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Select item 109179111.

Mapping of a hybrid insulin peptide in the inflamed islet β-cells from NOD mice

Janet M. Wenzlau, Orion J. Peterson, Anthony N. Vomund, James E. DiLisio, Anita Hohenstein, Kathryn Haskins, Xiaoxiao Wan

Front Immunol. 2024; 15: 1348131. Published online 2024 Feb 22. doi: 10.3389/fimmu.2024.1348131

PMCID:: PMC10917911

Abstract Article PDF–11M

Select item 75299802.

Low concentration IL-1β promotes islet amyloid formation by increasing hIAPP release from humanised mouse islets in vitro

Andrew T. Templin, Mahnaz Mellati, Daniel T. Meier, Nathalie Esser, Meghan F. Hogan, Joseph J. Castillo, Rehana Akter, Daniel P. Raleigh, Sakeneh Zraika, Rebecca L. Hull, Steven E. Kahn

Diabetologia. Author manuscript; available in PMC 2021 Nov 1.

Published in final edited form as: Diabetologia. 2020 Nov; 63(11): 2385–2395. Published online 2020 Jul 29. doi: 10.1007/s00125-020-05232-2

PMCID:: PMC7529980

Abstract Article PDF–973K

Select item 58893173.

Amylin and Diabetic Cardiomyopathy – Amylin-Induced Sarcolemmal Ca²⁺ Leak Is Independent of Diabetic Remodeling of Myocardium

Miao Liu, Amanda Hoskins, Nirmal Verma, Donald M Bers, Sanda Despa, Florin Despa

Biochim Biophys Acta. Author manuscript; available in PMC 2019 May 1.

Published in final edited form as: Biochim Biophys Acta. 2018 May; 1864(5 Pt B): 1923–1930. Published online 2017 Oct 21. doi: 10.1016/j.bbadis.2017.10.024

PMCID:: PMC5889317

Abstract Article PDF–2.0M

Select item 57153944.

Involvement of Amylin and Leptin in the Development of Projections from the Area Postrema to the Nucleus of the Solitary Tract

Kathrin Abegg, Andreas Hermann, Christina N. Boyle, Sebastien G. Bouret, Thomas A. Lutz, Thomas Riediger

Front Endocrinol (Lausanne) 2017; 8: 324. Published online 2017 Nov 28. doi: 10.3389/fendo.2017.00324

PMCID:: PMC5715394

Abstract Article PDF–1.1M

Select item 55841145.

Induction of IAPP amyloid deposition and associated diabetic abnormalities by a prion-like mechanism

Abhisek Mukherjee, Diego Morales-Scheihing, Natalia Salvadores, Ines Moreno-Gonzalez, Cesar Gonzalez, Kathleen Taylor-Presse, Nicolas Mendez, Mohammad Shahnawaz, A. Osama Gaber, Omaima M. Sabek, Daniel W. Fraga, Claudio Soto

J Exp Med. 2017 Sep 4; 214(9): 2591–2610. doi: 10.1084/jem.20161134

PMCID:: PMC5584114

Abstract Article PDF–2.4M

Select item 50269226.

The S20G substitution in hIAPP is more amyloidogenic and cytotoxic than wild-type hIAPP in mouse islets

Daniel T. Meier, Leon Entrup, Andrew T. Templin, Meghan F. Hogan, Mahnaz Mellati, Sakeneh Zraika, Rebecca L. Hull, Steven E. Kahn

Diabetologia. Author manuscript; available in PMC 2017 Oct 1.

Published in final edited form as: Diabetologia. 2016 Oct; 59(10): 2166–2171. Published online 2016 Sep 1. doi: 10.1007/s00125-016-4045-x

PMCID:: PMC5026922

Abstract Article PDF–255K

Select item 40207317.

