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Select item 26468921.

A Novel Gβγ-Subunit Inhibitor Selectively Modulates μ-Opioid-Dependent Antinociception and Attenuates Acute Morphine-Induced Antinociceptive Tolerance and Dependence

Jennifer L. Mathews, Alan V. Smrcka, Jean M. Bidlack

J Neurosci. 2008 Nov 19; 28(47): 12183–12189. doi: 10.1523/JNEUROSCI.2326-08.2008

PMCID:: PMC2646892

Abstract Article PDF–515K

Select item 178972.

Genetic alteration of phospholipase C β3 expression modulates behavioral and cellular responses to μ opioids

Wei Xie, Gary M. Samoriski, Jay P. McLaughlin, Valerie A. Romoser, Alan Smrcka, Patricia M. Hinkle, Jean M. Bidlack, Robert A. Gross, Huiping Jiang, Dianqing Wu

Proc Natl Acad Sci U S A. 1999 Aug 31; 96(18): 10385–10390. doi: 10.1073/pnas.96.18.10385

PMCID:: PMC17897

Abstract Article PDF–144K

Select item 74258663.

A subset of broadly responsive Type III taste cells contribute to the detection of bitter, sweet and umami stimuli

Debarghya Dutta Banik, Eric D. Benfey, Laura E. Martin, Kristen E. Kay, Gregory C. Loney, Amy R. Nelson, Zachary C. Ahart, Barrett T. Kemp, Bailey R. Kemp, Ann-Marie Torregrossa, Kathryn F. Medler

PLoS Genet. 2020 Aug; 16(8): e1008925. Published online 2020 Aug 13. doi: 10.1371/journal.pgen.1008925

PMCID:: PMC7425866

Abstract Article PDF–3.3M

Select item 43299864.

Critical Role for Mast Cell Stat5 Activity in Skin Inflammation

Tomoaki Ando, Wenbin Xiao, Peisong Gao, Siavash Namiranian, Kenji Matsumoto, Yoshiaki Tomimori, Hong Hong, Hirotaka Yamashita, Miho Kimura, Jun-ichi Kashiwakura, Tissa R. Hata, Kenji Izuhara, Michael F. Gurish, Axel Roers, Nicholas M. Rafaels, Kathleen C. Barnes, Colin Jamora, Yuko Kawakami, Toshiaki Kawakami

Cell Rep. Author manuscript; available in PMC 2015 Feb 16.

Published in final edited form as: Cell Rep. 2014 Jan 30; 6(2): 366–376. Published online 2014 Jan 9. doi: 10.1016/j.celrep.2013.12.029

PMCID:: PMC4329986

Abstract Article PDF–3.2M

Select item 29187125.

Synergistic Activation of Phospholipase C-β3 by Gα_q and Gβγ Describes a Simple Two-State Coincidence Detector

Finly Philip, Ganesh Kadamur, Rosa González Silos, Jimmy Woodson, Elliott M. Ross

Curr Biol. Author manuscript; available in PMC 2011 Aug 10.

Published in final edited form as: Curr Biol. 2010 Aug 10; 20(15): 1327–1335. Published online 2010 Jun 24. doi: 10.1016/j.cub.2010.06.013

PMCID:: PMC2918712

Abstract Article PDF–1.0M

Select item 89576056.

Novel role of pre-replication complex component cell division cycle 6 in retinal neovascularization

Raj Kumar, Gadiparthi N. Rao

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2023 Apr 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2022 Apr; 42(4): 407–427. Published online 2022 Mar 3. doi: 10.1161/ATVBAHA.121.317182

PMCID:: PMC8957605

Abstract Article PDF–4.8M

Select item 32288617.

PLCβ is Critical for T-cell Chemotaxis

Tami L. Bach, Qing-Min Chen, Wesley T. Kerr, John K. Choi, Dianqing Wu, Gary A. Koretzky, Sally Zigmond, Charles S. Abrams

J Immunol. Author manuscript; available in PMC 2011 Dec 1.

