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Select item 107211521.

ADORA2A-driven proline synthesis triggers epigenetic reprogramming in neuroendocrine prostate and lung cancers

Na Jing, Kai Zhang, Xinyu Chen, Kaiyuan Liu, Jinming Wang, Lingling Xiao, Wentian Zhang, Pengfei Ma, Penghui Xu, Chaping Cheng, Deng Wang, Huifang Zhao, Yuman He, Zhongzhong Ji, Zhixiang Xin, Yujiao Sun, Yingchao Zhang, Wei Bao, Yiming Gong, Liancheng Fan, Yiyi Ji, Guanglei Zhuang, Qi Wang, Baijun Dong, Pengcheng Zhang, Wei Xue, Wei-Qiang Gao, Helen He Zhu

J Clin Invest. 2023 Dec 15; 133(24): e168670. Published online 2023 Dec 15. doi: 10.1172/JCI168670

PMCID:: PMC10721152

Article PDF–22M

Select item 106362002.

ADORA2A promotes proliferation and inhibits apoptosis through PI3K/AKT pathway activation in colorectal carcinoma

Longyan Ran, Xiao Mou, Zhenglin Peng, Xiaochen Li, Meirong Li, Duo Xu, Zixi Yang, Xingwang Sun, Tao Yin

Sci Rep. 2023; 13: 19477. Published online 2023 Nov 9. doi: 10.1038/s41598-023-46521-1

PMCID:: PMC10636200

Article PDF–4.6M

Select item 102960923.

Molecular Biophysics of Class A G Protein Coupled Receptors–Lipids Interactome at a Glance—Highlights from the A_2A Adenosine Receptor

Efpraxia Tzortzini, Antonios Kolocouris

Biomolecules. 2023 Jun; 13(6): 957. Published online 2023 Jun 7. doi: 10.3390/biom13060957

PMCID:: PMC10296092

Article PDF–5.2M

Select item 101320524.

Striatopallidal adenosine A_2A receptor modulation of goal-directed behavior: Homeostatic control with cognitive flexibility

Jiang-Fan Chen, Doo-Sup Choi, Rodrigo A. Cunha

Neuropharmacology. Author manuscript; available in PMC 2024 Mar 15.

Published in final edited form as: Neuropharmacology. 2023 Mar 15; 226: 109421. Published online 2023 Jan 10. doi: 10.1016/j.neuropharm.2023.109421

PMCID:: PMC10132052

Article PDF–804K

Select item 100913805.

Role of adenosine A2a receptor in cancers and autoimmune diseases

Hongling Ye, Junqi Zhao, Xuejing Xu, Dagan Zhang, Han Shen, Sen Wang

Immun Inflamm Dis. 2023 Apr; 11(4): e826. Published online 2023 Apr 12. doi: 10.1002/iid3.826

PMCID:: PMC10091380

Article PDF–1015K

Select item 98130386.

Adenosine A_2A receptor availability in patients with early- and moderate-stage Parkinson’s disease

Imran Waggan, Eero Rissanen, Jouni Tuisku, Juho Joutsa, Semi Helin, Riitta Parkkola, Juha O. Rinne, Laura Airas

J Neurol. 2023; 270(1): 300–310. Published online 2022 Sep 2. doi: 10.1007/s00415-022-11342-1

PMCID:: PMC9813038

Article PDF–1.4M

Select item 96974257.

Analysis of ADORA2A rs5760423 and CYP1A2 rs762551 Genetic Variants in Patients with Alzheimer’s Disease

Vasileios Siokas, Dimitra S. Mouliou, Ioannis Liampas, Athina-Maria Aloizou, Vasiliki Folia, Elli Zoupa, Anastasios Papadimitriou, Eleftherios Lavdas, Dimitrios P. Bogdanos, Efthimios Dardiotis

Int J Mol Sci. 2022 Nov; 23(22): 14400. Published online 2022 Nov 19. doi: 10.3390/ijms232214400

PMCID:: PMC9697425

Article PDF–283K

Select item 95849858.

Adenosine A_2A receptor in schizophrenia: an in vivo brain PET imaging study

Tiago Reis Marques, Sridhar Natesan, Eugenii A. Rabiner, Graham E. Searle, Roger Gunn, Oliver D. Howes, Shitij Kapur

Psychopharmacology (Berl) 2022; 239(11): 3439–3445. Published online 2021 Jun 26. doi: 10.1007/s00213-021-05900-0

PMCID:: PMC9584985

Article PDF–585K

Select item 93894549.

