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Select item 78301351.

The Metabolic Role of GRK2 in Insulin Resistance and Associated Conditions

Daniela Sorriento, Maria Rosaria Rusciano, Valeria Visco, Antonella Fiordelisi, Federica Andrea Cerasuolo, Paolo Poggio, Michele Ciccarelli, Guido Iaccarino

Cells. 2021 Jan; 10(1): 167. Published online 2021 Jan 15. doi: 10.3390/cells10010167

PMCID:: PMC7830135

Abstract Article PDF–1.6M

Select item 78257362.

Nitric Oxide and S-Nitrosylation in Cardiac Regulation: G Protein-Coupled Receptor Kinase-2 and β-Arrestins as Targets

Gizem Kayki-Mutlu, Walter J. Koch

Int J Mol Sci. 2021 Jan; 22(2): 521. Published online 2021 Jan 7. doi: 10.3390/ijms22020521

PMCID:: PMC7825736

Abstract Article PDF–1.4M

Select item 76453803.

Mutations in GRK2 cause Jeune syndrome by impairing Hedgehog and canonical Wnt signaling

Michaela Bosakova, Sara P Abraham, Alexandru Nita, Eva Hruba, Marcela Buchtova, S Paige Taylor, Ivan Duran, Jorge Martin, Katerina Svozilova, Tomas Barta, Miroslav Varecha, Lukas Balek, Jiri Kohoutek, Tomasz Radaszkiewicz, Ganesh V Pusapati, Vitezslav Bryja, Eric T Rush, Isabelle Thiffault, Deborah A Nickerson, Michael J Bamshad, University of Washington Center for Mendelian Genomics, Rajat Rohatgi, Daniel H Cohn, Deborah Krakow, Pavel Krejci

EMBO Mol Med. 2020 Nov 6; 12(11): e11739. Published online 2020 Oct 14. doi: 10.15252/emmm.201911739

PMCID:: PMC7645380

Abstract Article PDF–7.1M

Select item 70419444.

Agonist-selective recruitment of engineered protein probes and of GRK2 by opioid receptors in living cells

Miriam Stoeber, Damien Jullié, Joy Li, Soumen Chakraborty, Susruta Majumdar, Nevin A Lambert, Aashish Manglik, Mark von Zastrow

eLife. 2020; 9: e54208. Published online 2020 Feb 25. doi: 10.7554/eLife.54208

PMCID:: PMC7041944

Abstract Article PDF–3.9M

Select item 67613585.

GRK2 promotes growth of medulloblastoma cells and protects them from chemotherapy-induced apoptosis

Anup S. Pathania, Xiuhai Ren, Min Y. Mahdi, Gregory M. Shackleford, Anat Erdreich-Epstein

Sci Rep. 2019; 9: 13902. Published online 2019 Sep 25. doi: 10.1038/s41598-019-50157-5

PMCID:: PMC6761358

Abstract Article PDF–3.9M

Select item 54668976.

Targeting GPCR-Gβγ-GRK2 signaling as a novel strategy for treating cardiorenal pathologies

Valeria Rudomanova, Burns C. Blaxall

Biochim Biophys Acta. Author manuscript; available in PMC 2018 Aug 1.

Published in final edited form as: Biochim Biophys Acta. 2017 Aug; 1863(8): 1883–1892. Published online 2017 Jan 25. doi: 10.1016/j.bbadis.2017.01.020

PMCID:: PMC5466897

Abstract Article PDF–608K

Select item 53506637.

Enhanced GRK2 Expression and Desensitization of βAR Vasodilatation in Hypertensive Patients

Raffaele Izzo, Ersilia Cipolletta, Michele Ciccarelli, Alfonso Campanile, Gaetano Santulli, Gianluigi Palumbo, Antonio Vasta, Salvatore Formisano, Bruno Trimarco, Guido Iaccarino

Clin Transl Sci. 2008 Dec; 1(3): 215–220. Published online 2008 Oct 8. doi: 10.1111/j.1752-8062.2008.00050.x

PMCID:: PMC5350663

Abstract Article PDF–1.3M

Select item 52642528.

