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Select item 107714271.

Blood DNA methylation profiling identifies cathepsin Z dysregulation in pulmonary arterial hypertension

Anna Ulrich, Yukyee Wu, Harmen Draisma, John Wharton, Emilia M. Swietlik, Inês Cebola, Eleni Vasilaki, Zhanna Balkhiyarova, Marjo-Riitta Jarvelin, Juha Auvinen, Karl-Heinz Herzig, J. Gerry Coghlan, James Lordan, Colin Church, Luke S. Howard, Joanna Pepke-Zaba, Mark Toshner, Stephen J. Wort, David G. Kiely, Robin Condliffe, Allan Lawrie, Stefan Gräf, Nicholas W. Morrell, Martin R. Wilkins, Inga Prokopenko, Christopher J. Rhodes

Nat Commun. 2024; 15: 330. Published online 2024 Jan 6. doi: 10.1038/s41467-023-44683-0

PMCID:: PMC10771427

Abstract Article PDF–2.7M

Select item 88368692.

Upregulation of Cathepsin X in Glioblastoma: Interplay with γ-Enolase and the Effects of Selective Cathepsin X Inhibitors

Bernarda Majc, Anamarija Habič, Metka Novak, Ana Rotter, Andrej Porčnik, Jernej Mlakar, Vera Župunski, Urša Pečar Fonović, Damijan Knez, Nace Zidar, Stanislav Gobec, Janko Kos, Tamara Lah Turnšek, Anja Pišlar, Barbara Breznik

Int J Mol Sci. 2022 Feb; 23(3): 1784. Published online 2022 Feb 4. doi: 10.3390/ijms23031784

PMCID:: PMC8836869

Abstract Article PDF–3.4M

Select item 83658733.

Decreased levels of cathepsin Z mRNA expressed by immune blood cells: diagnostic and prognostic implications in prostate cancer

A.A.S. Batista, B.M. Franco, M.M. Perez, E.G. Pereira, T. Rodrigues, M.L. Wroclawski, F.L.A. Fonseca, E.R. Suarez

Braz J Med Biol Res. 2021; 54(10): e11439. Published online 2021 Aug 6. doi: 10.1590/1414-431X2021e11439

PMCID:: PMC8365873

Abstract Article PDF–501K

Select item 60814054.

Increased expression and altered localization of cathepsin Z are associated with progression to jaundice stage in primary biliary cholangitis

Yoshihiro Aiba, Kenichi Harada, Masahiro Ito, Takashi Suematsu, Shinichi Aishima, Yuki Hitomi, Nao Nishida, Minae Kawashima, Mitsuhisa Takatsuki, Susumu Eguchi, Shinji Shimoda, Hitomi Nakamura, Atsumasa Komori, Seigo Abiru, Shinya Nagaoka, Kiyoshi Migita, Hiroshi Yatsuhashi, Katsushi Tokunaga, Minoru Nakamura

Sci Rep. 2018; 8: 11808. Published online 2018 Aug 7. doi: 10.1038/s41598-018-30146-w

PMCID:: PMC6081405

Abstract Article PDF–6.1M

Select item 40212605.

Prognostic and predictive value of cathepsin X in serum from colorectal cancer patients

Tjaša Vižin, Ib Jarle Christensen, Michael Wilhelmsen, Hans Jørgen Nielsen, Janko Kos

BMC Cancer. 2014; 14: 259. Published online 2014 Apr 13. doi: 10.1186/1471-2407-14-259

PMCID:: PMC4021260

Abstract Article PDF–265K

Select item 30789866.

Genetic Susceptibility to Tuberculosis Associated with Cathepsin Z Haplotype in a Ugandan Household Contact Study

Allison R. Baker, Sarah Zalwango, LaShaunda L. Malone, Robert P. Igo, Jr., Feiyou Qiu, Mary Nsereko, Mark D. Adams, Pamela Supelak, Harriet Mayanja-Kizza, W. Henry Boom, Catherine M. Stein

Hum Immunol. Author manuscript; available in PMC 2012 May 1.

