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Select item 108055101.

Novel, pathogenic insertion variant of GSDME associates with autosomal dominant hearing loss in a large Chinese pedigree

Jingliang Cheng, Ting Li, Qi Tan, Jiewen Fu, Lianmei Zhang, Luquan Yang, Baixu Zhou, Lisha Yang, Shangyi Fu, Alora Grace Linehan, Junjiang Fu

J Cell Mol Med. 2024 Jan; 28(1): e18004. Published online 2023 Oct 20. doi: 10.1111/jcmm.18004

PMCID:: PMC10805510

Abstract Article PDF–3.9M

Select item 93810412.

Zika virus causes placental pyroptosis and associated adverse fetal outcomes by activating GSDME

Zikai Zhao, Qi Li, Usama Ashraf, Mengjie Yang, Wenjing Zhu, Jun Gu, Zheng Chen, Changqin Gu, Youhui Si, Shengbo Cao, Jing Ye

eLife. 2022; 11: e73792. Published online 2022 Aug 16. doi: 10.7554/eLife.73792

PMCID:: PMC9381041

Abstract Article PDF–8.7M

Select item 89240003.

Gasdermin E mediates resistance of pancreatic adenocarcinoma to enzymatic digestion through a YBX1–mucin pathway

Jiadi Lv, Yuying Liu, Siqi Mo, Yabo Zhou, Fengye Chen, Feiran Cheng, Cong Li, Dilizhatai Saimi, Mengyu Liu, Huafeng Zhang, Ke Tang, Jingwei Ma, Zhenfeng Wang, Qiangqiang Zhu, Wei-Min Tong, Bo Huang

Nat Cell Biol. 2022; 24(3): 364–372. Published online 2022 Mar 15. doi: 10.1038/s41556-022-00857-4

PMCID:: PMC8924000

Abstract Article PDF–17M

Select item 87418464.

Apoptin induces pyroptosis of colorectal cancer cells via the GSDME-dependent pathway

Zirui Liu, Yiquan Li, Yilong Zhu, Nan Li, Wenjie Li, Chao Shang, Gaojie Song, Shanzhi Li, Jianan Cong, Tingyu Li, Zhiru Xiu, Jing Lu, Chenchen Ge, Xia Yang, Yaru Li, Lili Sun, Xiao Li, Ningyi Jin

Int J Biol Sci. 2022; 18(2): 717–730. Published online 2022 Jan 1. doi: 10.7150/ijbs.64350

PMCID:: PMC8741846

Abstract Article PDF–3.0M

Select item 85947435.

Virus-mediated inactivation of anti-apoptotic Bcl-2 family members promotes Gasdermin E-dependent pyroptosis in barrier epithelial cells

Megan H. Orzalli, Aleksandra Prochera, Laurellee Payne, Avi Smith, Jonathan A. Garlick, Jonathan C. Kagan

Immunity. Author manuscript; available in PMC 2022 Jul 13.

Published in final edited form as: Immunity. 2021 Jul 13; 54(7): 1447–1462.e5. Published online 2021 May 11. doi: 10.1016/j.immuni.2021.04.012

PMCID:: PMC8594743

Abstract Article PDF–2.5M

Select item 83902046.

Prognostic role of DFNA5 in head and neck squamous cell carcinoma revealed by systematic expression analysis

Zhiguo Liu, Hongyan Liu, Qian Dong, Hongyu Li, Bin Zhang, Yufeng Liu, Limei Zhong, Haikuo Tang

BMC Cancer. 2021; 21: 951. Published online 2021 Aug 25. doi: 10.1186/s12885-021-08692-w

PMCID:: PMC8390204

Abstract Article PDF–5.9M

Select item 74452647.

GSDME enhances Cisplatin sensitivity to regress non-small cell lung carcinoma by mediating pyroptosis to trigger antitumor immunocyte infiltration

Zhouyangfan Peng, Pengfei Wang, Wei Song, Qingmei Yao, Yinjia Li, Linglong Liu, Yapei Li, Sufang Zhou

Signal Transduct Target Ther. 2020; 5: 159. Published online 2020 Aug 24. doi: 10.1038/s41392-020-00274-9

PMCID:: PMC7445264

Article PDF–1.4M

Select item 73125368.

DFNA5 (GSDME) c.991-15_991-13delTTC: Founder Mutation or Mutational Hotspot?

Kevin T. Booth, Hela Azaiez, Richard J. H. Smith

Int J Mol Sci. 2020 Jun; 21(11): 3951. Published online 2020 May 31. doi: 10.3390/ijms21113951

PMCID:: PMC7312536

Abstract Article PDF–1.3M

Select item 65369219.

Methylation analysis of Gasdermin E shows great promise as a biomarker for colorectal cancer

Joe Ibrahim, Ken Op de Beeck, Erik Fransen, Lieselot Croes, Matthias Beyens, Arvid Suls, Wim Vanden Berghe, Marc Peeters, Guy Van Camp

Cancer Med. 2019 May; 8(5): 2133–2145. Published online 2019 Apr 16. doi: 10.1002/cam4.2103

PMCID:: PMC6536921

Abstract Article PDF–1.1M

Select item 628819210.

Gasdermin E Does Not Limit Apoptotic Cell Disassembly by Promoting Early Onset of Secondary Necrosis in Jurkat T Cells and THP-1 Monocytes

Rochelle Tixeira, Bo Shi, Michael A. F. Parkes, Amy L. Hodge, Sarah Caruso, Mark D. Hulett, Amy A. Baxter, Thanh Kha Phan, Ivan K. H. Poon

Front Immunol. 2018; 9: 2842. Published online 2018 Dec 4. doi: 10.3389/fimmu.2018.02842

PMCID:: PMC6288192

Abstract Article PDF–1.3M

Select item 597672311.

