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Select item 100524101.

Identification and in vitro functional assessment of 10 CYP2C9 variants found in Chinese Han subjects

Qing Zhang, Yuying Qi, Shuanghu Wang, Fangling Zhao, Lili Zou, Quan Zhou, Peiwu Geng, Yun Hong, Hang Yang, Qingfeng Luo, Jianping Cai, Hualan Wu, Dongxu Wang, Hao Chen, Jiefu Yang, Dapeng Dai

Front Endocrinol (Lausanne) 2023; 14: 1139805. Published online 2023 Mar 15. doi: 10.3389/fendo.2023.1139805

PMCID:: PMC10052410

Abstract Article PDF–3.1M

Select item 100062452.

CYP2C9 Polymorphisms and the Risk of Cardiovascular Events in Patients Treated with Clopidogrel: Combined Data from the POPular Genetics and POPular AGE Trials

Wout W. A. van den Broek, Nabil Mani, Jaouad Azzahhafi, Jurriën M. ten Berg

Am J Cardiovasc Drugs. 2023; 23(2): 165–172. Published online 2023 Feb 14. doi: 10.1007/s40256-022-00565-2

PMCID:: PMC10006245

Abstract Article PDF–1.3M

Select item 99763943.

Global distribution of functionally important CYP2C9 alleles and their inferred metabolic consequences

Yitian Zhou, Lenka Nevosadová, Erik Eliasson, Volker M. Lauschke

Hum Genomics. 2023; 17: 15. Published online 2023 Feb 28. doi: 10.1186/s40246-023-00461-z

PMCID:: PMC9976394

Abstract Article PDF–2.2M

Select item 99236884.

Biotransformation of Bisphenol by Human Cytochrome P450 2C9 Enzymes: A Density Functional Theory Study

Artur Hermano Sampaio Dias, Rolly Yadav, Thirakorn Mokkawes, Asheesh Kumar, Munir S. Skaf, Chivukula V. Sastri, Devesh Kumar, Sam P. de Visser

Inorg Chem. 2023 Feb 6; 62(5): 2244–2256. Published online 2023 Jan 18. doi: 10.1021/acs.inorgchem.2c03984

PMCID:: PMC9923688

Abstract Article PDF–5.5M

Select item 93223465.

The Impact of CYP2C9*11 Allelic Variant on the Pharmacokinetics of Phenytoin and (S)‐Warfarin

Maor Wanounou, Chanan Shaul, Zahi Abu Ghosh, Shoshana Alamia, Yoseph Caraco

Clin Pharmacol Ther. 2022 Jul; 112(1): 156–163. Published online 2022 May 5. doi: 10.1002/cpt.2613

PMCID:: PMC9322346

Abstract Article PDF–307K

Select item 88178656.

Genetic Analysis of CYP2C9 with Reference to Drug Response in Epilepsy Patients of Pakistan

Hafsa Maqbool, Tayyaba Saleem, Nadeem Sheikh, Aqsa Ashfaq

Genet Res (Camb) 2022; 2022: 1451007. Published online 2022 Jan 29. doi: 10.1155/2022/1451007

PMCID:: PMC8817865

Abstract Article PDF–1.0M

Select item 85086947.

Insights into the Genetic Variations of Human Cytochrome P450 2C9: Structural Analysis, Characterization and Comparison

Sonia J. Parikh, Sumit Kamat, Margaret Phillips, Samuel P. Boyson, Thomas Yarbrough, Dylan Davie, Qinghai Zhang, Karen C. Glass, Manish B. Shah

Int J Mol Sci. 2021 Oct; 22(19): 10206. Published online 2021 Sep 22. doi: 10.3390/ijms221910206

PMCID:: PMC8508694

Abstract Article PDF–3.3M

Select item 84561678.

Massively parallel characterization of CYP2C9 variant enzyme activity and abundance

Clara J. Amorosi, Melissa A. Chiasson, Matthew G. McDonald, Lai Hong Wong, Katherine A. Sitko, Gabriel Boyle, John P. Kowalski, Allan E. Rettie, Douglas M. Fowler, Maitreya J. Dunham

Am J Hum Genet. 2021 Sep 2; 108(9): 1735–1751. Published online 2021 Jul 26. doi: 10.1016/j.ajhg.2021.07.001

PMCID:: PMC8456167

Abstract Article PDF–4.5M

Select item 83848679.

Impact of genetic and non-genetic factors on hepatic CYP2C9 expression and activity in Hungarian subjects

Ferenc Fekete, Katalin Mangó, Máté Déri, Evelyn Incze, Annamária Minus, Katalin Monostory

Sci Rep. 2021; 11: 17081. Published online 2021 Aug 24. doi: 10.1038/s41598-021-96590-3

PMCID:: PMC8384867

Abstract Article PDF–1.2M

Select item 800838110.

In Vivo Functional Effects of CYP2C9 M1L, a Novel and Common Variant in the Yup’ik Alaska Native Population

Lindsay M. Henderson, Scarlett E. Hopkins, Bert B. Boyer, Timothy A. Thornton, Allan E. Rettie, Kenneth E. Thummel

Drug Metab Dispos. 2021 May; 49(5): 345–352. Published online 2021 May. doi: 10.1124/dmd.120.000301

PMCID:: PMC8008381

Abstract Article PDF–1014K

Select item 784287511.

Functional characterization of the defective CYP2C9 variant CYP2C9*18

Jian Liu, Hao Chen, Shuang‐Hu Wang, Quan Zhou, Pei‐Wu Geng, Yun‐Fang Zhou, Hua‐Lan Wu, Hai‐Feng Shi, Fang Wang, Jie‐Fu Yang, Jian‐Ping Cai, Da‐Peng Dai

Pharmacol Res Perspect. 2021 Feb; 9(1): e00718. Published online 2021 Jan 28. doi: 10.1002/prp2.718

PMCID:: PMC7842875

Abstract Article PDF–925K

Select item 783138212.

