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Select item 112277261.

Essential role of p21^Waf1/Cip1 in the modulation of post-traumatic hippocampal Neural Stem Cells response

Francesco Chiani, Valentina Mastrorilli, Nicole Marchetti, Andrea Macioce, Chiara Nappi, Georgios Strimpakos, Miriam Pasquini, Alessia Gambadoro, Jonathan Isacco Battistini, Debora Cutuli, Laura Petrosini, Sara Marinelli, Raffaella Scardigli, Stefano Farioli Vecchioli

Stem Cell Res Ther. 2024; 15: 197. Published online 2024 Jul 6. doi: 10.1186/s13287-024-03787-0

PMCID:: PMC11227726

Abstract Article PDF–7.1M

Select item 111785382.

Osteochondroprogenitor cells and neutrophils expressing p21 and senescence markers modulate fracture repair

Dominik Saul, Madison L. Doolittle, Jennifer L. Rowsey, Mitchell N. Froemming, Robyn L. Kosinsky, Stephanie J. Vos, Ming Ruan, Nathan K. LeBrasseur, Abhishek Chandra, Robert J. Pignolo, João F. Passos, Joshua N. Farr, David G. Monroe, Sundeep Khosla

J Clin Invest. 2024 Jun 17; 134(12): e179834. Published online 2024 May 16. doi: 10.1172/JCI179834

PMCID:: PMC11178538

Abstract Article PDF–7.8M

Select item 101693653.

P21 facilitates macrophage chemotaxis by promoting CCL7 in the lung epithelial cell lines treated with radiation and bleomycin

Xinglong Liu, Liang Zeng, Yuchuan Zhou, Xinrui Zhao, Lin Zhu, Jianghong Zhang, Yan Pan, Chunlin Shao, Jiamei Fu

J Transl Med. 2023; 21: 314. Published online 2023 May 9. doi: 10.1186/s12967-023-04177-5

PMCID:: PMC10169365

Abstract Article PDF–6.4M

Select item 101209034.

p21 facilitates chronic lung inflammation via epithelial and endothelial cells

Naama Levi, Nurit Papismadov, Julia Majewska, Lior Roitman, Noa Wigoda, Raya Eilam, Michael Tsoory, Ron Rotkopf, Yossi Ovadya, Hagay Akiva, Ofer Regev, Valery Krizhanovsky

Aging (Albany NY) 2023 Apr 15; 15(7): 2395–2417. Published online 2023 Mar 30. doi: 10.18632/aging.204622

PMCID:: PMC10120903

Abstract Article PDF–2.0M

Select item 98453775.

Timing and cell specificity of senescence drives postnatal lung development and injury

Hongwei Yao, Joselynn Wallace, Abigail L. Peterson, Alejandro Scaffa, Salu Rizal, Katy Hegarty, Hajime Maeda, Jason L. Chang, Nathalie Oulhen, Jill A. Kreiling, Kelsey E. Huntington, Monique E. De Paepe, Guilherme Barbosa, Phyllis A. Dennery

Nat Commun. 2023; 14: 273. Published online 2023 Jan 17. doi: 10.1038/s41467-023-35985-4

PMCID:: PMC9845377

Abstract Article PDF–4.7M

Select item 97245936.

Elimination of radiation-induced senescence in the brain tumor microenvironment attenuates glioblastoma recurrence

Eliot Fletcher-Sananikone, Suman Kanji, Nozomi Tomimatsu, Luis Fernando Macedo Di Cristofaro, Rahul K. Kollipara, Debabrata Saha, John R. Floyd, Patrick Sung, Robert Hromas, Terry C. Burns, Ralf Kittler, Amyn A. Habib, Bipasha Mukherjee, Sandeep Burma

Cancer Res. Author manuscript; available in PMC 2022 Dec 6.

Published in final edited form as: Cancer Res. 2021 Dec 1; 81(23): 5935–5947. Published online 2021 Sep 27. doi: 10.1158/0008-5472.CAN-21-0752

PMCID:: PMC9724593

Abstract Article PDF–2.4M

Select item 82028637.

Cdkn1a transcript variant 2 is a marker of aging and cellular senescence

José Alberto López-Domínguez, Sandra Rodríguez-López, Ulises Ahumada-Castro, Pierre-Yves Desprez, Maria Konovalenko, Remi-Martin Laberge, César Cárdenas, José Manuel Villalba, Judith Campisi

Aging (Albany NY) 2021 May 31; 13(10): 13380–13392. Published online 2021 May 25. doi: 10.18632/aging.203110

PMCID:: PMC8202863

Abstract Article PDF–1.7M

Select item 77935658.

p21CIP1 promotes mammary cancer initiating cells via activation of Wnt/TCF1/CyclinD1 signaling

Outhiriaradjou Benard, Xia Qian, Huizhi Liang, Zuen Ren, Kimita Suyama, Larry Norton, Rachel B. Hazan

Mol Cancer Res. Author manuscript; available in PMC 2021 Jan 8.

Published in final edited form as: Mol Cancer Res. 2019 Jul; 17(7): 1571–1581. Published online 2019 Apr 9. doi: 10.1158/1541-7786.MCR-18-1044

PMCID:: PMC7793565

Abstract Article PDF–1.7M

Select item 73745859.

Autophagy is involved in the protective effect of p21 on LPS-induced cardiac dysfunction

Sihui Huang, Man Xu, Libo Liu, Jingjing Yang, Huibo Wang, Chunxia Wan, Wei Deng, Qizhu Tang

Cell Death Dis. 2020 Jul; 11(7): 554. Published online 2020 Jul 21. doi: 10.1038/s41419-020-02765-7

PMCID:: PMC7374585

Abstract Article PDF–2.4M

Select item 719300810.

