PMC Links for Gene (Select 121665) - PMC

Select item 89184731.

N-terminome analyses underscore the prevalence of SPPL3-mediated intramembrane proteolysis among Golgi-resident enzymes and its role in Golgi enzyme secretion

Laura Hobohm, Tomas Koudelka, Fenja H. Bahr, Jule Truberg, Sebastian Kapell, Sarah-Sophie Schacht, Daniel Meisinger, Marion Mengel, Alexander Jochimsen, Anna Hofmann, Lukas Heintz, Andreas Tholey, Matthias Voss

Cell Mol Life Sci. 2022 Mar; 79(3): 185. Published online 2022 Mar 13. doi: 10.1007/s00018-022-04163-y

PMCID:: PMC8918473

Abstract Article PDF–8.5M

Select item 87221042.

The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class I-Mediated Immune Responses

Marlieke L.M. Jongsma, Antonius A. de Waard, Matthijs Raaben, Tao Zhang, Birol Cabukusta, René Platzer, Vincent A. Blomen, Anastasia Xagara, Tamara Verkerk, Sophie Bliss, Xiangrui Kong, Carolin Gerke, Lennert Janssen, Elmer Stickel, Stephanie Holst, Rosina Plomp, Arend Mulder, Soldano Ferrone, Frans H.J. Claas, Mirjam H.M. Heemskerk, Marieke Griffioen, Anne Halenius, Hermen Overkleeft, Johannes B. Huppa, Manfred Wuhrer, Thijn R. Brummelkamp, Jacques Neefjes, Robbert M. Spaapen

Immunity. Author manuscript; available in PMC 2022 Jan 12.

Published in final edited form as: Immunity. 2021 Jan 12; 54(1): 132–150.e9. Published online 2020 Dec 2. doi: 10.1016/j.immuni.2020.11.003

Correction in:: Immunity. 2021 Feb 9; 54(2): 387.

PMCID:: PMC8722104

Abstract Article PDF–3.7M

Select item 35279273.

Foamy Virus Envelope Protein Is a Substrate for Signal Peptide Peptidase-like 3 (SPPL3)

Matthias Voss, Akio Fukumori, Peer-Hendrik Kuhn, Ulrike Künzel, Bärbel Klier, Gudula Grammer, Martina Haug-Kröper, Elisabeth Kremmer, Stefan F. Lichtenthaler, Harald Steiner, Bernd Schröder, Christian Haass, Regina Fluhrer

J Biol Chem. 2012 Dec 21; 287(52): 43401–43409. Published online 2012 Nov 6. doi: 10.1074/jbc.M112.371369

PMCID:: PMC3527927

Abstract Article PDF–2.6M

Select item 44587224.

Secretome Analysis Identifies Novel Signal Peptide Peptidase-Like 3 (SPPL3) Substrates and Reveals a Role of SPPL3 in Multiple Golgi Glycosylation Pathways

Peer-Hendrik Kuhn, Matthias Voss, Martina Haug-Kröper, Bernd Schröder, Ute Schepers, Stefan Bräse, Christian Haass, Stefan F. Lichtenthaler, Regina Fluhrer

Mol Cell Proteomics. 2015 Jun; 14(6): 1584–1598. Published online 2015 Mar 31. doi: 10.1074/mcp.M115.048298

PMCID:: PMC4458722

Abstract Article PDF–1.5M

Select item 42826385.

Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation

Matthias Voss, Ulrike Künzel, Fabian Higel, Peer-Hendrik Kuhn, Alessio Colombo, Akio Fukumori, Martina Haug-Kröper, Bärbel Klier, Gudula Grammer, Andreas Seidl, Bernd Schröder, Reinhard Obst, Harald Steiner, Stefan F Lichtenthaler, Christian Haass, Regina Fluhrer

EMBO J. 2014 Dec 17; 33(24): 2890–2905. Published online 2014 Oct 29. doi: 10.15252/embj.201488375

PMCID:: PMC4282638

Abstract Article PDF–1.3M

Select item 42724246.

A Protease-Independent Function for SPPL3 in NFAT Activation

Stefanie L. Makowski, Zhaoquan Wang, Joel L. Pomerantz

Mol Cell Biol. 2015 Jan; 35(2): 451–467. Prepublished online 2014 Nov 10. Published online 2014 Dec 22. doi: 10.1128/MCB.01124-14

PMCID:: PMC4272424

Abstract Article PDF–5.3M

Select item 26287357.

