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Select item 111666531.

Construction of a nomogram for predicting HNSCC distant metastasis and identification of EIF5A as a hub gene

Xin Chen, Ying Zhang, Sheng Chen, Yan Yang, Guowen Sun, Peng Pan

Sci Rep. 2024; 14: 13367. Published online 2024 Jun 11. doi: 10.1038/s41598-024-64197-z

PMCID:: PMC11166653

Abstract Article PDF–9.1M

Select item 99138142.

Renal Ischemia Tolerance Mediated by eIF5A Hypusination Inhibition Is Regulated by a Specific Modulation of the Endoplasmic Reticulum Stress

Nicolas Melis, Isabelle Rubera, Sebastien Giraud, Marc Cougnon, Christophe Duranton, Mallorie Poet, Gisèle Jarretou, Raphaël Thuillier, Laurent Counillon, Thierry Hauet, Luc Pellerin, Michel Tauc, Didier F. Pisani

Cells. 2023 Feb; 12(3): 409. Published online 2023 Jan 25. doi: 10.3390/cells12030409

PMCID:: PMC9913814

Abstract Article PDF–3.6M

Select item 91173713.

Post-translational formation of hypusine in eIF5A: implications in human neurodevelopment

Myung Hee Park, Rajesh Kumar Kar, Siddharth Banka, Alban Ziegler, Wendy K. Chung

Amino Acids. 2022; 54(4): 485–499. Published online 2021 Jul 17. doi: 10.1007/s00726-021-03023-6

PMCID:: PMC9117371

Abstract Article PDF–1.9M

Select item 76661544.

A translational program that suppresses metabolism to shield the genome

Nathan C. Balukoff, J. J. David Ho, Phaedra R. Theodoridis, Miling Wang, Michael Bokros, Lis M. Llanio, Jonathan R. Krieger, Jonathan H. Schatz, Stephen Lee

Nat Commun. 2020; 11: 5755. Published online 2020 Nov 13. doi: 10.1038/s41467-020-19602-2

PMCID:: PMC7666154

Abstract Article PDF–2.7M

Select item 69170435.

Suppression of Ribosomal Pausing by eIF5A Is Necessary to Maintain the Fidelity of Start Codon Selection

Hema Manjunath, He Zhang, Frederick Rehfeld, Jaeil Han, Tsung-Cheng Chang, Joshua T. Mendell

Cell Rep. Author manuscript; available in PMC 2019 Dec 17.

Published in final edited form as: Cell Rep. 2019 Dec 3; 29(10): 3134–3146.e6. doi: 10.1016/j.celrep.2019.10.129

PMCID:: PMC6917043

Abstract Article PDF–1.5M

Select item 61340746.

EIF5A1 promotes trophoblast migration and invasion via ARAF-mediated activation of the integrin/ERK signaling pathway

Jing Zhang, Hui-Qin Mo, Fu-Ju Tian, Wei-Hong Zeng, Xiao-Rui Liu, Xiao-Ling Ma, Xiao Li, Shi Qin, Cui-Fang Fan, Yi Lin

Cell Death Dis. 2018 Sep; 9(9): 926. Published online 2018 Sep 11. doi: 10.1038/s41419-018-0971-5

PMCID:: PMC6134074

Abstract Article PDF–2.9M

Select item 48675787.

Global quantitative proteomics reveal up-regulation of endoplasmic reticulum stress response proteins upon depletion of eIF5A in HeLa cells

Ajeet Mandal, Swati Mandal, Myung Hee Park

Sci Rep. 2016; 6: 25795. Published online 2016 May 16. doi: 10.1038/srep25795

PMCID:: PMC4867578

Abstract Article PDF–1.6M

Select item 47456538.

Blocking eIF5A Modification in Cervical Cancer Cells Alters the Expression of Cancer-Related Genes and Suppresses Cell Proliferation

Elisabeth Mémin, Mainul Hoque, Mohit R. Jain, Debra S. Heller, Hong Li, Bernadette Cracchiolo, Hartmut M. Hanauske-Abel, Tsafi Pe’ery, Michael B. Mathews

Cancer Res. Author manuscript; available in PMC 2016 Feb 8.

