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Select item 95132661.

Functional characterization of two variants of mitochondrial topoisomerase TOP1MT that impact regulation of the mitochondrial genome

Iman Al Khatib, Jingti Deng, Andrew Symes, Marina Kerr, Hongliang Zhang, Shar-yin Naomi Huang, Yves Pommier, Aneal Khan, Timothy E. Shutt

J Biol Chem. 2022 Oct; 298(10): 102420. Published online 2022 Aug 24. doi: 10.1016/j.jbc.2022.102420

PMCID:: PMC9513266

Abstract Article PDF–4.1M

Select item 56330432.

TOP1MT deficiency promotes GC invasion and migration via the enhancements of LDHA expression and aerobic glycolysis

Hongqiang Wang, Rui Zhou, Li Sun, Jianling Xia, Xuchun Yang, Changqie Pan, Na Huang, Min Shi, Jianping Bin, Yulin Liao, Wangjun Liao

Endocr Relat Cancer. 2017 Nov; 24(11): 565–578. Published online 2017 Sep 5. doi: 10.1530/ERC-17-0058

PMCID:: PMC5633043

Abstract Article PDF–3.1M

Select item 31594363.

Coordinated regulation of mitochondrial topoisomerase IB with mitochondrial nuclear encoded genes and MYC

Gabriele Zoppoli, Céline Douarre, Ilaria Dalla Rosa, Hongfang Liu, William Reinhold, Yves Pommier

Nucleic Acids Res. 2011 Aug; 39(15): 6620–6632. Published online 2011 Apr 29. doi: 10.1093/nar/gkr208

PMCID:: PMC3159436

Abstract Article PDF–12M

Select item 27706734.

Adaptation of topoisomerase I paralogs to nuclear and mitochondrial DNA

Ilaria Dalla Rosa, Steffi Goffart, Melanie Wurm, Constanze Wiek, Frank Essmann, Stefan Sobek, Peter Schroeder, Hongliang Zhang, Jean Krutmann, Helmut Hanenberg, Klaus Schulze-Osthoff, Christian Mielke, Yves Pommier, Fritz Boege, Morten O. Christensen

Nucleic Acids Res. 2009 Oct; 37(19): 6414–6428. Published online 2009 Aug 31. doi: 10.1093/nar/gkp708

PMCID:: PMC2770673

Abstract Article PDF–34M

Select item 585135.

Human mitochondrial topoisomerase I

Hongliang Zhang, Juana M. Barceló, Benson Lee, Glenda Kohlhagen, Drazen B. Zimonjic, Nicholas C. Popescu, Yves Pommier

Proc Natl Acad Sci U S A. 2001 Sep 11; 98(19): 10608–10613. Published online 2001 Aug 28. doi: 10.1073/pnas.191321998

PMCID:: PMC58513

Abstract Article PDF–433K

Select item 96389426.

Two type I topoisomerases maintain DNA topology in human mitochondria

Katja E Menger, James Chapman, Héctor Díaz-Maldonado, Mushtaq M Khazeem, Dasha Deen, Direnis Erdinc, John W Casement, Valeria Di Leo, Angela Pyle, Alejandro Rodríguez-Luis, Ian G Cowell, Maria Falkenberg, Caroline A Austin, Thomas J Nicholls

Nucleic Acids Res. 2022 Oct 28; 50(19): 11154–11174. Published online 2022 Oct 10. doi: 10.1093/nar/gkac857

PMCID:: PMC9638942

Abstract Article PDF–10M

Select item 63251247.

The mitochondrial type IB topoisomerase drives mitochondrial translation and carcinogenesis

S. A. Baechler, V. M. Factor, I. Dalla Rosa, A. Ravji, D. Becker, S. Khiati, L. M. Miller Jenkins, M. Lang, C. Sourbier, S. A. Michaels, L. M. Neckers, H. L. Zhang, A. Spinazzola, S. N. Huang, J. U. Marquardt, Y. Pommier

Nat Commun. 2019; 10: 83. Published online 2019 Jan 8. doi: 10.1038/s41467-018-07922-3

PMCID:: PMC6325124

Abstract Article PDF–2.5M

Select item 36361788.

