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Select item 105092781.

Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodents

Yachao He, Ibrahim Kaya, Reza Shariatgorji, Johan Lundkvist, Lars U. Wahlberg, Anna Nilsson, Dejan Mamula, Jan Kehr, Justyna Zareba-Paslawska, Henrik Biverstål, Karima Chergui, Xiaoqun Zhang, Per E. Andren, Per Svenningsson

Nat Commun. 2023; 14: 5804. Published online 2023 Sep 19. doi: 10.1038/s41467-023-41539-5

PMCID:: PMC10509278

Abstract Article PDF–4.8M

Select item 66055992.

Spiral Ganglion Degeneration and Hearing Loss as a Consequence of Satellite Cell Death in Saposin B-Deficient Mice

Omar Akil, Ying Sun, Sarath Vijayakumar, Wujuan Zhang, Tiffany Ku, Chi-Kyou Lee, Sherri Jones, Gregory A. Grabowski, Lawrence R. Lustig

J Neurosci. 2015 Feb 18; 35(7): 3263–3275. doi: 10.1523/JNEUROSCI.3920-13.2015

PMCID:: PMC6605599

Abstract Article PDF–6.3M

Select item 37223253.

Altered autophagy in the mice with a deficiency of saposin A and saposin B

Ying Sun, Gregory A. Grabowski

Autophagy. 2013 Jul 1; 9(7): 1115–1116. Published online 2013 May 6. doi: 10.4161/auto.24919

PMCID:: PMC3722325

Abstract Article PDF–975K

Select item 37085214.

Tissue-specific effects of saposin A and saposin B on glycosphingolipid degradation in mutant mice

Ying Sun, Matt Zamzow, Huimin Ran, Wujuan Zhang, Brian Quinn, Sonya Barnes, David P. Witte, Kenneth D.R. Setchell, Michael T. Williams, Charles V. Vorhees, Gregory A. Grabowski

Hum Mol Genet. 2013 Jun 15; 22(12): 2435–2450. Published online 2013 Feb 27. doi: 10.1093/hmg/ddt096

PMCID:: PMC3708521

Abstract Article PDF–1.6M

Select item 36215635.

Regional expression of prosaposin in the wild-type and saposin D-deficient mouse brain detected by an anti-mouse prosaposin-specific antibody

Azusa Yoneshige, Kunihiko Suzuki, Naoya Kojima, Junko Matsuda

Proc Jpn Acad Ser B Phys Biol Sci. 2009 Nov; 85(9): 422–434. doi: 10.2183/pjab.85.422

PMCID:: PMC3621563

Abstract Article PDF–7.7M

Select item 28254946.

A Stretch of 17 Amino Acids in the Prosaposin C Terminus Is Critical for Its Binding to Sortilin and Targeting to Lysosomes

Libin Yuan, Carlos R. Morales

J Histochem Cytochem. 2010 Mar; 58(3): 287–300. doi: 10.1369/jhc.2009.955203

PMCID:: PMC2825494

Abstract Article PDF–2.2M

Select item 18874897.

Developmental and tissue-specific expression of prosaposin mRNA in murine tissues.

Y. Sun, D. P. Witte, G. A. Grabowski

Am J Pathol. 1994 Dec; 145(6): 1390–1398.

PMCID:: PMC1887489

Summary Page Browse PDF–2.5M

Select item 10616158.

The Exon 8-Containing Prosaposin Gene Splice Variant Is Dispensable for Mouse Development, Lysosomal Function, and Secretion

Tsadok Cohen, Wojtek Auerbach, Liat Ravid, Jacques Bodennec, Amos Fein, Anthony H. Futerman, Alexandra L. Joyner, Mia Horowitz

Mol Cell Biol. 2005 Mar; 25(6): 2431–2440. doi: 10.1128/MCB.25.6.2431-2440.2005

PMCID:: PMC1061615

Abstract Article PDF–428K

Select item 100976589.

Targeting neuronal lysosomal dysfunction caused by β-glucocerebrosidase deficiency with an enzyme-based brain shuttle construct

Alexandra Gehrlein, Vinod Udayar, Nadia Anastasi, Martino L. Morella, Iris Ruf, Doris Brugger, Sophia von der Mark, Ralf Thoma, Arne Rufer, Dominik Heer, Nina Pfahler, Anton Jochner, Jens Niewoehner, Luise Wolf, Matthias Fueth, Martin Ebeling, Roberto Villaseñor, Yanping Zhu, Matthew C. Deen, Xiaoyang Shan, Zahra Ehsaei, Verdon Taylor, Ellen Sidransky, David J. Vocadlo, Per-Ola Freskgård, Ravi Jagasia

Nat Commun. 2023; 14: 2057. Published online 2023 Apr 12. doi: 10.1038/s41467-023-37632-4

PMCID:: PMC10097658

Abstract Article PDF–3.6M

Select item 961830610.

Treatment of a genetic brain disease by CNS-wide microglia replacement

Yohei Shibuya, Kevin K Kumar, Marius Marc-Daniel Mader, Yongjin Yoo, Luis Angel Ayala, Mu Zhou, Manuel Alexander Mohr, Gernot Neumayer, Ishan Kumar, Ryo Yamamoto, Paul Marcoux, Benjamin Liou, F Chris Bennett, Hiromitsu Nakauchi, Ying Sun, Xiaoke Chen, Frank L. Heppner, Tony Wyss-Coray, Thomas C. Südhof, Marius Wernig

Sci Transl Med. Author manuscript; available in PMC 2022 Oct 30.

Published in final edited form as: Sci Transl Med. 2022 Mar 16; 14(636): eabl9945. Published online 2022 Mar 16. doi: 10.1126/scitranslmed.abl9945

PMCID:: PMC9618306

Abstract Article PDF–4.1M

Select item 957038811.

