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Select item 70261841.

A truncating Aspm allele leads to a complex cognitive phenotype and region-specific reductions in parvalbuminergic neurons

Lillian Garrett, Yoon Jeung Chang, Kristina M. Niedermeier, Tamara Heermann, Wolfgang Enard, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabě de Angelis, Wieland B. Huttner, Wolfgang Wurst, Sabine M. Hölter

Transl Psychiatry. 2020; 10: 66. Published online 2020 Feb 13. doi: 10.1038/s41398-020-0686-0

PMCID:: PMC7026184

Abstract Article PDF–1.2M

Select item 34966852.

The Microtubule-Associated Protein ASPM Regulates Spindle Assembly and Meiotic Progression in Mouse Oocytes

Xiao-Ling Xu, Wei Ma, Yu-Bo Zhu, Chao Wang, Bing-Yuan Wang, Na An, Lei An, Yan Liu, Zhong-Hong Wu, Jian-Hui Tian

PLoS One. 2012; 7(11): e49303. Published online 2012 Nov 13. doi: 10.1371/journal.pone.0049303

PMCID:: PMC3496685

Abstract Article PDF–508K

Select item 30848513.

In Vivo Fate Analysis Reveals the Multipotent and Self-Renewal Features of Embryonic AspM Expressing Cells

Cinzia Marinaro, Erica Butti, Andrea Bergamaschi, Alessandro Papale, Roberto Furlan, Giancarlo Comi, Gianvito Martino, Luca Muzio

PLoS One. 2011; 6(4): e19419. Published online 2011 Apr 29. doi: 10.1371/journal.pone.0019419

PMCID:: PMC3084851

Abstract Article PDF–5.8M

Select item 47128784.

Aspm sustains postnatal cerebellar neurogenesis and medulloblastoma growth in mice

Scott E. Williams, Idoia Garcia, Andrew J. Crowther, Shiyi Li, Alyssa Stewart, Hedi Liu, Kendall J. Lough, Sean O'Neill, Katherine Veleta, Esteban A. Oyarzabal, Joseph R. Merrill, Yen-Yu Ian Shih, Timothy R. Gershon

Development. 2015 Nov 15; 142(22): 3921–3932. doi: 10.1242/dev.124271

PMCID:: PMC4712878

Abstract Article

Select item 100476935.

The Multiple Mitotic Roles of the ASPM Orthologous Proteins: Insight into the Etiology of ASPM-Dependent Microcephaly

Alyona V. Razuvaeva, Lucia Graziadio, Valeria Palumbo, Gera A. Pavlova, Julia V. Popova, Alexey V. Pindyurin, Silvia Bonaccorsi, Maria Patrizia Somma, Maurizio Gatti

Cells. 2023 Mar; 12(6): 922. Published online 2023 Mar 16. doi: 10.3390/cells12060922

PMCID:: PMC10047693

Abstract Article PDF–917K

Select item 31859636.

ASPM regulates Wnt signaling pathway activity in the developing brain

Joshua J. Buchman, Omer Durak, Li-Huei Tsai

Genes Dev. 2011 Sep 15; 25(18): 1909–1914. doi: 10.1101/gad.16830211

PMCID:: PMC3185963

Abstract Article PDF–998K

Select item 15024767.

Aspm specifically maintains symmetric proliferative divisions of neuroepithelial cells

Jennifer L. Fish, Yoichi Kosodo, Wolfgang Enard, Svante Pääbo, Wieland B. Huttner

Proc Natl Acad Sci U S A. 2006 Jul 5; 103(27): 10438–10443. Published online 2006 Jun 23. doi: 10.1073/pnas.0604066103

PMCID:: PMC1502476

Abstract Article PDF–2.6M

Select item 3742438.

Accelerated Evolution of the ASPM Gene Controlling Brain Size Begins Prior to Human Brain Expansion

Natalay Kouprina, Adam Pavlicek, Ganeshwaran H Mochida, Gregory Solomon, William Gersch, Young-Ho Yoon, Randall Collura, Maryellen Ruvolo, J. Carl Barrett, C. Geoffrey Woods, Christopher A Walsh, Jerzy Jurka, Vladimir Larionov

PLoS Biol. 2004 May; 2(5): e126. Published online 2004 Mar 23. doi: 10.1371/journal.pbio.0020126

PMCID:: PMC374243

Abstract Article PDF–447K

Select item 26620269.

