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Select item 103156221.

CDK7 controls E2F- and MYC-driven proliferative and metabolic vulnerabilities in multiple myeloma

Yao Yao, Jessica Fong Ng, Woojun Daniel Park, Mehmet Samur, Eugenio Morelli, Jessica Encinas Mayoral, Zuzana Chyra, Yan Xu, Sanika Derebail, Charles Epstein, Behnam Nabet, Marta Chesi, Nathanael S. Gray, Richard A. Young, Nicholas Kwiatkowski, Constantine Mitsiades, Kenneth C. Anderson, Charles Y. Lin, Nikhil C. Munshi, Mariateresa Fulciniti

Blood. 2023 Jun 8; 141(23): 2841–2852. Published online 2023 Mar 9. doi: 10.1182/blood.2022018885

PMCID:: PMC10315622

Abstract Article

Select item 72566312.

CDK7 Mediates the Beta-Adrenergic Signaling in Thermogenic Brown and White Adipose Tissues

Honglei Ji, Yizhe Chen, Judit Castillo-Armengol, René Dreos, Catherine Moret, Guy Niederhäuser, Brigitte Delacuisine, Isabel C. Lopez-Mejia, Pierre-Damien Denechaud, Lluis Fajas

iScience. 2020 Jun 26; 23(6): 101163. Published online 2020 May 15. doi: 10.1016/j.isci.2020.101163

PMCID:: PMC7256631

Abstract Article PDF–6.6M

Select item 56819593.

Cdk7 Is Required for Activity-Dependent Neuronal Gene Expression, Long-Lasting Synaptic Plasticity and Long-Term Memory

Guiqin He, Xiangyu Yang, Guo Wang, Junxia Qi, Rui Mao, Zhengping Wu, Zikai Zhou

Front Mol Neurosci. 2017; 10: 365. Published online 2017 Nov 7. doi: 10.3389/fnmol.2017.00365

PMCID:: PMC5681959

Abstract Article PDF–2.6M

Select item 42449104.

Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

Nicholas Kwiatkowski, Tinghu Zhang, Peter B Rahl, Brian J Abraham, Jessica Reddy, Scott B Ficarro, Anahita Dastur, Arnaud Amzallag, Sridhar Ramaswamy, Bethany Tesar, Christopher R Jenkins, Nancy M Hannett, Douglas McMillin, Takaomi Sanda, Taebo Sim, Nam Doo Kim, Thomas Look, Constantine Mitsiades, Andrew P Weng, Jennifer R Brown, Cyril H. Benes, Jarrod A Marto, Richard A Young, Nathanael S. Gray

Nature. Author manuscript; available in PMC 2015 Jan 31.

Published in final edited form as: Nature. 2014 Jul 31; 511(7511): 616–620. Published online 2014 Jun 22. doi: 10.1038/nature13393

PMCID:: PMC4244910

Abstract Article PDF–4.3M

Select item 3592615.

Activation of cyclin-dependent kinase 4 (cdk4) by mouse MO15-associated kinase.

M Matsuoka, J Y Kato, R P Fisher, D O Morgan, C J Sherr

Mol Cell Biol. 1994 Nov; 14(11): 7265–7275. doi: 10.1128/mcb.14.11.7265

PMCID:: PMC359261

Summary Page Browse PDF–3.2M

Select item 26306986.

SUMOylation Inhibits SF-1 Activity by Reducing CDK7-Mediated Serine 203 Phosphorylation

Wei-Hsiung Yang, Joanne H. Heaton, Holly Brevig, Sarmistha Mukherjee, Jorge A. Iñiguez-Lluhí, Gary D. Hammer

Mol Cell Biol. 2009 Feb; 29(3): 613–625. Published online 2008 Nov 17. doi: 10.1128/MCB.00295-08

PMCID:: PMC2630698

Abstract Article PDF–1.0M

Select item 49447617.

CDK7 and miR-210 Co-regulate Cell-Cycle Progression of Neural Progenitors in the Developing Neocortex

Aisha I. Abdullah, Haijun Zhang, Yanzhen Nie, Wei Tang, Tao Sun

Stem Cell Reports. 2016 Jul 12; 7(1): 69–79. Published online 2016 Jul 12. doi: 10.1016/j.stemcr.2016.06.005

PMCID:: PMC4944761

Abstract Article PDF–5.3M

Select item 26125008.

Mat1 Inhibits Peroxisome Proliferator-Activated Receptor γ-Mediated Adipocyte Differentiation

Katja Helenius, Ying Yang, Jukka Alasaari, Tomi P. Mäkelä

Mol Cell Biol. 2009 Jan; 29(2): 315–323. Published online 2008 Nov 3. doi: 10.1128/MCB.00347-08

PMCID:: PMC2612500

Abstract Article PDF–1.2M

Select item 28653089.

Functional Analysis of the Cdk7·Cyclin H·Mat1 Complex in Mouse Embryonic Stem Cells and Embryos

Shetal A. Patel, M. Celeste Simon

J Biol Chem. 2010 May 14; 285(20): 15587–15598. Published online 2010 Mar 15. doi: 10.1074/jbc.M109.081687

PMCID:: PMC2865308

Abstract Article PDF–4.1M

Select item 1054922610.

