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Select item 105437291.

Alveolar type II epithelial cell FASN maintains lipid homeostasis in experimental COPD

Li-Chao Fan, Keith McConn, Maria Plataki, Sarah Kenny, Niamh C. Williams, Kihwan Kim, Jennifer A. Quirke, Yan Chen, Maor Sauler, Matthias E. Möbius, Kuei-Pin Chung, Estela Area Gomez, Augustine M.K. Choi, Jin-Fu Xu, Suzanne M. Cloonan

JCI Insight. 2023 Aug 22; 8(16): e163403. Published online 2023 Aug 22. doi: 10.1172/jci.insight.163403

PMCID:: PMC10543729

Abstract Article PDF–11M

Select item 105102952.

High-intensity interval training induces lactylation of fatty acid synthase to inhibit lipid synthesis

Xuefei Chen, Wenhua Huang, Jingbo Zhang, Yanjun Li, Zheng Xing, Lanlan Guo, Hongfeng Jiang, Jing Zhang

BMC Biol. 2023; 21: 196. Published online 2023 Sep 19. doi: 10.1186/s12915-023-01698-9

PMCID:: PMC10510295

Abstract Article PDF–7.9M

Select item 104627133.

CircRREB1 mediates lipid metabolism related senescent phenotypes in chondrocytes through FASN post-translational modifications

Zhe Gong, Jinjin Zhu, Junxin Chen, Fan Feng, Haitao Zhang, Zheyuan Zhang, Chenxin Song, Kaiyu Liang, Shuhui Yang, Shunwu Fan, Xiangqian Fang, Shuying Shen

Nat Commun. 2023; 14: 5242. Published online 2023 Aug 28. doi: 10.1038/s41467-023-40975-7

PMCID:: PMC10462713

Abstract Article PDF–9.7M

Select item 100115204.

De novo lipogenesis fuels adipocyte autophagosome and lysosome membrane dynamics

Leslie A. Rowland, Adilson Guilherme, Felipe Henriques, Chloe DiMarzio, Sean Munroe, Nicole Wetoska, Mark Kelly, Keith Reddig, Gregory Hendricks, Meixia Pan, Xianlin Han, Olga R. Ilkayeva, Christopher B. Newgard, Michael P. Czech

Nat Commun. 2023; 14: 1362. Published online 2023 Mar 13. doi: 10.1038/s41467-023-37016-8

PMCID:: PMC10011520

Abstract Article PDF–5.3M

Select item 74333765.

Single-Cell RNA Profiling Reveals Adipocyte to Macrophage Signaling Sufficient to Enhance Thermogenesis

Felipe Henriques, Alexander H. Bedard, Adilson Guilherme, Mark Kelly, Jingyi Chi, Peng Zhang, Lawrence M. Lifshitz, Karl Bellvé, Leslie A. Rowland, Batuhan Yenilmez, Shreya Kumar, Yetao Wang, Jeremy Luban, Lee S. Weinstein, Jiandie D. Lin, Paul Cohen, Michael P. Czech

Cell Rep. Author manuscript; available in PMC 2020 Aug 18.

Published in final edited form as: Cell Rep. 2020 Aug 4; 32(5): 107998. doi: 10.1016/j.celrep.2020.107998

PMCID:: PMC7433376

Abstract Article PDF–3.4M

Select item 69547296.

Type I fatty acid synthase trapped in the octanoyl‐bound state

Alexander Rittner, Karthik S. Paithankar, Aaron Himmler, Martin Grininger

Protein Sci. 2020 Feb; 29(2): 589–605. Published online 2020 Jan 11. doi: 10.1002/pro.3797

PMCID:: PMC6954729

Abstract Article PDF–7.8M

Select item 59989817.

Fatty acid synthase is required for profibrotic TGF-β signaling

Mi-Yeon Jung, Jeong-Han Kang, Danielle M. Hernandez, Xueqian Yin, Mahefatiana Andrianifahanana, Youli Wang, Anatilde Gonzalez-Guerrico, Andrew H. Limper, Ruth Lupu, Edward B. Leof

FASEB J. 2018 Jul; 32(7): 3803–3815. Published online 2018 Feb 16. doi: 10.1096/fj.201701187R

PMCID:: PMC5998981

Abstract Article

Select item 59007508.