Published in final edited form as: Hum Immunol. 2011 May; 72(5): 426–430. Published online 2011 Feb 25. doi: 10.1016/j.humimm.2011.02.016

PMCID:: PMC3078986

Abstract Article PDF–335K

Select item 66015867.

KMT2A histone methyltransferase contributes to colorectal cancer development by promoting cathepsin Z transcriptional activation

Yang Fang, Dan Zhang, Tingting Hu, Hongyan Zhao, Xuan Zhao, Zhefeng Lou, Yongshan He, Wenzheng Qin, Jianfu Xia, Xiaohua Zhang, Le‐chi Ye

Cancer Med. 2019 Jul; 8(7): 3544–3552. Published online 2019 May 15. doi: 10.1002/cam4.2226

PMCID:: PMC6601586

Abstract Article PDF–1.5M

Select item 59664188.

NELFCD and CTSZ loci are associated with jaundice-stage progression in primary biliary cholangitis in the Japanese population

Nao Nishida, Yoshihiro Aiba, Yuki Hitomi, Minae Kawashima, Kaname Kojima, Yosuke Kawai, Kazuko Ueno, Hitomi Nakamura, Noriyo Yamashiki, Tomohiro Tanaka, Sumito Tamura, Akira Mori, Shintaro Yagi, Yuji Soejima, Tomoharu Yoshizumi, Mitsuhisa Takatsuki, Atsushi Tanaka, Kenichi Harada, Shinji Shimoda, Atsumasa Komori, Susumu Eguchi, Yoshihiko Maehara, Shinji Uemoto, Norihiro Kokudo, Masao Nagasaki, Katsushi Tokunaga, Minoru Nakamura

Sci Rep. 2018; 8: 8071. Published online 2018 May 23. doi: 10.1038/s41598-018-26369-6

PMCID:: PMC5966418

Abstract Article PDF–1.8M

Select item 31785789.

Overexpression of Cathepsin Z Contributes to Tumor Metastasis by Inducing Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma

Jian Wang, Leilei Chen, Yan Li, Xin-Yuan Guan

PLoS One. 2011; 6(9): e24967. Published online 2011 Sep 22. doi: 10.1371/journal.pone.0024967

PMCID:: PMC3178578

Abstract Article PDF–2.1M

Select item 311005010.

Polymorphisms in MC3R promoter and CTSZ 3′UTR are associated with tuberculosis susceptibility

Lindsey A Adams, Marlo Möller, Almut Nebel, Stefan Schreiber, Lize van der Merwe, Paul D van Helden, Eileen G Hoal

Eur J Hum Genet. 2011 Jun; 19(6): 676–681. Published online 2011 Feb 2. doi: 10.1038/ejhg.2011.1

PMCID:: PMC3110050

Abstract Article PDF–282K

Select item 264321011.

Mapping of a Novel Susceptibility Locus Suggests a Role for MC3R and CTSZ in Human Tuberculosis

Graham S. Cooke, Sarah J. Campbell, Steve Bennett, Christian Lienhardt, Keith P. W. J. McAdam, Giorgio Sirugo, Oumou Sow, Per Gustafson, Frank Mwangulu, Paul van Helden, Paul Fine, Eileen G. Hoal, Adrian V. S. Hill

Am J Respir Crit Care Med. 2008 Jul 15; 178(2): 203–207. Published online 2008 Apr 17. doi: 10.1164/rccm.200710-1554OC

PMCID:: PMC2643210

Abstract Article PDF–100K

Select item 618258012.

Cysteine cathepsins B, X and K expression in peri-arteriolar glioblastoma stem cell niches

Barbara Breznik, Clara Limbaeck Stokin, Janko Kos, Mohammed Khurshed, Vashendriya V. V. Hira, Roman Bošnjak, Tamara T. Lah, Cornelis J. F. Van Noorden

J Mol Histol. 2018; 49(5): 481–497. Published online 2018 Jul 25. doi: 10.1007/s10735-018-9787-y

PMCID:: PMC6182580

Abstract Article PDF–10M

Select item 306945913.

