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Select item 107467861.

Loss-of-function cancer-linked mutations in the EIF4G2 non-canonical translation initiation factor

Sara Meril, Marcela Bahlsen, Miriam Eisenstein, Alon Savidor, Yishai Levin, Shani Bialik, Shmuel Pietrokovski, Adi Kimchi

Life Sci Alliance. 2024 Mar; 7(3): e202302338. Published online 2023 Dec 21. doi: 10.26508/lsa.202302338

PMCID:: PMC10746786

Abstract Article PDF–1.9M

Select item 99776662.

Eukaryotic translation initiation factor eIF4G2 opens novel paths for protein synthesis in development, apoptosis and cell differentiation

Yudi Liu, Jiuwei Cui, Andrew R. Hoffman, Ji‐Fan Hu

Cell Prolif. 2023 Mar; 56(3): e13367. Published online 2022 Dec 22. doi: 10.1111/cpr.13367

PMCID:: PMC9977666

Abstract Article PDF–1.5M

Select item 94797413.

DAP5 drives translation of specific mRNA targets with upstream ORFs in human embryonic stem cells

Maya David, Tsviya Olender, Orel Mizrahi, Shira Weingarten-Gabbay, Gilgi Friedlander, Sara Meril, Nadav Goldberg, Alon Savidor, Yishai Levin, Vered Salomon, Noam Stern-Ginossar, Shani Bialik, Adi Kimchi

RNA. 2022 Oct; 28(10): 1325–1336. doi: 10.1261/rna.079194.122

PMCID:: PMC9479741

Abstract Article PDF–2.4M

Select item 68025104.

The mammalian host protein DAP5 facilitates the initial round of translation of Coxsackievirus B3 RNA

Pratik Dave, Biju George, Harsha Raheja, Priya Rani, Padmanava Behera, Saumitra Das

J Biol Chem. 2019 Oct 18; 294(42): 15386–15394. Published online 2019 Aug 27. doi: 10.1074/jbc.RA119.009000

PMCID:: PMC6802510

Abstract Article PDF–1.3M

Select item 64714405.

circEIF4G2 modulates the malignant features of cervical cancer via the miR-218/HOXA1 pathway

Yifan Mao, Liya Zhang, Yuan Li

Mol Med Rep. 2019 May; 19(5): 3714–3722. Published online 2019 Mar 14. doi: 10.3892/mmr.2019.10032

PMCID:: PMC6471440

Abstract Article PDF–1.5M

Select item 50662416.

Cap-independent translation by DAP5 controls cell fate decisions in human embryonic stem cells

Yael Yoffe, Maya David, Rinat Kalaora, Lital Povodovski, Gilgi Friedlander, Ester Feldmesser, Elena Ainbinder, Ann Saada, Shani Bialik, Adi Kimchi

Genes Dev. 2016 Sep 1; 30(17): 1991–2004. doi: 10.1101/gad.285239.116

PMCID:: PMC5066241

Abstract Article PDF–1.6M

Select item 48321017.

Cleavage of DAP5 by coxsackievirus B3 2A protease facilitates viral replication and enhances apoptosis by altering translation of IRES-containing genes

P J Hanson, X Ye, Y Qiu, H M Zhang, M G Hemida, F Wang, T Lim, A Gu, B Cho, H Kim, G Fung, D J Granville, D Yang

Cell Death Differ. 2016 May; 23(5): 828–840. Published online 2015 Nov 20. doi: 10.1038/cdd.2015.145

PMCID:: PMC4832101

Abstract Article PDF–11M

Select item 28055268.

Crystallization and preliminary X-ray diffraction analysis of the MIF4G domain of DAP5

Filipp Frank, Geneviève Virgili, Nahum Sonenberg, Bhushan Nagar

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Jan 1; 66(Pt 1): 15–19. Published online 2009 Dec 25. doi: 10.1107/S1744309109044315

PMCID:: PMC2805526

Abstract Article PDF–590K

Select item 3127599.

Suppression of cap-dependent translation in mitosis

Stéphane Pyronnet, Josée Dostie, Nahum Sonenberg

Genes Dev. 2001 Aug 15; 15(16): 2083–2093. doi: 10.1101/gad.889201

PMCID:: PMC312759

Abstract Article PDF–258K

Select item 23188710.

DAP-5, a novel homolog of eukaryotic translation initiation factor 4G isolated as a putative modulator of gamma interferon-induced programmed cell death.

N Levy-Strumpf, L P Deiss, H Berissi, A Kimchi

Mol Cell Biol. 1997 Mar; 17(3): 1615–1625. doi: 10.1128/mcb.17.3.1615

PMCID:: PMC231887

Summary PDF–994K

Select item 1089564811.

