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Items: 1 to 20 of 107

1.
Neural Progenitor Cell-Derived Extracellular Vesicles Enhance Blood-Brain Barrier Integrity by NF-κB (Nuclear Factor-κB)-Dependent Regulation of ABCB1 (ATP-Binding Cassette Transporter B1) in Stroke Mice
Lin Zhang, Irina Graf, Yaoyun Kuang, Xuan Zheng, Matteo Haupt, Arshad Majid, Ertugrul Kilic, Dirk M. Hermann, Marios-Nikos Psychogios, Martin S. Weber, Jasmin Ochs, Mathias Bähr, Thorsten R. Doeppner
Arterioscler Thromb Vasc Biol. 2021 Mar; 41(3): 1127–1145. Published online 2020 Dec 17. doi: 10.1161/ATVBAHA.120.315031
PMCID:
PMC7901534
AbstractArticlePDF–3.7M
2.
ATP-binding cassette transporters restrict drug delivery and efficacy against brain tumors even when blood-brain barrier integrity is lost
Mark C. de Gooijer, E. Marleen Kemper, Levi C.M. Buil, Ceren H. Çitirikkaya, Tessa Buckle, Jos H. Beijnen, Olaf van Tellingen
Cell Rep Med. 2021 Jan 19; 2(1): 100184. Published online 2021 Jan 19. doi: 10.1016/j.xcrm.2020.100184
PMCID:
PMC7817868
AbstractArticlePDF–2.7M
3.
L1210 Cells Overexpressing ABCB1 Drug Transporters Are Resistant to Inhibitors of the N- and O-glycosylation of Proteins
Lucia Pavlikova, Mario Seres, Milan Hano, Viera Bohacova, Ivana Sevcikova, Tomas Kyca, Albert Breier, Zdena Sulova
Molecules. 2017 Jul; 22(7): 1104. Published online 2017 Jul 3. doi: 10.3390/molecules22071104
PMCID:
PMC6152248
AbstractArticlePDF–1.2M
4.
Cooperativity between Verapamil and ATP Bound to the Efflux Transporter P-glycoprotein
Kaitlyn V. Ledwitch, Morgan E. Gibbs, Robert W. Barnes, Arthur G. Roberts
Biochem Pharmacol. Author manuscript; available in PMC 2017 Oct 15.
Published in final edited form as: Biochem Pharmacol. 2016 Oct 15; 118: 96–108. Published online 2016 Aug 13. doi: 10.1016/j.bcp.2016.08.013
PMCID:
PMC5341695
AbstractArticlePDF–1.7M
5.
Unravelling the complex drug–drug interactions of the cardiovascular drugs, verapamil and digoxin, with P-glycoprotein
Kaitlyn V. Ledwitch, Robert W. Barnes, Arthur G. Roberts
Biosci Rep. 2016 Apr; 36(2): e00309. Prepublished online 2016 Jan 27. Published online 2016 Mar 16. doi: 10.1042/BSR20150317
PMCID:
PMC4793304
AbstractArticlePDF–1.0M
6.
Incorporation of ABCB1-mediated transport into a physiologically-based pharmacokinetic model of docetaxel in mice
Susan F. Hudachek, Daniel L. Gustafson
J Pharmacokinet Pharmacodyn. Author manuscript; available in PMC 2015 Jan 13.
Published in final edited form as: J Pharmacokinet Pharmacodyn. 2013 Aug; 40(4): 437–449. Published online 2013 Apr 25. doi: 10.1007/s10928-013-9317-1
PMCID:
PMC4292804
AbstractArticlePDF–1.1M
7.
Directed evolution of P-glycoprotein cysteines reveals site-specific, non-conservative substitutions that preserve multidrug resistance
Douglas J. Swartz, Leo Mok, Sri K. Botta, Anukriti Singh, Guillermo A. Altenberg, Ina L. Urbatsch
Biosci Rep. 2014; 34(3): e00116. Prepublished online 2014 May 14. Published online 2014 Jun 25. doi: 10.1042/BSR20140062
PMCID:
PMC4069687
AbstractArticlePDF–1.7M
8.
Differential recognition of mdr1a and mdr1b gene products in multidrug resistant mouse tumour cell lines by different monoclonal antibodies.
M. A. Barrand, P. R. Twentyman
Br J Cancer. 1992 Feb; 65(2): 239–245. doi: 10.1038/bjc.1992.48
PMCID:
PMC1977717
SummaryPage BrowsePDF–3.7M
9.
The multidrug resistance P-glycoprotein modulates cell regulatory volume decrease.
M A Valverde, T D Bond, S P Hardy, J C Taylor, C F Higgins, J Altamirano, F J Alvarez-Leefmans
EMBO J. 1996 Sep 2; 15(17): 4460–4468.
PMCID:
PMC452175
SummaryPage BrowsePDF–1.6M
10.
Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance.
M Azzaria, E Schurr, P Gros
Mol Cell Biol. 1989 Dec; 9(12): 5289–5297. doi: 10.1128/mcb.9.12.5289
PMCID:
PMC363693
SummaryPage BrowsePDF–2.0M
11.