Cysteine Proteases Bleomycin Hydrolase and Cathepsin Z Mediate N-terminal Proteolysis and Toxicity of Mutant Huntingtin

Tamara Ratovitski, Ekaterine Chighladze, Elaine Waldron, Ricky R. Hirschhorn, Christopher A. Ross

J Biol Chem. 2011 Apr 8; 286(14): 12578–12589. Published online 2011 Feb 10. doi: 10.1074/jbc.M110.185348

PMCID:: PMC3069459

Abstract Article PDF–3.2M

Select item 336684214.

Cathepsins L and Z Are Critical in Degrading Polyglutamine-containing Proteins within Lysosomes

Nidhi Bhutani, Rosanna Piccirillo, Raphael Hourez, Prasanna Venkatraman, Alfred L. Goldberg

J Biol Chem. 2012 May 18; 287(21): 17471–17482. Published online 2012 Mar 26. doi: 10.1074/jbc.M112.352781

PMCID:: PMC3366842

Abstract Article PDF–2.4M

Select item 388060515.

A Genome- and Phenome-Wide Association Study to Identify Genetic Variants Influencing Platelet Count and Volume and their Pleiotropic Effects

Khader Shameer, Joshua C. Denny, Keyue Ding, Hayan Jouni, David R. Crosslin, Mariza de Andrade, Christopher G. Chute, Peggy Peissig, Jennifer A. Pacheco, Rongling Li, Lisa Bastarache, Abel N. Kho, Marylyn D Ritchie, Daniel R. Masys, Rex L. Chisholm, Eric B. Larson, Catherine A. McCarty, Dan M. Roden, Gail P. Jarvik, Iftikhar J. Kullo

Hum Genet. Author manuscript; available in PMC 2015 Jan 1.

Published in final edited form as: Hum Genet. 2014 Jan; 133(1): 10.1007/s00439-013-1355-7. Published online 2013 Sep 12. doi: 10.1007/s00439-013-1355-7

PMCID:: PMC3880605

Abstract Article PDF–2.2M

Select item 840632616.

Galectin-8 Senses Phagosomal Damage and Recruits Selective Autophagy Adapter TAX1BP1 To Control Mycobacterium tuberculosis Infection in Macrophages

Samantha L. Bell, Kayla L. Lopez, Jeffery S. Cox, Kristin L. Patrick, Robert O. Watson

mBio. 2021 Jul-Aug; 12(4): e01871-20. Published online 2021 Jul 6. doi: 10.1128/mBio.01871-20

PMCID:: PMC8406326

Abstract Article PDF–8.5M

Select item 804475517.

TRIM26 Induces Ferroptosis to Inhibit Hepatic Stellate Cell Activation and Mitigate Liver Fibrosis Through Mediating SLC7A11 Ubiquitination

Yiming Zhu, Chihao Zhang, Mingzhe Huang, Jiayun Lin, Xiao Fan, Tao Ni

Front Cell Dev Biol. 2021; 9: 644901. Published online 2021 Mar 25. doi: 10.3389/fcell.2021.644901

PMCID:: PMC8044755

Abstract Article PDF–3.7M

Select item 333529618.