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C9 and HLA-B Genotypes and Phenytoin Dosing: 2020 Update

Jason H. Karnes, Allan E. Rettie, Andrew A. Somogyi, Rachel Huddart, Alison E. Fohner, Christine M. Formea, Ming Ta Michael Lee, Adrian Llerena, Michelle Whirl-Carrillo, Teri E. Klein, Elizabeth J. Phillips, Scott Mintzer, Andrea Gaedigk, Kelly E. Caudle, John T. Callaghan

Clin Pharmacol Ther. Author manuscript; available in PMC 2022 Feb 1.

Published in final edited form as: Clin Pharmacol Ther. 2021 Feb; 109(2): 302–309. Published online 2020 Sep 6. doi: 10.1002/cpt.2008

PMCID:: PMC7831382

Abstract Article PDF–684K

Select item 765287613.

Variations in the frequencies of polymorphisms in the CYP2C9 gene in six major ethnicities of Pakistan

Sagheer Ahmed, Nadeem Altaf, Mahnoor Ejaz, Aisha Altaf, Aneela Amin, Kholood Janjua, Arif Ullah Khan, Imran Imran, Saeed Khan

Sci Rep. 2020; 10: 19370. Published online 2020 Nov 9. doi: 10.1038/s41598-020-76366-x

PMCID:: PMC7652876

Abstract Article PDF–1001K

Select item 756931214.

Structure of Cytochrome P450 2C9*2 in Complex with Losartan: Insights into the Effect of Genetic Polymorphism

Sonia J. Parikh, Chiara M. Evans, Juliet O. Obi, Qinghai Zhang, Keiko Maekawa, Karen C. Glass, Manish B. Shah

Mol Pharmacol. 2020 Nov; 98(5): 529–539. Published online 2020 Nov. doi: 10.1124/molpharm.120.000042

PMCID:: PMC7569312

Abstract Article PDF–1.7M

Select item 751135415.

Modulation of CYP2C9 activity and hydrogen peroxide production by cytochrome b₅

Javier Gómez-Tabales, Elena García-Martín, José A. G. Agúndez, Carlos Gutierrez-Merino

Sci Rep. 2020; 10: 15571. Published online 2020 Sep 23. doi: 10.1038/s41598-020-72284-0

PMCID:: PMC7511354

Abstract Article PDF–1.3M

Select item 736628616.

Heterologous Expression and Functional Characterization of Novel CYP2C9 Variants Identified in the Alaska Native People

Matthew G. McDonald, Lindsay M. Henderson, Sutapa Ray, Catherine K. Yeung, Amanda L. Johnson, John P. Kowalski, Helmut Hanenberg, Constanze Wiek, Kenneth E. Thummel, Allan E. Rettie

J Pharmacol Exp Ther. 2020 Aug; 374(2): 233–240. Published online 2020 Aug. doi: 10.1124/jpet.120.265850

PMCID:: PMC7366286

Abstract Article PDF–548K

Select item 734708517.

Factors influencing pharmacokinetics of warfarin in African–Americans: implications for pharmacogenetic dosing algorithms

Rui Nagai, Minami Ohara, Larisa H Cavallari, Katarzyna Drozda, Shitalben R Patel, Edith A Nutescu, Minoli A Perera, Wenndy Hernandez, Naoko Kaneko, Manabu Hibiya, Harumi Takahashi

Pharmacogenomics. Author manuscript; available in PMC 2020 Jul 9.

Published in final edited form as: Pharmacogenomics. 2015; 16(3): 217–225. doi: 10.2217/pgs.14.160

PMCID:: PMC7347085

Abstract Article PDF–710K

Select item 727168218.

CYP2C9, a Metabolic CYP450s Enzyme, Plays Critical Roles in Activating Ellagic Acid in Human Intestinal Epithelial Cells

Yang Gu, Wei Hou, Xin-yu Shen, Shi-xuan Zhuo, Hao-ran Zhang, Ming-hui Ji, Mei-juan Chen, Yuan-yuan Guo

Med Sci Monit. 2020; 26: e923104-1–e923104-8. Prepublished online 2020 Mar 30. Published online 2020 May 26. doi: 10.12659/MSM.923104

PMCID:: PMC7271682

Abstract Article PDF–643K

Select item 721112019.

The presence of two reduced function variants in CYP2C9 influences the acute response to glipizide

L. Chen, J. H. Li, V. Kaur, A. Muhammad, M. Fernandez, M. S. Hudson, A. B. Goldfine, J. C. Florez

Diabet Med. Author manuscript; available in PMC 2021 Dec 1.

Published in final edited form as: Diabet Med. 2020 Dec; 37(12): 2124–2130. Published online 2019 Nov 25. doi: 10.1111/dme.14176

PMCID:: PMC7211120

Abstract Article PDF–666K

Select item 681796620.

CYP2C9*2 is associated with indomethacin treatment failure for patent ductus arteriosus

Sydney R Rooney, Elaine L Shelton, Ida Aka, Christian M Shaffer, Ronald I Clyman, John M Dagle, Kelli Ryckman, Tamorah R Lewis, Jeff Reese, Sara L Van Driest, Prince J Kannankeril

Pharmacogenomics. 2019 Aug; 20(13): 939–946. Published online 2019 Sep 5. doi: 10.2217/pgs-2019-0079

PMCID:: PMC6817966

Abstract Article PDF–438K

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