Hepatitis C Virus NS5A Protein Down-regulates the Expression of Spindle Gene Aspm through PKR-p38 Signaling Pathway

Shun-Chi Wu, Shin C. Chang, Hung-Yi Wu, Pei-Ju Liao, Ming-Fu Chang

J Biol Chem. 2008 Oct 24; 283(43): 29396–29404. doi: 10.1074/jbc.M802821200

PMCID:: PMC2662026

Abstract Article PDF–617K

Select item 1083944810.

The transcription factor NF-YA is crucial for neural progenitor maintenance during brain development

Tomoyuki Yamanaka, Masaru Kurosawa, Aya Yoshida, Tomomi Shimogori, Akiko Hiyama, Sankar N. Maity, Nobutaka Hattori, Hideaki Matsui, Nobuyuki Nukina

J Biol Chem. 2024 Feb; 300(2): 105629. Published online 2024 Jan 8. doi: 10.1016/j.jbc.2024.105629

PMCID:: PMC10839448

Abstract Article PDF–5.2M

Select item 504837911.

ASPM and CITK regulate spindle orientation by affecting the dynamics of astral microtubules

Marta Gai, Federico T Bianchi, Cristiana Vagnoni, Fiammetta Vernì, Silvia Bonaccorsi, Selina Pasquero, Gaia E Berto, Francesco Sgrò, Alessandra MA Chiotto, Laura Annaratone, Anna Sapino, Anna Bergo, Nicoletta Landsberger, Jacqueline Bond, Wieland B Huttner, Ferdinando Di Cunto

EMBO Rep. 2016 Oct; 17(10): 1396–1409. Published online 2016 Aug 25. doi: 10.15252/embr.201541823

Correction in:: EMBO Rep. 2017 Oct; 18(10): 1870.

PMCID:: PMC5048379

Abstract Article PDF–4.1M

Select item 1068646912.

Loss of Aspm causes increased apoptosis of developing neural cells during mouse cerebral corticogenesis

Madoka Tonosaki, Akira Fujimori, Takeshi Yaoi, Kyoko Itoh

PLoS One. 2023; 18(11): e0294893. Published online 2023 Nov 29. doi: 10.1371/journal.pone.0294893

PMCID:: PMC10686469

Abstract Article PDF–3.0M

Select item 294470813.

Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline

Jeremy N. Pulvers, Jarosław Bryk, Jennifer L. Fish, Michaela Wilsch-Bräuninger, Yoko Arai, Dora Schreier, Ronald Naumann, Jussi Helppi, Bianca Habermann, Johannes Vogt, Robert Nitsch, Attila Tóth, Wolfgang Enard, Svante Pääbo, Wieland B. Huttner

Proc Natl Acad Sci U S A. 2010 Sep 21; 107(38): 16595–16600. Published online 2010 Sep 7. doi: 10.1073/pnas.1010494107

PMCID:: PMC2944708

Abstract Article PDF–1.4M

Select item 519921614.

Microcephaly proteins Wdr62 and Aspm define a mother centriole complex regulating centriole biogenesis, apical complex and cell fate

Divya Jayaraman, Andrew Kodani, Dilenny M. Gonzalez, Joseph D. Mancias, Ganeshwaran H. Mochida, Cristiana Vagnoni, Jeffrey Johnson, Nevan Krogan, J. Wade Harper, Jeremy F. Reiter, Timothy W. Yu, Byoung-il Bae, Christopher A. Walsh

Neuron. Author manuscript; available in PMC 2017 Nov 23.

Published in final edited form as: Neuron. 2016 Nov 23; 92(4): 813–828. Published online 2016 Oct 27. doi: 10.1016/j.neuron.2016.09.056

PMCID:: PMC5199216

Abstract Article PDF–3.5M

Select item 485606815.