An unexpected link between fatty acid synthase and cholesterol synthesis in proinflammatory macrophage activation

Richard G. Carroll, Zbigniew Zasłona, Silvia Galván-Peña, Emma L. Koppe, Daniel C. Sévin, Stefano Angiari, Martha Triantafilou, Kathy Triantafilou, Louise K. Modis, Luke A. O'Neill

J Biol Chem. 2018 Apr 13; 293(15): 5509–5521. Published online 2018 Feb 20. doi: 10.1074/jbc.RA118.001921

PMCID:: PMC5900750

Abstract Article PDF–2.9M

Select item 58814959.

De novo fatty acid synthesis by Schwann cells is essential for peripheral nervous system myelination

Laura Montani, Jorge A. Pereira, Camilla Norrmén, Hartmut B.F. Pohl, Elisa Tinelli, Martin Trötzmüller, Gianluca Figlia, Penelope Dimas, Belinda von Niederhäusern, Rachel Schwager, Sebastian Jessberger, Clay F. Semenkovich, Harald C. Köfeler, Ueli Suter

J Cell Biol. 2018 Apr 2; 217(4): 1353–1368. doi: 10.1083/jcb.201706010

PMCID:: PMC5881495

Abstract Article PDF–3.5M

Select item 381839810.

Fatty Acid Synthase as a Factor Required for Exercise-Induced Cognitive Enhancement and Dentate Gyrus Cellular Proliferation

Nataliya E. Chorna, Iván J. Santos-Soto, Nestor M. Carballeira, Joan L. Morales, Janneliz de la Nuez, Alma Cátala-Valentin, Anatoliy P. Chornyy, Adrinel Vázquez-Montes, Sandra Peña De Ortiz

PLoS One. 2013; 8(11): e77845. Published online 2013 Nov 5. doi: 10.1371/journal.pone.0077845

PMCID:: PMC3818398

Abstract Article PDF–1.9M

Select item 358213611.

Muscle lipogenesis balances insulin sensitivity and strength through calcium signaling

Katsuhiko Funai, Haowei Song, Li Yin, Irfan J. Lodhi, Xiaochao Wei, Jun Yoshino, Trey Coleman, Clay F. Semenkovich

J Clin Invest. 2013 Mar 1; 123(3): 1229–1240. Published online 2013 Feb 8. doi: 10.1172/JCI65726

Correction in:: J Clin Invest. 2013 Aug 1; 123(8): 3634.

PMCID:: PMC3582136

Abstract Article PDF–3.3M

Select item 316245412.

Fatty Acid Synthase Modulates Homeostatic Responses to Myocardial Stress

Babak Razani, Haixia Zhang, P. Christian Schulze, Joel D. Schilling, John Verbsky, Irfan J. Lodhi, Veli K. Topkara, Chu Feng, Trey Coleman, Attila Kovacs, Daniel P. Kelly, Jeffrey E. Saffitz, Gerald W. Dorn, II, Colin G. Nichols, Clay F. Semenkovich

J Biol Chem. 2011 Sep 2; 286(35): 30949–30961. Published online 2011 Jul 8. doi: 10.1074/jbc.M111.230508

PMCID:: PMC3162454

Abstract Article PDF–3.0M

Select item 265665613.

Inactivation of hypothalamic FAS protects mice from diet-induced obesity and inflammation

Manu V. Chakravarthy, Yimin Zhu, Li Yin, Trey Coleman, Kirk L. Pappan, Connie A. Marshall, Michael L. McDaniel, Clay F. Semenkovich

J Lipid Res. 2009 Apr; 50(4): 630–640. doi: 10.1194/jlr.M800379-JLR200

PMCID:: PMC2656656

Abstract Article PDF–1.6M

Select item 125359814.

Inhibition of hypothalamic fatty acid synthase triggers rapid activation of fatty acid oxidation in skeletal muscle

Seung Hun Cha, Zhiyuan Hu, Shigeru Chohnan, M. Daniel Lane

Proc Natl Acad Sci U S A. 2005 Oct 11; 102(41): 14557–14562. Published online 2005 Oct 3. doi: 10.1073/pnas.0507300102

PMCID:: PMC1253598

Abstract Article PDF–499K

Select item 16445115.

