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Select item 108351371.

Tracking the role of Aire in immune tolerance to the eye with a TCR transgenic mouse model

Mianmian Yin, Jennifer A. Smith, Marissa Chou, Jackie Chan, Yingyos Jittayasothorn, Douglas B. Gould, Rachel R. Caspi, Mark S. Anderson, Anthony L. DeFranco

Proc Natl Acad Sci U S A. 2024 Jan 30; 121(5): e2311487121. Published online 2024 Jan 23. doi: 10.1073/pnas.2311487121

PMCID:: PMC10835137

Abstract Article PDF–4.2M

Select item 107323152.

Aire drives steroid hormone biosynthesis by medullary thymic epithelial cells

Matthew D. Taves, Kaitlynn M. Donahue, Jing Bian, Margaret C. Cam, Jonathan D. Ashwell

Sci Immunol. Author manuscript; available in PMC 2023 Dec 20.

Published in final edited form as: Sci Immunol. 2023 Aug 25; 8(86): eabo7975. Published online 2023 Aug 18. doi: 10.1126/sciimmunol.abo7975

PMCID:: PMC10732315

Abstract Article PDF–1.6M

Select item 98488103.

Characterisation of APS-1 Experimental Models Is Crucial for Development of Novel Therapies

Sarah Almaghrabi, Thomas Lovewell, Mimoun Azzouz, Rachid Tazi Ahnini

Biomed Res Int. 2023; 2023: 7960443. Published online 2023 Jan 11. doi: 10.1155/2023/7960443

PMCID:: PMC9848810

Abstract Article PDF–2.2M

Select item 95633084.

AIRE in Male Fertility: A New Hypothesis

Jana Petrusová, Jasper Manning, Dominik Filipp

Cells. 2022 Oct; 11(19): 3168. Published online 2022 Oct 9. doi: 10.3390/cells11193168

PMCID:: PMC9563308

Abstract Article PDF–935K

Select item 95499325.

A synthetic tear protein resolves dry eye through promoting corneal nerve regeneration

Yael Efraim, Feeling Yu Ting Chen, Ka Neng Cheong, Eliza A. Gaylord, Nancy A. McNamara, Sarah M. Knox

Cell Rep. Author manuscript; available in PMC 2022 Oct 10.

Published in final edited form as: Cell Rep. 2022 Aug 30; 40(9): 111307. doi: 10.1016/j.celrep.2022.111307

PMCID:: PMC9549932

Abstract Article PDF–2.7M

Select item 93630196.

Extrathymic Aire-expressing cells support maternal-fetal tolerance

Eva Gillis-Buck, Haleigh Miller, Marina Sirota, Stephan J. Sanders, Vasilis Ntranos, Mark S. Anderson, James M. Gardner, Tippi C. MacKenzie

Sci Immunol. Author manuscript; available in PMC 2022 Aug 9.

Published in final edited form as: Sci Immunol. 2021 Jul 16; 6(61): eabf1968. doi: 10.1126/sciimmunol.abf1968

PMCID:: PMC9363019

Abstract Article PDF–2.1M

Select item 89522727.

The absence of the autoimmune regulator gene (AIRE) impairs the three-dimensional structure of medullary thymic epithelial cell spheroids

Ana Carolina Monteleone-Cassiano, Janaina A. Dernowsek, Romario S. Mascarenhas, Amanda Freire Assis, Dimitrius Pitol, Natalia Chermont Santos Moreira, Elza Tiemi Sakamoto-Hojo, João Paulo Mardegan Issa, Eduardo A. Donadi, Geraldo Aleixo Passos

BMC Mol Cell Biol. 2022; 23: 15. Published online 2022 Mar 24. doi: 10.1186/s12860-022-00414-9

PMCID:: PMC8952272

Abstract Article PDF–3.8M

Select item 88559358.

Single-Cell Multiomics Defines Tolerogenic Extrathymic Aire-Expressing Populations with Unique Homology to Thymic Epithelium

Jiaxi Wang, Caleb A. Lareau, Jhoanne Bautista, Alexander Gupta, Katalin Sandor, Joe Germino, Yajie Yin, Matt Arvedson, Gabriella C. Reeder, Nathan T. Cramer, Fang Xie, Vasilis Ntranos, Ansuman T. Satpathy, Mark S. Anderson, James M. Gardner

Sci Immunol. Author manuscript; available in PMC 2022 May 12.

