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Select item 95904511.

The interconnected relationships between middle ear bulla size, cavitation defects, and chronic otitis media revealed in a syndromic mouse model

Juan M. Fons, Natalie J. Milmoe, Michael R. G. Dack, Leena Joshi, Hannah Thompson, Abigail S. Tucker

Front Genet. 2022; 13: 933416. Published online 2022 Oct 10. doi: 10.3389/fgene.2022.933416

PMCID:: PMC9590451

Abstract Article PDF–3.0M

Select item 81180852.

The Eya1 phosphatase mediates Shh-driven symmetric cell division of cerebellar granule cell precursors

Daniel J. Merk, Pengcheng Zhou, Samuel M. Cohen, Maria F. Pazyra-Murphy, Grace H. Hwang, Kristina J. Rehm, Jose Alfaro, Christopher M. Reid, Xuesong Zhao, Eunyoung Park, Pin-Xian Xu, Jennifer A. Chan, Michael J. Eck, Kellie J. Nazemi, Corey C. Harwell, Rosalind A. Segal

Dev Neurosci. Author manuscript; available in PMC 2022 Jan 20.

Published in final edited form as: Dev Neurosci. 2020; 42(5-6): 170–186. Published online 2021 Jan 20. doi: 10.1159/000512976

PMCID:: PMC8118085

Abstract Article PDF–2.7M

Select item 39061603.

BOR-Syndrome-Associated Eya1 Mutations Lead to Enhanced Proteasomal Degradation of Eya1 Protein

Amna Musharraf, Dagmar Kruspe, Jürgen Tomasch, Birgit Besenbeck, Christoph Englert, Kathrin Landgraf

PLoS One. 2014; 9(1): e87407. Published online 2014 Jan 29. doi: 10.1371/journal.pone.0087407

PMCID:: PMC3906160

Abstract Article PDF–1.5M

Select item 44184434.

The Eya1 Phosphatase Promotes Shh Signaling during Hindbrain Development and Oncogenesis

Adriana Eisner, Maria Pazyra-Murphy, Ershela Durresi, Pengcheng Zhou, Xuesong Zhao, Emily C. Chadwick, Pin-Xian Xu, R. Tyler Hillman, Matthew P. Scott, Michael E. Greenberg, Rosalind A. Segal

Dev Cell. Author manuscript; available in PMC 2016 Apr 6.

Published in final edited form as: Dev Cell. 2015 Apr 6; 33(1): 22–35. Published online 2015 Mar 26. doi: 10.1016/j.devcel.2015.01.033

PMCID:: PMC4418443

Abstract Article PDF–2.1M

Select item 37557455.

EYA1 Phosphatase Function Is Essential To Drive Breast Cancer Cell Proliferation Through Cyclin D1

Kongming Wu, Zhaoming Li, Shaoxin Cai, Lifeng Tian, Ke Chen, Jing Wang, Junbo Hu, Ye Sun, Xue Li, Adam Ertel, Richard G. Pestell

Cancer Res. Author manuscript; available in PMC 2014 Jul 15.

Published in final edited form as: Cancer Res. 2013 Jul 15; 73(14): 4488–4499. Published online 2013 May 1. doi: 10.1158/0008-5472.CAN-12-4078

PMCID:: PMC3755745

Abstract Article PDF–2.7M

Select item 236746.

Mouse Eya genes are expressed during limb tendon development and encode a transcriptional activation function

Pin-Xian Xu, Jane Cheng, Jonathan A. Epstein, Richard L. Maas

Proc Natl Acad Sci U S A. 1997 Oct 28; 94(22): 11974–11979. doi: 10.1073/pnas.94.22.11974

PMCID:: PMC23674

Abstract Article PDF–537K

Select item 55931767.

Six1 is essential for differentiation and patterning of the mammalian auditory sensory epithelium

Ting Zhang, Jinshu Xu, Pascal Maire, Pin-Xian Xu

PLoS Genet. 2017 Sep; 13(9): e1006967. Published online 2017 Sep 11. doi: 10.1371/journal.pgen.1006967

PMCID:: PMC5593176

Abstract Article PDF–40M

Select item 4342628.

