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Select item 63821751.

Modeling Edar expression reveals the hidden dynamics of tooth signaling center patterning

Alexa Sadier, Monika Twarogowska, Klara Steklikova, Luke Hayden, Anne Lambert, Pascal Schneider, Vincent Laudet, Maria Hovorakova, Vincent Calvez, Sophie Pantalacci

PLoS Biol. 2019 Feb; 17(2): e3000064. Published online 2019 Feb 7. doi: 10.1371/journal.pbio.3000064

PMCID:: PMC6382175

Abstract Article PDF–3.4M

Select item 27625402.

Enhanced Edar Signalling Has Pleiotropic Effects on Craniofacial and Cutaneous Glands

Shie Hong Chang, Stephanie Jobling, Keith Brennan, Denis J. Headon

PLoS One. 2009; 4(10): e7591. Published online 2009 Oct 26. doi: 10.1371/journal.pone.0007591

PMCID:: PMC2762540

Abstract Article PDF–431K

Select item 90106273.

A Foxo1-Klf2-S1pr1-Gnai1-Rac1 signaling axis is a critical mediator of Ostm1 regulatory network in T lymphopoiesis

Marie S. Mutabaruka, Monica Pata, Jean Vacher

iScience. 2022 Apr 15; 25(4): 104160. Published online 2022 Mar 25. doi: 10.1016/j.isci.2022.104160

PMCID:: PMC9010627

Abstract Article PDF–5.7M

Select item 49674744.

Ectodysplasin A Pathway Contributes to Human and Murine Skin Repair

Clare L. Garcin, Kenneth M. Huttner, Neil Kirby, Pascal Schneider, Matthew J. Hardman

J Invest Dermatol. 2016 May; 136(5): 1022–1030. doi: 10.1016/j.jid.2015.09.002

PMCID:: PMC4967474

Abstract Article

Select item 48740315.

A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation

Kaustubh Adhikari, Macarena Fuentes-Guajardo, Mirsha Quinto-Sánchez, Javier Mendoza-Revilla, Juan Camilo Chacón-Duque, Victor Acuña-Alonzo, Claudia Jaramillo, William Arias, Rodrigo Barquera Lozano, Gastón Macín Pérez, Jorge Gómez-Valdés, Hugo Villamil-Ramírez, Tábita Hunemeier, Virginia Ramallo, Caio C. Silva de Cerqueira, Malena Hurtado, Valeria Villegas, Vanessa Granja, Carla Gallo, Giovanni Poletti, Lavinia Schuler-Faccini, Francisco M. Salzano, Maria- Cátira Bortolini, Samuel Canizales-Quinteros, Michael Cheeseman, Javier Rosique, Gabriel Bedoya, Francisco Rothhammer, Denis Headon, Rolando González-José, David Balding, Andrés Ruiz-Linares

Nat Commun. 2016; 7: 11616. Published online 2016 May 19. doi: 10.1038/ncomms11616

PMCID:: PMC4874031

Abstract Article PDF–1.3M

Select item 47735146.

A genome-wide association scan in admixed Latin Americans identifies loci influencing facial and scalp hair features

Kaustubh Adhikari, Tania Fontanil, Santiago Cal, Javier Mendoza-Revilla, Macarena Fuentes-Guajardo, Juan-Camilo Chacón-Duque, Farah Al-Saadi, Jeanette A. Johansson, Mirsha Quinto-Sanchez, Victor Acuña-Alonzo, Claudia Jaramillo, William Arias, Rodrigo Barquera Lozano, Gastón Macín Pérez, Jorge Gómez-Valdés, Hugo Villamil-Ramírez, Tábita Hunemeier, Virginia Ramallo, Caio C. Silva de Cerqueira, Malena Hurtado, Valeria Villegas, Vanessa Granja, Carla Gallo, Giovanni Poletti, Lavinia Schuler-Faccini, Francisco M. Salzano, Maria-Cátira Bortolini, Samuel Canizales-Quinteros, Francisco Rothhammer, Gabriel Bedoya, Rolando Gonzalez-José, Denis Headon, Carlos López-Otín, Desmond J. Tobin, David Balding, Andrés Ruiz-Linares

Nat Commun. 2016; 7: 10815. Published online 2016 Mar 1. doi: 10.1038/ncomms10815

PMCID:: PMC4773514

Abstract Article PDF–2.2M

Select item 42695457.

Pharmacological Stimulation of Edar Signaling in the Adult Enhances Sebaceous Gland Size and Function

Christine Kowalczyk-Quintas, Sonia Schuepbach-Mallepell, Laure Willen, Terry K. Smith, Kenneth Huttner, Neil Kirby, Denis J. Headon, Pascal Schneider

J Invest Dermatol. Author manuscript; available in PMC 2015 Aug 1.