Published in final edited form as: Sci Immunol. 2021 Nov 12; 6(65): eabl5053. Published online 2021 Nov 12. doi: 10.1126/sciimmunol.abl5053

PMCID:: PMC8855935

Abstract Article PDF–3.7M

Select item 84212629.

Mechanistic dissection of dominant AIRE mutations in mouse models reveals AIRE autoregulation

Yael Goldfarb, Tal Givony, Noam Kadouri, Jan Dobeš, Cristina Peligero-Cruz, Itay Zalayat, Golda Damari, Bareket Dassa, Shifra Ben-Dor, Yael Gruper, Bergithe E. Oftedal, Eirik Bratland, Martina M. Erichsen, Amund Berger, Ayelet Avin, Shir Nevo, Uku Haljasorg, Yael Kuperman, Adi Ulman, Rebecca Haffner-Krausz, Ziv Porat, Ulus Atasoy, Dena Leshkowitz, Eystein S. Husebye, Jakub Abramson

J Exp Med. 2021 Nov 1; 218(11): e20201076. Published online 2021 Sep 3. doi: 10.1084/jem.20201076

PMCID:: PMC8421262

Abstract Article PDF–8.2M

Select item 789144010.

A novel method to identify Post‐Aire stages of medullary thymic epithelial cell differentiation

Pedro Ferreirinha, Camila Ribeiro, Junko Morimoto, Jonathan J. M. Landry, Minoru Matsumoto, Catarina Meireles, Andrea J. White, Izumi Ohigashi, Leonor Araújo, Vladimir Benes, Yousuke Takahama, Graham Anderson, Mitsuru Matsumoto, Nuno L. Alves

Eur J Immunol. 2021 Feb; 51(2): 311–318. Published online 2020 Sep 15. doi: 10.1002/eji.202048764

PMCID:: PMC7891440

Abstract Article PDF–1.8M

Select item 734386711.

Absence of central tolerance in Aire-deficient mice synergizes with immune-checkpoint inhibition to enhance antitumor responses

Asiel A. Benitez, Sara Khalil-Agüero, Anjali Nandakumar, Namita T. Gupta, Wen Zhang, Gurinder S. Atwal, Andrew J. Murphy, Matthew A. Sleeman, Sokol Haxhinasto

Commun Biol. 2020; 3: 355. Published online 2020 Jul 8. doi: 10.1038/s42003-020-1083-1

PMCID:: PMC7343867

Abstract Article PDF–1.9M

Select item 727029412.

Aire Gene Influences the Length of the 3′ UTR of mRNAs in Medullary Thymic Epithelial Cells

Ernna H. Oliveira, Amanda F. Assis, Cesar A. Speck-Hernandez, Max Jordan Duarte, Geraldo A. Passos

Front Immunol. 2020; 11: 1039. Published online 2020 May 28. doi: 10.3389/fimmu.2020.01039

PMCID:: PMC7270294

Abstract Article PDF–861K

Select item 720546913.

Aire-dependent genes undergo Clp1-mediated 3’UTR shortening associated with higher transcript stability in the thymus

Clotilde Guyon, Nada Jmari, Francine Padonou, Yen-Chin Li, Olga Ucar, Noriyuki Fujikado, Fanny Coulpier, Christophe Blanchet, David E Root, Matthieu Giraud

eLife. 2020; 9: e52985. Published online 2020 Apr 29. doi: 10.7554/eLife.52985

PMCID:: PMC7205469

Abstract Article PDF–2.4M

Select item 711813314.

Dual functions of Aire CARD multimerization in the transcriptional regulation of T cell tolerance

Yu-San Huoh, Bin Wu, Sehoon Park, Darren Yang, Kushagra Bansal, Emily Greenwald, Wesley P. Wong, Diane Mathis, Sun Hur

Nat Commun. 2020; 11: 1625. Published online 2020 Apr 2. doi: 10.1038/s41467-020-15448-w

PMCID:: PMC7118133

Abstract Article PDF–4.5M

Select item 693659315.

