvsky, R. Ariel Gomez, Peter Igarashi, Hillel J. Gitelman, Oliver Smithies

Proc Natl Acad Sci U S A. 2000 May 9; 97(10): 5434–5439. Published online 2000 Apr 25. doi: 10.1073/pnas.090091297

PMCID:: PMC25846

Abstract Article PDF–272K

Select item 100855689.

A novel mouse model for an inducible gene modification in the renal thick ascending limb

Laurent Bourqui, Denise V. Winter, Alex Odermatt, Dominique Loffing-Cueni, Johannes Loffing

Am J Physiol Renal Physiol. 2023 May 1; 324(5): F446–F460. Published online 2023 Mar 9. doi: 10.1152/ajprenal.00250.2022

PMCID:: PMC10085568

Abstract Article

Select item 955290910.

Tubular-specific CDK12 knockout causes a defect in urine concentration due to premature cleavage of the slc12a1 gene

Bin Wang, Yao Wang, Yi Wen, Yi-Lin Zhang, Wei-Jie Ni, Tao-Tao Tang, Jing-Yuan Cao, Qing Yin, Wei Jiang, Di Yin, Zuo-Lin Li, Lin-Li Lv, Bi-Cheng Liu

Mol Ther. 2022 Oct 5; 30(10): 3300–3312. Published online 2022 May 16. doi: 10.1016/j.ymthe.2022.05.012

PMCID:: PMC9552909

Abstract Article PDF–5.0M

Select item 698581811.

Regulation of NKCC2B by TNF-α in response to salt restriction

Shoujin Hao, Joseph Salzo, Mary Hao, Nicholas R. Ferreri

Am J Physiol Renal Physiol. 2020 Jan 1; 318(1): F273–F282. Published online 2019 Dec 9. doi: 10.1152/ajprenal.00388.2019

PMCID:: PMC6985818

Abstract Article

Select item 623073612.

With no lysine kinase 4 modulates sodium potassium 2 chloride cotransporter activity in vivo

Andrew S. Terker, Maria Castañeda-Bueno, Mohammed Z. Ferdaus, Ryan J. Cornelius, Kayla J. Erspamer, Xiao-Tong Su, Lauren N. Miller, James A. McCormick, Wen-Hui Wang, Gerardo Gamba, Chao-Ling Yang, David H. Ellison

Am J Physiol Renal Physiol. 2018 Oct 1; 315(4): F781–F790. Published online 2018 Feb 7. doi: 10.1152/ajprenal.00485.2017

PMCID:: PMC6230736

Abstract Article

Select item 474946113.

Interleukin-1 augments salt retention in angiotensin II-induced hypertension via nitric oxide-dependent regulation of the NKCC2 sodium co-transporter

Jiandong Zhang, Nathan P. Rudemiller, Mehul B. Patel, Norah S. Karlovich, Min Wu, Alicia A. McDonough, Robert Griffiths, Matthew A. Sparks, Alexander D. Jeffs, Steven D. Crowley

Cell Metab. Author manuscript; available in PMC 2017 Feb 9.

Published in final edited form as: Cell Metab. 2016 Feb 9; 23(2): 360–368. Published online 2015 Dec 17. doi: 10.1016/j.cmet.2015.11.013

PMCID:: PMC4749461

Abstract Article PDF–689K

Select item 462329814.

Increased Slc12a1 expression in β-cells and improved glucose disposal in Slc12a2 heterozygous mice

Saeed Alshahrani, Mohammed Mashari Almutairi, Shams Kursan, Eduardo Dias-Junior, Mohamed Mahmoud Almiahuob, Lydia Aguilar-Bryan, Mauricio Di Fulvio

J Endocrinol. 2015 Dec; 227(3): 153–165. Prepublished online 2015 Sep 23. doi: 10.1530/JOE-15-0327

PMCID:: PMC4623298

Abstract Article PDF–577K

Select item 360271615.