Six1 and Eya1 Expression Can Reprogram Adult Muscle from the Slow-Twitch Phenotype into the Fast-Twitch Phenotype

Raphaelle Grifone, Christine Laclef, François Spitz, Soledad Lopez, Josiane Demignon, Jacques-Emmanuel Guidotti, Kiyoshi Kawakami, Pin-Xian Xu, Robert Kelly, Basil J. Petrof, Dominique Daegelen, Jean-Paul Concordet, Pascal Maire

Mol Cell Biol. 2004 Jul; 24(14): 6253–6267. doi: 10.1128/MCB.24.14.6253-6267.2004

PMCID:: PMC434262

Abstract Article PDF–901K

Select item 88444959.

Six1 and Six2 of the Sine Oculis Homeobox Subfamily are Not Functionally Interchangeable in Mouse Nephron Formation

Jinshu Xu, Jun Li, Aarthi Ramakrishnan, Hanen Yan, Li Shen, Pin-Xian Xu

Front Cell Dev Biol. 2022; 10: 815249. Published online 2022 Feb 1. doi: 10.3389/fcell.2022.815249

PMCID:: PMC8844495

Abstract Article PDF–5.7M

Select item 543728810.

Identification of mouse cochlear progenitors that develop hair and supporting cells in the organ of Corti

Jinshu Xu, Hiroo Ueno, Chelsea Y. Xu, Binglai Chen, Irving L. Weissman, Pin-Xian Xu

Nat Commun. 2017; 8: 15046. Published online 2017 May 11. doi: 10.1038/ncomms15046

PMCID:: PMC5437288

Abstract Article PDF–2.5M

Select item 362308911.

The Phosphatase-Transcription Activator EYA1 Is Targeted by Anaphase-Promoting Complex/Cdh1 for Degradation at M-to-G₁ Transition

Jianbo Sun, Zoi Karoulia, Elaine Y. M. Wong, Mohi Ahmed, Keiji Itoh, Pin-Xian Xu

Mol Cell Biol. 2013 Mar; 33(5): 927–936. doi: 10.1128/MCB.01516-12

PMCID:: PMC3623089

Abstract Article PDF–2.4M

Select item 956126012.

The transcriptional coactivator Eya1 exerts transcriptional repressive activity by interacting with REST corepressors and REST-binding sequences to maintain nephron progenitor identity

Jun Li, Chunming Cheng, Jinshu Xu, Ting Zhang, Bengu Tokat, Georgia Dolios, Aarthi Ramakrishnan, Li Shen, Rong Wang, Pin-Xian Xu

Nucleic Acids Res. 2022 Oct 14; 50(18): 10343–10359. Published online 2022 Sep 21. doi: 10.1093/nar/gkac760

PMCID:: PMC9561260

Abstract Article PDF–9.9M

Select item 710296213.

Dynamic changes in cis-regulatory occupancy by Six1 and its cooperative interactions with distinct cofactors drive lineage-specific gene expression programs during progressive differentiation of the auditory sensory epithelium

Jun Li, Ting Zhang, Aarthi Ramakrishnan, Bernd Fritzsch, Jinshu Xu, Elaine Y M Wong, Yong-Hwee Eddie Loh, Jianqiang Ding, Li Shen, Pin-Xian Xu

Nucleic Acids Res. 2020 Apr 6; 48(6): 2880–2896. Published online 2020 Jan 20. doi: 10.1093/nar/gkaa012

PMCID:: PMC7102962

Abstract Article PDF–7.5M

Select item 448553414.

Eya-Six are necessary for survival of nephrogenic cord progenitors and inducing nephric duct development prior to ureteric bud formation

Jinshu Xu, Pin-Xian Xu

Dev Dyn. Author manuscript; available in PMC 2016 Jul 1.

Published in final edited form as: Dev Dyn. 2015 Jul; 244(7): 866–873. Published online 2015 Jun 18. doi: 10.1002/dvdy.24282

PMCID:: PMC4485534

Abstract Article PDF–1.5M

Select item 405430615.

