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Select item 78526071.

Activation of proprotein convertase in the mouse habenula causes depressive-like behaviors through remodeling of extracellular matrix

Hikaru Ito, Kanako Nozaki, Kenji Sakimura, Manabu Abe, Shigeto Yamawaki, Hidenori Aizawa

Neuropsychopharmacology. 2021 Jan; 46(2): 442–454. Published online 2020 Sep 17. doi: 10.1038/s41386-020-00843-0

PMCID:: PMC7852607

Abstract Article PDF–4.8M

Select item 13176382.

Deletion of the Gene Encoding Proprotein Convertase 5/6 Causes Early Embryonic Lethality in the Mouse

Rachid Essalmani, Josée Hamelin, Jadwiga Marcinkiewicz, Ann Chamberland, Majambu Mbikay, Michel Chrétien, Nabil G. Seidah, Annik Prat

Mol Cell Biol. 2006 Jan; 26(1): 354–361. doi: 10.1128/MCB.26.1.354-361.2006

PMCID:: PMC1317638

Abstract Article PDF–441K

Select item 82134033.

In Vivo Analysis of the Contribution of Proprotein Convertases to the Processing of FGF23

Omar Al Rifai, Delia Susan-Resiga, Rachid Essalmani, John W. M. Creemers, Nabil G. Seidah, Mathieu Ferron

Front Endocrinol (Lausanne) 2021; 12: 690681. Published online 2021 Jun 4. doi: 10.3389/fendo.2021.690681

PMCID:: PMC8213403

Abstract Article PDF–6.4M

Select item 469984.

cDNA structure of the mouse and rat subtilisin/kexin-like PC5: a candidate proprotein convertase expressed in endocrine and nonendocrine cells.

J Lusson, D Vieau, J Hamelin, R Day, M Chrétien, N G Seidah

Proc Natl Acad Sci U S A. 1993 Jul 15; 90(14): 6691–6695. doi: 10.1073/pnas.90.14.6691

PMCID:: PMC46998

Summary Page Browse PDF–1.5M

Select item 27461785.

The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: in vivo mouse model

Xiaowei Sun, Rachid Essalmani, Nabil G Seidah, Annik Prat

Mol Cancer. 2009; 8: 73. Published online 2009 Sep 8. doi: 10.1186/1476-4598-8-73

PMCID:: PMC2746178

Abstract Article PDF–1.2M

Select item 21210966.

The isoforms of proprotein convertase PC5 are sorted to different subcellular compartments

J Cell Biol. 1996 Dec 1; 135(5): 1261–1275. doi: 10.1083/jcb.135.5.1261

PMCID:: PMC2121096

Summary PDF–1.8M

Select item 46401997.

Variant mapping and mutation discovery in inbred mice using next-generation sequencing

Jabier Gallego-Llamas, Andrew E. Timms, Krista A. Geister, Anna Lindsay, David R. Beier

BMC Genomics. 2015; 16: 913. Published online 2015 Nov 9. doi: 10.1186/s12864-015-2173-1

PMCID:: PMC4640199

Abstract Article PDF–1.7M

Select item 30508898.

Role of PCSK5 Expression in Mouse Ovarian Follicle Development: Identification of the Inhibin α- and β-Subunits as Candidate Substrates

Monica Antenos, Lei Lei, Min Xu, Anjali Malipatil, Sarah Kiesewetter, Teresa K. Woodruff

PLoS One. 2011; 6(3): e17348. Published online 2011 Mar 8. doi: 10.1371/journal.pone.0017348

PMCID:: PMC3050889

Abstract Article PDF–2.4M

Select item 22992179.

In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate

Rachid Essalmani, Ahmed Zaid, Jadwiga Marcinkiewicz, Ann Chamberland, Antonella Pasquato, Nabil G. Seidah, Annik Prat

Proc Natl Acad Sci U S A. 2008 Apr 15; 105(15): 5750–5755. Published online 2008 Mar 31. doi: 10.1073/pnas.0709428105

PMCID:: PMC2299217

Abstract Article PDF–1.2M

Select item 566335010.

Proprotein convertase furin regulates osteocalcin and bone endocrine function

Omar Al Rifai, Jacqueline Chow, Julie Lacombe, Catherine Julien, Denis Faubert, Delia Susan-Resiga, Rachid Essalmani, John W.M. Creemers, Nabil G. Seidah, Mathieu Ferron

J Clin Invest. 2017 Nov 1; 127(11): 4104–4117. Published online 2017 Oct 3. doi: 10.1172/JCI93437

PMCID:: PMC5663350

Abstract Article PDF–5.4M

Select item 548156311.

Thrombin activation of protein C requires prior processing by a liver proprotein convertase

Rachid Essalmani, Delia Susan-Resiga, Johann Guillemot, Woojin Kim, Vatsal Sachan, Zuhier Awan, Ann Chamberland, Marie-Claude Asselin, Kévin Ly, Roxane Desjardins, Robert Day, Annik Prat, Nabil G. Seidah

J Biol Chem. 2017 Jun 23; 292(25): 10564–10573. Published online 2017 May 3. doi: 10.1074/jbc.M116.770040

Correction in:: J Biol Chem. 2017 Aug 18; 292(33): 13565.