NKCC2A and NFAT5 regulate renal TNF production induced by hypertonic NaCl intake

Shoujin Hao, Lars Bellner, Nicholas R. Ferreri

Am J Physiol Renal Physiol. 2013 Mar 1; 304(5): F533–F542. Published online 2012 Dec 26. doi: 10.1152/ajprenal.00243.2012

PMCID:: PMC3602716

Abstract Article

Select item 312988716.

Tumor necrosis factor-α is an endogenous inhibitor of Na⁺-K⁺-2Cl⁻ cotransporter (NKCC2) isoform A in the thick ascending limb

Sailaja Battula, Shoujin Hao, Paulina L. Pedraza, Charles T. Stier, Nicholas R. Ferreri

Am J Physiol Renal Physiol. 2011 Jul; 301(1): F94–F100. Published online 2011 Apr 20. doi: 10.1152/ajprenal.00650.2010

PMCID:: PMC3129887

Abstract Article

Select item 305902817.

Secretory Carrier Membrane Protein 2 Regulates Exocytic Insertion of NKCC2 into the Cell Membrane

Nancy Zaarour, Nadia Defontaine, Sylvie Demaretz, Anie Azroyan, Lydie Cheval, Kamel Laghmani

J Biol Chem. 2011 Mar 18; 286(11): 9489–9502. Published online 2011 Jan 4. doi: 10.1074/jbc.M110.166546

PMCID:: PMC3059028

Abstract Article PDF–2.5M

Select item 257614618.

Isoforms of renal Na-K-2Cl cotransporter NKCC2: expression and functional significance

Hayo Castrop, Jurgen Schnermann

Am J Physiol Renal Physiol. 2008 Oct; 295(4): F859–F866. Published online 2008 May 21. doi: 10.1152/ajprenal.00106.2008

PMCID:: PMC2576146

Abstract Article

Select item 423737219.

Uromodulin Retention in Thick Ascending Limb of Henle's Loop Affects SCD1 in Neighboring Proximal Tubule: Renal Transcriptome Studies in Mouse Models of Uromodulin-Associated Kidney Disease

Marion Horsch, Johannes Beckers, Helmut Fuchs, Valérie Gailus-Durner, Martin Hrabě de Angelis, Birgit Rathkolb, Eckhard Wolf, Bernhard Aigner, Elisabeth Kemter

PLoS One. 2014; 9(11): e113125. Published online 2014 Nov 19. doi: 10.1371/journal.pone.0113125

PMCID:: PMC4237372

Abstract Article PDF–890K

Select item 319105920.

Activation of the Bumetanide-sensitive Na⁺,K⁺,2Cl⁻ Cotransporter (NKCC2) Is Facilitated by Tamm-Horsfall Protein in a Chloride-sensitive Manner

Kerim Mutig, Thomas Kahl, Turgay Saritas, Michael Godes, Pontus Persson, James Bates, Hajamohideen Raffi, Luca Rampoldi, Shinichi Uchida, Carsten Hille, Carsten Dosche, Satish Kumar, Maria Castañeda-Bueno, Gerardo Gamba, Sebastian Bachmann

J Biol Chem. 2011 Aug 26; 286(34): 30200–30210. Published online 2011 Jul 7. doi: 10.1074/jbc.M111.222968

PMCID:: PMC3191059

Abstract Article PDF–5.0M

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PMC Links for Gene (Select 20495) (72)
PMC
NAC domain-containing protein 2-like [Citrus sinensis]
NAC domain-containing protein 2-like [Citrus sinensis]
gi|1389618549|ref|XP_024953201.1|

Protein
txid435591[Organism] (22)
GEO DataSets
phosphoglucose isomerase, partial [Hirtodrosophila mediohispida]
phosphoglucose isomerase, partial [Hirtodrosophila mediohispida]
gi|2079607103|gb|QYU72199.1|

Protein
phosphoglucose isomerase, partial [Dichaetophora aff. flava sp.4 (Toda)]
phosphoglucose isomerase, partial [Dichaetophora aff. flava sp.4 (Toda)]
gi|2079607075|gb|QYU72185.1|

Protein

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