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Select item 112336391.

PKM2 aggregation drives metabolism reprograming during aging process

Juntao Bie, Ridong Li, Yutong Li, Chen Song, Zhaoming Chen, Tianzhuo Zhang, Zhiheng Tang, Li Su, Liangyi Zhu, Jiaxin Wang, You Wan, Jun Chen, Xiaoyun Liu, Tingting Li, Jianyuan Luo

Nat Commun. 2024; 15: 5761. Published online 2024 Jul 9. doi: 10.1038/s41467-024-50242-y

PMCID:: PMC11233639

Abstract Article PDF–4.9M

Select item 111033862.

Pyruvate kinase M2 sustains cardiac mitochondrial integrity in septic cardiomyopathy by regulating PHB2-dependent mitochondrial biogenesis

Jiaxi Ren, Bin Ren, Tong Fu, Yanchun Ma, Ying Tan, Shuxiang Zhang, Yan Li, Qi Wang, Xing Chang, Ying Tong

Int J Med Sci. 2024; 21(6): 983–993. Published online 2024 Apr 8. doi: 10.7150/ijms.94577

PMCID:: PMC11103386

Abstract Article PDF–2.6M

Select item 108497813.

Pyruvate kinase M2 regulates kidney fibrosis through pericyte glycolysis during the progression from acute kidney injury to chronic kidney disease

Yulan Chen, Xueyuan Bai, Jianwen Chen, Mengjie Huang, Quan Hong, Qing Ouyang, Xuefeng Sun, Yan Zhang, Jiaona Liu, Xu Wang, Lingling Wu, Xiangmei Chen

Cell Prolif. 2024 Feb; 57(2): e13548. Published online 2023 Sep 25. doi: 10.1111/cpr.13548

PMCID:: PMC10849781

Abstract Article PDF–4.2M

Select item 105204884.

Glycolytic enzyme PKM2 regulates cell senescence but not inflammation in the process of osteoarthritis: PKM2 regulates chondrocyte senescence via p16 ^INK4a transcription

Bo Liu, Chenzhong Wang, Ziyu Weng, Yi Yang, Hong Zhao, Yueqi Zhang, Qinming Fei, Yi Shi, Chi Zhang

Acta Biochim Biophys Sin (Shanghai) 2023 Sep 25; 55(9): 1425–1433. Published online 2023 Jul 31. doi: 10.3724/abbs.2023062

PMCID:: PMC10520488

Abstract Article PDF–1.9M

Select item 101589475.

Overexpressed PKM2 promotes macrophage phagocytosis and atherosclerosis

Xiaochen Gai, Fangming Liu, Yuting Wu, Baohui Zhang, Bufu Tang, Kezhuo Shang, Lianmei Wang, Haihong Zhang, Yixin Chen, Shuhui Yang, Weiwei Deng, Peng Li, Jing Wang, Hongbing Zhang

Animal Model Exp Med. 2023 Apr; 6(2): 92–102. Published online 2022 Aug 16. doi: 10.1002/ame2.12266

PMCID:: PMC10158947

Abstract Article PDF–6.3M

Select item 99402186.

Pyruvate Kinase 2, an Energy Metabolism Related Enzyme, May Have a Neuroprotective Function in Retinal Degeneration

Jiaming Zhou, Per Ekström

ASN Neuro. 2023 Jan-Dec; 15: 17590914231151534. Published online 2023 Feb 17. doi: 10.1177/17590914231151534

PMCID:: PMC9940218

Abstract Article PDF–1.8M

Select item 97469147.

Single-cell transcriptome analyses reveal microglia types associated with proliferative retinopathy

Zhiping Liu, Huidong Shi, Jiean Xu, Qiuhua Yang, Qian Ma, Xiaoxiao Mao, Zhimin Xu, Yaqi Zhou, Qingen Da, Yongfeng Cai, David J.R. Fulton, Zheng Dong, Akrit Sodhi, Ruth B. Caldwell, Yuqing Huo

JCI Insight. 2022 Dec 8; 7(23): e160940. Published online 2022 Dec 8. doi: 10.1172/jci.insight.160940

PMCID:: PMC9746914

Abstract Article PDF–20M

Select item 90509138.

