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Items: 1 to 20 of 36

1.
Roquin1 inhibits the proliferation of breast cancer cells by inducing G1/S cell cycle arrest via selectively destabilizing the mRNAs of cell cycle–promoting genes
Wenbao Lu, Meicen Zhou, Bing Wang, Xueting Liu, Bingwei Li
J Exp Clin Cancer Res. 2020; 39: 255. Published online 2020 Nov 23. doi: 10.1186/s13046-020-01766-w
PMCID:
PMC7686734
AbstractArticlePDF–3.1M
2.
Combined disruption of T cell inflammatory regulators Regnase-1 and Roquin-1 enhances antitumor activity of engineered human T cells
David Mai, Omar Johnson, Jordan Reff, Ting-Jia Fan, John Scholler, Neil C. Sheppard, Carl H. June
Proc Natl Acad Sci U S A. 2023 Mar 21; 120(12): e2218632120. Published online 2023 Mar 15. doi: 10.1073/pnas.2218632120
PMCID:
PMC10041166
AbstractArticlePDF–787K
3.
Dynamic Regulation of the Nexus Between Stress Granules, Roquin, and Regnase-1 Underlies the Molecular Pathogenesis of Warfare Vesicants
Ritesh Kumar Srivastava, Bharat Mishra, Suhail Muzaffar, Marina S. Gorbatyuk, Anupam Agarwal, M. Shahid Mukhtar, Mohammad Athar
Front Immunol. 2021; 12: 809365. Published online 2022 Jan 10. doi: 10.3389/fimmu.2021.809365
PMCID:
PMC8784689
AbstractArticlePDF–41M
4.
MNSFβ Regulates TNFα Production by Interacting with RC3H1 in Human Macrophages, and Dysfunction of MNSFβ in Decidual Macrophages Is Associated With Recurrent Pregnancy Loss
Xing-Xing Zhen, Long Yang, Yan Gu, Qian Yang, Wen-Wen Gu, Ya-Ping He, Yan-Ling Wang, Jian Wang
Front Immunol. 2021; 12: 691908. Published online 2021 Sep 13. doi: 10.3389/fimmu.2021.691908
PMCID:
PMC8473736
AbstractArticlePDF–3.7M
5.
Roquin – a multifunctional regulator of immune homeostasis
J. S. Schaefer, J. R. Klein
Genes Immun. Author manuscript; available in PMC 2016 Jun 17.
Published in final edited form as: Genes Immun. 2016 Mar; 17(2): 79–84. Published online 2015 Dec 17. doi: 10.1038/gene.2015.58
PMCID:
PMC4777649
AbstractArticlePDF–343K
6.
MicroRNA signatures differentiate Crohn’s disease from ulcerative colitis
Jeremy S Schaefer, Taraq Attumi, Antone R Opekun, Bincy Abraham, Jason Hou, Harold Shelby, David Y Graham, Charles Streckfus, John R Klein
BMC Immunol. 2015; 16: 5. Published online 2015 Feb 10. doi: 10.1186/s12865-015-0069-0
PMCID:
PMC4335694
AbstractArticlePDF–2.5M
7.
ROQUIN/RC3H1 Alterations Are Not Found in Angioimmunoblastic T-Cell Lymphoma
Tiphanie Auguste, Marion Travert, Karin Tarte, Patricia Amé-Thomas, Catherine Artchounin, Nadine Martin-Garcia, Aurélien de Reynies, Laurence de Leval, Philippe Gaulard, Marie-Hélène Delfau-Larue
PLoS One. 2013; 8(6): e64536. Published online 2013 Jun 25. doi: 10.1371/journal.pone.0064536
PMCID:
PMC3692505
AbstractArticlePDF–430K
8.
Structural basis for the recognition of transiently structured AU-rich elements by Roquin
Oliver Binas, Jan-Niklas Tants, Stephen A Peter, Robert Janowski, Elena Davydova, Johannes Braun, Dierk Niessing, Harald Schwalbe, Julia E Weigand, Andreas Schlundt
Nucleic Acids Res. 2020 Jul 27; 48(13): 7385–7403. Published online 2020 Jun 3. doi: 10.1093/nar/gkaa465
PMCID:
PMC7367199
AbstractArticlePDF–8.1M
9.
Structure of human Roquin-2 and its complex with constitutive-decay element RNA
Shunya Sakurai, Umeharu Ohto, Toshiyuki Shimizu
Acta Crystallogr F Struct Biol Commun. 2015 Aug 1; 71(Pt 8): 1048–1054. Published online 2015 Jul 29. doi: 10.1107/S2053230X15011887
PMCID:
PMC4528940
AbstractArticlePDF–1.4M
10.
The ROQ domain of Roquin recognizes mRNA constitutive decay element and double-stranded RNA
Dazhi Tan, Mi Zhou, Megerditch Kiledjian, Liang Tong
Nat Struct Mol Biol. Author manuscript; available in PMC 2015 Feb 1.
Published in final edited form as: Nat Struct Mol Biol. 2014 Aug; 21(8): 679–685. Published online 2014 Jul 13. doi: 10.1038/nsmb.2857
PMCID:
PMC4125485
AbstractArticlePDF–1.3M
11.
A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation
S. J. Tavernier, V. Athanasopoulos, P. Verloo, G. Behrens, J. Staal, D. J. Bogaert, L. Naesens, M. De Bruyne, S. Van Gassen, E. Parthoens, J. Ellyard, J. Cappello, L. X. Morris, H. Van Gorp, G. Van Isterdael, Y. Saeys, M. Lamkanfi, P. Schelstraete, J. Dehoorne, V. Bordon, R. Van Coster, B. N. Lambrecht, B. Menten, R. Beyaert, C. G. Vinuesa, V. Heissmeyer, M. Dullaers, F. Haerynck
Nat Commun. 2019; 10: 4779. Published online 2019 Oct 21. doi: 10.1038/s41467-019-12704-6
Correction in:
Nat Commun. 2019; 10: 5337.