Expression of wild‐type and mutant S20G hIAPP in physiologic knock‐in mouse models fails to induce islet amyloid formation, but induces mild glucose intolerance

Henry J Hiddinga, Setsuya Sakagashira, Masayuki Ishigame, Pranathi Madde, Tokio Sanke, Kishio Nanjo, Yogish C Kudva, James J Lee, Jan van Deursen, Norman L Eberhardt

J Diabetes Investig. 2012 Mar 28; 3(2): 138–147. Published online 2011 Oct 11. doi: 10.1111/j.2040-1124.2011.00166.x

PMCID:: PMC4020731

Abstract Article PDF–682K

Select item 31613338.

Islet Amyloid Polypeptide Is a Target Antigen for Diabetogenic CD4⁺ T Cells

Thomas Delong, Rocky L. Baker, Nichole Reisdorph, Richard Reisdorph, Roger L. Powell, Michael Armstrong, Gene Barbour, Brenda Bradley, Kathryn Haskins

Diabetes. 2011 Sep; 60(9): 2325–2330. Published online 2011 Aug 20. doi: 10.2337/db11-0288

PMCID:: PMC3161333

Abstract Article PDF–998K

Select item 25704019.

Small Interfering RNA–Mediated Suppression of Proislet Amyloid Polypeptide Expression Inhibits Islet Amyloid Formation and Enhances Survival of Human Islets in Culture

Lucy Marzban, Alejandra Tomas, Thomas C. Becker, Lawrence Rosenberg, Jose Oberholzer, Paul E. Fraser, Philippe A. Halban, C. Bruce Verchere

Diabetes. 2008 Nov; 57(11): 3045–3055. doi: 10.2337/db08-0485

Correction in:: Diabetes. 2016 Mar; 65(3): 818.

PMCID:: PMC2570401

Abstract Article PDF–1.3M

Select item 194992610.

Islet amyloid development in a mouse strain lacking endogenous islet amyloid polypeptide (IAPP) but expressing human IAPP.

G. T. Westermark, S. Gebre-Medhin, D. F. Steiner, P. Westermark

Mol Med. 2000 Dec; 6(12): 998–1007.

PMCID:: PMC1949926

Summary PDF–122K

Select item 3897511.

Spontaneous diabetes mellitus in transgenic mice expressing human islet amyloid polypeptide.

J Janson, W C Soeller, P C Roche, R T Nelson, A J Torchia, D K Kreutter, P C Butler

Proc Natl Acad Sci U S A. 1996 Jul 9; 93(14): 7283–7288. doi: 10.1073/pnas.93.14.7283

PMCID:: PMC38975

Summary Page Browse PDF–2.5M

Select item 882581112.

Amylin-Calcitonin receptor signaling in the medial preoptic area mediates affiliative social behaviors in female mice

Kansai Fukumitsu, Misato Kaneko, Teppo Maruyama, Chihiro Yoshihara, Arthur J. Huang, Thomas J. McHugh, Shigeyoshi Itohara, Minoru Tanaka, Kumi O. Kuroda

Nat Commun. 2022; 13: 709. Published online 2022 Feb 8. doi: 10.1038/s41467-022-28131-z

PMCID:: PMC8825811

Abstract Article PDF–10M

Select item 486146013.

Differential Activation of Innate Immune Pathways by Distinct Islet Amyloid Polypeptide (IAPP) Aggregates

Clara Westwell-Roper, Heather C. Denroche, Jan A. Ehses, C. Bruce Verchere

J Biol Chem. 2016 Apr 22; 291(17): 8908–8917. Published online 2016 Jan 19. doi: 10.1074/jbc.M115.712455

PMCID:: PMC4861460

Abstract Article PDF–2.1M

Select item 381567614.

CD4 T cells reactive to an IAPP peptide accumulate in the pancreas and contribute to disease pathogenesis in NOD mice

Rocky L. Baker, Thomas Delong, Gene Barbour, Brenda Bradley, Maki Nakayama, Kathryn Haskins

J Immunol. Author manuscript; available in PMC 2014 Oct 15.

Published in final edited form as: J Immunol. 2013 Oct 15; 191(8): 10.4049/jimmunol.1301480. Published online 2013 Sep 16. doi: 10.4049/jimmunol.1301480

PMCID:: PMC3815676

Abstract Article PDF–647K

Select item 378040615.