Breast cancer cell mesenchymal transition and metastasis directed by DAP5/eIF3d-mediated selective mRNA translation

Amandine Alard, Olga Katsara, Tiffany Rios-Fuller, Columba de la Parra, Ugur Ozerdem, Amanda Ernlund, Robert J. Schneider

Cell Rep. Author manuscript; available in PMC 2024 Feb 26.

Published in final edited form as: Cell Rep. 2023 Jun 27; 42(6): 112646. Published online 2023 Jun 13. doi: 10.1016/j.celrep.2023.112646

PMCID:: PMC10895648

Abstract Article PDF–3.2M

Select item 1086029912.

MicroRNA-877-5p promotes osteoblast differentiation by targeting EIF4G2 expression

YingChao Shen, Yang Zhang, Qiang Wang, Bo Jiang, XiaoWei Jiang, Bin Luo

J Orthop Surg Res. 2024; 19: 134. Published online 2024 Feb 12. doi: 10.1186/s13018-023-04396-y

PMCID:: PMC10860299

Abstract Article PDF–4.8M

Select item 1032589113.

Translational fidelity screens in mammalian cells reveal eIF3 and eIF4G2 as regulators of start codon selectivity

Richard She, Jingchuan Luo, Jonathan S Weissman

Nucleic Acids Res. 2023 Jul 7; 51(12): 6355–6369. Published online 2023 May 5. doi: 10.1093/nar/gkad329

PMCID:: PMC10325891

Abstract Article PDF–1.4M

Select item 880999614.

Long non-coding RNA (LncRNA) SNHG7/ Eukaryotic translation initiation factor 4 gamma 2 (EIF4G2) involves in the malignant events of ovarian cancer cells with paclitaxel resistant

Jin Zhang, Rui Zhang, Yongju Ye

Bioengineered. 2021; 12(2): 10541–10552. Published online 2021 Dec 1. doi: 10.1080/21655979.2021.1999555

PMCID:: PMC8809996

Abstract Article PDF–3.9M

Select item 863291815.

A DAP5/eIF3d alternate mRNA translation mechanism promotes differentiation and immune suppression by human regulatory T cells

Viviana Volta, Sandra Pérez-Baos, Columba de la Parra, Olga Katsara, Amanda Ernlund, Sophie Dornbaum, Robert J. Schneider

Nat Commun. 2021; 12: 6979. Published online 2021 Nov 30. doi: 10.1038/s41467-021-27087-w

PMCID:: PMC8632918

Abstract Article PDF–2.6M

Select item 785210216.

MiR-144-3p-mediated dysregulation of EIF4G2 contributes to the development of hepatocellular carcinoma through the ERK pathway

Shuangshuang Li, Jiajia Shao, Guohua Lou, Chao Wu, Yanning Liu, Min Zheng

J Exp Clin Cancer Res. 2021; 40: 53. Published online 2021 Feb 1. doi: 10.1186/s13046-021-01853-6

PMCID:: PMC7852102

Abstract Article PDF–4.4M

Select item 749498617.

MicroRNA-197 regulates chondrocyte proliferation, migration, and inflammation in pathogenesis of osteoarthritis by targeting EIF4G2

Shijie Gao, Liang Liu, Shibo Zhu, Dawei Wang, Qiang Wu, Guangzhi Ning, Shiqing Feng

Biosci Rep. 2020 Sep 30; 40(9): BSR20192095. Published online 2020 Sep 16. doi: 10.1042/BSR20192095

PMCID:: PMC7494986

Abstract Article PDF–1.5M

Select item 745009718.

5′-UTR recruitment of the translation initiation factor eIF4GI or DAP5 drives cap-independent translation of a subset of human mRNAs

Solomon A. Haizel, Usha Bhardwaj, Ruben L. Gonzalez, Jr., Somdeb Mitra, Dixie J. Goss

J Biol Chem. 2020 Aug 14; 295(33): 11693–11706. Published online 2020 Jun 22. doi: 10.1074/jbc.RA120.013678

PMCID:: PMC7450097

Abstract Article PDF–3.0M

Select item 390729719.

Down-Regulation of eIF4GII by miR-520c-3p Represses Diffuse Large B Cell Lymphoma Development

Krystyna Mazan-Mamczarz, X. Frank Zhao, Bojie Dai, James J. Steinhardt, Raymond J. Peroutka, Kimberly L. Berk, Ari L. Landon, Mariola Sadowska, Yongqing Zhang, Elin Lehrmann, Kevin G. Becker, Rita Shaknovich, Zhenqiu Liu, Ronald B. Gartenhaus

PLoS Genet. 2014 Jan; 10(1): e1004105. Published online 2014 Jan 30. doi: 10.1371/journal.pgen.1004105