CDK8 and CDK19 act redundantly to control the CFTR pathway in the intestinal epithelium

Susana Prieto, Geronimo Dubra, Alain Camasses, Ana Bella Aznar, Christina Begon‐Pescia, Elisabeth Simboeck, Nelly Pirot, François Gerbe, Lucie Angevin, Philippe Jay, Liliana Krasinska, Daniel Fisher

EMBO Rep. 2023 Feb; 24(2): e54261. Published online 2022 Dec 22. doi: 10.15252/embr.202154261

PMCID:: PMC10549226

Abstract Article PDF–11M

Select item 15521311.

The Histidine Triad Protein Hint Is Not Required for Murine Development or Cdk7 Function

Nina Korsisaari, Derrick J. Rossi, Keijo Luukko, Kay Huebner, Mark Henkemeyer, Tomi P. Mäkelä

Mol Cell Biol. 2003 Jun; 23(11): 3929–3935. doi: 10.1128/MCB.23.11.3929-3935.2003

PMCID:: PMC155213

Abstract Article PDF–413K

Select item 216939212.

AIRE Recruits P-TEFb for Transcriptional Elongation of Target Genes in Medullary Thymic Epithelial Cells

Irena Oven, Naděžda Brdičková, Jiri Kohoutek, Tomaž Vaupotič, Mojca Narat, B. Matija Peterlin

Mol Cell Biol. 2007 Dec; 27(24): 8815–8823. Published online 2007 Oct 15. doi: 10.1128/MCB.01085-07

PMCID:: PMC2169392

Abstract Article PDF–409K

Select item 336543113.

Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion

Miguel Ganuza, Cristina Sáiz-Ladera, Marta Cañamero, Gonzalo Gómez, Ralph Schneider, María A Blasco, David Pisano, Jesús M Paramio, David Santamaría, Mariano Barbacid

EMBO J. 2012 May 30; 31(11): 2498–2510. Published online 2012 Apr 13. doi: 10.1038/emboj.2012.94

PMCID:: PMC3365431

Abstract Article PDF–2.1M

Select item 727402414.

A Survey of Essential Genome Stability Genes Reveals That Replication Stress Mitigation Is Critical for Peri-Implantation Embryogenesis

Georgia R. Kafer, Anthony J. Cesare

Front Cell Dev Biol. 2020; 8: 416. Published online 2020 May 29. doi: 10.3389/fcell.2020.00416

PMCID:: PMC7274024

Abstract Article PDF–1.3M

Select item 621500915.

Asxl1 exerts an antiproliferative effect on mouse lung maturation via epigenetic repression of the E2f1-Nmyc axis

Seungtae Moon, Sun-Kyoung Im, Nackhyoung Kim, Hyesook Youn, Ui-Hyun Park, Joo-Yeon Kim, A.-Reum Kim, So-Jung An, Ji-Hoon Kim, Woong Sun, Jin-Taek Hwang, Eun-Joo Kim, Soo-Jong Um

Cell Death Dis. 2018 Nov; 9(11): 1118. Published online 2018 Nov 2. doi: 10.1038/s41419-018-1171-z

PMCID:: PMC6215009

Abstract Article PDF–2.7M

Select item 739691916.

Hankyu Lee, Hyuk Wan Ko

BMB Rep. 2020 Jul 31; 53(7): 367–372. Published online 2020 Jul 31. doi: 10.5483/BMBRep.2020.53.7.295

PMCID:: PMC7396919

Abstract Article PDF–23M

Select item 955395117.

Neonatal ketone body elevation regulates postnatal heart development by promoting cardiomyocyte mitochondrial maturation and metabolic reprogramming

Danyang Chong, Yayun Gu, Tongyu Zhang, Yu Xu, Dandan Bu, Zhong Chen, Na Xu, Liangkui Li, Xiyu Zhu, Haiquan Wang, Yangqing Li, Feng Zheng, Dongjin Wang, Peng Li, Li Xu, Zhibin Hu, Chaojun Li

Cell Discov. 2022; 8: 106. Published online 2022 Oct 11. doi: 10.1038/s41421-022-00447-6

PMCID:: PMC9553951

Abstract Article PDF–3.8M

Select item 492482618.

Misregulation of Alternative Splicing in a Mouse Model of Rett Syndrome

Ronghui Li, Qiping Dong, Xinni Yuan, Xin Zeng, Yu Gao, Cassandra Chiao, Hongda Li, Xinyu Zhao, Sunduz Keles, Zefeng Wang, Qiang Chang

PLoS Genet. 2016 Jun; 12(6): e1006129. Published online 2016 Jun 28. doi: 10.1371/journal.pgen.1006129

PMCID:: PMC4924826

Abstract Article PDF–1.9M

Select item 856411719.

Alternative Functions of Cell Cycle-Related and DNA Repair Proteins in Post-mitotic Neurons

Remi Akagawa, Yo-ichi Nabeshima, Takeshi Kawauchi

Front Cell Dev Biol. 2021; 9: 753175. Published online 2021 Oct 20. doi: 10.3389/fcell.2021.753175

PMCID:: PMC8564117

Abstract Article PDF–2.2M

Select item 18788520.

A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome

Jens Hansen, Thomas Floss, Petra Van Sloun, Ernst-Martin Füchtbauer, Franz Vauti, Hans-Hennig Arnold, Frank Schnütgen, Wolfgang Wurst, Harald von Melchner, Patricia Ruiz

Proc Natl Acad Sci U S A. 2003 Aug 19; 100(17): 9918–9922. Published online 2003 Aug 6. doi: 10.1073/pnas.1633296100

PMCID:: PMC187885

Abstract Article PDF–287K

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