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Select item 105120811.

Complement factor D regulates collagen type I expression and fibroblast migration to enhance human tendon repair and healing outcomes

Junyu Chen, Jin Wang, David A. Hart, Zongke Zhou, Paul W. Ackermann, Aisha S. Ahmed

Front Immunol. 2023; 14: 1225957. Published online 2023 Sep 6. doi: 10.3389/fimmu.2023.1225957

PMCID:: PMC10512081

Abstract Article PDF–4.9M

Select item 104241542.

The Role of Adipsin, Complement Factor D, in the Pathogenesis of Graves’ Orbitopathy

Hyeong Ju Byeon, Min Kyung Chae, JaeSang Ko, Eun Jig Lee, Don O. Kikkawa, Sun Young Jang, Jin Sook Yoon

Invest Ophthalmol Vis Sci. 2023 Aug; 64(11): 13. Published online 2023 Aug 9. doi: 10.1167/iovs.64.11.13

PMCID:: PMC10424154

Abstract Article PDF–7.1M

Select item 88785973.

Adipsin Serum Concentrations and Adipose Tissue Expression in People with Obesity and Type 2 Diabetes

Margarete Milek, Yusef Moulla, Matthias Kern, Christine Stroh, Arne Dietrich, Michael R Schön, Daniel Gärtner, Tobias Lohmann, Miriam Dressler, Peter Kovacs, Michael Stumvoll, Matthias Blüher, Esther Guiu-Jurado

Int J Mol Sci. 2022 Feb; 23(4): 2222. Published online 2022 Feb 17. doi: 10.3390/ijms23042222

PMCID:: PMC8878597

Abstract Article PDF–1.6M

Select item 84587974.

Complement Factor D as a Strategic Target for Regulating the Alternative Complement Pathway

Jonathan Barratt, Ilene Weitz

Front Immunol. 2021; 12: 712572. Published online 2021 Sep 9. doi: 10.3389/fimmu.2021.712572

PMCID:: PMC8458797

Abstract Article PDF–9.4M

Select item 82340125.

Complement Factor D (adipsin) Levels Are Elevated in Acquired Partial Lipodystrophy (Barraquer–Simons syndrome)

Fernando Corvillo, Laura González-Sánchez, Alberto López-Lera, Emilia Arjona, Giovanni Ceccarini, Ferruccio Santini, David Araújo-Vilar, Rebecca J Brown, Joan Villarroya, Francesc Villarroya, Santiago Rodríguez de Córdoba, Teresa Caballero, Pilar Nozal, Margarita López-Trascasa

Int J Mol Sci. 2021 Jun; 22(12): 6608. Published online 2021 Jun 21. doi: 10.3390/ijms22126608

PMCID:: PMC8234012

Abstract Article PDF–23M

Select item 75968496.

Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition

Jia Yu, Xuan Yuan, Hang Chen, Shruti Chaturvedi, Evan M. Braunstein, Robert A. Brodsky

Blood. 2020 Oct 29; 136(18): 2080–2089. Prepublished online 2020 Sep 2. doi: 10.1182/blood.2020008248

PMCID:: PMC7596849

Abstract Article

Select item 68504827.

Senescent dermal fibroblasts negatively influence fibroblast extracellular matrix‐related gene expression partly via secretion of complement factor D

Tomonobu Ezure, Misato Sugahara, Satoshi Amano

Biofactors. 2019 Jul-Aug; 45(4): 556–562. Published online 2019 Apr 26. doi: 10.1002/biof.1512

PMCID:: PMC6850482

Abstract Article PDF–1.2M

Select item 68140998.

Association between plasma adipsin level and mild cognitive impairment in Chinese patients with type 2 diabetes: a cross-sectional study

Dan Guo, Yang Yuan, Rong Huang, Sai Tian, Jiaqi Wang, Hongyan Lin, Ke An, Jin Han, Shaohua Wang

BMC Endocr Disord. 2019; 19: 108. Published online 2019 Oct 24. doi: 10.1186/s12902-019-0431-y

PMCID:: PMC6814099

Abstract Article PDF–555K

Select item 39495229.

Ensemble refinement shows conformational flexibility in crystal structures of human complement factor D

Federico Forneris, B. Tom Burnley, Piet Gros

Acta Crystallogr D Biol Crystallogr. 2014 Mar 1; 70(Pt 3): 733–743. Published online 2014 Feb 15. doi: 10.1107/S1399004713032549

PMCID:: PMC3949522

Abstract Article PDF–2.4M

Select item 333993410.