Published in final edited form as: Cancer Res. 2014 Jan 15; 74(2): 552–562. Published online 2013 Nov 12. doi: 10.1158/0008-5472.CAN-13-0474

PMCID:: PMC4745653

Abstract Article PDF–992K

Select item 47325239.

The translation factor eIF5A and human cancer

Michael B. Mathews, John W. B. Hershey

Biochim Biophys Acta. Author manuscript; available in PMC 2016 Jul 1.

Published in final edited form as: Biochim Biophys Acta. 2015 Jul; 1849(7): 836–844. Published online 2015 May 13. doi: 10.1016/j.bbagrm.2015.05.002

PMCID:: PMC4732523

Abstract Article PDF–513K

Select item 470600610.

Eukaryotic Translation Initiation Factor 5A (EIF5A) Regulates Pancreatic Cancer Metastasis by Modulating RhoA and Rho-associated Kinase (ROCK) Protein Expression Levels

Ken Fujimura, Sunkyu Choi, Meghan Wyse, Jan Strnadel, Tracy Wright, Richard Klemke

J Biol Chem. 2015 Dec 11; 290(50): 29907–29919. Published online 2015 Oct 19. doi: 10.1074/jbc.M115.687418

PMCID:: PMC4706006

Abstract Article PDF–2.0M

Select item 368216111.

Down-regulation of eIF5A-2 prevents epithelial-mesenchymal transition in non-small-cell lung cancer cells

Guo-dong Xu, Xin-bao Shi, Le-bo Sun, Qing-yun Zhou, Da-wei Zheng, Huo-shun Shi, Yong-liang Che, Zi-shan Wang, Guo-feng Shao

J Zhejiang Univ Sci B. 2013 Jun; 14(6): 460–467. doi: 10.1631/jzus.B1200200

PMCID:: PMC3682161

Abstract Article PDF–735K

Select item 300359812.

Inactivation of eukaryotic initiation factor 5A (eIF5A) by specific acetylation of its hypusine residue by spermidine/spermine acetyltransferase 1 (SSAT1)

Seung Bum LEE, Jong Hwan PARK, J.E. FOLK, Jason A. DECK, Anthony E. PEGG, Masaaki SOKABE, Christopher S. FRASER, Myung Hee PARK

Biochem J. Author manuscript; available in PMC 2010 Dec 17.

Published in final edited form as: Biochem J. 2010 Dec 15; 433(1): 205–213. doi: 10.1042/BJ20101322

PMCID:: PMC3003598

Abstract Article PDF–588K

Select item 277051813.

Inhibition of HIV-1 gene expression by Ciclopirox and Deferiprone, drugs that prevent hypusination of eukaryotic initiation factor 5A

Mainul Hoque, Hartmut M Hanauske-Abel, Paul Palumbo, Deepti Saxena, Darlene D'Alliessi Gandolfi, Myung Hee Park, Tsafi Pe'ery, Michael B Mathews

Retrovirology. 2009; 6: 90. Published online 2009 Oct 13. doi: 10.1186/1742-4690-6-90

PMCID:: PMC2770518

Abstract Article PDF–955K

Select item 273770814.

The effect of hypusine modification on the intracellular localization of eIF5A

Seung Bum Lee, Jong Hwan Park, Jorn Kaevel, Monika Sramkova, Roberto Weigert, Myung Hee Park

Biochem Biophys Res Commun. Author manuscript; available in PMC 2010 Jun 12.

Published in final edited form as: Biochem Biophys Res Commun. 2009 Jun 12; 383(4): 497–502. Published online 2009 Apr 18. doi: 10.1016/j.bbrc.2009.04.049

PMCID:: PMC2737708

Abstract Article PDF–1.9M

Select item 253660815.

