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Select item 104278741.

Loss of normal Alzheimer's disease-associated Presenilin 2 function alters antiseizure medicine potency and tolerability in the 6-Hz focal seizure model

Leanne M. Lehmann, Melissa Barker-Haliski

Front Neurol. 2023; 14: 1223472. Published online 2023 Aug 1. doi: 10.3389/fneur.2023.1223472

PMCID:: PMC10427874

Abstract Article PDF–3.1M

Select item 79098022.

Calcium Signaling and Mitochondrial Function in Presenilin 2 Knock-Out Mice: Looking for Any Loss-of-Function Phenotype Related to Alzheimer’s Disease

Alice Rossi, Luisa Galla, Chiara Gomiero, Lorena Zentilin, Mauro Giacca, Valentina Giorgio, Tito Calì, Tullio Pozzan, Elisa Greotti, Paola Pizzo

Cells. 2021 Feb; 10(2): 204. Published online 2021 Jan 21. doi: 10.3390/cells10020204

PMCID:: PMC7909802

Abstract Article PDF–3.7M

Select item 74620873.

Loss of Presenilin 2 Age-Dependently Alters Susceptibility to Acute Seizures and Kindling Acquisition

Megan Beckman, Kevin Knox, Zachery Koneval, Carole Smith, Suman Jayadev, Melissa Barker-Haliski

Neurobiol Dis. Author manuscript; available in PMC 2021 Mar 1.

Published in final edited form as: Neurobiol Dis. 2020 Mar; 136: 104719. Published online 2019 Dec 17. doi: 10.1016/j.nbd.2019.104719

PMCID:: PMC7462087

Abstract Article PDF–934K

Select item 70168924.

Dampened Slow Oscillation Connectivity Anticipates Amyloid Deposition in the PS2APP Mouse Model of Alzheimer’s Disease

Alessandro Leparulo, Mufti Mahmud, Elena Scremin, Tullio Pozzan, Stefano Vassanelli, Cristina Fasolato

Cells. 2020 Jan; 9(1): 54. Published online 2019 Dec 24. doi: 10.3390/cells9010054

PMCID:: PMC7016892

Abstract Article PDF–5.0M

Select item 108480495.

Presenilin‐2 knock‐In mice show severe depressive behavior via DVL3 downregulation

Seung Sik Yoo, Dong Won Lee, Hyeon Joo Ham, In Jun Yeo, Ju Young Chang, Jaesuk Yun, Dong Ju Son, Sang‐Bae Han, Jin Tae Hong

CNS Neurosci Ther. 2024 Feb; 30(2): e14370. Published online 2023 Jul 27. doi: 10.1111/cns.14370

PMCID:: PMC10848049

Abstract Article PDF–2.9M

Select item 106174046.

Interictal spikes in Alzheimer’s disease: Preclinical evidence for dominance of the dentate gyrus and cholinergic control by the medial septum

Christos Panagiotis Lisgaras, Helen E. Scharfman

Neurobiol Dis. Author manuscript; available in PMC 2023 Oct 31.

Published in final edited form as: Neurobiol Dis. 2023 Oct 15; 187: 106294. Published online 2023 Sep 14. doi: 10.1016/j.nbd.2023.106294

PMCID:: PMC10617404

Abstract Article PDF–4.6M

Select item 103505657.

Guizhi Fuling capsule relieves memory deficits by inhibition of microglial neuroinflammation through blocking JAK2/STAT3 pathway in presenilin1/2 conditional double knockout mice

Guang Yang, Yuting Tong, Xingyu Wang, Chenyi Zhao, Zongtao Ba, Reaila Ahelijiang, Xinjuan Liu, Waimao Gao, Yan Zhao, Yining Gu, Jianmei Yang, Ying Xu

Front Immunol. 2023; 14: 1185570. Published online 2023 Jul 3. doi: 10.3389/fimmu.2023.1185570

PMCID:: PMC10350565

Abstract Article PDF–7.1M

Select item 100086878.