The Canonical Wnt Signal Restricts the Glycogen Synthase Kinase 3/Fbw7-Dependent Ubiquitination and Degradation of Eya1 Phosphatase

Ye Sun, Xue Li

Mol Cell Biol. 2014 Jul; 34(13): 2409–2417. doi: 10.1128/MCB.00104-14

PMCID:: PMC4054306

Abstract Article PDF–1.8M

Select item 328543416.

Eya1-Six1 interaction is sufficient to induce hair cell fate in the cochlea by activating Atoh1 expression in cooperation with Sox2

Mohi Ahmed, Elaine Y-M. Wong, Jianbo Sun, Jinshu Xu, Feng Wang, Pin-Xian Xu

Dev Cell. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Dev Cell. 2012 Feb 14; 22(2): 377–390. doi: 10.1016/j.devcel.2011.12.006

PMCID:: PMC3285434

Abstract Article PDF–4.1M

Select item 250455217.

A Comparative Study of Eya1 and Eya4 Protein Function and Its Implication in Branchio-oto-renal Syndrome and DFNA10

Yuzhou Zhang, Boyd M. Knosp, Mark Maconochie, Rick A. Friedman, Richard J.H. Smith

J Assoc Res Otolaryngol. 2004 Sep; 5(3): 295–304. Published online 2004 Jun 24. doi: 10.1007/s10162-004-4044-3

PMCID:: PMC2504552

Abstract Article PDF–382K

Select item 221337118.

Eya4-deficient mice are a model for heritable otitis media

Frederic F.S. Depreux, Keith Darrow, David A. Conner, Roland D. Eavey, M. Charles Liberman, Christine E. Seidman, J.G. Seidman

J Clin Invest. 2008 Feb 1; 118(2): 651–658. doi: 10.1172/JCI32899

PMCID:: PMC2213371

Abstract Article PDF–949K

Select item 41956219.

SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1–SIX1–DNA complexes

Rainer G. Ruf, Pin-Xian Xu, Derek Silvius, Edgar A. Otto, Frank Beekmann, Ulla T. Muerb, Shrawan Kumar, Thomas J. Neuhaus, Markus J. Kemper, Richard M. Raymond, Jr., Patrick D. Brophy, Jennifer Berkman, Michael Gattas, Valentine Hyland, Eva-Maria Ruf, Charles Schwartz, Eugene H. Chang, Richard J. H. Smith, Constantine A. Stratakis, Dominique Weil, Christine Petit, Friedhelm Hildebrandt

Proc Natl Acad Sci U S A. 2004 May 25; 101(21): 8090–8095. Published online 2004 May 12. doi: 10.1073/pnas.0308475101

PMCID:: PMC419562

Abstract Article PDF–597K

Select item 279133220.

Non-homeodomain regions of Hox proteins mediate activation versus repression of Six2 via a single enhancer site in vivo

Alisha R. Yallowitz, Ke-Qin Gong, Ilea T. Swinehart, Lisa T. Nelson, Deneen M. Wellik

Dev Biol. Author manuscript; available in PMC 2010 Nov 1.

Published in final edited form as: Dev Biol. 2009 Nov 1; 335(1): 156–165. Published online 2009 Aug 28. doi: 10.1016/j.ydbio.2009.08.020

PMCID:: PMC2791332

Abstract Article PDF–3.9M

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PMC Links for Gene (Select 14048) (104)
PMC
eyes absent homolog 1 isoform X5 [Mus musculus]
eyes absent homolog 1 isoform X5 [Mus musculus]
gi|568905234|ref|XP_006495515.1|

Protein
BioProjects for Gene (Select 55743) (4)
BioProject
Nucleotide Links for Gene (Select 55743) (23)
Nucleotide
Homo sapiens checkpoint with forkhead and ring finger domains (CHFR), transcript...
Homo sapiens checkpoint with forkhead and ring finger domains (CHFR), transcript variant 5, mRNA
gi|239048908|ref|NM_001161347.1|

Nucleotide

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