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Select item 93244631.

The Dct^−/− Mouse Model to Unravel Retinogenesis Misregulation in Patients with Albinism

Angèle Tingaud-Sequeira, Elina Mercier, Vincent Michaud, Benoît Pinson, Ivet Gazova, Etienne Gontier, Fanny Decoeur, Lisa McKie, Ian J. Jackson, Benoît Arveiler, Sophie Javerzat

Genes (Basel) 2022 Jul; 13(7): 1164. Published online 2022 Jun 27. doi: 10.3390/genes13071164

PMCID:: PMC9324463

Abstract Article PDF–1.8M

Select item 55480022.

Soyasaponin Ag inhibits α-MSH-induced melanogenesis in B16F10 melanoma cells via the downregulation of TRP-2

Seung Hwan Yang, Aristides M. Tsatsakis, George Tzanakakis, Hong-Suk Kim, Bao Le, Maria Sifaki, Demetrios A. Spandidos, Chigen Tsukamoto, Kirill S. Golokhvast, Boris N. Izotov, Gyuhwa Chung

Int J Mol Med. 2017 Sep; 40(3): 631–636. Published online 2017 Jul 10. doi: 10.3892/ijmm.2017.3061

PMCID:: PMC5548002

Abstract Article PDF–610K

Select item 37842113.

Melanocyte-specific CD8⁺ T cells are associated with epidermal depigmentation in a novel mouse model of vitiligo

S You, Y-H Cho, J-S Byun, E-C Shin

Clin Exp Immunol. 2013 Oct; 174(1): 38–44. Published online 2013 Sep 8. doi: 10.1111/cei.12146

PMCID:: PMC3784211

Abstract Article PDF–732K

Select item 37561484.

Cytomegalovirus-based based cancer vaccines expressing TRP2 induce rejection of melanoma in mice

Guangwu Xu, Tameka Smith, Finn Grey, Ann B. Hill

Biochem Biophys Res Commun. Author manuscript; available in PMC 2014 Jul 26.

Published in final edited form as: Biochem Biophys Res Commun. 2013 Jul 26; 437(2): 287–291. Published online 2013 Jun 27. doi: 10.1016/j.bbrc.2013.06.068

PMCID:: PMC3756148

Abstract Article PDF–816K

Select item 37181805.

Controlled insertional mutagenesis using a LINE-1 (ORFeus) gene-trap mouse model

Kathryn A. O’Donnell, Wenfeng An, Christina T. Schrum, Sarah J. Wheelan, Jef D. Boeke

Proc Natl Acad Sci U S A. 2013 Jul 16; 110(29): E2706–E2713. Published online 2013 Jul 1. doi: 10.1073/pnas.1302504110

PMCID:: PMC3718180

Abstract Article PDF–1.2M

Select item 33836936.

I-SceI-Mediated Double-Strand Break Does Not Increase the Frequency of Homologous Recombination at the Dct Locus in Mouse Embryonic Stem Cells

Myriam Fenina, Dominique Simon-Chazottes, Sandrine Vandormael-Pournin, Jihane Soueid, Francina Langa, Michel Cohen-Tannoudji, Bruno A. Bernard, Jean-Jacques Panthier

PLoS One. 2012; 7(6): e39895. Published online 2012 Jun 26. doi: 10.1371/journal.pone.0039895

PMCID:: PMC3383693

Abstract Article PDF–1.0M

Select item 12769227.

Mutations in dopachrome tautomerase (Dct) affect eumelanin/pheomelanin synthesis, but do not affect intracellular trafficking of the mutant protein

Gertrude-E. Costin, Julio C. Valencia, Kazumasa Wakamatsu, Shosuke Ito, Francisco Solano, Adina L. Milac, Wilfred D. Vieira, Yuji Yamaguchi, François Rouzaud, Andrei-J. Petrescu, M. Lynn Lamoreux, Vincent J. Hearing

Biochem J. 2005 Oct 15; 391(Pt 2): 249–259. Prepublished online 2005 Jun 16. Published online 2005 Oct 10. doi: 10.1042/BJ20042070

PMCID:: PMC1276922

Abstract Article PDF–1.3M

Select item 12169288.

Molecular mechanism for catalysis by a new zinc-enzyme, dopachrome tautomerase.