Involvement of CDKN1A (p21) in cellular senescence in response to heat and irradiation stress during preimplantation development

Sun-A Ock, Jason G. Knott, Inchul Choi

Cell Stress Chaperones. 2020 May; 25(3): 503–508. Published online 2020 Apr 6. doi: 10.1007/s12192-020-01090-4

PMCID:: PMC7193008

Abstract Article PDF–365K

Select item 692045311.

Increased double strand breaks in diabetic β-cells with a p21 response that limits apoptosis

Vanessa S. Y. Tay, Surabhi Devaraj, Tracy Koh, Guo Ke, Karen C. Crasta, Yusuf Ali

Sci Rep. 2019; 9: 19341. Published online 2019 Dec 18. doi: 10.1038/s41598-019-54554-8

PMCID:: PMC6920453

Abstract Article PDF–3.6M

Select item 656674212.

Zoledronate induces cell cycle arrest and differentiation by upregulating p21 in mouse MC3T3-E1 preosteoblasts

Kuo-Chin Huang, Tsan-Wen Huang, Po-Yao Chuang, Tien-Yu Yang, Shun-Fu Chang

Int J Med Sci. 2019; 16(5): 751–756. Published online 2019 May 10. doi: 10.7150/ijms.32612

PMCID:: PMC6566742

Abstract Article PDF–524K

Select item 648302913.

Acute kidney injury induces dramatic p21 upregulation via a novel, glucocorticoid-activated, pathway

Richard A. Zager, Ali C. M. Johnson

Am J Physiol Renal Physiol. 2019 Apr 1; 316(4): F674–F681. Published online 2019 Jan 30. doi: 10.1152/ajprenal.00571.2018

PMCID:: PMC6483029

Abstract Article

Select item 645787114.

Absence of p21^{(WAF1/CIP1/SDI1)} protects against osteopenia and minimizes bone loss after ovariectomy in a mouse model

Priyatha Premnath, Leah Ferrie, Dante Louie, Steven Boyd, Roman Krawetz

PLoS One. 2019; 14(4): e0215018. Published online 2019 Apr 10. doi: 10.1371/journal.pone.0215018

PMCID:: PMC6457871

Abstract Article PDF–2.5M

Select item 629328815.

Plasma and urinary p21: potential biomarkers of AKI and renal aging

Ali C. Johnson, Richard A. Zager

Am J Physiol Renal Physiol. 2018 Nov 1; 315(5): F1329–F1335. Published online 2018 Aug 1. doi: 10.1152/ajprenal.00328.2018

PMCID:: PMC6293288

Abstract Article

Select item 621542516.

17-DMAG regulates p21 expression to induce chondrogenesis in vitro and in vivo

Karri L. Bertram, Nadia Narendran, Pankaj Tailor, Christina Jablonski, Catherine Leonard, Edward Irvine, Ricarda Hess, Anand O. Masson, Saleem Abubacker, Kristina Rinker, Jeff Biernaskie, Robin M. Yates, Paul Salo, Aru Narendran, Roman J. Krawetz

Dis Model Mech. 2018 Oct 1; 11(10): dmm033662. Published online 2018 Oct 8. doi: 10.1242/dmm.033662

PMCID:: PMC6215425

Abstract Article

Select item 583916717.

Effects of p21 deletion in mouse models of premature aging

Erica K. Benson, Bo Zhao, David A. Sassoon, Sam W. Lee, Stuart A. Aaronson

Cell Cycle. Author manuscript; available in PMC 2018 Mar 6.

Published in final edited form as: Cell Cycle. 2009 Jul 1; 8(13): 2002–2004. Published online 2009 Jul 12. doi: 10.4161/cc.8.13.8997

PMCID:: PMC5839167

Abstract Article PDF–56K

Select item 582103818.

Loss of p21 promoted tumorigenesis in the background of telomere dysfunctions induced by TRF2 and Wrn deficiency

Xiaoyu Si, Chihao Shao, Jing Li, Shuting Jia, Wenru Tang, Jihong Zhang, Julun Yang, Xiaoming Wu, Ying Luo

Int J Biol Sci. 2018; 14(2): 165–177. Published online 2018 Jan 14. doi: 10.7150/ijbs.23477

PMCID:: PMC5821038

Abstract Article PDF–2.0M

Select item 567935019.

p21^−/− mice exhibit enhanced bone regeneration after injury

Priyatha Premnath, Britta Jorgenson, Ricarda Hess, Pankaj Tailor, Dante Louie, Jaymi Taiani, Steven Boyd, Roman Krawetz

BMC Musculoskelet Disord. 2017; 18: 435. Published online 2017 Nov 9. doi: 10.1186/s12891-017-1790-z

PMCID:: PMC5679350

Abstract Article PDF–1.2M

Select item 550555820.

Anti-inflammatory activity of chloroquine and amodiaquine through p21-mediated suppression of T cell proliferation and Th1 cell differentiation

Sera Oh, Ji Hyun Shin, Eun Jung Jang, Hee Yeon Won, Hyo Kyeong Kim, Mi-Gyeong Jeong, Kwang Soo Kim, Eun Sook Hwang

Biochem Biophys Res Commun. Author manuscript; available in PMC 2017 Jul 11.

Published in final edited form as: Biochem Biophys Res Commun. 2016 May 27; 474(2): 345–350. Published online 2016 Apr 22. doi: 10.1016/j.bbrc.2016.04.105

PMCID:: PMC5505558

Abstract Article PDF–887K

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