G Protein-coupled Receptor Kinase 2 (GRK2) Promotes Breast Tumorigenesis Through a HDAC6-Pin1 Axis

Laura Nogués, Clara Reglero, Verónica Rivas, Alicia Salcedo, Vanesa Lafarga, Maria Neves, Paula Ramos, Marta Mendiola, Alberto Berjón, Kostas Stamatakis, Xiao Zhen Zhou, Kun Ping Lu, David Hardisson, Federico Mayor, Jr., Petronila Penela

EBioMedicine. 2016 Nov; 13: 132–145. Published online 2016 Oct 1. doi: 10.1016/j.ebiom.2016.09.030

PMCID:: PMC5264252

Abstract Article PDF–2.7M

Select item 51373049.

G-protein-coupled receptor kinase 2 and endothelial dysfunction: molecular insights and pathophysiological mechanisms

Kumiko Taguchi, Takayuki Matsumoto, Tsuneo Kobayashi

J Smooth Muscle Res. 2015; 51: 37–49. Published online 2015 Oct 8. doi: 10.1540/jsmr.51.37

PMCID:: PMC5137304

Abstract Article PDF–500K

Select item 458186310.

A KSHV microRNA Directly Targets G Protein-Coupled Receptor Kinase 2 to Promote the Migration and Invasion of Endothelial Cells by Inducing CXCR2 and Activating AKT Signaling

Minmin Hu, Cong Wang, Wan Li, Weiping Lu, Zhiqiang Bai, Di Qin, Qin Yan, Jianzhong Zhu, Brian J. Krueger, Rolf Renne, Shou-Jiang Gao, Chun Lu

PLoS Pathog. 2015 Sep; 11(9): e1005171. Published online 2015 Sep 24. doi: 10.1371/journal.ppat.1005171

PMCID:: PMC4581863

Abstract Article PDF–19M

Select item 420859811.

GRK2 in the Heart: A GPCR Kinase and Beyond

Zheng Maggie Huang, Erhe Gao, J. Kurt Chuprun, Walter J. Koch

Antioxid Redox Signal. 2014 Nov 10; 21(14): 2032–2043. doi: 10.1089/ars.2014.5876

PMCID:: PMC4208598

Abstract Article PDF–528K

Select item 418676512.

si-RNA-Mediated Silencing of ADRBK1 Gene Attenuates Breast Cancer Cell Proliferation

Chen Zhang, Xianzhen Chen, Yongxin Li, Himaya S.W.A, Jie Wu, Xiujuan Shi, Xiaoqing Liu, Sekwon Kim

Cancer Biother Radiopharm. 2014 Oct 1; 29(8): 303–309. doi: 10.1089/cbr.2014.1653

Correction in:: Cancer Biother Radiopharm. 2018 Oct 1; 33(8): 363.

PMCID:: PMC4186765

Abstract Article PDF–398K

Select item 415568813.

Mapping the Putative G Protein-coupled Receptor (GPCR) Docking Site on GPCR Kinase 2: INSIGHTS FROM INTACT CELL PHOSPHORYLATION AND RECRUITMENT ASSAYS

Alexandre Beautrait, Kevin R. Michalski, Thomas S. Lopez, Katelynn M. Mannix, Devin J. McDonald, Amber R. Cutter, Christopher B. Medina, Aaron M. Hebert, Charnelle J. Francis, Michel Bouvier, John J. G. Tesmer, Rachel Sterne-Marr

J Biol Chem. 2014 Sep 5; 289(36): 25262–25275. Published online 2014 Jul 21. doi: 10.1074/jbc.M114.593178

PMCID:: PMC4155688

Abstract Article PDF–2.0M

Select item 409575614.

GRK2 – A Link Between Myocardial Contractile Function and Cardiac Metabolism

Meryl C. Woodall, Michele Ciccarelli, Benjamin P. Woodall, Walter J. Koch

Circ Res. Author manuscript; available in PMC 2015 May 9.

Published in final edited form as: Circ Res. 2014 May 9; 114(10): 1661–1670. doi: 10.1161/CIRCRESAHA.114.300513

PMCID:: PMC4095756

Abstract Article PDF–1.1M

Select item 383743315.

GRK2 and group I mGluR mediate inflammation-induced sensitization to excitotoxic neurodegeneration

Vincent Degos, Stéphane Peineau, Cora Nijboer, Angela M. Kaindl, Stéphanie Sigaut, Géraldine Favrais, Frank Plaisant, Natacha Teissier, Elodie Gouadon, Alain Lombet, Elie Saliba, Graham L. Collingridge, Mervyn Maze, Ferdinando Nicoletti, Cobi Heijnen, Jean Mantz, Annemieke Kavelaars, Pierre Gressens

Ann Neurol. Author manuscript; available in PMC 2014 May 1.

