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Select item 106689851.

LEO1 Is Required for Efficient Entry into Quiescence, Control of H3K9 Methylation and Gene Expression in Human Fibroblasts

Marc Laurent, Lina Cordeddu, Yasaman Zahedi, Karl Ekwall

Biomolecules. 2023 Nov; 13(11): 1662. Published online 2023 Nov 17. doi: 10.3390/biom13111662

PMCID:: PMC10668985

Abstract Article PDF–4.6M

Select item 101986292.

CDK12 and Integrator-PP2A complex modulates LEO1 phosphorylation for processive transcription elongation

Min Qiu, Zhinang Yin, Honghong Wang, Lingyu Lei, Conghui Li, Yali Cui, Rong Dai, Peiyuan Yang, Ying Xiang, Qiuzi Li, Junhui Lv, Zhuang Hu, Min Chen, Hai-Bing Zhou, Pingping Fang, Ruijing Xiao, Kaiwei Liang

Sci Adv. 2023 May; 9(20): eadf8698. Published online 2023 May 19. doi: 10.1126/sciadv.adf8698

PMCID:: PMC10198629

Abstract Article PDF–2.3M

Select item 82162833.

LEO1 is a partner for Cockayne syndrome protein B (CSB) in response to transcription-blocking DNA damage

Vinod Tiwari, Tomasz Kulikowicz, David M Wilson, 3rd, Vilhelm A Bohr

Nucleic Acids Res. 2021 Jun 21; 49(11): 6331–6346. Published online 2021 Jun 7. doi: 10.1093/nar/gkab458

PMCID:: PMC8216283

Abstract Article PDF–6.6M

Select item 39058924.

Structural insights into Paf1 complex assembly and histone binding

Xinlei Chu, Xiaohong Qin, Huisha Xu, Lei Li, Zheng Wang, Fengzhi Li, Xingqiao Xie, Hao Zhou, Yuequan Shen, Jiafu Long

Nucleic Acids Res. 2013 Dec; 41(22): 10619–10629. Published online 2013 Sep 14. doi: 10.1093/nar/gkt819

PMCID:: PMC3905892

Abstract Article PDF–5.0M

Select item 33320585.

Depletion of Trypanosome CTR9 Leads to Gene Expression Defects

Benard A. Ouna, Benson Nyambega, Theresa Manful, Claudia Helbig, Matilda Males, Abeer Fadda, Christine Clayton

PLoS One. 2012; 7(4): e34256. Published online 2012 Apr 20. doi: 10.1371/journal.pone.0034256

PMCID:: PMC3332058

Abstract Article PDF–432K

Select item 30606696.

Transcriptional activators enhance polyadenylation of mRNA precursors

Takashi Nagaike, Charlotte Logan, Ikuko Hotta, Orit Rozenblatt-Rosen, Matthew Meyerson, James L. Manley

Mol Cell. Author manuscript; available in PMC 2012 Feb 18.

Published in final edited form as: Mol Cell. 2011 Feb 18; 41(4): 409–418. doi: 10.1016/j.molcel.2011.01.022

PMCID:: PMC3060669

Abstract Article PDF–1.6M

Select item 59551487.

PAF1 complex interactions with SETDB1 mediate promoter H3K9 methylation and transcriptional repression of Hoxa9 and Meis1 in acute myeloid leukemia

James Ropa, Nirmalya Saha, Zhiling Chen, Justin Serio, Wei Chen, Dattatreya Mellacheruvu, Lili Zhao, Venkatesha Basrur, Alexey I. Nesvizhskii, Andrew G. Muntean

Oncotarget. 2018 Apr 24; 9(31): 22123–22136. Published online 2018 Apr 24. doi: 10.18632/oncotarget.25204

PMCID:: PMC5955148

Abstract Article PDF–4.4M

Select item 5434158.

The Parafibromin Tumor Suppressor Protein Is Part of a Human Paf1 Complex

Orit Rozenblatt-Rosen, Christina M. Hughes, Suraj J. Nannepaga, Kalai Selvi Shanmugam, Terry D. Copeland, Tad Guszczynski, James H. Resau, Matthew Meyerson

Mol Cell Biol. 2005 Jan; 25(2): 612–620. doi: 10.1128/MCB.25.2.612-620.2005

PMCID:: PMC543415

Abstract Article PDF–443K

Select item 33264819.

Histone H3R17me2a mark recruits human RNA Polymerase-Associated Factor 1 Complex to activate transcription

Jiacai Wu, Wei Xu

Proc Natl Acad Sci U S A. 2012 Apr 10; 109(15): 5675–5680. Published online 2012 Mar 26. doi: 10.1073/pnas.1114905109

PMCID:: PMC3326481

Abstract Article PDF–632K

Select item 258226610.