Further evidence for “gain-of-function” mechanism of DFNA5 related hearing loss

Hongyang Wang, Jing Guan, Liping Guan, Ju Yang, Kaiwen Wu, Qiongfen Lin, Wenping Xiong, Lan Lan, Cui Zhao, Linyi Xie, Lan Yu, Dan Bing, Lidong Zhao, Dayong Wang, Qiuju Wang

Sci Rep. 2018; 8: 8424. Published online 2018 May 30. doi: 10.1038/s41598-018-26554-7

PMCID:: PMC5976723

Abstract Article PDF–2.6M

Select item 589607212.

Large-scale analysis of DFNA5 methylation reveals its potential as biomarker for breast cancer

Lieselot Croes, Matthias Beyens, Erik Fransen, Joe Ibrahim, Wim Vanden Berghe, Arvid Suls, Marc Peeters, Patrick Pauwels, Guy Van Camp, Ken Op de Beeck

Clin Epigenetics. 2018; 10: 51. Published online 2018 Apr 11. doi: 10.1186/s13148-018-0479-y

PMCID:: PMC5896072

Abstract Article PDF–1.4M

Select item 580562113.

Exonic mutations and exon skipping: lessons learned from DFNA5

Kevin T Booth, Hela Azaiez, Kimia Kahrizi, Donghong Wang, Yuzhou Zhang, Kathy Frees, Carla Nishimura, Hossein Najmabadi, Richard J Smith

Hum Mutat. Author manuscript; available in PMC 2019 Mar 1.

Published in final edited form as: Hum Mutat. 2018 Mar; 39(3): 433–440. Published online 2018 Jan 11. doi: 10.1002/humu.23384

PMCID:: PMC5805621

Abstract Article PDF–680K

Select item 545826114.

DFNA5 promoter methylation a marker for breast tumorigenesis

Lieselot Croes, Ken Op de Beeck, Patrick Pauwels, Wim Vanden Berghe, Marc Peeters, Erik Fransen, Guy Van Camp

Oncotarget. 2017 May 9; 8(19): 31948–31958. Published online 2017 Mar 29. doi: 10.18632/oncotarget.16654

PMCID:: PMC5458261

Abstract Article PDF–3.8M

Select item 472557115.

IVS8+1 DelG, a Novel Splice Site Mutation Causing DFNA5 Deafness in a Chinese Family

Mei-Na Li-Yang, Xiao-Fei Shen, Qin-Jun Wei, Jun Yao, Ya-Jie Lu, Xin Cao, Guang-Qian Xing

Chin Med J (Engl) 2015 Sep 20; 128(18): 2510–2515. doi: 10.4103/0366-6999.164980

PMCID:: PMC4725571

Abstract Article PDF–1.4M

Select item 343383816.

Evidence for a founder mutation causing DFNA5 hearing loss in East Asians

Hong-Joon Park, Hyun-Ju Cho, Jeong-In Baek, Tamar Ben-Yosef, Tae-Jun Kwon, Andrew J Griffith, Un-Kyung Kim

J Hum Genet. Author manuscript; available in PMC 2012 Sep 5.

Published in final edited form as: J Hum Genet. 2010 Jan; 55(1): 59–62. Published online 2009 Nov 13. doi: 10.1038/jhg.2009.114

PMCID:: PMC3433838

Abstract Article PDF–937K

Select item 309471717.

Methylation of the DFNA5 increases risk of lymph node metastasis in human breast cancer

Myoung Sook Kim, Cinthia Lebron, Jatin K. Nagpal, Young Kwang Chae, Xiaofei Chang, Yiping Huang, Tony Chuang, Keishi Yamashita, Barry Trink, Edward A. Ratovitski, Joseph A. Califano, David Sidransky

Biochem Biophys Res Commun. Author manuscript; available in PMC 2011 May 15.

Published in final edited form as: Biochem Biophys Res Commun. 2008 May 23; 370(1): 38–43. Published online 2008 Mar 17. doi: 10.1016/j.bbrc.2008.03.026

PMCID:: PMC3094717

Abstract Article PDF–985K

Select item 269560618.

In CEM cells the autosomal deafness gene dfna5 is regulated by glucocorticoids and forskolin

M.S. Webb, A.L. Miller, E. Brad Thompson

J Steroid Biochem Mol Biol. Author manuscript; available in PMC 2009 Jun 12.

Published in final edited form as: J Steroid Biochem Mol Biol. 2007 Oct; 107(1-2): 15–21. Published online 2007 May 24. doi: 10.1016/j.jsbmb.2007.02.004

PMCID:: PMC2695606

Abstract Article PDF–606K

Select item 1042429619.

AMIGO2 attenuates innate cisplatin sensitivity by suppression of GSDME‐conferred pyroptosis in non‐small cell lung cancer

Lian‐kuai Chen, Shu‐ping Lin, Yong‐huan Xie, Xiang‐peng Tan, Ben‐han Xiong, Xiang‐feng Zeng, Cai‐rong Zhu, Shao‐yi Cao, Xiao‐yan Ye, Hong‐jiao Liu, Xiao‐ping Wu

J Cell Mol Med. 2023 Aug; 27(16): 2412–2423. Published online 2023 Jul 12. doi: 10.1111/jcmm.17827