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Select item 84752741.

P2RY12-Inhibitors Reduce Cancer-Associated Thrombosis and Tumor Growth in Pancreatic Cancers

Ana Luisa Palacios-Acedo, Soraya Mezouar, Diane Mège, Lydie Crescence, Christophe Dubois, Laurence Panicot-Dubois

Front Oncol. 2021; 11: 704945. Published online 2021 Sep 13. doi: 10.3389/fonc.2021.704945

PMCID:: PMC8475274

Abstract Article PDF–14M

Select item 81726022.

Prolyl Endopeptidase Gene Disruption Improves Gut Dysbiosis and Non-alcoholic Fatty Liver Disease in Mice Induced by a High-Fat Diet

Daixi Jiang, Jianbin Zhang, Shuangzhe Lin, Yuqin Wang, Yuanwen Chen, Jiangao Fan

Front Cell Dev Biol. 2021; 9: 628143. Published online 2021 May 20. doi: 10.3389/fcell.2021.628143

PMCID:: PMC8172602

Abstract Article PDF–12M

Select item 71543883.

Prolyl endopeptidase gene disruption attenuates high fat diet-induced nonalcoholic fatty liver disease in mice by improving hepatic steatosis and inflammation

Dai-Xi Jiang, Jian-Bin Zhang, Meng-Ting Li, Shuang-Zhe Lin, Yu-Qin Wang, Yuan-Wen Chen, Jian-Gao Fan

Ann Transl Med. 2020 Mar; 8(5): 218. doi: 10.21037/atm.2020.01.14

PMCID:: PMC7154388

Abstract Article PDF–14M

Select item 41365684.

Hypothalamic prolyl endopeptidase (PREP) regulates pancreatic insulin and glucagon secretion in mice

Jung Dae Kim, Chitoku Toda, Giuseppe D’Agostino, Caroline J. Zeiss, Ralph J. DiLeone, John D. Elsworth, Richard G. Kibbey, Owen Chan, Brandon K. Harvey, Christopher T. Richie, Mari Savolainen, Timo Myöhänen, Jin Kwon Jeong, Sabrina Diano

Proc Natl Acad Sci U S A. 2014 Aug 12; 111(32): 11876–11881. Published online 2014 Jul 28. doi: 10.1073/pnas.1406000111

Correction in:: Proc Natl Acad Sci U S A. 2014 Sep 23; 111(38): 14003.

PMCID:: PMC4136568

Abstract Article PDF–1.2M

Select item 38414005.

Prolyl Endopeptidase-Deficient Mice Have Reduced Synaptic Spine Density in the CA1 Region of the Hippocampus, Impaired LTP, and Spatial Learning and Memory

Giuseppe D'Agostino, Jung Dae Kim, Zhong-Wu Liu, Jin Kwon Jeong, Shigetomo Suyama, Antonio Calignano, Xiao-Bing Gao, Michael Schwartz, Sabrina Diano

Cereb Cortex. 2013 Aug; 23(8): 2007–2014. Published online 2012 Jul 5. doi: 10.1093/cercor/bhs199

PMCID:: PMC3841400

Abstract Article PDF–2.5M

Select item 30438176.

Cigarette smoke-induced lung emphysema in mice is associated with prolyl endopeptidase, an enzyme involved in collagen breakdown

Saskia Braber, Pim J. Koelink, Paul A. J. Henricks, Patricia L. Jackson, Frans P. Nijkamp, Johan Garssen, Aletta D. Kraneveld, J. Edwin Blalock, Gert Folkerts

Am J Physiol Lung Cell Mol Physiol. 2011 Feb; 300(2): L255–L265. Published online 2010 Nov 26. doi: 10.1152/ajplung.00304.2010

PMCID:: PMC3043817

Abstract Article

Select item 27437527.

Maternal influence of prolyl endopeptidase on fat mass of adult progeny

Craig H. Warden, Janis S. Fisler, Glenda Espinal, Bertrand Perroud

Int J Obes (Lond) Author manuscript; available in PMC 2010 Mar 1.

Published in final edited form as: Int J Obes (Lond). 2009 Sep; 33(9): 1013–1022. Published online 2009 Jun 30. doi: 10.1038/ijo.2009.129

PMCID:: PMC2743752

Abstract Article PDF–727K

Select item 27281288.

Issues About the Physiological Functions of Prolyl Oligopeptidase Based on Its Discordant Spatial Association With Substrates and Inconsistencies Among mRNA, Protein Levels, and Enzymatic Activity

Timo T. Myöhänen, J. Arturo García-Horsman, Jofre Tenorio-Laranga, Pekka T. Männistö

J Histochem Cytochem. 2009 Sep; 57(9): 831–848. doi: 10.1369/jhc.2009.953711

PMCID:: PMC2728128

Abstract Article PDF–919K

Select item 57841349.

Removal of prolyl oligopeptidase reduces alpha-synuclein toxicity in cells and in vivo

Reinis Svarcbahs, Ulrika H. Julku, Susanna Norrbacka, Timo T. Myöhänen

Sci Rep. 2018; 8: 1552. Published online 2018 Jan 24. doi: 10.1038/s41598-018-19823-y

PMCID:: PMC5784134

Abstract Article PDF–7.2M

Select item 269892810.

In vivo multiplex quantitative analysis of 3 forms of alpha melanocyte stimulating hormone in pituitary of prolyl endopeptidase deficient mice

Bertrand Perroud, Rudy J Alvarado, Glenda M Espinal, Alex R Morado, Brett S Phinney, Craig H Warden

Mol Brain. 2009; 2: 14. Published online 2009 Jun 2. doi: 10.1186/1756-6606-2-14

PMCID:: PMC2698928

Abstract Article PDF–440K

Select item 365164311.

