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Select item 109283291.

Inhibiting IL11RA to mitigate hepatic metastasis in skin cutaneous melanoma: Comprehensive insights from in vitro and in vivo investigations

Zhen‐Guo Zhang, Hong‐Mei Zhu, Huai‐Kang Hua

Skin Res Technol. 2024 Mar; 30(3): e13618. Published online 2024 Mar 11. doi: 10.1111/srt.13618

PMCID:: PMC10928329

Abstract Article PDF–2.2M

Select item 97222652.

Interleukin-11 receptor subunit α-1 is required for maximal airway responsiveness to methacholine after acute exposure to ozone

Richard A. Johnston, Constance L. Atkins, Saad R. Siddiqui, William T. Jackson, Nicholas C. Mitchell, Chantal Y. Spencer, Albert W. Pilkington, 4th, Michael L. Kashon, Ikram U. Haque

Am J Physiol Regul Integr Comp Physiol. 2022 Dec 1; 323(6): R921–R934. Published online 2022 Oct 25. doi: 10.1152/ajpregu.00213.2022

PMCID:: PMC9722265

Abstract Article

Select item 28498293.

IL11 Antagonist Inhibits Uterine Stromal Differentiation, Causing Pregnancy Failure in Mice

Ellen Menkhorst, Lois Salamonsen, Lorraine Robb, Evdokia Dimitriadis

Biol Reprod. 2009 May; 80(5): 920–927. Prepublished online 2009 Jan 14. doi: 10.1095/biolreprod.108.073601

PMCID:: PMC2849829

Abstract Article PDF–4.4M

Select item 5355454.

Uterine extracellular matrix components are altered during defective decidualization in interleukin-11 receptor α deficient mice

Christine A White, Lorraine Robb, Lois A Salamonsen

Reprod Biol Endocrinol. 2004; 2: 76. Published online 2004 Nov 10. doi: 10.1186/1477-7827-2-76

PMCID:: PMC535545

Abstract Article PDF–6.2M

Select item 97231205.

Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease

Anissa A. Widjaja, Sivakumar Viswanathan, Shamini G. Shekeran, Eleonora Adami, Wei-Wen Lim, Sonia Chothani, Jessie Tan, Joyce Wei Ting Goh, Hui Mei Chen, Sze Yun Lim, Carine M. Boustany-Kari, Julie Hawkins, Enrico Petretto, Norbert Hübner, Sebastian Schafer, Thomas M. Coffman, Stuart A. Cook

Nat Commun. 2022; 13: 7497. Published online 2022 Dec 5. doi: 10.1038/s41467-022-35306-1

PMCID:: PMC9723120

Abstract Article PDF–7.9M

Select item 85606416.

Interleukin-11 receptor expression on monocytes is dispensable for their recruitment and pathogen uptake during Leishmania major infection

Iris Baars, Juliane Lokau, Ina Sauerland, Andreas J. Müller, Christoph Garbers

Cytokine. 2021 Dec; 148: None. doi: 10.1016/j.cyto.2021.155699

PMCID:: PMC8560641

Abstract Article

Select item 82668137.

Benjamin Ng, Anissa A. Widjaja, Sivakumar Viswanathan, Jinrui Dong, Sonia P. Chothani, Stella Lim, Shamini G. Shekeran, Jessie Tan, Narelle E. McGregor, Emma C. Walker, Natalie A. Sims, Sebastian Schafer, Stuart A. Cook

Sci Rep. 2021; 11: 14088. Published online 2021 Jul 8. doi: 10.1038/s41598-021-93623-9

PMCID:: PMC8266813

Abstract Article PDF–7.3M

Select item 77825048.

Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH

Jinrui Dong, Sivakumar Viswanathan, Eleonora Adami, Brijesh K. Singh, Sonia P. Chothani, Benjamin Ng, Wei Wen Lim, Jin Zhou, Madhulika Tripathi, Nicole S. J. Ko, Shamini G. Shekeran, Jessie Tan, Sze Yun Lim, Mao Wang, Pei Min Lio, Paul M. Yen, Sebastian Schafer, Stuart A. Cook, Anissa A. Widjaja

Nat Commun. 2021; 12: 66. Published online 2021 Jan 4. doi: 10.1038/s41467-020-20303-z

PMCID:: PMC7782504

Abstract Article PDF–10M

Select item 52176809.

