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Select item 70109781.

Delineation of a Human Mendelian Disorder of the DNA Demethylation Machinery: TET3 Deficiency

David B. Beck, Ana Petracovici, Chongsheng He, Hannah W. Moore, Raymond J. Louie, Muhammad Ansar, Sofia Douzgou, Sivagamy Sithambaram, Trudie Cottrell, Regie Lyn P. Santos-Cortez, Eloise J. Prijoles, Renee Bend, Boris Keren, Cyril Mignot, Marie-Christine Nougues, Katrin Õunap, Tiia Reimand, Sander Pajusalu, Muhammad Zahid, Muhammad Arif Nadeem Saqib, Julien Buratti, Eleanor G. Seaby, Kirsty McWalter, Aida Telegrafi, Dustin Baldridge, Marwan Shinawi, Suzanne M. Leal, G. Bradley Schaefer, Roger E. Stevenson, Siddharth Banka, Roberto Bonasio, Jill A. Fahrner

Am J Hum Genet. 2020 Feb 6; 106(2): 234–245. Published online 2020 Jan 9. doi: 10.1016/j.ajhg.2019.12.007

PMCID:: PMC7010978

Abstract Article PDF–2.3M

Select item 68161712.

Increased expression of TET3 predicts unfavorable prognosis in patients with ovarian cancer-a bioinformatics integrative analysis

Tiefeng Cao, Wenwei Pan, Xiaoli Sun, Huimin Shen

J Ovarian Res. 2019; 12: 101. Published online 2019 Oct 27. doi: 10.1186/s13048-019-0575-4

PMCID:: PMC6816171

Abstract Article PDF–2.3M

Select item 62914453.

Reduced mRNA and Protein Expression Levels of Tet Methylcytosine Dioxygenase 3 in Endothelial Progenitor Cells of Patients of Type 2 Diabetes With Peripheral Artery Disease

Shi Zhao, Ting Jia, Yang Tang, Xiaotong Zhang, Hong Mao, Xiaojia Tian, Rui Li, Lu Ma, Guoxun Chen

Front Immunol. 2018; 9: 2859. Published online 2018 Dec 6. doi: 10.3389/fimmu.2018.02859

PMCID:: PMC6291445

Abstract Article PDF–823K

Select item 55476034.

Methylcytosine dioxygenase TET3 interacts with thyroid hormone nuclear receptors and stabilizes their association to chromatin

Wenyue Guan, Romain Guyot, Jacques Samarut, Frédéric Flamant, Jiemin Wong, Karine Cécile Gauthier

Proc Natl Acad Sci U S A. 2017 Aug 1; 114(31): 8229–8234. Published online 2017 Jul 17. doi: 10.1073/pnas.1702192114

PMCID:: PMC5547603

Abstract Article PDF–1.0M

Select item 42705855.

TET3 mediates the activation of human hepatic stellate cells via modulating the expression of long non-coding RNA HIF1A-AS1

Qing-Qing Zhang, Ming-Yi Xu, Yin Qu, Jun-Jie Hu, Zheng-Hong Li, Qi-Di Zhang, Lun-Gen Lu

Int J Clin Exp Pathol. 2014; 7(11): 7744–7751. Published online 2014 Oct 15.

PMCID:: PMC4270585

Abstract Article PDF–1.4M

Select item 95251196.

TET3 epigenetically controls feeding and stress response behaviors via AGRP neurons

Di Xie, Bernardo Stutz, Feng Li, Fan Chen, Haining Lv, Matija Sestan-Pesa, Jonatas Catarino, Jianlei Gu, Hongyu Zhao, Christopher E. Stoddard, Gordon G. Carmichael, Marya Shanabrough, Hugh S. Taylor, Zhong-Wu Liu, Xiao-Bing Gao, Tamas L. Horvath, Yingqun Huang

J Clin Invest. 2022 Oct 3; 132(19): e162365. Published online 2022 Oct 3. doi: 10.1172/JCI162365

PMCID:: PMC9525119

Abstract Article PDF–3.3M

Select item 87086917.