Published in final edited form as: J Immunol. 2007 Aug 15; 179(4): 2223–2227. doi: 10.4049/jimmunol.179.4.2223

PMCID:: PMC3228861

Abstract Article PDF–2.9M

Select item 31246188.

Phospholipase C-β3 regulates FcεRI-mediated mast cell activation by recruiting the protein phosphatase SHP-1

Wenbin Xiao, Jun-ichi Kashiwakura, Hong Hong, Hiroki Yasudo, Tomoaki Ando, Mari Maeda-Yamamoto, Dianqing Wu, Yuko Kawakami, Toshiaki Kawakami

Immunity. Author manuscript; available in PMC 2012 Jun 24.

Published in final edited form as: Immunity. 2011 Jun 24; 34(6): 893–904. Published online 2011 Jun 16. doi: 10.1016/j.immuni.2011.04.010

PMCID:: PMC3124618

Abstract Article PDF–2.2M

Select item 30313879.

Lyn- and PLC-β3–dependent regulation of SHP-1 phosphorylation controls Stat5 activity and myelomonocytic leukemia-like disease

Wenbin Xiao, Tomoaki Ando, Huan-You Wang, Yuko Kawakami, Toshiaki Kawakami

Blood. 2010 Dec 23; 116(26): 6003–6013. Prepublished online 2010 Sep 21. doi: 10.1182/blood-2010-05-283937

PMCID:: PMC3031387

Abstract Article

Select item 212923810.

Phospholipase C β3 deficiency leads to macrophage hypersensitivity to apoptotic induction and reduction of atherosclerosis in mice

Zhenglong Wang, Bei Liu, Ping Wang, Xuemei Dong, Carlos Fernandez-Hernando, Zhong Li, Timothy Hla, Zihai Li, Kevin Claffey, Jonathan D. Smith, Dianqing Wu

J Clin Invest. 2008 Jan 2; 118(1): 195–204. Published online 2007 Dec 13. doi: 10.1172/JCI33139

PMCID:: PMC2129238

Abstract Article PDF–856K

Select item 189511511.

The relative role of PLCβ and PI3Kγ in platelet activation

Lurong Lian, Yanfeng Wang, Julia Draznin, Don Eslin, Joel S. Bennett, Mortimer Poncz, Dianqing Wu, Charles S. Abrams

Blood. 2005 Jul 1; 106(1): 110–117. Prepublished online 2005 Feb 10. doi: 10.1182/blood-2004-05-2005

PMCID:: PMC1895115

Abstract Article

Select item 121738812.

Phospholipase C in mouse oocytes: characterization of beta and gamma isoforms and their possible involvement in sperm-induced Ca2+ spiking.

G Dupont, O M McGuinness, M H Johnson, M J Berridge, F Borgese

Biochem J. 1996 Jun 1; 316(Pt 2): 583–591. doi: 10.1042/bj3160583

PMCID:: PMC1217388

Summary PDF–1.1M

Select item 324193013.

A PLCβ/PI3Kγ-GSK3 signaling pathway regulates cofilin phosphatase slingshot2 and neutrophil polarization and chemotaxis

Wenwen Tang, Yong Zhang, Wenwen Xu, T. Kendall Harden, John Sondek, Le Sun, Lin Li, Dianqing Wu

Dev Cell. Author manuscript; available in PMC 2012 Dec 13.

Published in final edited form as: Dev Cell. 2011 Dec 13; 21(6): 1038–1050. doi: 10.1016/j.devcel.2011.10.023

PMCID:: PMC3241930

Abstract Article PDF–4.2M

Select item 270875114.

TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms

Noritaka Imamachi, Goon Ho Park, Hyosang Lee, David J. Anderson, Melvin I. Simon, Allan I. Basbaum, Sang-Kyou Han

Proc Natl Acad Sci U S A. 2009 Jul 7; 106(27): 11330–11335. Published online 2009 Jun 29. doi: 10.1073/pnas.0905605106

PMCID:: PMC2708751

Abstract Article PDF–1.0M

Select item 242736515.

