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Select item 61361781.

The new 6q27 tumor suppressor DACT2, frequently silenced by CpG methylation, sensitizes nasopharyngeal cancer cells to paclitaxel and 5-FU toxicity via β-catenin/Cdc25c signaling and G2/M arrest

Yan Zhang, Jiangxia Fan, Yichao Fan, Lili Li, Xiaoqian He, Qin Xiang, Junhao Mu, Danfeng Zhou, Xuejuan Sun, Yucheng Yang, Guosheng Ren, Qian Tao, Tingxiu Xiang

Clin Epigenetics. 2018; 10: 26. Published online 2018 Feb 27. doi: 10.1186/s13148-018-0459-2

PMCID:: PMC6136178

Abstract Article PDF–4.8M

Select item 54683162.

Methylation of DACT2 promotes breast cancer development by activating Wnt signaling

Jingyi Li, Meiying Zhang, Tao He, Hongxia Li, Tingting Cao, Lili Zheng, Mingzhou Guo

Sci Rep. 2017; 7: 3325. Published online 2017 Jun 12. doi: 10.1038/s41598-017-03647-3

PMCID:: PMC5468316

Abstract Article PDF–4.8M

Select item 53401163.

DACT2 silencing by promoter CpG methylation disrupts its regulation of epithelial-to-mesenchymal transition and cytoskeleton reorganization in breast cancer cells

Tingxiu Xiang, Yichao Fan, Chunhong Li, Lili Li, Ying Ying, Junhao Mu, Weiyan Peng, Yixiao Feng, Michael Oberst, Kathleen Kelly, Guosheng Ren, Qian Tao

Oncotarget. 2016 Oct 25; 7(43): 70924–70935. Published online 2016 Sep 29. doi: 10.18632/oncotarget.12341

PMCID:: PMC5340116

Abstract Article PDF–5.4M

Select item 49512634.

Methylation of DACT2 accelerates esophageal cancer development by activating Wnt signaling

Meiying Zhang, Enqiang Linghu, Qimin Zhan, Tao He, Baoping Cao, Malcolm V. Brock, James G. Herman, Rong Xiang, Mingzhou Guo

Oncotarget. 2016 Apr 5; 7(14): 17957–17969. Published online 2016 Feb 23. doi: 10.18632/oncotarget.7647

PMCID:: PMC4951263

Abstract Article PDF–7.3M

Select item 47616445.

DACT2 is a functional tumor suppressor through inhibiting Wnt/β-catenin pathway and associated with poor survival in colon cancer

S Wang, Y Dong, Y Zhang, X Wang, L Xu, S Yang, X Li, H Dong, L Xu, L Su, S S M Ng, Z Chang, J J Sung, X Zhang, J Yu

Oncogene. 2015 May 14; 34(20): 2575–2585. Published online 2014 Jul 14. doi: 10.1038/onc.2014.201

PMCID:: PMC4761644

Abstract Article PDF–4.6M

Select item 42230436.

Methylation of DACT2 Promotes Papillary Thyroid Cancer Metastasis by Activating Wnt Signaling

Zhiyan Zhao, James G. Herman, Malcolm V. Brock, Jindong Sheng, Meiying Zhang, Baoguo Liu, Mingzhou Guo

PLoS One. 2014; 9(11): e112336. Published online 2014 Nov 6. doi: 10.1371/journal.pone.0112336

PMCID:: PMC4223043

Abstract Article PDF–3.3M

Select item 40615657.

Epigenetic regulation of DACT2, a key component of the Wnt signalling pathway in human lung cancer

Yan Jia, Yunsheng Yang, Malcolm V Brock, Qimin Zhan, James G Herman, Mingzhou Guo

J Pathol. Author manuscript; available in PMC 2014 Jun 18.

Published in final edited form as: J Pathol. 2013 Jun; 230(2): 194–204. doi: 10.1002/path.4073

PMCID:: PMC4061565

Abstract Article PDF–1.7M

Select item 36740468.

Epigenetic regulation of the Wnt signaling inhibitor DACT2 in human hepatocellular carcinoma

Xiaomei Zhang, Yunsheng Yang, Xuefeng Liu, James G. Herman, Malcolm V. Brock, Julien D.F. Licchesi, Wen Yue, Xuetao Pei, Mingzhou Guo

Epigenetics. 2013 Apr 1; 8(4): 373–382. Published online 2013 Feb 28. doi: 10.4161/epi.24113

PMCID:: PMC3674046

Abstract Article PDF–2.1M

Select item 36053959.