MUTATIONAL ANALYSES OF HUMAN eIF5A-1: IDENTIFICATION OF AMINO ACID RESIDUES CRITICAL FOR HYPUSINE MODIFICATION AND eIF5A ACTIVITY*

Veridiana S. P. Cano, Geoung A Jeon, Hans E. Johansson, C. Allen Henderson, Jong-Hwan Park, Sandro R. Valentini, John W. B. Hershey, Myung Hee Park

FEBS J. Author manuscript; available in PMC 2008 Sep 15.

Published in final edited form as: FEBS J. 2008 Jan; 275(1): 44–58. Published online 2007 Dec 6. doi: 10.1111/j.1742-4658.2007.06172.x

PMCID:: PMC2536608

Abstract Article PDF–2.9M

Select item 1047170416.

Targeted inhibition of eIF5A^hpu suppresses tumor growth and polarization of M2-like tumor-associated macrophages in oral cancer

Jincheng Zeng, Ziyu Ye, Shihong Shi, Yanfang Liang, Qingyu Meng, Qunzhou Zhang, Anh D. Le

Cell Death Dis. 2023 Aug; 14(8): 579. Published online 2023 Aug 31. doi: 10.1038/s41419-023-06109-z

PMCID:: PMC10471704

Abstract Article PDF–7.7M

Select item 1009392117.

Comparison of Human Eukaryotic Translation Initiation Factors 5A1 and 5AL1: Identification of Amino Acid Residues Important for EIF5A1 Lysine 50 Hypusination and Its Protein Stability

Yu-Yao Wu, Gao-Qi Wu, Na-Li Cai, Yan-Ming Xu, Andy T. Y. Lau

Int J Mol Sci. 2023 Apr; 24(7): 6067. Published online 2023 Mar 23. doi: 10.3390/ijms24076067

PMCID:: PMC10093921

Abstract Article PDF–3.3M

Select item 1004282118.

Cryo-EM structure of human eIF5A-DHS complex reveals the molecular basis of hypusination-associated neurodegenerative disorders

Elżbieta Wątor, Piotr Wilk, Artur Biela, Michał Rawski, Krzysztof M. Zak, Wieland Steinchen, Gert Bange, Sebastian Glatt, Przemysław Grudnik

Nat Commun. 2023; 14: 1698. Published online 2023 Mar 27. doi: 10.1038/s41467-023-37305-2

PMCID:: PMC10042821

Abstract Article PDF–7.9M

Select item 786490219.

Impaired eIF5A function causes a Mendelian disorder that is partially rescued in model systems by spermidine

Víctor Faundes, Martin D. Jennings, Siobhan Crilly, Sarah Legraie, Sarah E. Withers, Sara Cuvertino, Sally J. Davies, Andrew G. L. Douglas, Andrew E. Fry, Victoria Harrison, Jeanne Amiel, Daphné Lehalle, William G. Newman, Patricia Newkirk, Judith Ranells, Miranda Splitt, Laura A. Cross, Carol J. Saunders, Bonnie R. Sullivan, Jorge L. Granadillo, Christopher T. Gordon, Paul R. Kasher, Graham D. Pavitt, Siddharth Banka

Nat Commun. 2021; 12: 833. Published online 2021 Feb 5. doi: 10.1038/s41467-021-21053-2

PMCID:: PMC7864902

Abstract Article PDF–5.5M

Select item 772939620.

Blockade of EIF5A hypusination limits colorectal cancer growth by inhibiting MYC elongation

Sonia Coni, Silvia Maria Serrao, Zuleyha Nihan Yurtsever, Laura Di Magno, Rosa Bordone, Camilla Bertani, Valerio Licursi, Zaira Ianniello, Paola Infante, Marta Moretti, Marialaura Petroni, Francesca Guerrieri, Alessandro Fatica, Alberto Macone, Enrico De Smaele, Lucia Di Marcotullio, Giuseppe Giannini, Marella Maroder, Enzo Agostinelli, Gianluca Canettieri

Cell Death Dis. 2020 Dec; 11(12): 1045. Published online 2020 Dec 10. doi: 10.1038/s41419-020-03174-6

PMCID:: PMC7729396

Abstract Article PDF–2.2M

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