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Items: 1 to 20 of 528

1.
The Evolution of Genetic Variability at the LRRK2 Locus
Dylan T. Guenther, Jordan Follett, Rim Amouri, Samia Ben Sassi, Faycel Hentati, Matthew J. Farrer
Genes (Basel) 2024 Jul; 15(7): 878. Published online 2024 Jul 3. doi: 10.3390/genes15070878
PMCID:
PMC11275506
AbstractArticlePDF–1.0M
2.
Genetic analysis and natural history of Parkinson’s disease due to the LRRK2 G2019S variant
Matthew J Kmiecik, Steven Micheletti, Daniella Coker, Karl Heilbron, Jingchunzi Shi, Keaton Stagaman, Teresa Filshtein Sonmez, Pierre Fontanillas, Suyash Shringarpure, Madeleine Wetzel, Helen M Rowbotham, Paul Cannon, Janie F Shelton, David A Hinds, Joyce Y Tung, 23andMe Research Team , Michael V Holmes, Stella Aslibekyan, Lucy Norcliffe-Kaufmann
Brain. 2024 Jun; 147(6): 1996–2008. Published online 2024 May 28. doi: 10.1093/brain/awae073
PMCID:
PMC11146432
AbstractArticlePDF–855K
3.
The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway
José M. Bravo-San Pedro, Mireia Niso-Santano, Rubén Gómez-Sánchez, Elisa Pizarro-Estrella, Ana Aiastui-Pujana, Ana Gorostidi, Vicente Climent, Rakel López de Maturana, Rosario Sanchez-Pernaute, Adolfo López de Munain, José M. Fuentes, Rosa A. González-Polo
Cell Mol Life Sci. 2013 Jan; 70(1): 121–136. Published online 2012 Jul 8. doi: 10.1007/s00018-012-1061-y
PMCID:
PMC11113213
AbstractArticlePDF–1.0M
4.
Multi-tracer PET correlation analysis reveals disease-specific patterns in Parkinson’s disease and asymptomatic LRRK2 pathogenic variant carriers compared to healthy controls
Julia G. Mannheim, Jessie Fanglu Fu, Tilman Wegener, Ivan S. Klyuzhin, Nasim Vafai, Elham Shahinfard, Jessamyn McKenzie, Audrey Strongosky, Zbigniew K. Wszolek, A. Jon Stoessl, Vesna Sossi
Neuroimage Clin. 2024; 42: 103600. Published online 2024 Apr 1. doi: 10.1016/j.nicl.2024.103600
PMCID:
PMC11015486
AbstractArticlePDF–2.7M
5.
Comprehensive analysis of clinical and biological features in Parkinson's disease associated with the LRRK2 G2019S mutation: Data from the PPMI study
Xiaohui Sun, Kaixin Dou, Li Xue, Yijie Xie, Yong Yang, Anmu Xie
Clin Transl Sci. 2024 Jan; 17(1): e13720. Published online 2024 Jan 23. doi: 10.1111/cts.13720
PMCID:
PMC10804919
AbstractArticlePDF–3.5M
6.
Human iPSC-derived microglia carrying the LRRK2-G2019S mutation show a Parkinson’s disease related transcriptional profile and function
Sohvi Ohtonen, Luca Giudice, Henna Jäntti, Mohammad Feroze Fazaludeen, Anastasia Shakirzyanova, Mireia Gómez-Budia, Nelli-Noora Välimäki, Jonna Niskanen, Nea Korvenlaita, Ilkka Fagerlund, Jari Koistinaho, Mahmood Amiry-Moghaddam, Ekaterina Savchenko, Laurent Roybon, Šárka Lehtonen, Paula Korhonen, Tarja Malm
Sci Rep. 2023; 13: 22118. Published online 2023 Dec 13. doi: 10.1038/s41598-023-49294-9
PMCID:
PMC10719377
AbstractArticlePDF–3.9M
7.
Differences in EEG Event-Related Potentials during Dual Task in Parkinson’s Disease Carriers and Non-Carriers of the G2019S-LRRK2 Mutation
Eden Shkury, Shani Danziger-Schragenheim, Zoya Katzir, Yael Ezra, Nir Giladi, Anat Mirelman, Inbal Maidan
Sensors (Basel) 2023 Oct; 23(19): 8266. Published online 2023 Oct 6. doi: 10.3390/s23198266
PMCID:
PMC10575245
AbstractArticlePDF–2.0M
8.
The Avidity of Autoreactive Alpha-Synuclein Antibodies in Leucine-Rich Repeat Kinase 2 Mutation Carriers Is Not Altered Compared to Healthy Controls or Patients with Parkinson’s Disease
Alexandra Albus, Yannick Kronimus, Monika Burg-Roderfeld, Hendrik van der Wurp, Dieter Willbold, Tamar Ziehm, Richard Dodel, Jean Alexander Ross
Biomolecules. 2023 Sep; 13(9): 1303. Published online 2023 Aug 25. doi: 10.3390/biom13091303
PMCID:
PMC10526238
AbstractArticlePDF–571K
9.
Leucine-rich repeat kinase 2 at a glance
Christiane Zhu, Susanne Herbst, Patrick A. Lewis
J Cell Sci. 2023 Sep 1; 136(17): jcs259724. Published online 2023 Sep 12. doi: 10.1242/jcs.259724
PMCID:
PMC10508695
AbstractArticle
10.