Reduced expression of DACT2 promotes hepatocellular carcinoma progression: involvement of methylation-mediated gene silencing

Sheng Gao, Zhe Yang, Zhi-Yun Zheng, Jia Yao, Feng Zhang, Li-Ming Wu, Hai-Yang Xie, Lin zhou, Shu-Sen Zheng

World J Surg Oncol. 2013; 11: 57. Published online 2013 Mar 7. doi: 10.1186/1477-7819-11-57

PMCID:: PMC3605395

Abstract Article PDF–2.9M

Select item 522553410.

Aberrant methylation of DACT1 and DACT2 are associated with tumor progression and poor prognosis in esophageal squamous cell carcinoma

Yan-li Guo, Bao-En Shan, Wei Guo, Zhi-Ming Dong, Zhen Zhou, Su-Peng Shen, Xin Guo, Jia Liang, Gang Kuang

J Biomed Sci. 2017; 24: 6. Published online 2017 Jan 11. doi: 10.1186/s12929-016-0308-6

PMCID:: PMC5225534

Abstract Article PDF–4.2M

Select item 609106311.

TET1 exerts its anti-tumor functions via demethylating DACT2 and SFRP2 to antagonize Wnt/β-catenin signaling pathway in nasopharyngeal carcinoma cells

Jiangxia Fan, Yan Zhang, Junhao Mu, Xiaoqian He, Bianfei Shao, Dishu Zhou, Weiyan Peng, Jun Tang, Yu Jiang, Guosheng Ren, Tingxiu Xiang

Clin Epigenetics. 2018; 10: 103. Published online 2018 Aug 3. doi: 10.1186/s13148-018-0535-7

PMCID:: PMC6091063

Abstract Article PDF–7.5M

Select item 544221212.

Prognostic significance of the methylation of Wnt pathway antagonists—CXXC4, DACT2, and the inhibitors of sonic hedgehog signaling—ZIC1, ZIC4, and HHIP in head and neck squamous cell carcinomas

Jarosław Paluszczak, Dorota Wiśniewska, Magdalena Kostrzewska-Poczekaj, Katarzyna Kiwerska, Reidar Grénman, Daniela Mielcarek-Kuchta, Małgorzata Jarmuż-Szymczak

Clin Oral Investig. 2017; 21(5): 1777–1788. Published online 2016 Aug 23. doi: 10.1007/s00784-016-1946-5

PMCID:: PMC5442212

Abstract Article PDF–728K

Select item 724843013.

Comparative exome sequencing reveals novel candidate genes for retinitis pigmentosa

Zhen Yi, Jiamin Ouyang, Wenmin Sun, Shiqiang Li, Xueshan Xiao, Qingjiong Zhang

EBioMedicine. 2020 Jun; 56: 102792. Published online 2020 May 23. doi: 10.1016/j.ebiom.2020.102792

Correction in:: EBioMedicine. 2022 Mar; 77: 103913.

PMCID:: PMC7248430

Abstract Article PDF–3.4M

Select item 447088314.

Pilomyxoid Astrocytoma (PMA) Shows Significant Differences in Gene Expression vs. Pilocytic Astrocytoma (PA) and Variable Tendency Toward Maturation to PA

Bette K. Kleinschmidt‐DeMasters, Andrew M. Donson, Hannes Vogel, Nicholas K. Foreman

Brain Pathol. 2015 Jul; 25(4): 429–440. Published online 2015 Jan 27. doi: 10.1111/bpa.12239

PMCID:: PMC4470883

Abstract Article PDF–1.7M

Select item 442436415.

The Wnt Signaling Antagonist Dapper1 Accelerates Dishevelled2 Degradation via Promoting Its Ubiquitination and Aggregate-induced Autophagy

Benyu Ma, Bofeng Liu, Weipeng Cao, Chan Gao, Zhen Qi, Yuanheng Ning, Ye-Guang Chen

J Biol Chem. 2015 May 8; 290(19): 12346–12354. Published online 2015 Mar 30. doi: 10.1074/jbc.M115.654590

PMCID:: PMC4424364

Abstract Article PDF–2.7M

Select item 367499316.

Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits

Joshua C. Randall, Thomas W. Winkler, Zoltán Kutalik, Sonja I. Berndt, Anne U. Jackson, Keri L. Monda, Tuomas O. Kilpeläinen, Tõnu Esko, Reedik Mägi, Shengxu Li, Tsegaselassie Workalemahu, Mary F. Feitosa, Damien C. Croteau-Chonka, Felix R. Day, Tove Fall, Teresa Ferreira, Stefan Gustafsson, Adam E. Locke, Iain Mathieson, Andre Scherag, Sailaja Vedantam, Andrew R. Wood, Liming Liang, Valgerdur Steinthorsdottir, Gudmar Thorleifsson, Emmanouil T. Dermitzakis, Antigone S. Dimas, Fredrik Karpe, Josine L. Min, George Nicholson, Deborah J. Clegg, Thomas Person, Jon P. Krohn, Sabrina Bauer, Christa Buechler, Kristina Eisinger, DIAGRAM Consortium, Amélie Bonnefond, Philippe Froguel, MAGIC Investigators, Jouke-Jan Hottenga, Inga Prokopenko, Lindsay L. Waite, Tamara B. Harris, Albert Vernon Smith, Alan R. Shuldiner, Wendy L. McArdle, Mark J. Caulfield, Patricia B. Munroe, Henrik Grönberg, Yii-Der Ida Chen, Guo Li, Jacques S. Beckmann, Toby Johnson, Unnur Thorsteinsdottir, Maris Teder-Laving, Kay-Tee Khaw, Nicholas J. Wareham, Jing Hua Zhao, Najaf Amin, Ben A. Oostra, Aldi T. Kraja, Michael A. Province, L. Adrienne Cupples, Nancy L. Heard-Costa, Jaakko Kaprio, Samuli Ripatti, Ida Surakka, Francis S. Collins, Jouko Saramies, Jaakko Tuomilehto, Antti Jula, Veikko Salomaa, Jeanette Erdmann, Christian Hengstenberg, Christina Loley, Heribert Schunkert, Claudia Lamina, H. Erich Wichmann, Eva Albrecht, Christian Gieger, Andrew A. Hicks, Åsa Johansson, Peter P. Pramstaller, Sekar Kathiresan, Elizabeth K. Speliotes, Brenda Penninx, Anna-Liisa Hartikainen, Marjo-Riitta Jarvelin, Ulf Gyllensten, Dorret I. Boomsma, Harry Campbell, James F. Wilson, Stephen J. Chanock, Martin Farrall, Anuj Goel, Carolina Medina-Gomez, Fernando Rivadeneira, Karol Estrada, André G. Uitterlinden, Albert Hofman, M. Carola Zillikens, Martin den Heijer, Lambertus A. Kiemeney, Andrea Maschio, Per Hall, Jonathan Tyrer, Alexander Teumer, Henry Völzke, Peter Kovacs, Anke Tönjes, Massimo Mangino, Tim D. Spector, Caroline Hayward, Igor Rudan, Alistair S. Hall, Nilesh J. Samani, Antony Paul Attwood, Jennifer G. Sambrook, Joseph Hung, Lyle J. Palmer, Marja-Liisa Lokki, Juha Sinisalo, Gabrielle Boucher, Heikki Huikuri, Mattias Lorentzon, Claes Ohlsson, Niina Eklund, Johan G. Eriksson, Cristina Barlassina, Carlo Rivolta, Ilja M. Nolte, Harold Snieder, Melanie M. Van der Klauw, Jana V. Van Vliet-Ostaptchouk, Pablo V. Gejman, Jianxin Shi, Kevin B. Jacobs, Zhaoming Wang, Stephan J. L. Bakker, Irene Mateo Leach, Gerjan Navis, Pim van der Harst, Nicholas G. Martin, Sarah E. Medland, Grant W. Montgomery, Jian Yang, Daniel I. Chasman, Paul M. Ridker, Lynda M. Rose, Terho Lehtimäki, Olli Raitakari, Devin Absher, Carlos Iribarren, Hanneke Basart, Kees G. Hovingh, Elina Hyppönen, Chris Power, Denise Anderson, John P. Beilby, Jennie Hui, Jennifer Jolley, Hendrik Sager, Stefan R. Bornstein, Peter E. H. Schwarz, Kati Kristiansson, Markus Perola, Jaana Lindström, Amy J. Swift, Matti Uusitupa, Mustafa Atalay, Timo A. Lakka, Rainer Rauramaa, Jennifer L. Bolton, Gerry Fowkes, Ross M. Fraser, Jackie F. Price, Krista Fischer, Kaarel KrjutÅ¡kov, Andres Metspalu, Evelin Mihailov, Claudia Langenberg, Jian'an Luan, Ken K. Ong, Peter S. Chines, Sirkka M. Keinanen-Kiukaanniemi, Timo E. Saaristo, Sarah Edkins, Paul W. Franks, Göran Hallmans, Dmitry Shungin, Andrew David Morris, Colin N. A. Palmer, Raimund Erbel, Susanne Moebus, Markus M. Nöthen, Sonali Pechlivanis, Kristian Hveem, Narisu Narisu, Anders Hamsten, Steve E. Humphries, Rona J. Strawbridge, Elena Tremoli, Harald Grallert, Barbara Thorand, Thomas Illig, Wolfgang Koenig, Martina Müller-Nurasyid, Annette Peters, Bernhard O. Boehm, Marcus E. Kleber, Winfried März, Bernhard R. Winkelmann, Johanna Kuusisto, Markku Laakso, Dominique Arveiler, Giancarlo Cesana, Kari Kuulasmaa, Jarmo Virtamo, John W. G. Yarnell, Diana Kuh, Andrew Wong, Lars Lind, Ulf de Faire, Bruna Gigante, Patrik K. E. Magnusson, Nancy L. Pedersen, George Dedoussis, Maria Dimitriou, Genovefa Kolovou, Stavroula Kanoni, Kathleen Stirrups, Lori L. Bonnycastle, Inger Njølstad, Tom Wilsgaard, Andrea Ganna, Emil Rehnberg, Aroon Hingorani, Mika Kivimaki, Meena Kumari, Themistocles L. Assimes, Inês Barroso, Michael Boehnke, Ingrid B. Borecki, Panos Deloukas, Caroline S. Fox, Timothy Frayling, Leif C. Groop, Talin Haritunians, David Hunter, Erik Ingelsson, Robert Kaplan, Karen L. Mohlke, Jeffrey R. O'Connell, David Schlessinger, David P. Strachan, Kari Stefansson, Cornelia M. van Duijn, Gonçalo R. Abecasis, Mark I. McCarthy, Joel N. Hirschhorn, Lu Qi, Ruth J. F. Loos, Cecilia M. Lindgren, Kari E. North, Iris M. Heid