The parafibromin tumor suppressor protein inhibits cell proliferation by repression of the c-myc proto-oncogene

Ling Lin, Jian-Hua Zhang, Leelamma M. Panicker, William F. Simonds

Proc Natl Acad Sci U S A. 2008 Nov 11; 105(45): 17420–17425. Published online 2008 Nov 5. doi: 10.1073/pnas.0710725105

PMCID:: PMC2582266

Abstract Article PDF–675K

Select item 510183011.

SHP2 Tyrosine Phosphatase Converts Parafibromin/Cdc73 from a Tumor Suppressor to an Oncogenic Driver

Atsushi Takahashi, Ryouhei Tsutsumi, Ippei Kikuchi, Chikashi Obuse, Yasuhiro Saito, Azadeh Seidi, Robert Karisch, Minerva Fernandez, Taewoo Cho, Naomi Ohnishi, Orit Rozenblatt-Rosen, Matthew Meyerson, Benjamin G. Neel, Masanori Hatakeyama

Mol Cell. Author manuscript; available in PMC 2016 Nov 9.

Published in final edited form as: Mol Cell. 2011 Jul 8; 43(1): 45–56. doi: 10.1016/j.molcel.2011.05.014

PMCID:: PMC5101830

Abstract Article PDF–1.3M

Select item 114060112.

The HRPT2 Tumor Suppressor Gene Product Parafibromin Associates with Human PAF1 and RNA Polymerase II

Armelle Yart, Matthias Gstaiger, Christiane Wirbelauer, Maria Pecnik, Dimitrios Anastasiou, Daniel Hess, Wilhelm Krek

Mol Cell Biol. 2005 Jun; 25(12): 5052–5060. doi: 10.1128/MCB.25.12.5052-5060.2005

PMCID:: PMC1140601

Abstract Article PDF–522K

Select item 117600313.

The human PAF complex coordinates transcription with events downstream of RNA synthesis

Bing Zhu, Subhrangsu S. Mandal, Anh-Dung Pham, Yong Zheng, Hediye Erdjument-Bromage, Surinder K. Batra, Paul Tempst, Danny Reinberg

Genes Dev. 2005 Jul 15; 19(14): 1668–1673. doi: 10.1101/gad.1292105

PMCID:: PMC1176003

Abstract Article PDF–360K

Select item 288888814.

The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis

Andrew G. Muntean, Jiaying Tan, Kajal Sitwala, Yongsheng Huang, Joel Bronstein, James A. Connelly, Venkatesha Basrur, Kojo S. J. Elenitoba-Johnson, Jay L. Hess

Cancer Cell. Author manuscript; available in PMC 2011 Jun 15.

Published in final edited form as: Cancer Cell. 2010 Jun 15; 17(6): 609–621. doi: 10.1016/j.ccr.2010.04.012

PMCID:: PMC2888888

Abstract Article PDF–3.0M

Select item 244668115.

Direct Interactions between the Paf1 Complex and a Cleavage and Polyadenylation Factor Are Revealed by Dissociation of Paf1 from RNA Polymerase II

Kristen Nordick, Matthew G. Hoffman, Joan L. Betz, Judith A. Jaehning

Eukaryot Cell. 2008 Jul; 7(7): 1158–1167. Published online 2008 May 9. doi: 10.1128/EC.00434-07

PMCID:: PMC2446681

Abstract Article PDF–649K

Select item 285390816.

The Human PAF1 Complex Acts in Chromatin Transcription Elongation Both Independently and Cooperatively with SII/TFIIS

Jaehoon Kim, Mohamed Guermah, Robert G. Roeder

Cell. Author manuscript; available in PMC 2011 Feb 19.

Published in final edited form as: Cell. 2010 Feb 19; 140(4): 491–503. doi: 10.1016/j.cell.2009.12.050

PMCID:: PMC2853908

Abstract Article PDF–1.0M

Select item 261566517.

The tumor suppressor Cdc73 functionally associates with CPSF and CstF 3′ mRNA processing factors

Orit Rozenblatt-Rosen, Takashi Nagaike, Joshua M. Francis, Syuzo Kaneko, Karen A. Glatt, Christina M. Hughes, Thomas LaFramboise, James L. Manley, Matthew Meyerson

Proc Natl Acad Sci U S A. 2009 Jan 20; 106(3): 755–760. Published online 2009 Jan 9. doi: 10.1073/pnas.0812023106