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Select item 110935431.

Induction of p16Ink4a Gene Expression in Heme Protein–Induced AKI and by Heme: Pathophysiologic Implications

Karl A. Nath, Raman Deep Singh, Anthony J. Croatt, Allan W. Ackerman, Joseph P. Grande, Daniel R. O'Brien, Vesna D. Garovic, Christopher M. Adams, Tamara Tchkonia, James L. Kirkland

Kidney360. 2024 Apr; 5(4): 501–514. Published online 2024 Feb 21. doi: 10.34067/KID.0000000000000395

PMCID:: PMC11093543

Abstract Article PDF–1.1M

Select item 109438012.

Rejuvenating aged microglia by p16^ink4a-siRNA-loaded nanoparticles increases amyloid-β clearance in animal models of Alzheimer’s disease

Hyo Jung Shin, In Soo Kim, Seung Gyu Choi, Kayoung Lee, Hyewon Park, Juhee Shin, Dayoung Kim, Jaewon Beom, Yoon Young Yi, Deepak Prasad Gupta, Gyun Jee Song, Won-Suk Chung, C. Justin Lee, Dong Woon Kim

Mol Neurodegener. 2024; 19: 25. Published online 2024 Mar 16. doi: 10.1186/s13024-024-00715-x

PMCID:: PMC10943801

Abstract Article PDF–8.9M

Select item 107981353.

Dietary Folate and Cofactors Accelerate Age-dependent p16 Epimutation to Promote Intestinal Tumorigenesis

Li Yang, Robert C. Peery, Leah M. Farmer, Xia Gao, Yiqun Zhang, Chad J. Creighton, Lanjing Zhang, Lanlan Shen

Cancer Res Commun. 2024 Jan; 4(1): 164–169. Published online 2024 Jan 19. doi: 10.1158/2767-9764.CRC-23-0356

PMCID:: PMC10798135

Abstract Article PDF–2.6M

Select item 106210694.

Transcriptome analysis reveals genes associated with stem cell activation by physical exercise in the dentate gyrus of aged p16Ink4a knockout mice

Laura Micheli, Giorgio D'Andrea, Teresa Maria Creanza, Daniel Volpe, Nicola Ancona, Raffaella Scardigli, Felice Tirone

Front Cell Dev Biol. 2023; 11: 1270892. Published online 2023 Oct 19. doi: 10.3389/fcell.2023.1270892

PMCID:: PMC10621069

Abstract Article PDF–3.0M

Select item 104105725.

p16 ^INK4A Drives Non-Alcoholic Fatty Liver Disease Phenotypes in High Fat Diet Fed Mice via Biliary E2F1/FOXO1/IGF-1 Signaling

Debjyoti Kundu, Lindsey Kennedy, Tianhao Zhou, Burcin Ekser, Vik Meadows, Amelia Sybenga, Konstantina Kyritsi, Lixian Chen, Ludovica Ceci, Nan Wu, Chaodong Wu, Shannon Glaser, Guido Carpino, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Heather Francis

Hepatology. Author manuscript; available in PMC 2023 Aug 9.

Published in final edited form as: Hepatology. 2023 Jul 1; 78(1): 243–257. Published online 2023 Feb 20. doi: 10.1097/HEP.0000000000000307

PMCID:: PMC10410572

Abstract Article PDF–4.5M

Select item 103868866.

First-in-class multifunctional TYMS nonclassical antifolate inhibitor with potent in vivo activity that prolongs survival

Maria V. Guijarro, Patrick C. Kellish, Peter E. Dib, Nicholas G. Paciaroni, Akbar Nawab, Jacob Andring, Lidia Kulemina, Nicholas V. Borrero, Carlos Modenutti, Michael Feely, Elham Nasri, Robert P. Seifert, Xiaoping Luo, Richard L. Bennett, Daniil Shabashvili, Jonathan D. Licht, Robert McKenna, Adrian Roitberg, Robert W. Huigens, III, Frederic J. Kaye, Maria Zajac-Kaye

JCI Insight. 2023 May 22; 8(10): e158798. Published online 2023 May 22. doi: 10.1172/jci.insight.158798

PMCID:: PMC10386886

Abstract Article PDF–2.8M

Select item 103159907.

Developmental Expression of the Cell Cycle Regulator p16^INK4a in Retinal Glial Cells: A Novel Marker for Immature Ocular Astrocytes?