Critical Contribution of Nuclear Factor Erythroid 2-related Factor 2 (NRF2) to Electrophile-induced Interleukin-11 Production

Takashi Nishina, Yutaka Deguchi, Ryosuke Miura, Soh Yamazaki, Yasuhiro Shinkai, Yuko Kojima, Ko Okumura, Yoshito Kumagai, Hiroyasu Nakano

J Biol Chem. 2017 Jan 6; 292(1): 205–216. Published online 2016 Nov 21. doi: 10.1074/jbc.M116.744755

PMCID:: PMC5217680

Abstract Article PDF–2.5M

Select item 411746510.

Optimal Attenuation of Experimental Autoimmune Encephalomyelitis by Intravenous Immunoglobulin Requires an Intact Interleukin-11 Receptor

Carlyn A. Figueiredo, Paulina C. Drohomyrecky, Stephen D. S. McCarthy, Danila Leontyev, Xue-Zhong Ma, Donald R. Branch, Shannon E. Dunn

PLoS One. 2014; 9(7): e101947. Published online 2014 Jul 31. doi: 10.1371/journal.pone.0101947

Correction in:: PLoS One. 2014; 9(11): e113001.

PMCID:: PMC4117465

Abstract Article PDF–1.4M

Select item 302713911.

Interleukin-11 regulates autoimmune demyelination

Blake T. Gurfein, Yueting Zhang, Carolina B. López, Azeb Tadesse Argaw, Andleeb Zameer, Thomas M. Moran, Gareth R. John

J Immunol. Author manuscript; available in PMC 2011 Jan 26.

Published in final edited form as: J Immunol. 2009 Oct 1; 183(7): 4229–4240. Published online 2009 Sep 4. doi: 10.4049/jimmunol.0900622

PMCID:: PMC3027139

Abstract Article PDF–3.3M

Select item 121793912.

Two differentially expressed interleukin-11 receptor genes in the mouse genome.

P Bilinski, M A Hall, H Neuhaus, C Gissel, J K Heath, A Gossler

Biochem J. 1996 Dec 1; 320(Pt 2): 359–363. doi: 10.1042/bj3200359

PMCID:: PMC1217939

Summary PDF–421K

Select item 1012513013.

IL11 (Interleukin-11) Causes Emphysematous Lung Disease in a Mouse Model of Marfan Syndrome

Benjamin Ng, Chen Xie, Liping Su, Fathima F. Kuthubudeen, Xiu-Yi Kwek, Daryl Yeong, Chee Jian Pua, Stuart A. Cook, Wei-Wen Lim

Arterioscler Thromb Vasc Biol. 2023 May; 43(5): 739–754. Published online 2023 Apr 27. doi: 10.1161/ATVBAHA.122.318802

PMCID:: PMC10125130

Abstract Article PDF–6.9M

Select item 808677114.

Colitis-induced IL11 promotes colon carcinogenesis

Hong Wang, David H Wang, Xu Yang, Yuhai Sun, Chung S Yang

Carcinogenesis. 2021 Apr; 42(4): 557–569. Published online 2020 Nov 16. doi: 10.1093/carcin/bgaa122

PMCID:: PMC8086771

Abstract Article PDF–1.3M

Select item 757612315.

Interleukin-11 is important for vascular smooth muscle phenotypic switching and aortic inflammation, fibrosis and remodeling in mouse models

Wei-Wen Lim, Ben Corden, Benjamin Ng, Konstantinos Vanezis, Giuseppe D’Agostino, Anissa A. Widjaja, Wei-Hua Song, Chen Xie, Liping Su, Xiu-Yi Kwek, Nicole G. Z. Tee, Jinrui Dong, Nicole S. J. Ko, Mao Wang, Chee Jian Pua, Muhammad H. Jamal, Beeyong Soh, Sivakumar Viswanathan, Sebastian Schafer, Stuart A. Cook

Sci Rep. 2020; 10: 17853. Published online 2020 Oct 20. doi: 10.1038/s41598-020-74944-7

PMCID:: PMC7576123

Abstract Article PDF–14M

Select item 580708216.

