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Select item 111666011.

Sonic Hedgehog activates prostaglandin signaling to stabilize primary cilium length

Shariq S. Ansari, Miriam E. Dillard, Yan Zhang, Mary Ashley Austria, Naoko Boatwright, Elaine L. Shelton, Daniel P. Stewart, Amanda Johnson, Christina E. Wang, Brandon M. Young, Zoran Rankovic, Baranda S. Hansen, Shondra M. Pruett-Miller, Alexandre F. Carisey, John D. Schuetz, Camenzind G. Robinson, Stacey K. Ogden

J Cell Biol. 2024 Sep 2; 223(9): e202306002. Published online 2024 Jun 10. doi: 10.1083/jcb.202306002

PMCID:: PMC11166601

Abstract Article PDF–7.3M

Select item 106430042.

A novel role for PGE₂-EP₄ in the developmental programming of the mouse ductus arteriosus: consequences for vessel maturation and function

Michael T. Yarboro, Naoko Boatwright, Deanna C. Sekulich, Christopher W. Hooper, Ting Wong, Stanley D. Poole, Courtney D. Berger, Alexus J. Brown, Christopher S. Jetter, Jennifer M. S. Sucre, Elaine L. Shelton, Jeff Reese

Am J Physiol Heart Circ Physiol. 2023 Oct 1; 325(4): H687–H701. Published online 2023 Aug 11. doi: 10.1152/ajpheart.00294.2023

PMCID:: PMC10643004

Abstract Article

Select item 75103603.

EP4 signalling is essential for controlling islet inflammation by causing a shift in macrophage polarization in obesity/type 2 diabetes

Mika Yasui-Kato, Suthomwong Patlada, Masayuki Yokode, Kaeko Kamei, Manabu Minami

Diab Vasc Dis Res. 2020 Jul-Aug; 17(4): 1479164120945675. Published online 2020 Jul 28. doi: 10.1177/1479164120945675

PMCID:: PMC7510360

Abstract Article PDF–1.2M

Select item 74062484.

Endothelial cell prostaglandin E₂ receptor EP4 is essential for blood pressure homeostasis

Hu Xu, Bingying Fang, Shengnan Du, Sailun Wang, Qingwei Li, Xiao Jia, Chengzhen Bao, Lan Ye, Xue Sui, Lei Qian, Zhilin Luan, Guangrui Yang, Feng Zheng, Nanping Wang, Lihong Chen, Xiaoyan Zhang, Youfei Guan

JCI Insight. 2020 Jul 9; 5(13): e138505. Published online 2020 Jul 9. doi: 10.1172/jci.insight.138505

PMCID:: PMC7406248

Abstract Article PDF–4.4M

Select item 68115355.

Epithelial EP4 plays an essential role in maintaining homeostasis in colon

Yoshihide Matsumoto, Yuki Nakanishi, Takuto Yoshioka, Yuichi Yamaga, Tomonori Masuda, Yuichi Fukunaga, Makoto Sono, Takaaki Yoshikawa, Munemasa Nagao, Osamu Araki, Satoshi Ogawa, Norihiro Goto, Yukiko Hiramatsu, Richard M. Breyer, Akihisa Fukuda, Hiroshi Seno

Sci Rep. 2019; 9: 15244. Published online 2019 Oct 23. doi: 10.1038/s41598-019-51639-2

PMCID:: PMC6811535

Abstract Article PDF–2.3M

Select item 64867606.

VSMC-specific EP4 deletion exacerbates angiotensin II-induced aortic dissection by increasing vascular inflammation and blood pressure

Hu Xu, Shengnan Du, Bingying Fang, Chaojie Li, Xiao Jia, Senfeng Zheng, Sailun Wang, Qingwei Li, Wen Su, Nanping Wang, Feng Zheng, Lihong Chen, Xiaoyan Zhang, Jan-Åke Gustafsson, Youfei Guan

Proc Natl Acad Sci U S A. 2019 Apr 23; 116(17): 8457–8462. Published online 2019 Apr 4. doi: 10.1073/pnas.1902119116

PMCID:: PMC6486760

Abstract Article PDF–1.5M

Select item 61173077.

Application of a dye-based mitochondrion-thermometry to determine the receptor downstream of prostaglandin E₂ involved in the regulation of hepatocyte metabolism

Lei Shen, Tao-Rong Xie, Run-Zhou Yang, Yan Chen, Jian-Sheng Kang

Sci Rep. 2018; 8: 13065. Published online 2018 Aug 30. doi: 10.1038/s41598-018-31356-y

PMCID:: PMC6117307

Abstract Article PDF–6.8M

Select item 59405728.

Overexpression of Prostaglandin E2 EP4 Receptor Improves Cardiac Function after Myocardial Infarction

Timothy D. Bryson, Xiaosong Gu, Remonda M. Khalil, Safa Khan, Liping Zhu, Jiang Xu, Edward Peterson, Xiao-Ping Yang, Pamela Harding

J Mol Cell Cardiol. Author manuscript; available in PMC 2019 May 1.