Cristina Martinez-Fernandez de la Camara, Tina Storm, Ahmed Salman, Thomas Burgoyne, Martin Qvist Rasmussen, Harry O. Orlans, Angela J. Russell, Stephen G. Davies, Alun R. Barnard, Robert E. MacLaren

J Histochem Cytochem. 2023 Jun; 71(6): 301–320. Published online 2023 Jun 23. doi: 10.1369/00221554231184286

PMCID:: PMC10315990

Abstract Article PDF–11M

Select item 101271438.

Oxylipin-PPARγ-initiated Adipocyte Senescence Propagates Secondary Senescence in the Bone Marrow

Xiaonan Liu, Yiru Gu, Surendra Kumar, Sahran Amin, Qiaoyue Guo, Jiekang Wang, Ching-Lien Fang, Xu Cao, Mei Wan

Cell Metab. Author manuscript; available in PMC 2024 Apr 4.

Published in final edited form as: Cell Metab. 2023 Apr 4; 35(4): 667–684.e6. doi: 10.1016/j.cmet.2023.03.005

PMCID:: PMC10127143

Abstract Article PDF–3.9M

Select item 99845359.

ARF suppression by MYC but not MYCN confers increased malignancy of aggressive pediatric brain tumors

Oliver J. Mainwaring, Holger Weishaupt, Miao Zhao, Gabriela Rosén, Anna Borgenvik, Laura Breinschmid, Annemieke D. Verbaan, Stacey Richardson, Dean Thompson, Steven C. Clifford, Rebecca M. Hill, Karl Annusver, Anders Sundström, Karl O. Holmberg, Maria Kasper, Sonja Hutter, Fredrik J. Swartling

Nat Commun. 2023; 14: 1221. Published online 2023 Mar 3. doi: 10.1038/s41467-023-36847-9

PMCID:: PMC9984535

Abstract Article PDF–4.7M

Select item 992569310.

Clearance of p16Ink4a-positive cells in a mouse transgenic model does not change β-cell mass and has limited effects on their proliferative capacity

Nadine Bahour, Lucia Bleichmar, Cristian Abarca, Emeline Wilmann, Stephanie Sanjines, Cristina Aguayo-Mazzucato

Aging (Albany NY) 2023 Jan 31; 15(2): 441–458. Published online 2023 Jan 12. doi: 10.18632/aging.204483

PMCID:: PMC9925693

Abstract Article PDF–1.8M

Select item 988421711.

Immortalized murine tenocyte cells: a novel and innovative tool for tendon research

Gil Lola Oreff, Barbara Maurer, Ahmed N. ELKhamary, Iris Gerner, Veronika Sexl, Florien Jenner

Sci Rep. 2023; 13: 1566. Published online 2023 Jan 28. doi: 10.1038/s41598-023-28318-4

PMCID:: PMC9884217

Abstract Article PDF–3.0M

Select item 953005012.

Endothelial senescence mediates hypoxia-induced vascular remodeling by modulating PDGFB expression

Priscilla Kyi, Kathryn Hendee, Tendai Hunyenyiwa, Kienna Matus, Tadanori Mammoto, Akiko Mammoto

Front Med (Lausanne) 2022; 9: 908639. Published online 2022 Sep 20. doi: 10.3389/fmed.2022.908639

PMCID:: PMC9530050

Abstract Article PDF–5.3M

Select item 852606113.

Modulation of fracture healing by the transient accumulation of senescent cells

Dominik Saul, David G Monroe, Jennifer L Rowsey, Robyn Laura Kosinsky, Stephanie J Vos, Madison L Doolittle, Joshua N Farr, Sundeep Khosla

eLife. 2021; 10: e69958. Published online 2021 Oct 7. doi: 10.7554/eLife.69958

PMCID:: PMC8526061

Abstract Article PDF–9.1M

Select item 812570214.

p16-3MR: A Novel Model to Study Cellular Senescence in Cigarette Smoke-Induced Lung Injuries

Gagandeep Kaur, Isaac K. Sundar, Irfan Rahman

Int J Mol Sci. 2021 May; 22(9): 4834. Published online 2021 May 3. doi: 10.3390/ijms22094834

PMCID:: PMC8125702

Abstract Article PDF–4.7M

Select item 810351415.