F Solano, C Jiménez-Cervantes, J H Martínez-Liarte, J C García-Borrón, J R Jara, J A Lozano

Biochem J. 1996 Jan 15; 313(Pt 2): 447–453. doi: 10.1042/bj3130447

PMCID:: PMC1216928

Summary PDF–395K

Select item 5564829.

A second tyrosinase-related protein, TRP-2, is a melanogenic enzyme termed DOPAchrome tautomerase.

K Tsukamoto, I J Jackson, K Urabe, P M Montague, V J Hearing

EMBO J. 1992 Feb; 11(2): 519–526. doi: 10.1002/j.1460-2075.1992.tb05082.x

PMCID:: PMC556482

Summary Page Browse PDF–2.2M

Select item 923783810.

Topical therapy for regression and melanoma prevention of congenital giant nevi

Yeon Sook Choi, Tal H. Erlich, Max von Franque, Inbal Rachmin, Jessica L. Flesher, Erik B. Schiferle, Yi Zhang, Marcello Pereira da Silva, Alva Jiang, Allison S. Dobry, Mack Su, Sharon Germana, Sebastian Lacher, Orly Freund, Ezra Feder, Jose L. Cortez, Suyeon Ryu, Tamar Babila Propp, Yedidyah Leo Samuels, Labib R. Zakka, Marjan Azin, Christin E. Burd, Norman E. Sharpless, X. Shirley Liu, Clifford Meyer, William Gerald Austen, Jr., Branko Bojovic, Curtis L. Cetrulo, Jr., Martin C. Mihm, Dave S. Hoon, Shadmehr Demehri, Elena B. Hawryluk, David E. Fisher

Cell. Author manuscript; available in PMC 2023 Jun 9.

Published in final edited form as: Cell. 2022 Jun 9; 185(12): 2071–2085.e12. Published online 2022 May 12. doi: 10.1016/j.cell.2022.04.025

PMCID:: PMC9237838

Abstract Article PDF–3.9M

Select item 634591611.

Phenotypic analysis of Myo10 knockout (Myo10^tm2/tm2) mice lacking full-length (motorized) but not brain-specific headless myosin X

Anne C. Bachg, Markus Horsthemke, Boris V. Skryabin, Tim Klasen, Nina Nagelmann, Cornelius Faber, Emma Woodham, Laura M. Machesky, Sandra Bachg, Richard Stange, Hyun-Woo Jeong, Ralf H. Adams, Martin Bähler, Peter J. Hanley

Sci Rep. 2019; 9: 597. Published online 2019 Jan 24. doi: 10.1038/s41598-018-37160-y

PMCID:: PMC6345916

Abstract Article PDF–4.8M

Select item 377891912.

HSP70i Accelerates Depigmentation in a Mouse Model of Autoimmune Vitiligo

Cecele J. Denman, James McCracken, Vidhya Hariharan, Jared Klarquist, Kepa Oyarbide-Valencia, José A. Guevara-Patiño, I. Caroline Le Poole

J Invest Dermatol. Author manuscript; available in PMC 2013 Sep 20.

Published in final edited form as: J Invest Dermatol. 2008 Aug; 128(8): 2041–2048. Published online 2008 Mar 13. doi: 10.1038/jid.2008.45

PMCID:: PMC3778919

Abstract Article PDF–2.2M

Select item 38167913.

Melanocytes and Pigmentation Are Affected in Dopachrome Tautomerase Knockout Mice

Laurence Guyonneau, Fabien Murisier, Anita Rossier, Alexandre Moulin, Friedrich Beermann

Mol Cell Biol. 2004 Apr; 24(8): 3396–3403. doi: 10.1128/MCB.24.8.3396-3403.2004

PMCID:: PMC381679

Abstract Article PDF–338K

Select item 28043514.

A cDNA encoding tyrosinase-related protein maps to the brown locus in mouse.

I J Jackson

Proc Natl Acad Sci U S A. 1988 Jun; 85(12): 4392–4396. doi: 10.1073/pnas.85.12.4392

Correction in:: Proc Natl Acad Sci U S A. 1989 Feb; 86(3): 997.

PMCID:: PMC280435

Summary Page Browse PDF–1.2M

Select item 4435815.

Piebald lethal (sl) acts early to disrupt the development of neural crest-derived melanocytes.

W J Pavan, S M Tilghman

Proc Natl Acad Sci U S A. 1994 Jul 19; 91(15): 7159–7163. doi: 10.1073/pnas.91.15.7159

PMCID:: PMC44358

Summary Page Browse PDF–1.8M

Select item 534468616.