International Union of Pharmacology. XXV. Nomenclature and Classification of Adenosine Receptors

BERTIL B. FREDHOLM, ADRIAAN P. IJZERMAN, KENNETH A. JACOBSON, KARL-NORBERT KLOTZ, JOEL LINDEN

Pharmacol Rev. Author manuscript; available in PMC 2022 Aug 19.

Published in final edited form as: Pharmacol Rev. 2001 Dec; 53(4): 527–552.

PMCID:: PMC9389454

Article PDF–1.3M

Select item 910126410.

A_2A Adenosine Receptor: A Possible Therapeutic Target for Alzheimer’s Disease by Regulating NLRP3 Inflammasome Activity?

Stefania Merighi, Manuela Nigro, Alessia Travagli, Silvia Pasquini, Pier Andrea Borea, Katia Varani, Fabrizio Vincenzi, Stefania Gessi

Int J Mol Sci. 2022 May; 23(9): 5056. Published online 2022 May 2. doi: 10.3390/ijms23095056

PMCID:: PMC9101264

Article PDF–909K

Select item 883505111.

Non-Invasive Assessment of Locally Overexpressed Human Adenosine 2A Receptors in the Heart of Transgenic Mice

Daniel Gündel, Thu Hang Lai, Sladjana Dukic-Stefanovic, Rodrigo Teodoro, Winnie Deuther-Conrad, Magali Toussaint, Klaus Kopka, Rareş-Petru Moldovan, Peter Boknik, Britt Hofmann, Ulrich Gergs, Joachim Neumann, Peter Brust

Int J Mol Sci. 2022 Feb; 23(3): 1025. Published online 2022 Jan 18. doi: 10.3390/ijms23031025

PMCID:: PMC8835051

Article PDF–2.5M

Select item 865421812.

Deciphering conformational selectivity in the A_2A adenosine G protein-coupled receptor by free energy simulations

Willem Jespers, Laura H. Heitman, Adriaan P. IJzerman, Eddy Sotelo, Gerard J. P. van Westen, Johan Åqvist, Hugo Gutiérrez-de-Terán

PLoS Comput Biol. 2021 Nov; 17(11): e1009152. Published online 2021 Nov 24. doi: 10.1371/journal.pcbi.1009152

PMCID:: PMC8654218

Article PDF–3.5M

Select item 832851413.

Homo-oligomerization of the human adenosine A_2A receptor is driven by the intrinsically disordered C-terminus

Khanh Dinh Quoc Nguyen, Michael Vigers, Eric Sefah, Susanna Seppälä, Jennifer Paige Hoover, Nicole Star Schonenbach, Blake Mertz, Michelle Ann O'Malley, Songi Han

eLife. 2021; 10: e66662. Published online 2021 Jul 16. doi: 10.7554/eLife.66662

PMCID:: PMC8328514

Article PDF–2.1M

Select item 819589314.

Increased expression of adenosine 2A receptors in metastatic renal cell carcinoma is associated with poorer response to anti-vascular endothelial growth factor agents and anti-PD-1/Anti-CTLA4 antibodies and shorter survival

Takao Kamai, Toshiki Kijima, Toyonori Tsuzuki, Akinori Nukui, Hideyuki Abe, Kyoko Arai, Ken-Ichiro Yoshida

Cancer Immunol Immunother. 2021 Jul; 70(7): 2009–2021. Published online 2021 Jan 8. doi: 10.1007/s00262-020-02843-x

PMCID:: PMC8195893

Article PDF–1.8M

Select item 803682015.

Adenosine A_2A Receptors Are Upregulated in Peripheral Blood Mononuclear Cells from Atrial Fibrillation Patients

Héctor Godoy-Marín, Romain Duroux, Kenneth A. Jacobson, Concepció Soler, Hildegard Colino-Lage, Veronica Jiménez-Sábado, José Montiel, Leif Hove-Madsen, Francisco Ciruela

Int J Mol Sci. 2021 Apr; 22(7): 3467. Published online 2021 Mar 27. doi: 10.3390/ijms22073467