Transmembrane BAX inhibitor motif containing 6 suppresses presenilin-2 to preserve mitochondrial integrity after myocardial ischemia-reperfusion injury

Li Ma, Lihan Liao, Na Zhou, Huikang Tao, Hao Zhou, Ying Tan, Weidan Chen, Fan Cao, Xinxin Chen

Int J Biol Sci. 2023; 19(4): 1228–1240. Published online 2023 Feb 13. doi: 10.7150/ijbs.81100

PMCID:: PMC10008687

Abstract Article PDF–7.2M

Select item 98855629.

Presenilins regulate synaptic plasticity in the perforant pathways of the hippocampus

Sang Hun Lee, Vadim Y. Bolshakov, Jie Shen

Mol Brain. 2023; 16: 17. Published online 2023 Jan 30. doi: 10.1186/s13041-023-01009-x

PMCID:: PMC9885562

Abstract Article PDF–4.0M

Select item 900804410.

Presenilin 2 N141I mutation induces hyperactive immune response through the epigenetic repression of REV-ERBα

Hyeri Nam, Younghwan Lee, Boil Kim, Ji-Won Lee, Seohyeon Hwang, Hyun-Kyu An, Kyung Min Chung, Youngjin Park, Jihyun Hong, Kyungjin Kim, Eun-Kyoung Kim, Han Kyoung Choe, Seong-Woon Yu

Nat Commun. 2022; 13: 1972. Published online 2022 Apr 13. doi: 10.1038/s41467-022-29653-2

PMCID:: PMC9008044

Abstract Article PDF–6.8M

Select item 848256811.

Loss of presenilin function enhances tau phosphorylation and aggregation in mice

Carlos M. Soto-Faguás, Paula Sanchez-Molina, Carlos A. Saura

Acta Neuropathol Commun. 2021; 9: 162. Published online 2021 Sep 30. doi: 10.1186/s40478-021-01259-7

PMCID:: PMC8482568

Abstract Article PDF–3.4M

Select item 661913412.

Dysregulation of Hypoxia-Inducible Factor by Presenilin/γ-Secretase Loss-of-Function Mutations

Muriel R. Kaufmann, Sandra Barth, Uwe Konietzko, Bei Wu, Sascha Egger, Reiner Kunze, Hugo H. Marti, Meike Hick, Ulrike Müller, Gieri Camenisch, Roland H. Wenger

J Neurosci. 2013 Jan 30; 33(5): 1915–1926. doi: 10.1523/JNEUROSCI.3402-12.2013

PMCID:: PMC6619134

Abstract Article PDF–1.5M

Select item 659623813.

Proteolytic Processing of Neurexins by Presenilins Sustains Synaptic Vesicle Release

Emilia Servián-Morilla, Estefanía Robles-Lanuza, Ana C. Sánchez-Hidalgo, Rafael J. Camacho-Garcia, Juan A. Paez-Gomez, Fabiola Mavillard, Carlos A. Saura, Amalia Martinez-Mir, Francisco G. Scholl

J Neurosci. 2018 Jan 24; 38(4): 901–917. doi: 10.1523/JNEUROSCI.1357-17.2017

PMCID:: PMC6596238

Abstract Article PDF–5.6M

Select item 628701414.

Inhibition of the Neuronal Calcium Sensor DREAM Modulates Presenilin-2 Endoproteolysis

Rocío Naranjo, Paz González, Alejandro Lopez-Hurtado, Xosé M. Dopazo, Britt Mellström, José R. Naranjo

Front Mol Neurosci. 2018; 11: 449. Published online 2018 Dec 3. doi: 10.3389/fnmol.2018.00449

PMCID:: PMC6287014

Abstract Article PDF–1.4M

Select item 596268615.