Myeloid Cell PKM2 Deletion Enhances Efferocytosis and Reduces Atherosclerosis

Prakash Doddapattar, Rishabh Dev, Madankumar Ghatge, Rakesh B. Patel, Manish Jain, Nirav Dhanesha, Steven R. Lentz, Anil K. Chauhan

Circ Res. Author manuscript; available in PMC 2023 Apr 29.

Published in final edited form as: Circ Res. 2022 Apr 29; 130(9): 1289–1305. Published online 2022 Apr 11. doi: 10.1161/CIRCRESAHA.121.320704

PMCID:: PMC9050913

Abstract Article PDF–3.6M

Select item 88743619.

PKM2 promotes neutrophil activation and cerebral thromboinflammation: therapeutic implications for ischemic stroke

Nirav Dhanesha, Rakesh B. Patel, Prakash Doddapattar, Madankumar Ghatge, Gagan D. Flora, Manish Jain, Daniel Thedens, Heena Olalde, Mariia Kumskova, Enrique C. Leira, Anil K. Chauhan

Blood. 2022 Feb 24; 139(8): 1234–1245. doi: 10.1182/blood.2021012322

PMCID:: PMC8874361

Abstract Article

Select item 885705810.

PKM2 is essential for bladder cancer growth and maintenance

Yong Xia, Xing Wang, Yan Liu, Ellen Shapiro, Herbert Lepor, Moon-shong Tang, Tung-Tien Sun, Xue-Ru Wu

Cancer Res. Author manuscript; available in PMC 2022 Aug 15.

Published in final edited form as: Cancer Res. 2022 Feb 15; 82(4): 571–585. doi: 10.1158/0008-5472.CAN-21-0403

PMCID:: PMC8857058

Abstract Article PDF–1.8M

Select item 860183811.

PKM2 Is a Potential Diagnostic and Therapeutic Target for Retinitis Pigmentosa

Peiwen Zhu, Qian Yang, Gang Li, Qing Chang

Dis Markers. 2021; 2021: 1602797. Published online 2021 Nov 11. doi: 10.1155/2021/1602797

PMCID:: PMC8601838

Abstract Article PDF–2.5M

Select item 856208212.

Pyruvate Kinase M2 Supports Muscle Progenitor Cell Proliferation but Is Dispensable for Skeletal Muscle Regeneration after Injury

Jamie E Blum, Brandon J Gheller, Abby Benvie, Martha S Field, Elena Panizza, Nathaniel M Vacanti, Daniel Berry, Anna Thalacker-Mercer

J Nutr. 2021 Nov; 151(11): 3313–3328. Published online 2021 Aug 12. doi: 10.1093/jn/nxab251

PMCID:: PMC8562082

Abstract Article PDF–6.4M

Select item 851320913.

Pyruvate kinase isoform M2 impairs cognition in systemic lupus erythematosus by promoting microglial synaptic pruning via the β-catenin signaling pathway

Li Lu, Hailin Wang, Xuan Liu, Liping Tan, Xiaoyue Qiao, Jiali Ni, Yang Sun, Jun Liang, Yayi Hou, Huan Dou

J Neuroinflammation. 2021; 18: 229. Published online 2021 Oct 13. doi: 10.1186/s12974-021-02279-9

PMCID:: PMC8513209

Abstract Article PDF–13M

Select item 845689114.

Dysregulation of Pyruvate Kinase M2 Promotes Inflammation in a Mouse Model of Obese Allergic Asthma

Allison M. Manuel, Cheryl van de Wetering, Maximilian MacPherson, Cuixia Erickson, Caliann Murray, Reem Aboushousha, Jos van der Velden, Anne E. Dixon, Matthew E. Poynter, Charles G. Irvin, Douglas J. Taatjes, Albert van der Vliet, Vikas Anathy, Yvonne M. W. Janssen-Heininger

Am J Respir Cell Mol Biol. 2021 Jun; 64(6): 709–721. Published online 2021 Mar 4. doi: 10.1165/rcmb.2020-0512OC

PMCID:: PMC8456891

Abstract Article PDF–2.2M

Select item 817352815.

