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Select item 43500921.

Lessons from Hepatocyte-Specific Cyp51 Knockout Mice: Impaired Cholesterol Synthesis Leads to Oval Cell-Driven Liver Injury

Gregor Lorbek, Martina Perše, Jera Jeruc, Peter Juvan, Francisco M. Gutierrez-Mariscal, Monika Lewinska, Rolf Gebhardt, Rok Keber, Simon Horvat, Ingemar Björkhem, Damjana Rozman

Sci Rep. 2015; 5: 8777. Published online 2015 Mar 5. doi: 10.1038/srep08777

PMCID:: PMC4350092

Abstract Article PDF–8.1M

Select item 43175702.

Identification of Natural RORγ Ligands that Regulate the Development of Lymphoid Cells

Fabio R. Santori, Pengxiang Huang, Serge A. van de Pavert, Eugene F. Douglass, Jr, David J. Leaver, Brad A. Haubrich, Rok Keber, Gregor Lorbek, Tanja Konijn, Brittany N. Rosales, Simon Horvat, Damjana Rozman, Alain Rahier, Reina E. Mebius, Fraydoon Rastinejad, W. David Nes, Dan R. Littman

Cell Metab. Author manuscript; available in PMC 2016 Feb 3.

Published in final edited form as: Cell Metab. 2015 Feb 3; 21(2): 286–297. doi: 10.1016/j.cmet.2015.01.004

PMCID:: PMC4317570

Abstract Article PDF–1.8M

Select item 42310843.

Hidden Disease Susceptibility and Sexual Dimorphism in the Heterozygous Knockout of Cyp51 from Cholesterol Synthesis

Monika Lewinska, Peter Juvan, Martina Perse, Jera Jeruc, Spela Kos, Gregor Lorbek, Ziga Urlep, Rok Keber, Simon Horvat, Damjana Rozman

PLoS One. 2014; 9(11): e112787. Published online 2014 Nov 13. doi: 10.1371/journal.pone.0112787

PMCID:: PMC4231084

Abstract Article PDF–7.1M

Select item 36464664.

Male germ cell-specific knockout of cholesterogenic cytochrome P450 lanosterol 14α-demethylase (Cyp51)

Rok Keber, Jure Ačimovič, Gregor Majdič, Helena Motaln, Damjana Rozman, Simon Horvat

J Lipid Res. 2013 Jun; 54(6): 1653–1661. doi: 10.1194/jlr.M035717

PMCID:: PMC3646466

Abstract Article PDF–994K

Select item 27598225.

Reducing CYP51 inhibits follicle-stimulating hormone induced resumption of mouse oocyte meiosis in vitro

Chao Wang, Baoshan Xu, Bo Zhou, Cheng Zhang, Jie Yang, Hong Ouyang, Gang Ning, Meijia Zhang, Jianzhong Shen, Guoliang Xia

J Lipid Res. 2009 Nov; 50(11): 2164–2172. doi: 10.1194/jlr.M800533-JLR200

PMCID:: PMC2759822

Abstract Article PDF–1.0M

Select item 3316296.

Nucleotide sequence of cytochrome P450 L1A1 (lanosterol 14 alpha-demethylase) from Candida albicans.

M H Lai, D R Kirsch

Nucleic Acids Res. 1989 Jan 25; 17(2): 804. doi: 10.1093/nar/17.2.804

PMCID:: PMC331629

Summary Page Browse PDF–143K

Select item 76952487.

Chronic Disruption of the Late Cholesterol Synthesis Leads to Female-Prevalent Liver Cancer

Kaja Blagotinšek Cokan, Žiga Urlep, Gregor Lorbek, Madlen Matz-Soja, Cene Skubic, Martina Perše, Jera Jeruc, Peter Juvan, Tadeja Režen, Damjana Rozman

Cancers (Basel) 2020 Nov; 12(11): 3302. Published online 2020 Nov 9. doi: 10.3390/cancers12113302

PMCID:: PMC7695248

Abstract Article PDF–5.2M

Select item 31907168.

Mouse Knockout of the Cholesterogenic Cytochrome P450 Lanosterol 14α-Demethylase (Cyp51) Resembles Antley-Bixler Syndrome

Rok Keber, Helena Motaln, Kay D. Wagner, Nataša Debeljak, Minoo Rassoulzadegan, Jure Ačimovič, Damjana Rozman, Simon Horvat

J Biol Chem. 2011 Aug 19; 286(33): 29086–29097. Published online 2011 Jun 25. doi: 10.1074/jbc.M111.253245

PMCID:: PMC3190716

Abstract Article PDF–4.8M

Select item 62628599.