Histone Deacetylase Inhibitor Alleviates the Neurodegenerative Phenotypes and Histone Dysregulation in Presenilins-Deficient Mice

Ting Cao, Xiaojuan Zhou, Xianjie Zheng, Yue Cui, Joe Z. Tsien, Chunxia Li, Huimin Wang

Front Aging Neurosci. 2018; 10: 137. Published online 2018 May 15. doi: 10.3389/fnagi.2018.00137

PMCID:: PMC5962686

Abstract Article PDF–3.0M

Select item 547297116.

Presenilins regulate synaptic plasticity and mitochondrial calcium homeostasis in the hippocampal mossy fiber pathway

Sang Hun Lee, David Lutz, Mohanad Mossalam, Vadim Y. Bolshakov, Michael Frotscher, Jie Shen

Mol Neurodegener. 2017; 12: 48. Published online 2017 Jun 15. doi: 10.1186/s13024-017-0189-5

PMCID:: PMC5472971

Abstract Article PDF–2.8M

Select item 451649117.

Presenilin-2 dampens intracellular Ca²⁺ stores by increasing Ca²⁺ leakage and reducing Ca²⁺ uptake

Lucia Brunello, Enrico Zampese, Cristina Florean, Tullio Pozzan, Paola Pizzo, Cristina Fasolato

J Cell Mol Med. 2009 Sep; 13(9b): 3358–3369. Published online 2009 Mar 27. doi: 10.1111/j.1582-4934.2009.00755.x

PMCID:: PMC4516491

Abstract Article PDF–1.2M

Select item 436287918.

Loss of spatial memory, learning and motor coordination during normal aging is accompanied by changes in brain presenilin 1 and 2 expression levels

Simon Kaja, Natalie Sumien, Vidhi V. Shah, Imran Puthawala, Alexandra N. Maynard, Nitasha Khullar, Andrew J. Payne, Michael J. Forster, Peter Koulen

Mol Neurobiol. Author manuscript; available in PMC 2016 Aug 1.

Published in final edited form as: Mol Neurobiol. 2015 Aug; 52(1): 545–554. Published online 2014 Sep 10. doi: 10.1007/s12035-014-8877-4

PMCID:: PMC4362879

Abstract Article PDF–1.8M

Select item 434635219.

Presenilin 2 influences miR146 level and activity in microglia

Suman Jayadev, Amanda Case, Betty Alajajian, Alison J. Eastman, Thomas Möller, Gwenn A. Garden

J Neurochem. Author manuscript; available in PMC 2015 Mar 2.

Published in final edited form as: J Neurochem. 2013 Dec; 127(5): 592–599. Published online 2013 Sep 30. doi: 10.1111/jnc.12400

PMCID:: PMC4346352

Abstract Article PDF–602K

Select item 379478920.

Ibuprofen Rescues Abnormalities in Periodontal Tissues in Conditional Presenilin 1 and Presenilin 2 Double Knockout Mice

Jiansheng Su, Jiamei Gu, Zhuo Dong, Bing Mei

Int J Mol Sci. 2013 Sep; 14(9): 18457–18469. Published online 2013 Sep 6. doi: 10.3390/ijms140918457

PMCID:: PMC3794789

Abstract Article PDF–1.5M

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PMC Links for Gene (Select 19165) (119)
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PREDICTED: Rattus norvegicus RAD9-HUS1-RAD1 interacting nuclear orphan 1 (Rhno1)...
PREDICTED: Rattus norvegicus RAD9-HUS1-RAD1 interacting nuclear orphan 1 (Rhno1), transcript variant X1, mRNA
gi|2678937261|ref|XM_063285911.1|

Nucleotide
PREDICTED: Homo sapiens MINDY lysine 48 deubiquitinase 3 (MINDY3), transcript va...
PREDICTED: Homo sapiens MINDY lysine 48 deubiquitinase 3 (MINDY3), transcript variant X3, mRNA
gi|2462521065|ref|XM_054366776.1|

Nucleotide

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