Fatty acid synthesis is essential in embryonic development: Fatty acid synthase null mutants and most of the heterozygotes die in utero

Subrahmanyam S. Chirala, Hua Chang, Martin Matzuk, Lutfi Abu-Elheiga, Jianqiang Mao, Kathleen Mahon, Milton Finegold, Salih J. Wakil

Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6358–6363. Published online 2003 May 8. doi: 10.1073/pnas.0931394100

PMCID:: PMC164451

Abstract Article PDF–270K

Select item 11751516.

Effect of a fatty acid synthase inhibitor on food intake and expression of hypothalamic neuropeptides

Teruhiko Shimokawa, Monica V. Kumar, M. Daniel Lane

Proc Natl Acad Sci U S A. 2002 Jan 8; 99(1): 66–71. Published online 2001 Dec 26. doi: 10.1073/pnas.012606199

PMCID:: PMC117515

Abstract Article PDF–224K

Select item 1090405817.

TRIM56 protects against nonalcoholic fatty liver disease by promoting the degradation of fatty acid synthase

Suowen Xu, Xiumei Wu, Sichen Wang, Mengyun Xu, Tingyu Fang, Xiaoxuan Ma, Meijie Chen, Jiajun Fu, Juan Guo, Song Tian, Tian Tian, Xu Cheng, Hailong Yang, Junjie Zhou, Zhenya Wang, Yanjun Yin, Wen Xu, Fen Xu, Jinhua Yan, Zhihua Wang, Sihui Luo, Xiao-Jing Zhang, Yan-Xiao Ji, Jianping Weng

J Clin Invest. 2024 Mar 1; 134(5): e166149. Published online 2024 Jan 11. doi: 10.1172/JCI166149

PMCID:: PMC10904058

Abstract Article PDF–21M

Select item 1082277718.

Proteolytic activation of fatty acid synthase signals pan-stress resolution

Hai Wei, Yi M. Weaver, Chendong Yang, Yuan Zhang, Guoli Hu, Courtney M. Karner, Matthew Sieber, Ralph J. DeBerardinis, Benjamin P. Weaver

Nat Metab. 2024; 6(1): 113–126. Published online 2024 Jan 2. doi: 10.1038/s42255-023-00939-z

PMCID:: PMC10822777

Abstract Article PDF–22M

Select item 1076203419.

Fatty acid synthesis suppresses dietary polyunsaturated fatty acid use

Anna Worthmann, Julius Ridder, Sharlaine Y. L. Piel, Ioannis Evangelakos, Melina Musfeldt, Hannah Voß, Marie O’Farrell, Alexander W. Fischer, Sangeeta Adak, Monica Sundd, Hasibullah Siffeti, Friederike Haumann, Katja Kloth, Tatjana Bierhals, Markus Heine, Paul Pertzborn, Mira Pauly, Julia-Josefine Scholz, Suman Kundu, Marceline M. Fuh, Axel Neu, Klaus Tödter, Maja Hempel, Uwe Knippschild, Clay F. Semenkovich, Hartmut Schlüter, Joerg Heeren, Ludger Scheja, Christian Kubisch, Christian Schlein

Nat Commun. 2024; 15: 45. Published online 2024 Jan 2. doi: 10.1038/s41467-023-44364-y

PMCID:: PMC10762034

Abstract Article PDF–1.0M

Select item 1023943720.

Overexpression of fatty acid synthase attenuates bleomycin induced lung fibrosis by restoring mitochondrial dysfunction in mice

Hyesun Shin, Shinhee Park, Jisu Hong, Ae-Rin Baek, Junehyuk Lee, Do-Jin Kim, An-Soo Jang, Su Sie Chin, Sung Hwan Jeong, Sung-Woo Park

Sci Rep. 2023; 13: 9044. Published online 2023 Jun 3. doi: 10.1038/s41598-023-36009-3

PMCID:: PMC10239437

Abstract Article PDF–5.2M

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PMC Links for Gene (Select 14104) (128)
PMC
Mus musculus H2A clustered histone 18 (H2ac18), mRNA
Mus musculus H2A clustered histone 18 (H2ac18), mRNA
gi|2260855219|ref|NM_013549.3|

Nucleotide
Mus musculus cDNA, clone:Y1G0121H08, strand:minus, reference:ENSEMBL:Mouse-Trans...
Mus musculus cDNA, clone:Y1G0121H08, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000039800, based on BLAT search
gi|56020485|dbj|AK196308.1|

Nucleotide

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