Potential role for pyruvate kinase M2 in the regulation of murine cardiac glycolytic flux during in vivo chronic hypoxia

Michal K. Handzlik, David J. Tooth, Dumitru Constantin-Teodosiu, Paul L. Greenhaff, Mark A. Cole

Biosci Rep. 2021 Jun 25; 41(6): BSR20203170. Published online 2021 Jun 2. doi: 10.1042/BSR20203170

PMCID:: PMC8173528

Abstract Article PDF–947K

Select item 804037016.

Modulation of PKM activity affects the differentiation of T_H17 cells

Scott M Seki, Kacper Posyniak, Rebecca McCloud, Dorian A Rosen, Anthony Fernández-Castañeda, Rebecca M Beiter, Vlad Serbulea, Sarah C Nanziri, Nikolas Hayes, Charles Spivey, Lelisa Gemta, Timothy N J Bullock, Ku-Lung Hsu, Alban Gaultier

Sci Signal. Author manuscript; available in PMC 2021 Apr 27.

Published in final edited form as: Sci Signal. 2020 Oct 27; 13(655): eaay9217. Published online 2020 Oct 27. doi: 10.1126/scisignal.aay9217

PMCID:: PMC8040370

Abstract Article PDF–2.9M

Select item 785104917.

Activator-Mediated Pyruvate Kinase M2 Activation Contributes to Endotoxin Tolerance by Promoting Mitochondrial Biogenesis

Zhujun Yi, Yilin Wu, Wenfeng Zhang, Tao Wang, Jianping Gong, Yao Cheng, Chunmu Miao

Front Immunol. 2020; 11: 595316. Published online 2021 Jan 19. doi: 10.3389/fimmu.2020.595316

PMCID:: PMC7851049

Abstract Article PDF–2.5M

Select item 740353018.

Pyruvate Kinase M2 in lung APCs regulates Alternaria-induced airway inflammation

Anil Kumar Jaiswal, Sangeet Makhija, Natalie Stahr, Maninder Sandey, Amol Suryawanshi, Amarjit Mishra

Immunobiology. Author manuscript; available in PMC 2020 Aug 5.

Published in final edited form as: Immunobiology. 2020 Jul; 225(4): 151956. Published online 2020 May 30. doi: 10.1016/j.imbio.2020.151956

PMCID:: PMC7403530

Abstract Article PDF–1.7M

Select item 721444619.

Role of pyruvate kinase M2-mediated metabolic reprogramming during podocyte differentiation

Qi Yuan, Jiao Miao, Qianqian Yang, Li Fang, Yi Fang, Hao Ding, Yang Zhou, Lei Jiang, Chunsun Dai, Ke Zen, Qi Sun, Junwei Yang

Cell Death Dis. 2020 May; 11(5): 355. Published online 2020 May 11. doi: 10.1038/s41419-020-2481-5

PMCID:: PMC7214446

Abstract Article PDF–2.5M

Select item 716995820.

Heat shock protein 90 relieves heat stress damage of myocardial cells by regulating Akt and PKM2 signaling in vivo

Xiao-Hui Zhang, Jia-Xin Wu, Jun-Zhou Sha, Bo Yang, Jia-Rui Sun, En-Dong Bao

Int J Mol Med. 2020 Jun; 45(6): 1888–1908. Published online 2020 Mar 31. doi: 10.3892/ijmm.2020.4560

PMCID:: PMC7169958

Abstract Article PDF–2.3M

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PMC Links for Gene (Select 18746) (162)
PMC
PREDICTED: Epinephelus fuscoguttatus kirre like nephrin family adhesion molecule...
PREDICTED: Epinephelus fuscoguttatus kirre like nephrin family adhesion molecule 3b (kirrel3b), transcript variant X7, mRNA
gi|2276572433|ref|XM_049576347.1|

Nucleotide
PREDICTED: Mus musculus pyruvate kinase, muscle (Pkm), transcript variant X6, mR...
PREDICTED: Mus musculus pyruvate kinase, muscle (Pkm), transcript variant X6, mRNA
gi|1907195589|ref|XM_006510856.3|

Nucleotide
kirrel3b [Epinephelus fuscoguttatus]
kirrel3b [Epinephelus fuscoguttatus]
Gene ID:125888766

Gene

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