Role of Cdkn2a in the Emery–Dreifuss Muscular Dystrophy Cardiac Phenotype

Gloria Pegoli, Marika Milan, Pierluigi Giuseppe Manti, Andrea Bianchi, Federica Lucini, Philina Santarelli, Claudia Bearzi, Roberto Rizzi, Chiara Lanzuolo

Biomolecules. 2021 Apr; 11(4): 538. Published online 2021 Apr 6. doi: 10.3390/biom11040538

PMCID:: PMC8103514

Abstract Article PDF–51M

Select item 786390316.

CDKN2A/p16INK4a suppresses hepatic fatty acid oxidation through the AMPKα2-SIRT1-PPARα signaling pathway

Yann Deleye, Alexia Karen Cotte, Sarah Anissa Hannou, Nathalie Hennuyer, Lucie Bernard, Bruno Derudas, Sandrine Caron, Vanessa Legry, Emmanuelle Vallez, Emilie Dorchies, Nathalie Martin, Steve Lancel, Jean Sébastien Annicotte, Kadiombo Bantubungi, Albin Pourtier, Violeta Raverdy, François Pattou, Philippe Lefebvre, Corinne Abbadie, Bart Staels, Joel T. Haas, Réjane Paumelle

J Biol Chem. 2020 Dec 11; 295(50): 17310–17322. Published online 2020 Oct 9. doi: 10.1074/jbc.RA120.012543

PMCID:: PMC7863903

Abstract Article PDF–3.0M

Select item 775973817.

Unique Transcriptome Changes in Peripheral B Cells Revealed by Comparing Age Groups From Naive or Vaccinated Mice, Including snoRNA and Cdkn2a

Robin L Baudier, Kevin J Zwezdaryk, Malwina Czarny-Ratajczak, Lauren H Kodroff, Deborah E Sullivan, Elizabeth B Norton

J Gerontol A Biol Sci Med Sci. 2020 Dec; 75(12): 2326–2332. Published online 2020 Aug 1. doi: 10.1093/gerona/glaa165

PMCID:: PMC7759738

Abstract Article PDF–8.6M

Select item 765001118.

Downregulation of p16 Decreases Biliary Damage and Liver Fibrosis in the Mdr2^−/− Mouse Model of Primary Sclerosing Cholangitis

Konstantina Kyritsi, Heather Francis, Tianhao Zhou, Ludovica Ceci, Nan Wu, Zhihong Yang, Fanyin Meng, Lixian Chen, Leonardo Baiocchi, Debjyoti Kundu, Lindsey Kennedy, Suthat Liangpunsakul, Chaodong Wu, Shannon Glaser, Gianfranco Alpini

Gene Expr. 2020; 20(2): 89–103. Published online 2020 Nov 11. doi: 10.3727/105221620X15889714507961

PMCID:: PMC7650011

Abstract Article PDF–34M

Select item 742385019.

CDKN2A/B homozygous deletion is associated with early recurrence in meningiomas

Philipp Sievers, Thomas Hielscher, Daniel Schrimpf, Damian Stichel, David E. Reuss, Anna S. Berghoff, Marian C. Neidert, Hans-Georg Wirsching, Christian Mawrin, Ralf Ketter, Werner Paulus, Guido Reifenberger, Katrin Lamszus, Manfred Westphal, Nima Etminan, Miriam Ratliff, Christel Herold-Mende, Stefan M. Pfister, David T. W. Jones, Michael Weller, Patrick N. Harter, Wolfgang Wick, Matthias Preusser, Andreas von Deimling, Felix Sahm

Acta Neuropathol. 2020; 140(3): 409–413. Published online 2020 Jul 8. doi: 10.1007/s00401-020-02188-w

PMCID:: PMC7423850

Article PDF–987K

Select item 728410320.

Loss of ARF/INK4A Promotes Liver Progenitor Cell Transformation Toward Tumorigenicity Supporting Their Role in Hepatocarcinogenesis

Robyn P. Strauss, Katherine M. Audsley, Adam M. Passman, Joanne H. van Vuuren, Megan L. Finch-Edmondson, Bernard A. Callus, George C. Yeoh

Gene Expr. 2020; 20(1): 39–52. Published online 2020 Jun 12. doi: 10.3727/105221620X15874935364268

PMCID:: PMC7284103

Abstract Article PDF–31M

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