Identification of prolyl carboxypeptidase as an alternative enzyme for processing of renal angiotensin II using mass spectrometry

Nadja Grobe, Nathan M. Weir, Orly Leiva, Frank S. Ong, Kenneth E. Bernstein, Alvin H. Schmaier, Mariana Morris, Khalid M. Elased

Am J Physiol Cell Physiol. 2013 May 15; 304(10): C945–C953. Published online 2013 Feb 7. doi: 10.1152/ajpcell.00346.2012

PMCID:: PMC3651643

Abstract Article

Select item 1013605112.

D-Aspartate Depletion Perturbs Steroidogenesis and Spermatogenesis in Mice

Alessandra Santillo, Sara Falvo, Massimo Venditti, Anna Di Maio, Gabriella Chieffi Baccari, Francesco Errico, Alessandro Usiello, Sergio Minucci, Maria Maddalena Di Fiore

Biomolecules. 2023 Apr; 13(4): 621. Published online 2023 Mar 30. doi: 10.3390/biom13040621

PMCID:: PMC10136051

Abstract Article PDF–4.1M

Select item 545567813.

Toll-Like Receptor 4 Engagement Mediates Prolyl Endopeptidase Release from Airway Epithelia via Exosomes

Tomasz Szul, Preston E. Bratcher, Kyle B. Fraser, Michele Kong, Rabindra Tirouvanziam, Sarah Ingersoll, Elizabeth Sztul, Sunil Rangarajan, J. Edwin Blalock, Xin Xu, Amit Gaggar

Am J Respir Cell Mol Biol. 2016 Mar; 54(3): 359–369. doi: 10.1165/rcmb.2015-0108OC

PMCID:: PMC5455678

Abstract Article PDF–1.7M

Select item 433524614.

Prolyl Oligopeptidase Enhances α-Synuclein Dimerization via Direct Protein-Protein Interaction

Mari H. Savolainen, Xu Yan, Timo T. Myöhänen, Henri J. Huttunen

J Biol Chem. 2015 Feb 20; 290(8): 5117–5126. Published online 2015 Jan 2. doi: 10.1074/jbc.M114.592931

PMCID:: PMC4335246

Abstract Article PDF–1.0M

Select item 2935915.

The effects of aging on gene expression in the hypothalamus and cortex of mice

Cecilia H. Jiang, Joe Z. Tsien, Peter G. Schultz, Yinghe Hu

Proc Natl Acad Sci U S A. 2001 Feb 13; 98(4): 1930–1934. doi: 10.1073/pnas.98.4.1930

PMCID:: PMC29359

Abstract Article PDF–79K

Select item 550326116.

Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program

John P. Sundberg, Soheil S. Dadras, Kathleen A. Silva, Victoria E. Kennedy, Gaven Garland, Stephen A. Murray, Beth A. Sundberg, Paul N. Schofield, C. Herbert Pratt

PLoS One. 2017; 12(7): e0180682. Published online 2017 Jul 10. doi: 10.1371/journal.pone.0180682

PMCID:: PMC5503261

Abstract Article PDF–31M

Select item 538122617.

Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function

Tingting Zhang, Wei Du, Andrew F. Wilson, Satoshi H. Namekawa, Paul R. Andreassen, Amom Ruhikanta Meetei, Qishen Pang

Sci Rep. 2017; 7: 45626. Published online 2017 Apr 5. doi: 10.1038/srep45626

PMCID:: PMC5381226

Abstract Article PDF–1.4M

Select item 529582118.

High-throughput discovery of novel developmental phenotypes

Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray

Nature. Author manuscript; available in PMC 2017 Mar 14.

Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356

Correction in:: Nature. 2017 Nov 16; 551(7680): 398.

PMCID:: PMC5295821

Abstract Article PDF–3.0M

Select item 396495519.

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data

Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, Terrence F. Meehan, Hugh Morgan, Julian Atienza-Herrero, Andrew Blake, Chao-Kung Chen, Richard Easty, Armida Di Fenza, Tanja Fiegel, Mark Grifiths, Alan Horne, Natasha A. Karp, Natalja Kurbatova, Jeremy C. Mason, Peter Matthews, Darren J. Oakley, Asfand Qazi, Jack Regnart, Ahmad Retha, Luis A. Santos, Duncan J. Sneddon, Jonathan Warren, Henrik Westerberg, Robert J. Wilson, David G. Melvin, Damian Smedley, Steve D. M. Brown, Paul Flicek, William C. Skarnes, Ann-Marie Mallon, Helen Parkinson

Nucleic Acids Res. 2014 Jan 1; 42(Database issue): D802–D809. Published online 2013 Nov 3. doi: 10.1093/nar/gkt977

PMCID:: PMC3964955

Abstract Article PDF–5.7M

Select item 16551120.

BayGenomics: a resource of insertional mutations in mouse embryonic stem cells

Doug Stryke, Michiko Kawamoto, Conrad C. Huang, Susan J. Johns, Leslie A. King, Courtney A. Harper, Elaine C. Meng, Roy E. Lee, Alice Yee, Larry L'Italien, Pao-Tien Chuang, Stephen G. Young, William C. Skarnes, Patricia C. Babbitt, Thomas E. Ferrin

Nucleic Acids Res. 2003 Jan 1; 31(1): 278–281. doi: 10.1093/nar/gkg064

PMCID:: PMC165511

Abstract Article PDF–217K

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