Amylin and leptin activate overlapping signalling pathways in an additive manner in mouse GT1-7 hypothalamic, C₂C₁₂ muscle and AML12 liver cell lines

H.-S. Moon, J. P. Chamberland, C. S. Mantzoros

Diabetologia. Author manuscript; available in PMC 2013 Sep 23.

Published in final edited form as: Diabetologia. 2012 Jan; 55(1): 215–225. Published online 2011 Oct 14. doi: 10.1007/s00125-011-2332-0

PMCID:: PMC3780406

Abstract Article PDF–721K

Select item 311478916.

Drosophila Melanogaster as a Model System for Studies of Islet Amyloid Polypeptide Aggregation

Sebastian Wolfgang Schultz, K. Peter R. Nilsson, Gunilla Torstensdotter Westermark

PLoS One. 2011; 6(6): e20221. Published online 2011 Jun 14. doi: 10.1371/journal.pone.0020221

PMCID:: PMC3114789

Abstract Article PDF–2.2M

Select item 611776317.

A Study of Short- and Long-term mRNA Levels of the Retn, Iapp, and Drd5 Genes in Obese Mice Induced with High-fat Diet

OZLEM TIMIRCI-KAHRAMAN, UMIT YILMAZ, NESIBE YILMAZ, AYDIN CEVIK, CEM HOROZOGLU, FARUK CELIK, MUHAMMED OGUZ GOKCE, ARZU ERGEN, ABDULLAH MELEKOGLU, UMIT ZEYBEK

In Vivo. 2018 Jul-Aug; 32(4): 813–817. Published online 2018 Jul 3. doi: 10.21873/invivo.112312

PMCID:: PMC6117763

Abstract Article PDF–117K

Select item 611031618.

CD4 T Cells Reactive to Hybrid Insulin Peptides Are Indicators of Disease Activity in the NOD Mouse

Rocky L. Baker, Braxton L. Jamison, Timothy A. Wiles, Robin S. Lindsay, Gene Barbour, Brenda Bradley, Thomas Delong, Rachel S. Friedman, Maki Nakayama, Kathryn Haskins

Diabetes. 2018 Sep; 67(9): 1836–1846. Published online 2018 Jul 5. doi: 10.2337/db18-0200

PMCID:: PMC6110316

Abstract Article PDF–1.2M

Select item 400208819.

Thioredoxin-interacting Protein Promotes Islet Amyloid Polypeptide Expression through miR-124a and FoxA2

Gu Jing, Clara Westwell-Roper, Junqin Chen, Guanlan Xu, C. Bruce Verchere, Anath Shalev

J Biol Chem. 2014 Apr 25; 289(17): 11807–11815. Published online 2014 Mar 13. doi: 10.1074/jbc.M113.525022

PMCID:: PMC4002088

Abstract Article PDF–1.9M

Select item 993831420.

Islet amyloid polypeptide does not suppress pancreatic cancer

Austin J. Taylor, Evgeniy Panzhinskiy, Paul C. Orban, Francis C. Lynn, David F. Schaeffer, James D. Johnson, Janel L. Kopp, C. Bruce Verchere

Mol Metab. 2023 Feb; 68: 101667. Published online 2023 Jan 5. doi: 10.1016/j.molmet.2023.101667

PMCID:: PMC9938314

Abstract Article PDF–2.7M

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PMC Links for Gene (Select 15874) (42)
PMC
BB396605 RIKEN full-length enriched, 0 day neonate cerebellum Mus musculus cDNA ...
BB396605 RIKEN full-length enriched, 0 day neonate cerebellum Mus musculus cDNA clone C230098E21 3', mRNA sequence
gi|16410807|gnl|dbEST|10005270|dbj| 605.2|

Nucleotide
Homo sapiens polymerase (RNA) I polypeptide D, 16kDa (POLR1D), transcript varian...
Homo sapiens polymerase (RNA) I polypeptide D, 16kDa (POLR1D), transcript variant 1, mRNA
gi|142366064|ref|NM_015972.2|

Nucleotide

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