Published in final edited form as: J Invest Dermatol. 2015 Feb; 135(2): 359–368. Published online 2014 Sep 10. doi: 10.1038/jid.2014.382

PMCID:: PMC4269545

Abstract Article PDF–1.7M

Select item 35756028.

Modeling recent human evolution in mice by expression of a selected EDAR variant

Yana G. Kamberov, Sijia Wang, Jingze Tan, Pascale Gerbault, Abigail Wark, Longzhi Tan, Yajun Yang, Shilin Li, Kun Tang, Hua Chen, Adam Powell, Yuval Itan, Dorian Fuller, Jason Lohmueller, Junhao Mao, Asa Schachar, Madeline Paymer, Elizabeth Hostetter, Elizabeth Byrne, Melissa Burnett, Andrew P. McMahon, Mark G. Thomas, Daniel E. Lieberman, Li Jin, Clifford J. Tabin, Bruce A. Morgan, Pardis C. Sabeti

Cell. Author manuscript; available in PMC 2014 Feb 14.

Published in final edited form as: Cell. 2013 Feb 14; 152(4): 691–702. doi: 10.1016/j.cell.2013.01.016

PMCID:: PMC3575602

Abstract Article PDF–2.1M

Select item 26597909.

Distinct Impacts of Eda and Edar Loss of Function on the Mouse Dentition

Cyril Charles, Sophie Pantalacci, Paul Tafforeau, Denis Headon, Vincent Laudet, Laurent Viriot

PLoS One. 2009; 4(4): e4985. Published online 2009 Apr 2. doi: 10.1371/journal.pone.0004985

PMCID:: PMC2659790

Abstract Article PDF–589K

Select item 176247210.

Involvement of the Edar Signaling in the Control of Hair Follicle Involution (Catagen)

Michael Y. Fessing, Tatyana Y. Sharova, Andrey A. Sharov, Ruzanna Atoyan, Vladimir A. Botchkarev

Am J Pathol. 2006 Dec; 169(6): 2075–2084. doi: 10.2353/ajpath.2006.060227

PMCID:: PMC1762472

Abstract Article PDF–854K

Select item 645135411.

Edar is a downstream target of beta-catenin and drives collagen accumulation in the mouse prostate

Kyle A. Wegner, Vatsal Mehta, Jeanette A. Johansson, Brett R. Mueller, Kimberly P. Keil, Lisa L. Abler, Paul C. Marker, M. Mark Taketo, Denis J. Headon, Chad M. Vezina

Biol Open. 2019 Mar 15; 8(3): bio037945. Published online 2019 Feb 11. doi: 10.1242/bio.037945

PMCID:: PMC6451354

Abstract Article PDF–1.4M

Select item 637084312.

The Ectodysplasin receptor EDAR acts as a tumor suppressor in melanoma by conditionally inducing cell death

Jonathan Vial, Amélie Royet, Philippe Cassier, Antonin Tortereau, Sarah Dinvaut, Denis Maillet, Lise Gratadou-Hupon, Marion Creveaux, Alexa Sadier, Garance Tondeur, Sophie Léon, Lauriane Depaepe, Sophie Pantalacci, Arnaud de la Fouchardière, Olivier Micheau, Stéphane Dalle, Vincent Laudet, Patrick Mehlen, Marie Castets

Cell Death Differ. 2019 Mar; 26(3): 443–454. Published online 2018 May 31. doi: 10.1038/s41418-018-0128-1

PMCID:: PMC6370843

Abstract Article PDF–2.0M

Select item 449181413.

A genome-wide association study identifies multiple loci for variation in human ear morphology

Kaustubh Adhikari, Guillermo Reales, Andrew J. P. Smith, Esra Konka, Jutta Palmen, Mirsha Quinto-Sanchez, Victor Acuña-Alonzo, Claudia Jaramillo, William Arias, Macarena Fuentes, María Pizarro, Rodrigo Barquera Lozano, Gastón Macín Pérez, Jorge Gómez-Valdés, Hugo Villamil-Ramírez, Tábita Hunemeier, Virginia Ramallo, Caio C. Silva de Cerqueira, Malena Hurtado, Valeria Villegas, Vanessa Granja, Carla Gallo, Giovanni Poletti, Lavinia Schuler-Faccini, Francisco M. Salzano, Maria- Cátira Bortolini, Samuel Canizales-Quinteros, Francisco Rothhammer, Gabriel Bedoya, Rosario Calderón, Javier Rosique, Michael Cheeseman, Mahmood F. Bhutta, Steve E. Humphries, Rolando Gonzalez-José, Denis Headon, David Balding, Andrés Ruiz-Linares

Nat Commun. 2015; 6: 7500. Published online 2015 Jun 24. doi: 10.1038/ncomms8500

PMCID:: PMC4491814

Abstract Article PDF–2.9M

Select item 1051717114.