Signaling and Cross-talk by C5a and UDP in Macrophages Selectively Use PLCβ3 to Regulate Intracellular Free Calcium

Tamara I. A. Roach, Robert A. Rebres, Iain D. C. Fraser, Dianne L. DeCamp, Keng-Mean Lin, Paul C. Sternweis, Mel I. Simon, William E. Seaman

J Biol Chem. 2008 Jun 20; 283(25): 17351–17361. doi: 10.1074/jbc.M800907200

PMCID:: PMC2427365

Abstract Article PDF–572K

Select item 148312616.

G-protein-coupled Receptor Agonists Activate Endogenous Phospholipase Cε and Phospholipase Cβ3 in a Temporally Distinct Manner

Grant G. Kelley, Katherine A. Kaproth-Joslin, Sarah E. Reks, Alan V. Smrcka, Richard J. H. Wojcikiewicz

J Biol Chem. Author manuscript; available in PMC 2006 Jun 28.

Published in final edited form as: J Biol Chem. 2006 Feb 3; 281(5): 2639–2648. Published online 2005 Nov 28. doi: 10.1074/jbc.M507681200

PMCID:: PMC1483126

Abstract Article PDF–533K

Select item 630990017.

Protective roles of adenosine A₁, A_2A, and A₃ receptors in skeletal muscle ischemia and reperfusion injury

Jingang Zheng, Rubio Wang, Edward Zambraski, Dan Wu, Kenneth A. Jacobson, Bruce T. Liang

Am J Physiol Heart Circ Physiol. Author manuscript; available in PMC 2018 Dec 28.

Published in final edited form as: Am J Physiol Heart Circ Physiol. 2007 Dec; 293(6): H3685–H3691. Published online 2007 Oct 5. doi: 10.1152/ajpheart.00819.2007

PMCID:: PMC6309900

Abstract Article PDF–935K

Select item 344777718.

Revealing the role of phospholipase Cβ3 in the regulation of VEGF-induced vascular permeability

Luke H. Hoeppner, Kathryn N. Phoenix, Karl J. Clark, Resham Bhattacharya, Xun Gong, Tracey E. Sciuto, Pawan Vohra, Sandip Suresh, Santanu Bhattacharya, Ann M. Dvorak, Stephen C. Ekker, Harold F. Dvorak, Kevin P. Claffey, Debabrata Mukhopadhyay

Blood. 2012 Sep 13; 120(11): 2167–2173. Prepublished online 2012 Jun 6. doi: 10.1182/blood-2012-03-417824

PMCID:: PMC3447777

Abstract Article

Select item 274433819.

Tumor Suppression by Phospholipase C-ß3 via SHP-1-Mediated Dephosphorylation of Stat5

Wenbin Xiao, Hong Hong, Yuko Kawakami, Yuko Kato, Dianqing Wu, Hiroki Yasudo, Akiko Kimura, Hiromi Kubagawa, Luigi F. Bertoli, Randall S. Davis, Luan A. Chau, Joaquin Madrenas, Cyrus C. Hsia, Anargyros Xenocostas, Thomas J. Kipps, Lothar Hennighausen, Atsushi Iwama, Hiromitsu Nakauchi, Toshiaki Kawakami

Cancer Cell. Author manuscript; available in PMC 2010 Aug 4.

Published in final edited form as: Cancer Cell. 2009 Aug 4; 16(2): 161–171. doi: 10.1016/j.ccr.2009.05.018

PMCID:: PMC2744338

Abstract Article PDF–2.2M

Select item 697754320.

Frontline Science: TNF‐α and GM‐CSF1 priming augments the role of SOS1/2 in driving activation of Ras, PI3K‐γ, and neutrophil proinflammatory responses

Sabine Suire, Fernando C. Baltanas, Anne Segonds‐Pichon, Keith Davidson, Eugenio Santos, Phillip T. Hawkins, Len R. Stephens

J Leukoc Biol. 2019 Oct; 106(4): 815–822. Published online 2019 Feb 5. doi: 10.1002/JLB.2HI0918-359RR

PMCID:: PMC6977543

Abstract Article PDF–1.0M

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