Genome-Wide Association Studies in an Isolated Founder Population from the Pacific Island of Kosrae

Jennifer K. Lowe, Julian B. Maller, Itsik Pe'er, Benjamin M. Neale, Jacqueline Salit, Eimear E. Kenny, Jessica L. Shea, Ralph Burkhardt, J. Gustav Smith, Weizhen Ji, Martha Noel, Jia Nee Foo, Maude L. Blundell, Vita Skilling, Laura Garcia, Marcia L. Sullivan, Heather E. Lee, Anna Labek, Hope Ferdowsian, Steven B. Auerbach, Richard P. Lifton, Christopher Newton-Cheh, Jan L. Breslow, Markus Stoffel, Mark J. Daly, David M. Altshuler, Jeffrey M. Friedman

PLoS Genet. 2009 Feb; 5(2): e1000365. Published online 2009 Feb 6. doi: 10.1371/journal.pgen.1000365

PMCID:: PMC2628735

Abstract Article PDF–377K

Select item 91063038.

Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors

Xu Feng, Mengfan Tang, Merve Dede, Dan Su, Guangsheng Pei, Dadi Jiang, Chao Wang, Zhen Chen, Mi Li, Litong Nie, Yun Xiong, Siting Li, Jeong-Min Park, Huimin Zhang, Min Huang, Klaudia Szymonowicz, Zhongming Zhao, Traver Hart, Junjie Chen

Sci Adv. 2022 May; 8(19): eabm6638. Published online 2022 May 13. doi: 10.1126/sciadv.abm6638

PMCID:: PMC9106303

Abstract Article PDF–918K

Select item 4036979.

The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment

Hilary F. Clark, Austin L. Gurney, Evangeline Abaya, Kevin Baker, Daryl Baldwin, Jennifer Brush, Jian Chen, Bernard Chow, Clarissa Chui, Craig Crowley, Bridget Currell, Bethanne Deuel, Patrick Dowd, Dan Eaton, Jessica Foster, Christopher Grimaldi, Qimin Gu, Philip E. Hass, Sherry Heldens, Arthur Huang, Hok Seon Kim, Laura Klimowski, Yisheng Jin, Stephanie Johnson, James Lee, Lhney Lewis, Dongzhou Liao, Melanie Mark, Edward Robbie, Celina Sanchez, Jill Schoenfeld, Somasekar Seshagiri, Laura Simmons, Jennifer Singh, Victoria Smith, Jeremy Stinson, Alicia Vagts, Richard Vandlen, Colin Watanabe, David Wieand, Kathryn Woods, Ming-Hong Xie, Daniel Yansura, Sothy Yi, Guoying Yu, Jean Yuan, Min Zhang, Zemin Zhang, Audrey Goddard, William I. Wood, Paul Godowski

Genome Res. 2003 Oct; 13(10): 2265–2270. doi: 10.1101/gr.1293003

Correction in:: Genome Res. 2003 Dec; 13(12): 2759.

PMCID:: PMC403697

Abstract Article PDF–120K

Select item 268304710.

Ubiquitin-mediated proteolysis of HuR by heat shock

Kotb Abdelmohsen, Subramanya Srikantan, Xiaoling Yang, Ashish Lal, Hyeon Ho Kim, Yuki Kuwano, Stefanie Galban, Kevin G Becker, Davida Kamara, Rafael de Cabo, Myriam Gorospe

EMBO J. 2009 May 6; 28(9): 1271–1282. Published online 2009 Mar 26. doi: 10.1038/emboj.2009.67

PMCID:: PMC2683047

Abstract Article PDF–1.4M

Select item 835296411.

Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer

Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko Duke, Jennifer Chen, Iris Fung, Jacqueline Watson, Matthew Rees, Austin M. Gabel, James D. Thomas, Robert K. Bradley, John K. Lee, Emily M. Hatch, Marina K. Baine, Natasha Rekhtman, Marc Ladanyi, Federica Piccioni, Alice H. Berger

Nat Commun. 2021; 12: 4789. Published online 2021 Aug 9. doi: 10.1038/s41467-021-24841-y

PMCID:: PMC8352964

Abstract Article PDF–4.5M

Select item 289646412.

Personalized Smoking Cessation: Interactions between Nicotine Dose, Dependence and Quit-Success Genotype Score

Jed E Rose, Frédérique M Behm, Tomas Drgon, Catherine Johnson, George R Uhl

Mol Med. 2010 Jul-Aug; 16(7-8): 247–253. Published online 2010 Mar 17. doi: 10.2119/molmed.2009.00159

Correction in:: Mol Med. 2012; 18(1): 729.

PMCID:: PMC2896464

Abstract Article PDF–2.4M

Select item 911973613.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 553161114.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 816503015.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011