Inhibiting Alternative Pathway Complement Activation by Targeting the Factor D Exosite

Kenneth J. Katschke, Jr., Ping Wu, Rajkumar Ganesan, Robert F. Kelley, Mary A. Mathieu, Philip E. Hass, Jeremy Murray, Daniel Kirchhofer, Christian Wiesmann, Menno van Lookeren Campagne

J Biol Chem. 2012 Apr 13; 287(16): 12886–12892. Published online 2012 Feb 23. doi: 10.1074/jbc.M112.345082

PMCID:: PMC3339934

Abstract Article PDF–1.7M

Select item 323090511.

Complement Factor D in Age-Related Macular Degeneration

Chloe M. Stanton, John R.W. Yates, Anneke I. den Hollander, Johanna M. Seddon, Anand Swaroop, Dwight Stambolian, Sascha Fauser, Carel Hoyng, Yi Yu, Kanda Atsuhiro, Kari Branham, Mohammad Othman, Wei Chen, Elod Kortvely, Kevin Chalmers, Caroline Hayward, Anthony T. Moore, Baljean Dhillon, Marius Ueffing, Alan F. Wright

Invest Ophthalmol Vis Sci. 2011 Nov; 52(12): 8828–8834. Published online 2011 Nov 11. doi: 10.1167/iovs.11-7933

PMCID:: PMC3230905

Abstract Article PDF–335K

Select item 299433412.

Lack of association of CFD polymorphisms with advanced age-related macular degeneration

Jiexi Zeng, Yuhong Chen, Zongzhong Tong, Xinrong Zhou, Chao Zhao, Kevin Wang, Guy Hughes, Daniel Kasuga, Matthew Bedell, Clara Lee, Henry Ferreyra, Igor Kozak, Weldon Haw, Jean Guan, Robert Shaw, William Stevenson, Paul D. Weishaar, Mark H. Nelson, Luosheng Tang, Kang Zhang

Mol Vis. 2010; 16: 2273–2278. Published online 2010 Nov 3.

PMCID:: PMC2994334

Abstract Article PDF–1.1M

Select item 292490813.

Complement - a key system for immune surveillance and homeostasis

Daniel Ricklin, George Hajishengallis, Kun Yang, John D. Lambris

Nat Immunol. Author manuscript; available in PMC 2011 Sep 1.

Published in final edited form as: Nat Immunol. 2010 Sep; 11(9): 785–797. Published online 2010 Aug 19. doi: 10.1038/ni.1923

PMCID:: PMC2924908

Abstract Article PDF–2.8M

Select item 116247314.

Factor D of the alternative pathway of human complement. Purification, alignment and N-terminal amino acid sequences of the major cyanogen bromide fragments, and localization of the serine residue at the active site.

D M Johnson, J Gagnon, K B Reid

Biochem J. 1980 Jun 1; 187(3): 863–874. doi: 10.1042/bj1870863

PMCID:: PMC1162473

Summary Page Browse PDF–1.7M

Select item 34996415.

Active site amino acid sequence of human factor D.

A E Davis, 3rd

Proc Natl Acad Sci U S A. 1980 Aug; 77(8): 4938–4942. doi: 10.1073/pnas.77.8.4938

PMCID:: PMC349964

Summary Page Browse PDF–946K

Select item 34843516.

Partial amino acid sequence of human factor D:homology with serine proteases.

J E Volanakis, A Bhown, J C Bennett, J E Mole

Proc Natl Acad Sci U S A. 1980 Feb; 77(2): 1116–1119. doi: 10.1073/pnas.77.2.1116

PMCID:: PMC348435

Summary Page Browse PDF–828K

Select item 932615517.

Elevated Adipsin and Reduced C5a Levels in the Maternal Serum and Follicular Fluid During Implantation Are Associated With Successful Pregnancy in Obese Women

Manjunath Ramanjaneya, Ilhame Diboun, Najeha Rizwana, Yaser Dajani, Lina Ahmed, Alexandra E. Butler, Thoraya Ali Almarzooqi, Mohammed Shahata, Moza Khalaf Al Bader, Einas Elgassim, Hasan Burjaq, Stephen L. Atkin, Abdul-Badi Abou-Samra, Mohamed A. Elrayess

Front Endocrinol (Lausanne) 2022; 13: 918320. Published online 2022 Jul 13. doi: 10.3389/fendo.2022.918320