Collaborating functions of BLM and DNA topoisomerase I in regulating human rDNA transcription

Patrick M. Grierson, Samir Acharya, Joanna Groden

Mutat Res. Author manuscript; available in PMC 2014 Mar 1.

Published in final edited form as: Mutat Res. 2013 Mar-Apr; 0: 89–96. Published online 2012 Dec 19. doi: 10.1016/j.mrfmmm.2012.12.002

PMCID:: PMC3636178

Abstract Article PDF–2.7M

Select item 25970909.

Mitochondrial topoisomerase I sites in the regulatory D-loop region of mitochondrial DNA

Hongliang Zhang, Yves Pommier

Biochemistry. Author manuscript; available in PMC 2008 Dec 8.

Published in final edited form as: Biochemistry. 2008 Oct 28; 47(43): 11196–11203. Published online 2008 Oct 1. doi: 10.1021/bi800774b

PMCID:: PMC2597090

Abstract Article PDF–1.0M

Select item 40781210.

Thirteen-exon-motif signature for vertebrate nuclear and mitochondrial type IB topoisomerases

Hongliang Zhang, Ling-Hua Meng, Drazen B. Zimonjic, Nicholas C. Popescu, Yves Pommier

Nucleic Acids Res. 2004; 32(7): 2087–2092. Published online 2004 Apr 19. doi: 10.1093/nar/gkh525

PMCID:: PMC407812

Abstract Article PDF–402K

Select item 1036039611.

Activation of the cGAS-STING innate immune response in cells with deficient mitochondrial topoisomerase TOP1MT

Iman Al Khatib, Jingti Deng, Yuanjiu Lei, Sylvia Torres-Odio, Gladys R Rojas, Laura E Newman, Brian K Chung, Andrew Symes, Hongliang Zhang, Shar-yin N Huang, Yves Pommier, Aneal Khan, Gerald S Shadel, Andrew Phillip West, William T Gibson, Timothy E Shutt

Hum Mol Genet. 2023 Aug 1; 32(15): 2422–2440. Published online 2023 May 2. doi: 10.1093/hmg/ddad062

PMCID:: PMC10360396

Abstract Article PDF–2.4M

Select item 301760212.

Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing

Wenyi Wang, Peidong Shen, Sreedevi Thiyagarajan, Shengrong Lin, Curtis Palm, Rita Horvath, Thomas Klopstock, David Cutler, Lynn Pique, Iris Schrijver, Ronald W. Davis, Michael Mindrinos, Terence P. Speed, Curt Scharfe

Nucleic Acids Res. 2011 Jan; 39(1): 44–58. Published online 2010 Sep 15. doi: 10.1093/nar/gkq750

PMCID:: PMC3017602

Abstract Article PDF–1.4M

Select item 743811213.

NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency

Joana G Marques, Berkley E Gryder, Blaz Pavlovic, Yeonjoo Chung, Quy A Ngo, Fabian Frommelt, Matthias Gstaiger, Young Song, Katharina Benischke, Dominik Laubscher, Marco Wachtel, Javed Khan, Beat W Schäfer

eLife. 2020; 9: e54993. Published online 2020 Aug 3. doi: 10.7554/eLife.54993

PMCID:: PMC7438112

Abstract Article PDF–4.5M

Select item 856959314.

Neddylation modification of the U3 snoRNA-binding protein RRP9 by Smurf1 promotes tumorigenesis

Meng-ge Du, Fan Liu, Yan Chang, Shuai Tong, Wei Liu, Yu-jiao Chen, Ping Xie

J Biol Chem. 2021 Nov; 297(5): 101307. Published online 2021 Oct 15. doi: 10.1016/j.jbc.2021.101307

Correction in:: J Biol Chem. 2022 Nov; 298(11): 102567.

PMCID:: PMC8569593

Abstract Article PDF–4.2M

Select item 589826615.