Coordination by Cdc42 of Actin, Contractility, and Adhesion for Melanoblast Movement in Mouse Skin

Emma F. Woodham, Nikki R. Paul, Benjamin Tyrrell, Heather J. Spence, Karthic Swaminathan, Michelle R. Scribner, Evangelos Giampazolias, Ann Hedley, William Clark, Frieda Kage, Daniel J. Marston, Klaus M. Hahn, Stephen W.G. Tait, Lionel Larue, Cord H. Brakebusch, Robert H. Insall, Laura M. Machesky

Curr Biol. 2017 Mar 6; 27(5): 624–637. doi: 10.1016/j.cub.2017.01.033

PMCID:: PMC5344686

Abstract Article PDF–12M

Select item 523595417.

GLI1⁺ progenitor cells in the adrenal capsule of the adult mouse give rise to heterotopic gonadal-like tissue

Julia Dörner, Verena Martinez Rodriguez, Ricarda Ziegler, Theresa Röhrig, Rebecca S. Cochran, Ronni M. Götz, Mark D. Levin, Marjut Pihlajoki, Markku Heikinheimo, David B. Wilson

Mol Cell Endocrinol. Author manuscript; available in PMC 2018 Feb 5.

Published in final edited form as: Mol Cell Endocrinol. 2017 Feb 5; 441: 164–175. Published online 2016 Aug 29. doi: 10.1016/j.mce.2016.08.043

PMCID:: PMC5235954

Abstract Article PDF–1.9M

Select item 446124518.

The chemokine SDF-1/CXCL12 regulates the migration of melanocyte progenitors in mouse hair follicles

Abdelhak Belmadani, Hosung Jung, Dongjun Ren, Richard J. Miller

Differentiation. Author manuscript; available in PMC 2015 Jun 9.

Published in final edited form as: Differentiation. 2009 Apr; 77(4): 395–411. Published online 2008 Dec 25. doi: 10.1016/j.diff.2008.10.015

PMCID:: PMC4461245

Abstract Article PDF–5.2M

Select item 391286919.

Fascin 1 is transiently expressed in mouse melanoblasts during development and promotes migration and proliferation

Yafeng Ma, Ang Li, William J. Faller, Silvana Libertini, Florencia Fiorito, David A. Gillespie, Owen J. Sansom, Shigeko Yamashiro, Laura M. Machesky

Development. 2013 May 15; 140(10): 2203–2211. doi: 10.1242/dev.089789

PMCID:: PMC3912869

Abstract Article

Select item 343799620.

Key Roles for Transforming Growth Factor β in Melanocyte Stem Cell Maintenance

Emi K. Nishimura, Misa Suzuki, Vivien Igras, Jinyan Du, Scott Lonning, Yoshiki Miyachi, Jürgen Roes, Friedrich Beermann, David E. Fisher

Cell Stem Cell. Author manuscript; available in PMC 2012 Sep 10.

Published in final edited form as: Cell Stem Cell. 2010 Feb 5; 6(2): 130–140. doi: 10.1016/j.stem.2009.12.010

PMCID:: PMC3437996

Abstract Article PDF–3.3M

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PMC Links for Gene (Select 13190) (90)
PMC
AGENCOURT_55147800 NICHD_XGC_Emb10 Xenopus laevis cDNA clone IMAGE:7981980 3', m...
AGENCOURT_55147800 NICHD_XGC_Emb10 Xenopus laevis cDNA clone IMAGE:7981980 3', mRNA sequence
gi|70890188|gnl|dbEST|30204825|gb|D 76.1|

Nucleotide
RecName: Full=L-dopachrome tautomerase; Short=DCT; Short=DT; AltName: Full=DOPAc...
RecName: Full=L-dopachrome tautomerase; Short=DCT; Short=DT; AltName: Full=DOPAchrome conversion factor; AltName: Full=DOPAchrome isomerase; AltName: Full=DOPAchrome oxidoreductase; AltName: Full=L-dopachrome Delta-isomerase; AltName: Full=SLATY locus protein; AltName: Full=Tyrosinase-related protein 2; Short=TRP-2; Short=TRP2; Flags: Precursor
gi|342187092|sp|P29812.2|TYRP2_MOUS

Protein

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