IL-11 is a crucial determinant of cardiovascular fibrosis

Sebastian Schafer, Sivakumar Viswanathan, Anissa A. Widjaja, Wei-Wen Lim, Aida Moreno-Moral, Daniel M. DeLaughter, Benjamin Ng, Giannino Patone, Kingsley Chow, Ester Khin, Jessie Tan, Sonia P. Chothani, Lei Ye, Owen J. L. Rackham, Nicole S. J. Ko, Norliza E. Sahib, Chee Jian Pua, Nicole T. G. Zhen, Chen Xie, Mao Wang, Henrike Maatz, Shiqi Lim, Kathrin Saar, Susanne Blachut, Enrico Petretto, Sabine Schmidt, Tracy Putoczki, Nuno Guimarães-Camboa, Hiroko Wakimoto, Sebastiaan van Heesch, Kristmundur Sigmundsson, See L. Lim, Jia L. Soon, Victor T. T. Chao, Yeow L. Chua, Teing E. Tan, Sylvia M. Evans, Yee J. Loh, Muhammad H. Jamal, Kim K. Ong, Kim C. Chua, Boon-Hean Ong, Mathew J. Chakaramakkil, Jonathan G. Seidman, Christine E. Seidman, Norbert Hubner, Kenny Y. K. Sin, Stuart A. Cook

Nature. Author manuscript; available in PMC 2018 Feb 9.

Published in final edited form as: Nature. 2017 Dec 7; 552(7683): 110–115. Published online 2017 Nov 13. doi: 10.1038/nature24676

PMCID:: PMC5807082

Abstract Article PDF–5.3M

Select item 316430817.

Pro- and anti-apoptotic actions of Stat1 versus Stat3 underlie neuroprotective and immunoregulatory functions of interleukin-11.

Jingya Zhang, Yueting Zhang, Dipankar J. Dutta, Azeb T. Argaw, Virginie Bonnamain, Jeremy Seto, David A. Braun, Andleeb Zameer, Fernand Hayot, Carolina B. Lòpez, Cedric S. Raine, Gareth R. John

J Immunol. Author manuscript; available in PMC 2012 Aug 1.

Published in final edited form as: J Immunol. 2011 Aug 1; 187(3): 1129–1141. Published online 2011 Jun 27. doi: 10.4049/jimmunol.1004066

PMCID:: PMC3164308

Abstract Article PDF–4.6M

Select item 258604918.

Endogenous IL-11 Signaling Is Essential in Th2- and IL-13–Induced Inflammation and Mucus Production

Chun Geun Lee, Dominik Hartl, Hiroshi Matsuura, Felicity M. Dunlop, Pierre D. Scotney, Louis J. Fabri, Andrew D. Nash, Ning-Yuan Chen, Chu-Yan Tang, Qingsheng Chen, Robert J. Homer, Manuel Baca, Jack A. Elias

Am J Respir Cell Mol Biol. 2008 Dec; 39(6): 739–746. Published online 2008 Jul 10. doi: 10.1165/rcmb.2008-0053OC

PMCID:: PMC2586049

Abstract Article PDF–447K

Select item 805240819.

Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer

Takashi Nishina, Yutaka Deguchi, Daisuke Ohshima, Wakami Takeda, Masato Ohtsuka, Shigeyuki Shichino, Satoshi Ueha, Soh Yamazaki, Mika Kawauchi, Eri Nakamura, Chiharu Nishiyama, Yuko Kojima, Satomi Adachi-Akahane, Mizuho Hasegawa, Mizuho Nakayama, Masanobu Oshima, Hideo Yagita, Kazutoshi Shibuya, Tetuo Mikami, Naohiro Inohara, Kouji Matsushima, Norihiro Tada, Hiroyasu Nakano

Nat Commun. 2021; 12: 2281. Published online 2021 Apr 16. doi: 10.1038/s41467-021-22450-3

PMCID:: PMC8052408

Abstract Article PDF–4.3M

Select item 341077220.

Evaluating the role of IL-11, a novel cytokine in the IL-6 family, in a mouse model of spinal cord injury

Newton Cho, Dung H Nguyen, Kajana Satkunendrarajah, Donald R Branch, Michael G Fehlings

J Neuroinflammation. 2012; 9: 134. Published online 2012 Jun 20. doi: 10.1186/1742-2094-9-134

PMCID:: PMC3410772

Abstract Article PDF–1017K

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