ZFP36L2 is a cell cycle-regulated CCCH protein necessary for DNA lesion-induced S-phase arrest

Aya Noguchi, Shungo Adachi, Naoto Yokota, Tomohisa Hatta, Tohru Natsume, Hiroyuki Kawahara

Biol Open. 2018 Mar 15; 7(3): bio031575. Published online 2018 Feb 15. doi: 10.1242/bio.031575

PMCID:: PMC5898266

Abstract Article PDF–3.4M

Select item 801772016.

SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors

Ukhyun Jo, Yasuhisa Murai, Sirisha Chakka, Lu Chen, Ken Cheng, Junko Murai, Liton Kumar Saha, Lisa M. Miller Jenkins, Yves Pommier

Proc Natl Acad Sci U S A. 2021 Feb 9; 118(6): e2015654118. Published online 2021 Feb 3. doi: 10.1073/pnas.2015654118

PMCID:: PMC8017720

Abstract Article PDF–1.9M

Select item 289380017.

A Large-scale genetic association study of esophageal adenocarcinoma risk

Chen-yu Liu, Michael C. Wu, Feng Chen, Monica Ter-Minassian, Kofi Asomaning, Rihong Zhai, Zhaoxi Wang, Li Su, Rebecca S. Heist, Matthew H. Kulke, Xihong Lin, Geoffrey Liu, David C. Christiani

Carcinogenesis. 2010 Jul; 31(7): 1259–1263. Published online 2010 May 7. doi: 10.1093/carcin/bgq092

PMCID:: PMC2893800

Abstract Article PDF–84K

Select item 458732218.

Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage

Romain Drissi, Marie-Line Dubois, Mélanie Douziech, François-Michel Boisvert

Mol Cell Proteomics. 2015 Jul; 14(7): 2002–2013. Published online 2015 May 11. doi: 10.1074/mcp.M115.048991

PMCID:: PMC4587322

Abstract Article PDF–3.0M

Select item 1110948319.

K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors

Anita Waltho, Oliver Popp, Christopher Lenz, Lukas Pluska, Mahil Lambert, Volker Dötsch, Philipp Mertins, Thomas Sommer

Life Sci Alliance. 2024 Aug; 7(8): e202402740. Published online 2024 May 21. doi: 10.26508/lsa.202402740

PMCID:: PMC11109483

Abstract Article PDF–2.9M

Select item 294347620.

Genetic Variants in Nuclear-Encoded Mitochondrial Genes Influence AIDS Progression

Sher L. Hendrickson, James A. Lautenberger, Leslie Wei Chinn, Michael Malasky, Efe Sezgin, Lawrence A. Kingsley, James J. Goedert, Gregory D. Kirk, Edward D. Gomperts, Susan P. Buchbinder, Jennifer L. Troyer, Stephen J. O'Brien

PLoS One. 2010; 5(9): e12862. Published online 2010 Sep 21. doi: 10.1371/journal.pone.0012862

PMCID:: PMC2943476

Abstract Article PDF–461K

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PMC Links for Gene (Select 116447) (28)
PMC
DNA topoisomerase I, mitochondrial isoform X7 [Homo sapiens]
DNA topoisomerase I, mitochondrial isoform X7 [Homo sapiens]
gi|2462617691|ref|XP_054215710.1|

Protein
PREDICTED: Homo sapiens DNA topoisomerase I mitochondrial (TOP1MT), transcript v...
PREDICTED: Homo sapiens DNA topoisomerase I mitochondrial (TOP1MT), transcript variant X3, mRNA
gi|2462617675|ref|XM_054359728.1|

Nucleotide
PREDICTED: Homo sapiens DNA topoisomerase I mitochondrial (TOP1MT), transcript v...
PREDICTED: Homo sapiens DNA topoisomerase I mitochondrial (TOP1MT), transcript variant X8, mRNA
gi|2217370733|ref|XM_047421336.1|

Nucleotide
DNA topoisomerase I, mitochondrial isoform 1 precursor [Homo sapiens]
DNA topoisomerase I, mitochondrial isoform 1 precursor [Homo sapiens]
gi|16418461|ref|NP_443195.1|

Protein

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