PMCID:: PMC5481563

Abstract Article PDF–1.1M

Select item 540700312.

Pcsk5 is required in the early cranio-cardiac mesoderm for heart development

Dorota Szumska, Milena Cioroch, Angela Keeling, Annik Prat, Nabil G. Seidah, Shoumo Bhattacharya

BMC Dev Biol. 2017; 17: 6. Published online 2017 Apr 26. doi: 10.1186/s12861-017-0148-y

PMCID:: PMC5407003

Abstract Article PDF–4.4M

Select item 273449313.

The Cell-Specific Pattern of Cholecystokinin Peptides in Endocrine Cells Versus Neurons Is Governed by the Expression of Prohormone Convertases 1/3, 2, and 5/6

Jens F. Rehfeld, Jens R. Bundgaard, Jens Hannibal, Xiaorong Zhu, Christina Norrbom, Donald F. Steiner, Lennart Friis-Hansen

Endocrinology. 2008 Apr; 149(4): 1600–1608. Published online 2007 Dec 20. doi: 10.1210/en.2007-0278

PMCID:: PMC2734493

Abstract Article

Select item 291844414.

PCSK9 is not involved in the degradation of LDL receptors and BACE1 in the adult mouse brain

Mali Liu, Guoxin Wu, Jennifer Baysarowich, Michael Kavana, George H. Addona, Kathleen K. Bierilo, John S. Mudgett, Guillaume Pavlovic, Ayesha Sitlani, John J. Renger, Brian K. Hubbard, Timothy S. Fisher, Celina V. Zerbinatti

J Lipid Res. 2010 Sep; 51(9): 2611–2618. doi: 10.1194/jlr.M006635

PMCID:: PMC2918444

Abstract Article PDF–1.0M

Select item 126642015.

The Cysteine-rich Domain of the Secreted Proprotein Convertases PC5A and PACE4 Functions as a Cell Surface Anchor and Interacts with Tissue Inhibitors of Metalloproteinases

Nadia Nour, Gaétan Mayer, John S. Mort, Alexandre Salvas, Majambu Mbikay, Charlotte J. Morrison, Christopher M. Overall, Nabil G. Seidah

Mol Biol Cell. 2005 Nov; 16(11): 5215–5226. doi: 10.1091/mbc.E05-06-0504

PMCID:: PMC1266420

Abstract Article PDF–545K

Select item 303935416.

In Vivo Evidence That Furin from Hepatocytes Inactivates PCSK9

Rachid Essalmani, Delia Susan-Resiga, Ann Chamberland, Marianne Abifadel, John W. Creemers, Catherine Boileau, Nabil G. Seidah, Annik Prat

J Biol Chem. 2011 Feb 11; 286(6): 4257–4263. Published online 2010 Dec 8. doi: 10.1074/jbc.M110.192104

PMCID:: PMC3039354

Abstract Article PDF–920K

Select item 214811317.

Regulation of Bone Morphogenetic Protein Activity by Pro Domains and Proprotein Convertases

Daniel B. Constam, Elizabeth J. Robertson

J Cell Biol. 1999 Jan 11; 144(1): 139–149. doi: 10.1083/jcb.144.1.139

PMCID:: PMC2148113

Abstract Article PDF–708K

Select item 319071418.

Latent Transforming Growth Factor β-Binding Proteins-2 and -3 Inhibit the Proprotein Convertase 5/6A

Xiaowei Sun, Rachid Essalmani, Delia Susan-Resiga, Annik Prat, Nabil G. Seidah

J Biol Chem. 2011 Aug 19; 286(33): 29063–29073. Published online 2011 Jun 23. doi: 10.1074/jbc.M111.242479

PMCID:: PMC3190714

Abstract Article PDF–2.2M

Select item 212092419.

SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis

J Cell Biol. 1996 Jul 1; 134(1): 181–191. doi: 10.1083/jcb.134.1.181

PMCID:: PMC2120924

Summary PDF–5.1M

Select item 2434320.

A widely expressed βIII spectrin associated with Golgi and cytoplasmic vesicles

Michael C. Stankewich, William T. Tse, Luanne L. Peters, Yeang Ch’ng, Kathryn M. John, Paul R. Stabach, Prasad Devarajan, Jon S. Morrow, Samuel E. Lux

Proc Natl Acad Sci U S A. 1998 Nov 24; 95(24): 14158–14163. doi: 10.1073/pnas.95.24.14158

PMCID:: PMC24343

Abstract Article PDF–492K

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Microgastrinae sp. CNCH0621 cytochrome oxidase subunit 1 (COI) gene, partial cds...
Microgastrinae sp. CNCH0621 cytochrome oxidase subunit 1 (COI) gene, partial cds; mitochondrial
gi|323109341|gnl|uoguelph|CNCHX480- I-5P|gb|HQ941847.1|

Nucleotide

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