The Genetic Basis of Baculum Size and Shape Variation in Mice

Nicholas G. Schultz, Jesse Ingels, Andrew Hillhouse, Keegan Wardwell, Peter L. Chang, James M. Cheverud, Cathleen Lutz, Lu Lu, Robert W. Williams, Matthew D. Dean

G3 (Bethesda) 2016 May; 6(5): 1141–1151. Published online 2016 Mar 1. doi: 10.1534/g3.116.027888

PMCID:: PMC4856068

Abstract Article PDF–1.2M

Select item 728652116.

Interaction of YAP with the Myb-MuvB (MMB) complex defines a transcriptional program to promote the proliferation of cardiomyocytes

Marco Gründl, Susanne Walz, Laura Hauf, Melissa Schwab, Kerstin Marcela Werner, Susanne Spahr, Clemens Schulte, Hans Michael Maric, Carsten P. Ade, Stefan Gaubatz

PLoS Genet. 2020 May; 16(5): e1008818. Published online 2020 May 29. doi: 10.1371/journal.pgen.1008818

PMCID:: PMC7286521

Abstract Article PDF–3.9M

Select item 502504417.

ASPM regulates symmetric stem cell division by tuning Cyclin E ubiquitination

Mario R. Capecchi, Amir Pozner

Nat Commun. Author manuscript; available in PMC 2016 Sep 15.

Published in final edited form as: Nat Commun. 2015; 6: 8763. Published online 2015 Nov 19. doi: 10.1038/ncomms9763

PMCID:: PMC5025044

Abstract Article PDF–5.3M

Select item 840999318.

Deficient adaptation to centrosome duplication defects in neural progenitors causes microcephaly and subcortical heterotopias

José González-Martínez, Andrzej W. Cwetsch, Diego Martínez-Alonso, Luis R. López-Sainz, Jorge Almagro, Anna Melati, Jesús Gómez, Manuel Pérez-Martínez, Diego Megías, Jasminka Boskovic, Javier Gilabert-Juan, Osvaldo Graña-Castro, Alessandra Pierani, Axel Behrens, Sagrario Ortega, Marcos Malumbres

JCI Insight. 2021 Aug 23; 6(16): e146364. Published online 2021 Aug 23. doi: 10.1172/jci.insight.146364

PMCID:: PMC8409993

Abstract Article PDF–27M

Select item 534112219.

Disruptions in asymmetric centrosome inheritance and WDR62-Aurora kinase B interactions in primary microcephaly

Paraskevi Sgourdou, Ketu Mishra-Gorur, Ichiko Saotome, Octavian Henagariu, Beyhan Tuysuz, Cynthia Campos, Keiko Ishigame, Krinio Giannikou, Jennifer L. Quon, Nenad Sestan, Ahmet O. Caglayan, Murat Gunel, Angeliki Louvi

Sci Rep. 2017; 7: 43708. Published online 2017 Mar 8. doi: 10.1038/srep43708

PMCID:: PMC5341122

Abstract Article PDF–3.4M

Select item 328549220.

FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis

Ji-hye Paik, Zhihu Ding, Rujuta Narurkar, Shakti Ramkissoon, Florian Muller, Walid S. Kamoun, Sung-Suk Chae, Hongwu Zheng, Haoqiang Ying, Jed Mahoney, David Hiller, Shan Jiang, Alexei Protppopov, Wing H. Wong, Lynda Chin, Keith L. Ligon, Ronald A. DePinho

Cell Stem Cell. Author manuscript; available in PMC 2012 Feb 23.

Published in final edited form as: Cell Stem Cell. 2009 Nov 6; 5(5): 540–553. doi: 10.1016/j.stem.2009.09.013

PMCID:: PMC3285492

Abstract Article PDF–4.3M

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PMC Links for Gene (Select 12316) (42)
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MIMAT0014956 AND (alive[prop]) (0)
Gene
MIMAT0016996 AND (alive[prop]) (0)
Gene
PREDICTED: Mus musculus abnormal spindle microtubule assembly (Aspm), transcript...
PREDICTED: Mus musculus abnormal spindle microtubule assembly (Aspm), transcript variant X2, mRNA
gi|1907067099|ref|XM_017312957.3|

Nucleotide
Homo sapiens G protein-coupled receptor 139 (GPR139), transcript variant 1, mRNA
Homo sapiens G protein-coupled receptor 139 (GPR139), transcript variant 1, mRNA
gi|972776255|ref|NM_001002911.3|

Nucleotide

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