TET3- and OGT-Dependent Expression of Genes Involved in Epithelial-Mesenchymal Transition in Endometrial Cancer

Piotr Ciesielski, Paweł Jóźwiak, Ewa Forma, Anna Krześlak

Int J Mol Sci. 2021 Dec; 22(24): 13239. Published online 2021 Dec 8. doi: 10.3390/ijms222413239

PMCID:: PMC8708691

Abstract Article PDF–2.2M

Select item 82538198.

Redirected nuclear glutamate dehydrogenase supplies Tet3 with α-ketoglutarate in neurons

Franziska R. Traube, Dilara Özdemir, Hanife Sahin, Constanze Scheel, Andrea F. Glück, Anna S. Geserich, Sabine Oganesian, Sarantos Kostidis, Katharina Iwan, René Rahimoff, Grazia Giorgio, Markus Müller, Fabio Spada, Martin Biel, Jürgen Cox, Martin Giera, Stylianos Michalakis, Thomas Carell

Nat Commun. 2021; 12: 4100. Published online 2021 Jul 2. doi: 10.1038/s41467-021-24353-9

PMCID:: PMC8253819

Abstract Article PDF–5.2M

Select item 70636789.

A Positive Feedback Loop of TET3 and TGF-β1 Promotes Liver Fibrosis

Yetao Xu, Xiaoli Sun, Ruling Zhang, Tiefeng Cao, Shi-Ying Cai, James L. Boyer, Xuchen Zhang, Da Li, Yingqun Huang

Cell Rep. Author manuscript; available in PMC 2020 Mar 10.

Published in final edited form as: Cell Rep. 2020 Feb 4; 30(5): 1310–1318.e5. doi: 10.1016/j.celrep.2019.12.092

PMCID:: PMC7063678

Abstract Article PDF–2.0M

Select item 699835810.

Epigenetic induction of tumor stemness via the lipopolysaccharide-TET3-HOXB2 signaling axis in esophageal squamous cell carcinoma

Fengkai Xu, Zhonghe Liu, Ronghua Liu, Chunlai Lu, Lin Wang, Wei Mao, Qiaoliang Zhu, Huankai Shou, Kunpeng Zhang, Yin Li, Yiwei Chu, Jie Gu, Di Ge

Cell Commun Signal. 2020; 18: 17. Published online 2020 Feb 3. doi: 10.1186/s12964-020-0510-8

PMCID:: PMC6998358

Abstract Article PDF–7.8M

Select item 538387111.

Distinct roles for TET family proteins in regulating human erythropoiesis

Hongxia Yan, Yaomei Wang, Xiaoli Qu, Jie Li, John Hale, Yumin Huang, Chao An, Julien Papoin, Xinhua Guo, Lixiang Chen, Qiaozhen Kang, Wei Li, Vincent P. Schulz, Patrick G. Gallagher, Christopher D. Hillyer, Narla Mohandas, Xiuli An

Blood. 2017 Apr 6; 129(14): 2002–2012. Prepublished online 2017 Feb 6. doi: 10.1182/blood-2016-08-736587

PMCID:: PMC5383871

Abstract Article

Select item 535212212.

Epigenetic silencing of TET2 and TET3 induces an EMT-like process in melanoma

Fuxing Gong, Yu Guo, Yiqian Niu, Jiawei Jin, Xiaojuan Zhang, Xiaoqian Shi, Limeng Zhang, Runting Li, Longxin Chen, Runlin Z. Ma

Oncotarget. 2017 Jan 3; 8(1): 315–328. Published online 2016 Nov 12. doi: 10.18632/oncotarget.13324

PMCID:: PMC5352122

Abstract Article PDF–6.9M

Select item 508698913.

Retinol and ascorbate drive erasure of epigenetic memory and enhance reprogramming to naïve pluripotency by complementary mechanisms

Timothy Alexander Hore, Ferdinand von Meyenn, Mirunalini Ravichandran, Martin Bachman, Gabriella Ficz, David Oxley, Fátima Santos, Shankar Balasubramanian, Tomasz P. Jurkowski, Wolf Reik

Proc Natl Acad Sci U S A. 2016 Oct 25; 113(43): 12202–12207. Published online 2016 Oct 11. doi: 10.1073/pnas.1608679113

PMCID:: PMC5086989

Abstract Article PDF–1.1M

Select item 485570514.