Published in final edited form as: J Mol Cell Cardiol. 2018 May; 118: 1–12. Published online 2018 Mar 6. doi: 10.1016/j.yjmcc.2018.03.005

PMCID:: PMC5940572

Abstract Article PDF–1.9M

Select item 55726849.

Prostaglandin E receptor-4 receptor mediates endothelial barrier–enhancing and anti-inflammatory effects of oxidized phospholipids

Olga Oskolkova, Grzegorz Gawlak, Yufeng Tian, Yunbo Ke, Nicolene Sarich, Sophia Son, Katrin Andreasson, Valery N. Bochkov, Anna A. Birukova, Konstantin G. Birukov

FASEB J. 2017 Sep; 31(9): 4187–4202. Published online 2017 May 1. doi: 10.1096/fj.201601232RR

PMCID:: PMC5572684

Abstract Article

Select item 539058610.

Paricalcitol Pretreatment Attenuates Renal Ischemia-Reperfusion Injury via Prostaglandin E₂ Receptor EP4 Pathway

Yu Ah Hong, Keum Jin Yang, So Young Jung, Ki Cheol Park, Hyunsu Choi, Jeong Min Oh, Sang Ju Lee, Yoon Kyung Chang, Cheol Whee Park, Chul Woo Yang, Suk Young Kim, Hyeon Seok Hwang

Oxid Med Cell Longev. 2017; 2017: 5031926. Published online 2017 Mar 29. doi: 10.1155/2017/5031926

Correction in:: Oxid Med Cell Longev. 2017; 2017: 1913954.

PMCID:: PMC5390586

Abstract Article PDF–5.0M

Select item 455247111.

Systemic EP4 Inhibition Increases Adhesion Formation in a Murine Model of Flexor Tendon Repair

Michael B. Geary, Caitlin A. Orner, Fatima Bawany, Hani A. Awad, Warren C. Hammert, Regis J. O’Keefe, Alayna E. Loiselle

PLoS One. 2015; 10(8): e0136351. Published online 2015 Aug 27. doi: 10.1371/journal.pone.0136351

PMCID:: PMC4552471

Abstract Article PDF–4.5M

Select item 446801212.

The roles of prostaglandin E₂ and D₂ in lipopolysaccharide-mediated changes in sleep

Yo Oishi, Kyoko Yoshida, Thomas E. Scammell, Yoshihiro Urade, Michael Lazarus, Clifford B. Saper

Brain Behav Immun. Author manuscript; available in PMC 2016 Jul 1.

Published in final edited form as: Brain Behav Immun. 2015 Jul; 47: 172–177. Published online 2014 Dec 20. doi: 10.1016/j.bbi.2014.11.019

PMCID:: PMC4468012

Abstract Article PDF–923K

Select item 430668913.

Activation of prostaglandin E₂-EP4 signaling reduces chemokine production in adipose tissue

Eva H. C. Tang, Yin Cai, Chi Kin Wong, Viviane Z. Rocha, Galina K. Sukhova, Koichi Shimizu, Ge Xuan, Paul M. Vanhoutte, Peter Libby, Aimin Xu

J Lipid Res. 2015 Feb; 56(2): 358–368. doi: 10.1194/jlr.M054817

PMCID:: PMC4306689

Abstract Article PDF–927K

Select item 413317614.

A Maladaptive Role for EP4 Receptors in Mouse Mesangial Cells

Guang-xia Yang, Yu-yin Xu, Ya-ping Fan, Jing Wang, Xiao-lan Chen, Yi-de Zhang, Jian-hua Wu

PLoS One. 2014; 9(8): e104091. Published online 2014 Aug 14. doi: 10.1371/journal.pone.0104091

PMCID:: PMC4133176

Abstract Article PDF–4.9M

Select item 399621515.

Suppression of Alzheimer-Associated Inflammation by Microglial Prostaglandin-E₂ EP4 Receptor Signaling

Nathaniel S. Woodling, Qian Wang, Prachi G. Priyam, Paul Larkin, Ju Shi, Jenny U. Johansson, Irene Zagol-Ikapitte, Olivier Boutaud, Katrin I. Andreasson

J Neurosci. 2014 Apr 23; 34(17): 5882–5894. doi: 10.1523/JNEUROSCI.0410-14.2014

PMCID:: PMC3996215

Abstract Article PDF–2.0M

Select item 388983616.

Prostaglandin E receptor EP4 is a therapeutic target in breast cancer cells with stem-like properties

Namita Kundu, Xinrong Ma, Tyler Kochel, Olga Goloubeva, Paul Staats, Keyata Thompson, Stuart Martin, Jocelyn Reader, Yukinori Take, Peter Collin, Amy Fulton

Breast Cancer Res Treat. 2014; 143(1): 19–31. Published online 2013 Nov 27. doi: 10.1007/s10549-013-2779-4