Astrocytes Differentiated from LRRK2-I1371V Parkinson’s-Disease-Induced Pluripotent Stem Cells Exhibit Similar Yield but Cell-Intrinsic Dysfunction in Glutamate Uptake and Metabolism, ATP Generation, and Nrf2-Mediated Glutathione Machinery
Roon Banerjee, Aishwarya Raj, Chandrakanta Potdar, Pramod Kumar Pal, Ravi Yadav, Nitish Kamble, Vikram Holla, Indrani Datta
Cells. 2023 Jun; 12(12): 1592. Published online 2023 Jun 8. doi: 10.3390/cells12121592
PMCID:
PMC10297190
AbstractArticlePDF–5.0M
11.
LRRK2 and Parkinson's disease: from genetics to targeted therapy
Yuri L. Sosero, Ziv Gan‐Or
Ann Clin Transl Neurol. 2023 Jun; 10(6): 850–864. Published online 2023 Apr 6. doi: 10.1002/acn3.51776
PMCID:
PMC10270275
AbstractArticlePDF–909K
12.
Overview of the Impact of Pathogenic LRRK2 Mutations in Parkinson’s Disease
Genta Ito, Naoko Utsunomiya-Tate
Biomolecules. 2023 May; 13(5): 845. Published online 2023 May 16. doi: 10.3390/biom13050845
PMCID:
PMC10216118
AbstractArticlePDF–3.4M
13.
Immunological Features of LRRK2 Function and Its Role in the Gut-Brain Axis Governing Parkinson’s Disease
Inga Peter, Warren Strober
J Parkinsons Dis. 2023; 13(3): 279–296. Prepublished online 2023 Apr 10. Published online 2023 May 9. doi: 10.3233/JPD-230021
PMCID:
PMC10200211
AbstractArticlePDF–899K
14.
LRRK2 Structure-Based Activation Mechanism and Pathogenesis
Xiaojuan Zhang, Arjan Kortholt
Biomolecules. 2023 Apr; 13(4): 612. Published online 2023 Mar 28. doi: 10.3390/biom13040612
PMCID:
PMC10135577
AbstractArticlePDF–1.9M
15.
Tissue specific LRRK2 interactomes reveal a distinct striatal functional unit
Yibo Zhao, Nikoleta Vavouraki, Ruth C. Lovering, Valentina Escott-Price, Kirsten Harvey, Patrick A. Lewis, Claudia Manzoni
PLoS Comput Biol. 2023 Jan; 19(1): e1010847. Published online 2023 Jan 30. doi: 10.1371/journal.pcbi.1010847
PMCID:
PMC9910798
AbstractArticlePDF–2.6M
16.
Is Glial Dysfunction the Key Pathogenesis of LRRK2-Linked Parkinson’s Disease?
Tatou Iseki, Yuzuru Imai, Nobutaka Hattori
Biomolecules. 2023 Jan; 13(1): 178. Published online 2023 Jan 15. doi: 10.3390/biom13010178
PMCID:
PMC9856048
AbstractArticlePDF–1.7M
17.
Structural basis for Parkinson’s disease-linked LRRK2’s binding to microtubules
David M. Snead, Mariusz Matyszewski, Andrea M. Dickey, Yu Xuan Lin, Andres E. Leschziner, Samara L. Reck-Peterson
Nat Struct Mol Biol. 2022; 29(12): 1196–1207. Published online 2022 Dec 12. doi: 10.1038/s41594-022-00863-y
PMCID:
PMC9758056
AbstractArticlePDF–13M
18.
LRRK2 and Lipid Pathways: Implications for Parkinson’s Disease
Jasmin Galper, Woojin S. Kim, Nicolas Dzamko
Biomolecules. 2022 Nov; 12(11): 1597. Published online 2022 Oct 30. doi: 10.3390/biom12111597
PMCID:
PMC9687231
AbstractArticlePDF–1.5M
19.
Connectivity of corticostriatal circuits in nonmanifesting LRRK2 G2385R and R1628P carriers
Dongling Zhang, Junye Yao, Jinghong Ma, Linlin Gao, Junyan Sun, Jiliang Fang, Hongjian He, Tao Wu
CNS Neurosci Ther. 2022 Dec; 28(12): 2024–2031. Published online 2022 Aug 7. doi: 10.1111/cns.13933
PMCID:
PMC9627388
AbstractArticlePDF–1.2M
20.
Functional Analyses of Two Novel LRRK2 Pathogenic Variants in Familial Parkinson′s Disease
Ilda Coku, Eugénie Mutez, Sabiha Eddarkaoui, Sébastien Carrier, Antoine Marchand, Claire Deldycke, Liesel Goveas, Guillaume Baille, Mélissa Tir, Romain Magnez, Xavier Thuru, Gaëlle Vermeersch, Wim Vandenberghe, Luc Buée, Luc Defebvre, Bernard Sablonnière, Marie‐Christine Chartier‐Harlin, Jean‐Marc Taymans, Vincent Huin
Mov Disord. 2022 Aug; 37(8): 1761–1767. Published online 2022 Jun 16. doi: 10.1002/mds.29124
PMCID:
PMC9543145
AbstractArticlePDF–1.2M

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