Retinoic acid-induced CYP51 nuclear translocation promotes meiosis prophase I process and is correlated to the expression of REC8 and STAG3 in mice

Xinyi Mu, Jia Wen, Qian Chen, Zhengpin Wang, Yijing Wang, Meng Guo, Yi Yang, JinRui Xu, Zhiqing Wei, Guoliang Xia, Mengye Yang, Chao Wang

Biol Open. 2018 Nov 15; 7(11): bio035626. Published online 2018 Nov 15. doi: 10.1242/bio.035626

PMCID:: PMC6262859

Abstract Article PDF–19M

Select item 524169610.

Disrupting Hepatocyte Cyp51 from Cholesterol Synthesis Leads to Progressive Liver Injury in the Developing Mouse and Decreases RORC Signalling

Žiga Urlep, Gregor Lorbek, Martina Perše, Jera Jeruc, Peter Juvan, Madlen Matz-Soja, Rolf Gebhardt, Ingemar Björkhem, Jason A. Hall, Richard Bonneau, Dan R. Littman, Damjana Rozman

Sci Rep. 2017; 7: 40775. Published online 2017 Jan 18. doi: 10.1038/srep40775

PMCID:: PMC5241696

Abstract Article PDF–2.0M

Select item 555356511.

Lanosterol modulates TLR4 mediated innate immune responses in macrophages

Elisa Araldi, Marta Fernández-Fuertes, Alberto Canfrán-Duque, Wenwen Tang, Gary W Cline, Julio Madrigal-Matute, Jordan S. Pober, Miguel A. Lasunción, Dianqing Wu, Carlos Fernández-Hernando, Yajaira Suárez

Cell Rep. Author manuscript; available in PMC 2017 Aug 11.

Published in final edited form as: Cell Rep. 2017 Jun 27; 19(13): 2743–2755. doi: 10.1016/j.celrep.2017.05.093

PMCID:: PMC5553565

Abstract Article PDF–1.5M

Select item 298834612.

Statins Promote the Degradation of Extracellular Amyloid β-Peptide by Microglia via Stimulation of Exosome-associated Insulin-degrading Enzyme (IDE) Secretion

Irfan Y. Tamboli, Esther Barth, Leonie Christian, Martin Siepmann, Sathish Kumar, Sandesh Singh, Karen Tolksdorf, Michael T. Heneka, Dieter Lütjohann, Patrick Wunderlich, Jochen Walter

J Biol Chem. 2010 Nov 26; 285(48): 37405–37414. Published online 2010 Sep 28. doi: 10.1074/jbc.M110.149468

PMCID:: PMC2988346

Abstract Article PDF–5.3M

Select item 537776013.

Normalization of Hepatic Homeostasis in the Npc1^nmf164 Mouse Model of Niemann-Pick Type C Disease Treated with the Histone Deacetylase Inhibitor Vorinostat

Andrew B. Munkacsi, Natalie Hammond, Remy T. Schneider, Dinindu S. Senanayake, Katsumi Higaki, Kirill Lagutin, Stephen J. Bloor, Daniel S. Ory, Robert A. Maue, Fannie W. Chen, Antonio Hernandez-Ono, Nicole Dahlson, Joyce J. Repa, Henry N. Ginsberg, Yiannis A. Ioannou, Stephen L. Sturley

J Biol Chem. 2017 Mar 17; 292(11): 4395–4410. Published online 2016 Dec 28. doi: 10.1074/jbc.M116.770578

PMCID:: PMC5377760

Abstract Article PDF–2.8M

Select item 486590114.

Mfsd2a Is a Transporter for the Essential ω-3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development

Bernice H. Wong, Jia Pei Chan, Amaury Cazenave-Gassiot, Rebecca W. Poh, Juat Chin Foo, Dwight L. A. Galam, Sujoy Ghosh, Long N. Nguyen, Veluchamy A. Barathi, Sia W. Yeo, Chi D. Luu, Markus R. Wenk, David L. Silver

J Biol Chem. 2016 May 13; 291(20): 10501–10514. Published online 2016 Mar 22. doi: 10.1074/jbc.M116.721340

PMCID:: PMC4865901

Abstract Article PDF–5.4M

Select item 278977715.

Differential expression and function of ABCG1 and ABCG4 during development and aging

Dragana D. Bojanic, Paul T. Tarr, Greg D. Gale, Desmond J. Smith, Dean Bok, Bryan Chen, Steven Nusinowitz, Anita Lövgren-Sandblom, Ingemar Björkhem, Peter A. Edwards

J Lipid Res. 2010 Jan; 51(1): 169–181. doi: 10.1194/jlr.M900250-JLR200