Published in final edited form as: Ann Neurol. 2013 May; 73(5): 10.1002/ana.23868. Published online 2013 Mar 14. doi: 10.1002/ana.23868

PMCID:: PMC3837433

Abstract Article PDF–807K

Select item 377194316.

G protein–coupled receptor kinase 2 (GRK2) is localized to centrosomes and mediates epidermal growth factor–promoted centrosomal separation

Christopher H. So, Allison Michal, Konstantin E. Komolov, Jiansong Luo, Jeffrey L. Benovic

Mol Biol Cell. 2013 Sep 15; 24(18): 2795–2806. doi: 10.1091/mbc.E13-01-0013

PMCID:: PMC3771943

Abstract Article PDF–3.2M

Select item 369548617.

MCARD-Mediated Gene Transfer of GRK2 Inhibitor in Ovine Model of Acute Myocardial Infarction

JaBaris D. Swain, Anthony S. Fargnoli, Michael G. Katz, Catherine E. Tomasulo, Marina Sumaroka, Kyle C. Richardville, Walter J. Koch, Joseph E. Rabinowitz, Charles R. Bridges

J Cardiovasc Transl Res. Author manuscript; available in PMC 2014 Apr 1.

Published in final edited form as: J Cardiovasc Transl Res. 2013 Apr; 6(2): 253–262. Published online 2012 Dec 1. doi: 10.1007/s12265-012-9418-z

PMCID:: PMC3695486

Abstract Article PDF–1.9M

Select item 341820218.

MicroRNA-124 as a novel treatment for persistent hyperalgesia

Hanneke LDM Willemen, Xiao-Jiao Huo, Qi-Liang Mao-Ying, Jitske Zijlstra, Cobi J Heijnen, Annemieke Kavelaars

J Neuroinflammation. 2012; 9: 143. Published online 2012 Jun 25. doi: 10.1186/1742-2094-9-143

PMCID:: PMC3418202

Abstract Article PDF–1.6M

Select item 301874919.

Dynamic Changes in Lymphocyte GRK2 Levels in Cardiac Transplant Patients: A Biomarker for Left Ventricular Function

Raphael E. Bonita, Philip W. Raake, Nicholas J. Otis, J. Kurt Chuprun, Talya Spivack, Abhijit Dasgupta, David J. Whellan, Paul J. Mather, Walter J. Koch

Clin Transl Sci. 2010 Feb; 3(1): 14–18. Published online 2010 Feb 24. doi: 10.1111/j.1752-8062.2010.00176.x

PMCID:: PMC3018749

Abstract Article PDF–1.1M

Select item 296651420.

Level of G Protein-Coupled Receptor Kinase-2 Determines Myocardial Ischemia-Reperfusion Injury via Pro- and Anti-Apoptotic Mechanisms

Henriette Brinks, Matthieu Boucher, Erhe Gao, J. Kurt Chuprun, Stéphanie Pesant, Philip W. Raake, Z. Maggie Huang, Xiaoliang Wang, Gang Qiu, Anna Gumpert, David M. Harris, Andrea D. Eckhart, Patrick Most, Walter J. Koch

Circ Res. Author manuscript; available in PMC 2011 Oct 29.

Published in final edited form as: Circ Res. 2010 Oct 29; 107(9): 1140–1149. Published online 2010 Sep 2. doi: 10.1161/CIRCRESAHA.110.221010

PMCID:: PMC2966514

Abstract Article PDF–1.2M

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PMC Links for Gene (Select 156) (121)
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Homo sapiens ribosomal protein L10 (RPL10), transcript variant 1, mRNA
Homo sapiens ribosomal protein L10 (RPL10), transcript variant 1, mRNA
gi|1774959489|ref|NM_006013.5|

Nucleotide
Bacteria
Bacteria
The differential effect of two cereal foods on gut environment: A randomized, controlled, double-blind, parallel-group study

BioProject
Scylla olivacea
Scylla olivacea
Gene expressions in Y-organ during different stages of orange mud crab

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Effect of GATA3 suppression gene expression in breast cancer cells.
Effect of GATA3 suppression gene expression in breast cancer cells.
Effect of GATA3 suppression gene expression in breast cancer cells.

BioProject

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