Bilirubin protects astrocytes from its own toxicity by inducing up-regulation and translocation of multidrug resistance-associated protein 1 (Mrp1)
Florinda Gennuso, Cristina Fernetti, Cataldo Tirolo, Nuccio Testa, Francesca L'Episcopo, Salvo Caniglia, Maria Concetta Morale, J. Donald Ostrow, Lorella Pascolo, Claudio Tiribelli, Bianca Marchetti
Proc Natl Acad Sci U S A. 2004 Feb 24; 101(8): 2470–2475. Published online 2004 Feb 17. doi: 10.1073/pnas.0308452100
PMCID:
PMC356974
AbstractArticlePDF–742K
12.
Imaging reversal of multidrug resistance in living mice with bioluminescence: MDR1 P-glycoprotein transports coelenterazine
Andrea Pichler, Julie L. Prior, David Piwnica-Worms
Proc Natl Acad Sci U S A. 2004 Feb 10; 101(6): 1702–1707. Published online 2004 Jan 30. doi: 10.1073/pnas.0304326101
PMCID:
PMC341825
AbstractArticlePDF–600K
13.
Isolation and characterization of DNA sequences amplified in multidrug-resistant hamster cells.
P Gros, J Croop, I Roninson, A Varshavsky, D E Housman
Proc Natl Acad Sci U S A. 1986 Jan; 83(2): 337–341. doi: 10.1073/pnas.83.2.337
PMCID:
PMC322853
SummaryPage BrowsePDF–1.7M
14.
The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus.
R J Arceci, J M Croop, S B Horwitz, D Housman
Proc Natl Acad Sci U S A. 1988 Jun; 85(12): 4350–4354. doi: 10.1073/pnas.85.12.4350
PMCID:
PMC280426
SummaryPage BrowsePDF–2.0M
15.
P-glycoprotein: a major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans.
E G Schuetz, A H Schinkel, M V Relling, J D Schuetz
Proc Natl Acad Sci U S A. 1996 Apr 30; 93(9): 4001–4005. doi: 10.1073/pnas.93.9.4001
PMCID:
PMC39475
SummaryPage BrowsePDF–1.2M
16.
Role of ABCB1 and ABCB4 in renal and biliary excretion of perfluorooctanoic acid in mice
Kazuyoshi Furukawa, Kahori Okamoto-Matsuda, Kouji H. Harada, Mutsuko Minata, Toshiaki Hitomi, Hatasu Kobayashi, Akio Koizumi
Environ Health Prev Med. 2024; 29: 21. Published online 2024 Mar 22. doi: 10.1265/ehpm.23-00284
PMCID:
PMC10965415
AbstractArticlePDF–1.2M
17.
Limited Impact of Murine Placental MDR1 on Fetal Exposure of Certain Drugs Explained by Bypass Transfer Between Adjacent Syncytiotrophoblast Layers
Arimi Fujita, Saki Noguchi, Rika Hamada, Satoko Inoue, Tsutomu Shimada, Satomi Katakura, Tetsuo Maruyama, Yoshimichi Sai, Tomohiro Nishimura, Masatoshi Tomi
Pharm Res. 2022; 39(7): 1645–1658. Published online 2022 Jan 26. doi: 10.1007/s11095-022-03165-6
PMCID:
PMC9246986
AbstractArticlePDF–582K
18.
P-gp expression inhibition mediates placental glucocorticoid barrier opening and fetal weight loss
Caiyun Ge, Dan Xu, Pengxia Yu, Man Fang, Juanjuan Guo, Dan Xu, Yuan Qiao, Sijia Chen, Yuanzhen Zhang, Hui Wang
BMC Med. 2021; 19: 311. Published online 2021 Dec 8. doi: 10.1186/s12916-021-02173-4
Correction in:
BMC Med. 2022; 20: 126.
PMCID:
PMC8653610
AbstractArticlePDF–6.9M
19.
Peripheral Hybrid CB1R and iNOS Antagonist MRI-1867 Displays Anti-Fibrotic Efficacy in Bleomycin-Induced Skin Fibrosis
Charles N. Zawatsky, Joshua K. Park, Jasmina Abdalla, George Kunos, Malliga R. Iyer, Resat Cinar
Front Endocrinol (Lausanne) 2021; 12: 744857. Published online 2021 Sep 28. doi: 10.3389/fendo.2021.744857
PMCID:
PMC8505776
AbstractArticlePDF–3.0M
20.
Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives
Ling Zou, Peter Spanogiannopoulos, Lindsey M. Pieper, Huan-Chieh Chien, Wenlong Cai, Natalia Khuri, Joshua Pottel, Bianca Vora, Zhanglin Ni, Eleftheria Tsakalozou, Wenjun Zhang, Brian K. Shoichet, Kathleen M. Giacomini, Peter J. Turnbaugh
Proc Natl Acad Sci U S A. 2020 Jul 7; 117(27): 16009–16018. Published online 2020 Jun 22. doi: 10.1073/pnas.1920483117
PMCID:
PMC7355017
AbstractArticlePDF–1.1M

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