TET3 inhibits TGF-β1-induced epithelial-mesenchymal transition by demethylating miR-30d precursor gene in ovarian cancer cells

Zhongxue Ye, Jie Li, Xi Han, Huilian Hou, He Chen, Xia Zheng, Jiaojiao Lu, Lijie Wang, Wei Chen, Xu Li, Le Zhao

J Exp Clin Cancer Res. 2016; 35: 72. Published online 2016 May 4. doi: 10.1186/s13046-016-0350-y

PMCID:: PMC4855705

Abstract Article PDF–2.2M

Select item 475919915.

Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes

Tuomas Laukka, Christopher J. Mariani, Tuukka Ihantola, John Z. Cao, Juho Hokkanen, William G. Kaelin, Jr., Lucy A. Godley, Peppi Koivunen

J Biol Chem. 2016 Feb 19; 291(8): 4256–4265. Published online 2015 Dec 23. doi: 10.1074/jbc.M115.688762

PMCID:: PMC4759199

Abstract Article PDF–1.7M

Select item 474284316.

Downregulation of TLX induces TET3 expression and inhibits glioblastoma stem cell self-renewal and tumorigenesis

Qi Cui, Su Yang, Peng Ye, E. Tian, Guoqiang Sun, Jiehua Zhou, Guihua Sun, Xiaoxuan Liu, Chao Chen, Kiyohito Murai, Chunnian Zhao, Krist T. Azizian, Lu Yang, Charles Warden, Xiwei Wu, Massimo D'Apuzzo, Christine Brown, Behnam Badie, Ling Peng, Arthur D. Riggs, John J. Rossi, Yanhong Shi

Nat Commun. 2016; 7: 10637. Published online 2016 Feb 3. doi: 10.1038/ncomms10637

PMCID:: PMC4742843

Abstract Article PDF–3.5M

Select item 1122941717.

Stage-specific regulation of DNA methylation by TET enzymes during human cardiac differentiation

Yahui Lan, Kelly M. Banks, Heng Pan, Nipun Verma, Gary R. Dixon, Ting Zhou, Bo Ding, Olivier Elemento, Shuibing Chen, Danwei Huangfu, Todd Evans

Cell Rep. Author manuscript; available in PMC 2024 Jul 8.

Published in final edited form as: Cell Rep. 2021 Dec 7; 37(10): 110095. doi: 10.1016/j.celrep.2021.110095

PMCID:: PMC11229417

Abstract Article PDF–3.1M

Select item 970583518.

Overexpression of Long Non-Coding RNA MIR22HG Represses Proliferation and Enhances Apoptosis via miR-629-5p/TET3 Axis in Osteosarcoma Cells

Haoliang Zhao, Ming Zhang, Xuejing Yang, Dong Song

J Microbiol Biotechnol. 2021 Oct 28; 31(10): 1331–1342. Published online 2021 Aug 9. doi: 10.4014/jmb.2106.06028

PMCID:: PMC9705835

Abstract Article PDF–4.9M

Select item 799855019.

Glyphosate and AMPA Induce Alterations in Expression of Genes Involved in Chromatin Architecture in Human Peripheral Blood Mononuclear Cells (In Vitro)

Ewelina Woźniak, Edyta Reszka, Ewa Jabłońska, Jaromir Michałowicz, Bogumiła Huras, Bożena Bukowska

Int J Mol Sci. 2021 Mar; 22(6): 2966. Published online 2021 Mar 15. doi: 10.3390/ijms22062966

PMCID:: PMC7998550

Abstract Article PDF–1.0M

Select item 706009820.

Integrin α6 signaling induces STAT3-TET3-mediated hydroxymethylation of genes critical for maintenance of glioma stem cells

Andreas Herrmann, Christoph Lahtz, Jieun Song, Maryam Aftabizadeh, Gregory A. Cherryholmes, Hong Xin, Tomasz Adamus, Heehyoung Lee, David Grunert, Brian Armstrong, Peiguo Chu, Christine Brown, Michael Lim, Stephen Forman, Hua Yu

Oncogene. Author manuscript; available in PMC 2020 Jun 9.

Published in final edited form as: Oncogene. 2020 Mar; 39(10): 2156–2169. Published online 2019 Dec 9. doi: 10.1038/s41388-019-1134-6

PMCID:: PMC7060098

Abstract Article PDF–2.6M

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