PMCID:
PMC6803705
AbstractArticlePDF–2.4M
12.
Loss of Roquin induces early death and immune deregulation but not autoimmunity
Arianna Bertossi, Martin Aichinger, Paola Sansonetti, Maciej Lech, Frauke Neff, Martin Pal, F. Thomas Wunderlich, Hans-Joachim Anders, Ludger Klein, Marc Schmidt-Supprian
J Exp Med. 2011 Aug 29; 208(9): 1749–1756. doi: 10.1084/jem.20110578
PMCID:
PMC3171092
AbstractArticlePDF–2.5M
13.
Human cytomegalovirus induces and exploits Roquin to counteract the IRF1-mediated antiviral state
Jaewon Song, Sanghyun Lee, Dong-Yeon Cho, Sungwon Lee, Hyewon Kim, Namhee Yu, Sanghyuk Lee, Kwangseog Ahn
Proc Natl Acad Sci U S A. 2019 Sep 10; 116(37): 18619–18628. Published online 2019 Aug 26. doi: 10.1073/pnas.1909314116
PMCID:
PMC6744924
AbstractArticlePDF–1.3M
14.
Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis
Monika Srivastava, Guowen Duan, Nadia J. Kershaw, Vicki Athanasopoulos, Janet H. C. Yeo, Toyoyuki Ose, Desheng Hu, Simon H. J. Brown, Slobodan Jergic, Hardip R. Patel, Alvin Pratama, Sashika Richards, Anil Verma, E. Yvonne Jones, Vigo Heissmeyer, Thomas Preiss, Nicholas E. Dixon, Mark M. W. Chong, Jeffrey J. Babon, Carola G. Vinuesa
Nat Commun. 2015 Feb 20; 6: 6253. Published online 2015 Feb 20. doi: 10.1038/ncomms7253
PMCID:
PMC4346627
AbstractArticlePDF–1.5M
15.
Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA
Nina Rehage, Elena Davydova, Christine Conrad, Gesine Behrens, Andreas Maiser, Jenny E. Stehklein, Sven Brenner, Juliane Klein, Aicha Jeridi, Anne Hoffmann, Eunhae Lee, Umberto Dianzani, Rob Willemsen, Regina Feederle, Kristin Reiche, Jörg Hackermüller, Heinrich Leonhardt, Sonia Sharma, Dierk Niessing, Vigo Heissmeyer
Nat Commun. 2018; 9: 299. Published online 2018 Jan 19. doi: 10.1038/s41467-017-02582-1
PMCID:
PMC5775257
AbstractArticlePDF–2.9M
16.
Identification of new high affinity targets for Roquin based on structural conservation
Johannes Braun, Sandra Fischer, Zhenjiang Z Xu, Hongying Sun, Dalia H Ghoneim, Anna T Gimbel, Uwe Plessmann, Henning Urlaub, David H Mathews, Julia E Weigand
Nucleic Acids Res. 2018 Dec 14; 46(22): 12109–12125. Published online 2018 Oct 8. doi: 10.1093/nar/gky908
PMCID:
PMC6294493
AbstractArticlePDF–3.6M
17.
New Insights into the RNA-Binding and E3 Ubiquitin Ligase Activities of Roquins
Qi Zhang, Lixin Fan, Feng Hou, Aiping Dong, Yun-Xing Wang, Yufeng Tong
Sci Rep. 2015; 5: 15660. Published online 2015 Oct 22. doi: 10.1038/srep15660
PMCID:
PMC4614863
AbstractArticlePDF–1.5M
18.
RNF219 attenuates global mRNA decay through inhibition of CCR4-NOT complex-mediated deadenylation
Fabian Poetz, Joshua Corbo, Yevgen Levdansky, Alexander Spiegelhalter, Doris Lindner, Vera Magg, Svetlana Lebedeva, Jörg Schweiggert, Johanna Schott, Eugene Valkov, Georg Stoecklin
Nat Commun. 2021; 12: 7175. Published online 2021 Dec 9. doi: 10.1038/s41467-021-27471-6
PMCID:
PMC8660800
AbstractArticlePDF–5.3M
19.
The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation
Christopher B. Nelson, Samuel Rogers, Kaushik Roychoudhury, Yaw Sing Tan, Caroline J. Atkinson, Alexander P. Sobinoff, Christopher G. Tomlinson, Anton Hsu, Robert Lu, Eloise Dray, Michelle Haber, Jamie I. Fletcher, Anthony J. Cesare, Rashmi S. Hegde, Hilda A. Pickett
Nat Commun. 2024; 15: 1385. Published online 2024 Feb 15. doi: 10.1038/s41467-024-45683-4
PMCID:
PMC10869800
AbstractArticlePDF–9.3M
20.
RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway
Yasuhiro Murakawa, Michael Hinz, Janina Mothes, Anja Schuetz, Michael Uhl, Emanuel Wyler, Tomoharu Yasuda, Guido Mastrobuoni, Caroline C. Friedel, Lars Dölken, Stefan Kempa, Marc Schmidt-Supprian, Nils Blüthgen, Rolf Backofen, Udo Heinemann, Jana Wolf, Claus Scheidereit, Markus Landthaler
Nat Commun. 2015; 6: 7367. Published online 2015 Jul 14. doi: 10.1038/ncomms8367
PMCID:
PMC4510711
AbstractArticlePDF–3.2M

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