Depletion of G9A attenuates imiquimod-induced psoriatic dermatitis via targeting EDAR-NF-κB signaling in keratinocyte

Zhiqin Fang, Yutong Wang, Bo Huang, Xiang Chen, Rundong Jiang, Mingzhu Yin

Cell Death Dis. 2023 Sep; 14(9): 627. Published online 2023 Sep 22. doi: 10.1038/s41419-023-06134-y

PMCID:: PMC10517171

Abstract Article PDF–9.7M

Select item 899092615.

The EDA-deficient mouse has Zymbal's gland hypoplasia and acute otitis externa

Jorge del-Pozo, Denis J. Headon, James D. Glover, Ali Azar, Sonia Schuepbach-Mallepell, Mahmood F. Bhutta, Jon Riddell, Scott Maxwell, Elspeth Milne, Pascal Schneider, Michael Cheeseman

Dis Model Mech. 2022 Mar 1; 15(3): dmm049034. Published online 2022 Mar 30. doi: 10.1242/dmm.049034

PMCID:: PMC8990926

Abstract Article

Select item 517995016.

Ectodysplasin signalling deficiency in mouse models of hypohidrotic ectodermal dysplasia leads to middle ear and nasal pathology

Ali Azar, Chiara Piccinelli, Helen Brown, Denis Headon, Michael Cheeseman

Hum Mol Genet. 2016 Aug 15; 25(16): 3564–3577. Published online 2016 Jul 4. doi: 10.1093/hmg/ddw202

PMCID:: PMC5179950

Abstract Article PDF–2.1M

Select item 1036323917.

Ectodysplasin signaling via Xedar is required for mammary gland morphogenesis

Abigail R. Wark, Daniel Aldea, Reiko R. Tomizawa, Blerina Kokalari, Bailey Warder, Yana G. Kamberov

J Invest Dermatol. Author manuscript; available in PMC 2024 Aug 1.

Published in final edited form as: J Invest Dermatol. 2023 Aug; 143(8): 1529–1537.e2. Published online 2023 Feb 18. doi: 10.1016/j.jid.2023.02.007

PMCID:: PMC10363239

Abstract Article PDF–1.0M

Select item 874093518.

Limb development genes underlie variation in human fingerprint patterns

Jinxi Li, James D. Glover, Haiguo Zhang, Meifang Peng, Jingze Tan, Chandana Basu Mallick, Dan Hou, Yajun Yang, Sijie Wu, Yu Liu, Qianqian Peng, Shijie C. Zheng, Edie I. Crosse, Alexander Medvinsky, Richard A. Anderson, Helen Brown, Ziyu Yuan, Shen Zhou, Yanqing Xu, John P. Kemp, Yvonne Y.W. Ho, Danuta Z. Loesch, Lizhong Wang, Yingxiang Li, Senwei Tang, Xiaoli Wu, Robin G. Walters, Kuang Lin, Ruogu Meng, Jun Lv, Jonathan M. Chernus, Katherine Neiswanger, Eleanor Feingold, David M. Evans, Sarah E. Medland, Nicholas G. Martin, Seth M. Weinberg, Mary L. Marazita, Gang Chen, Zhengming Chen, Yong Zhou, Michael Cheeseman, Lan Wang, Li Jin, Denis J. Headon, Sijia Wang

Cell. 2022 Jan 6; 185(1): 95–112.e18. doi: 10.1016/j.cell.2021.12.008

PMCID:: PMC8740935

Abstract Article

Select item 494375419.

PDGF signaling in the dermis and in dermal condensates is dispensable for hair follicle induction and formation

Amélie Rezza, Rachel Sennett, Manon Tanguy, Carlos Clavel, Michael Rendl

Exp Dermatol. Author manuscript; available in PMC 2016 Jul 13.

Published in final edited form as: Exp Dermatol. 2015 Jun; 24(6): 468–470. Published online 2015 Mar 25. doi: 10.1111/exd.12672

PMCID:: PMC4943754

Abstract Article PDF–332K

Select item 437272020.

Cxcr4 is transiently expressed in both epithelial and mesenchymal compartments of nascent hair follicles but is not required for follicle formation

Rachel Sennett, Amélie Rezza, Katherine L. Dauber, Carlos Clavel, Michael Rendl

Exp Dermatol. Author manuscript; available in PMC 2015 Oct 1.

Published in final edited form as: Exp Dermatol. 2014 Oct; 23(10): 748–750. doi: 10.1111/exd.12523

PMCID:: PMC4372720

Abstract Article PDF–1.5M

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