Decreased Prosaposin and Progranulin in the Cingulate Cortex Are Associated with Schizophrenia Pathophysiology

Yachao He, Xiaoqun Zhang, Ivana Flais, Per Svenningsson

Int J Mol Sci. 2022 Oct; 23(19): 12056. Published online 2022 Oct 10. doi: 10.3390/ijms231912056

PMCID:: PMC9570388

Abstract Article PDF–2.4M

Select item 730017512.

Neurofilament-Light Chain as Biomarker of Neurodegenerative and Rare Diseases With High Translational Value

Tina Loeffler, Irene Schilcher, Stefanie Flunkert, Birgit Hutter-Paier

Front Neurosci. 2020; 14: 579. Published online 2020 Jun 11. doi: 10.3389/fnins.2020.00579

PMCID:: PMC7300175

Abstract Article PDF–577K

Select item 695715413.

Characterization of the visceral and neuronal phenotype of 4L/PS-NA mice modeling Gaucher disease

Victoria Schiffer, Estibaliz Santiago-Mujika, Stefanie Flunkert, Staffan Schmidt, Martina Farcher, Tina Loeffler, Irene Schilcher, Maria Posch, Joerg Neddens, Ying Sun, Jan Kehr, Birgit Hutter-Paier

PLoS One. 2020; 15(1): e0227077. Published online 2020 Jan 13. doi: 10.1371/journal.pone.0227077

PMCID:: PMC6957154

Abstract Article PDF–5.4M

Select item 644758014.

Combination of acid β-glucosidase mutation and Saposin C deficiency in mice reveals Gba1 mutation dependent and tissue-specific disease phenotype

Benjamin Liou, Wujuan Zhang, Venette Fannin, Brian Quinn, Huimin Ran, Kui Xu, Kenneth D. R. Setchell, David Witte, Gregory A. Grabowski, Ying Sun

Sci Rep. 2019; 9: 5571. Published online 2019 Apr 3. doi: 10.1038/s41598-019-41914-7

PMCID:: PMC6447580

Abstract Article PDF–7.4M

Select item 581698315.

Mechano-signal transduction in mesenchymal stem cells induces prosaposin secretion to drive the proliferation of breast cancer cells

Seiichiro Ishihara, David R. Inman, Wan-Ju Li, Suzanne M. Ponik, Patricia J. Keely

Cancer Res. Author manuscript; available in PMC 2018 Nov 15.

Published in final edited form as: Cancer Res. 2017 Nov 15; 77(22): 6179–6189. Published online 2017 Sep 28. doi: 10.1158/0008-5472.CAN-17-0569

PMCID:: PMC5816983

Abstract Article PDF–2.1M

Select item 563050016.

The interaction between progranulin and prosaposin is mediated by granulins and the linker region between saposin B and C

Xiaolai Zhou, Peter M. Sullivan, Lirong Sun, Fenghua Hu

J Neurochem. Author manuscript; available in PMC 2018 Oct 1.

Published in final edited form as: J Neurochem. 2017 Oct; 143(2): 236–243. Published online 2017 Aug 4. doi: 10.1111/jnc.14110

PMCID:: PMC5630500

Abstract Article PDF–2.2M

Select item 465405717.

Neuronopathic Gaucher disease: dysregulated mRNAs and miRNAs in brain pathogenesis and effects of pharmacologic chaperone treatment in a mouse model

Nupur Dasgupta, You-hai Xu, Ronghua Li, Yanyan Peng, Manoj K. Pandey, Stuart L. Tinch, Benjamin Liou, Venette Inskeep, Wujuan Zhang, Kenneth D.R. Setchell, Mehdi Keddache, Gregory A. Grabowski, Ying Sun

Hum Mol Genet. 2015 Dec 15; 24(24): 7031–7048. Published online 2015 Sep 29. doi: 10.1093/hmg/ddv404

PMCID:: PMC4654057

Abstract Article PDF–1.0M

Select item 444005918.

Decrease in prosaposin in spermatozoon is associated with polychlorinated biphenyl exposure

Jia-Li Cai, Ling-Bin Sun, Zhi-Zhun Guo, Xiao-Ming Jiang, Guan-Chao Zheng, Hui-Ling Qiu, Ai-Guo Sha, Chong-Gang Wang, Jian-Zhi Ren, Zheng-Hong Zuo

Int J Clin Exp Pathol. 2015; 8(3): 2436–2448. Published online 2015 Mar 1.

PMCID:: PMC4440059

Abstract Article PDF–1.5M

Select item 393102919.

GPR37 Protein Trafficking to the Plasma Membrane Regulated by Prosaposin and GM1 Gangliosides Promotes Cell Viability

Ebba Gregorsson Lundius, Vladana Vukojević, Ellen Hertz, Nikolas Stroth, Andreas Cederlund, Masao Hiraiwa, Lars Terenius, Per Svenningsson

J Biol Chem. 2014 Feb 21; 289(8): 4660–4673. Published online 2013 Dec 26. doi: 10.1074/jbc.M113.510883

PMCID:: PMC3931029

Abstract Article PDF–3.1M

Select item 382825420.

Decrease in Prosaposin in the Dystrophic mdx Mouse Brain

Hui-ling Gao, Cheng Li, Hiroaki Nabeka, Tetsuya Shimokawa, Naoto Kobayashi, Shouichiro Saito, Zhan-You Wang, Ya-ming Cao, Seiji Matsuda

PLoS One. 2013; 8(11): e80032. Published online 2013 Nov 14. doi: 10.1371/journal.pone.0080032

PMCID:: PMC3828254

Abstract Article PDF–2.8M

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