PLoS Genet. 2013 Jun; 9(6): e1003500. Published online 2013 Jun 6. doi: 10.1371/journal.pgen.1003500

PMCID:: PMC3674993

Abstract Article PDF–2.9M

Select item 314165617.

All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinases

Saul Kivimäe, Xiao Yong Yang, Benjamin NR Cheyette

BMC Biochem. 2011; 12: 33. Published online 2011 Jun 30. doi: 10.1186/1471-2091-12-33

PMCID:: PMC3141656

Abstract Article PDF–3.2M

Select item 465716118.

PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion

Anna E. Dart, Gary M. Box, William Court, Madeline E. Gale, John P. Brown, Sarah E. Pinder, Suzanne A. Eccles, Claire M. Wells

J Cell Biol. 2015 Nov 23; 211(4): 863–879. doi: 10.1083/jcb.201501072

PMCID:: PMC4657161

Abstract Article PDF–8.1M

Select item 1626719.

Shotgun sequencing of the human transcriptome with ORF expressed sequence tags

Emmanuel Dias Neto, Ricardo Garcia Correa, Sergio Verjovski-Almeida, Marcelo R. S. Briones, Maria Aparecida Nagai, Wilson da Silva, Jr., Marco Antonio Zago, Silvana Bordin, Fernando Ferreira Costa, Gustavo Henrique Goldman, Alex F. Carvalho, Adriana Matsukuma, Gilson S. Baia, David H. Simpson, Adriana Brunstein, Paulo S. L. de Oliveira, Philipp Bucher, C. Victor Jongeneel, Michael J. O'Hare, Fernando Soares, Ricardo R. Brentani, Luis F. L. Reis, Sandro J. de Souza, Andrew J. G. Simpson

Proc Natl Acad Sci U S A. 2000 Mar 28; 97(7): 3491–3496. doi: 10.1073/pnas.97.7.3491

PMCID:: PMC16267

Abstract Article PDF–111K

Select item 933831320.

HSF1 phosphorylation establishes an active chromatin state via the TRRAP–TIP60 complex and promotes tumorigenesis

Mitsuaki Fujimoto, Ryosuke Takii, Masaki Matsumoto, Mariko Okada, Keiich I. Nakayama, Ryuichiro Nakato, Katsunori Fujiki, Katsuhiko Shirahige, Akira Nakai

Nat Commun. 2022; 13: 4355. Published online 2022 Jul 29. doi: 10.1038/s41467-022-32034-4

PMCID:: PMC9338313

Abstract Article PDF–2.8M

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