New gene functions in megakaryopoiesis and platelet formation

Christian Gieger, Aparna Radhakrishnan, Ana Cvejic, Weihong Tang, Eleonora Porcu, Giorgio Pistis, Jovana Serbanovic-Canic, Ulrich Elling, Alison H. Goodall, Yann Labrune, Lorna M. Lopez, Reedik Mägi, Stuart Meacham, Yukinori Okada, Nicola Pirastu, Rossella Sorice, Alexander Teumer, Katrin Voss, Weihua Zhang, Ramiro Ramirez-Solis, Joshua C. Bis, David Ellinghaus, Martin Gögele, Jouke-Jan Hottenga, Claudia Langenberg, Peter Kovacs, Paul F. O’Reilly, So-Youn Shin, Tõnu Esko, Jaana Hartiala, Stavroula Kanoni, Federico Murgia, Afshin Parsa, Jonathan Stephens, Pim van der Harst, C. Ellen van der Schoot, Hooman Allayee, Antony Attwood, Beverley Balkau, François Bastardot, Saonli Basu, Sebastian E. Baumeister, Ginevra Biino, Lorenzo Bomba, Amélie Bonnefond, François Cambien, John C. Chambers, Francesco Cucca, Pio D’Adamo, Gail Davies, Rudolf A. de Boer, Eco J. C. de Geus, Angela Döring, Paul Elliott, Jeanette Erdmann, David M. Evans, Mario Falchi, Wei Feng, Aaron R. Folsom, Ian H. Frazer, Quince D. Gibson, Nicole L. Glazer, Chris Hammond, Anna-Liisa Hartikainen, Susan R. Heckbert, Christian Hengstenberg, Micha Hersch, Thomas Illig, Ruth J. F. Loos, Jennifer Jolley, Kay Tee Khaw, Brigitte Kühnel, Marie-Christine Kyrtsonis, Vasiliki Lagou, Heather Lloyd-Jones, Thomas Lumley, Massimo Mangino, Andrea Maschio, Irene Mateo Leach, Barbara McKnight, Yasin Memari, Braxton D. Mitchell, Grant W. Montgomery, Yusuke Nakamura, Matthias Nauck, Gerjan Navis, Ute Nöthlings, Ilja M. Nolte, David J. Porteous, Anneli Pouta, Peter P. Pramstaller, Janne Pullat, Susan M. Ring, Jerome I. Rotter, Daniela Ruggiero, Aimo Ruokonen, Cinzia Sala, Nilesh J. Samani, Jennifer Sambrook, David Schlessinger, Stefan Schreiber, Heribert Schunkert, James Scott, Nicholas L. Smith, Harold Snieder, John M. Starr, Michael Stumvoll, Atsushi Takahashi, W. H. Wilson Tang, Kent Taylor, Albert Tenesa, Swee Lay Thein, Anke Tönjes, Manuela Uda, Sheila Ulivi, Dirk J. van Veldhuisen, Peter M. Visscher, Uwe Völker, H.-Erich Wichmann, Kerri L. Wiggins, Gonneke Willemsen, Tsun-Po Yang, Jing Hua Zhao, Paavo Zitting, John R. Bradley, George V. Dedoussis, Paolo Gasparini, Stanley L. Hazen, Andres Metspalu, Mario Pirastu, Alan R. Shuldiner, L. Joost van Pelt, Jaap-Jan Zwaginga, Dorret I. Boomsma, Ian J. Deary, Andre Franke, Philippe Froguel, Santhi K. Ganesh, Marjo-Riitta Jarvelin, Nicholas G. Martin, Christa Meisinger, Bruce M. Psaty, Timothy D. Spector, Nicholas J. Wareham, Jan-Willem N. Akkerman, Marina Ciullo, Panos Deloukas, Andreas Greinacher, Steve Jupe, Naoyuki Kamatani, Jyoti Khadake, Jaspal S. Kooner, Josef Penninger, Inga Prokopenko, Derek Stemple, Daniela Toniolo, Lorenz Wernisch, Serena Sanna, Andrew A. Hicks, Augusto Rendon, Manuel A. Ferreira, Willem H. Ouwehand, Nicole Soranzo

Nature. Author manuscript; available in PMC 2012 Apr 24.

Published in final edited form as: Nature. 2011 Nov 30; 480(7376): 201–208. Published online 2011 Nov 30. doi: 10.1038/nature10659

PMCID:: PMC3335296

Abstract Article PDF–862K

Select item 193358019.

A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition

Sarah E Harris, Helen Fox, Alan F Wright, Caroline Hayward, John M Starr, Lawrence J Whalley, Ian J Deary

BMC Genet. 2007; 8: 43. Published online 2007 Jul 2. doi: 10.1186/1471-2156-8-43

PMCID:: PMC1933580

Abstract Article PDF–397K

Select item 370996620.

HIV-1 Vpr Modulates Macrophage Metabolic Pathways: A SILAC-Based Quantitative Analysis

Carlos A. Barrero, Prasun K. Datta, Satarupa Sen, Satish Deshmane, Shohreh Amini, Kamel Khalili, Salim Merali

PLoS One. 2013; 8(7): e68376. Published online 2013 Jul 12. doi: 10.1371/journal.pone.0068376

PMCID:: PMC3709966

Abstract Article PDF–1.3M

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