Comprehensive analysis of a mouse model of spontaneous uveoretinitis using single-cell RNA sequencing

Jacob S. Heng, Sean F. Hackett, Genevieve L. Stein-O’Brien, Briana L. Winer, John Williams, Loyal A. Goff, Jeremy Nathans

Proc Natl Acad Sci U S A. 2019 Dec 26; 116(52): 26734–26744. Published online 2019 Dec 16. doi: 10.1073/pnas.1915571116

PMCID:: PMC6936593

Abstract Article PDF–3.7M

Select item 656186316.

Autoimmune Regulator is required in female mice for optimal embryonic development and implantation

Bryce D Warren, Soo H Ahn, Lynda K McGinnis, Geoffrey Grzesiak, Ren-Wei Su, Asgerally T Fazleabas, Lane K Christenson, Brian K Petroff, Margaret G Petroff

Biol Reprod. 2019 Jun; 100(6): 1492–1504. Published online 2019 Feb 16. doi: 10.1093/biolre/ioz023

PMCID:: PMC6561863

Abstract Article PDF–10M

Select item 627468117.

Deciphering Molecular and Phenotypic Changes Associated with Early Autoimmune Disease in the Aire-Deficient Mouse Model of Sjögren’s Syndrome

Feeling YuTing Chen, Eliza Gaylord, Nancy McNamara, Sarah Knox

Int J Mol Sci. 2018 Nov; 19(11): 3628. Published online 2018 Nov 17. doi: 10.3390/ijms19113628

PMCID:: PMC6274681

Abstract Article PDF–2.9M

Select item 594932718.

Aire Disruption Influences the Medullary Thymic Epithelial Cell Transcriptome and Interaction With Thymocytes

Cesar A. Speck-Hernandez, Amanda F. Assis, Rafaela F. Felicio, Larissa Cotrim-Sousa, Nicole Pezzi, Gabriel S. Lopes, Karina F. Bombonato-Prado, Silvana Giuliatti, Geraldo A. Passos

Front Immunol. 2018; 9: 964. Published online 2018 May 7. doi: 10.3389/fimmu.2018.00964

PMCID:: PMC5949327

Abstract Article PDF–2.0M

Select item 560511919.

Aire-deficient mice provide a model of corneal and lacrimal gland neuropathy in Sjögren's syndrome

Feeling Y. Chen, Albert Lee, Shaokui Ge, Sara Nathan, Sarah M. Knox, Nancy A. McNamara

PLoS One. 2017; 12(9): e0184916. Published online 2017 Sep 19. doi: 10.1371/journal.pone.0184916

PMCID:: PMC5605119

Abstract Article PDF–18M

Select item 530862220.

AIRE polymorphism, melanoma antigen-specific T cell immunity, and susceptibility to melanoma

Giuseppina Conteduca, Daniela Fenoglio, Alessia Parodi, Florinda Battaglia, Francesca Kalli, Simone Negrini, Samuele Tardito, Francesca Ferrera, Annalisa Salis, Enrico Millo, Giuseppe Pasquale, Giusi Barra, Gianluca Damonte, Francesco Indiveri, Soldano Ferrone, Gilberto Filaci

Oncotarget. 2016 Sep 20; 7(38): 60872–60884. Published online 2016 Aug 22. doi: 10.18632/oncotarget.11506

PMCID:: PMC5308622

Abstract Article PDF–2.0M

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PMC Links for Gene (Select 11634) (194)
PMC
Mus musculus autoimmune regulator (Aire), transcript variant 6, mRNA
Mus musculus autoimmune regulator (Aire), transcript variant 6, mRNA
gi|409168285|ref|NM_001271553.1|

Nucleotide
Rattus norvegicus myb-like, SWIRM and MPN domains 1 (Mysm1), transcript variant ...
Rattus norvegicus myb-like, SWIRM and MPN domains 1 (Mysm1), transcript variant 2, mRNA
gi|2707682272|ref|NM_001428927.1|

Nucleotide
deubiquitinase MYSM1 isoform X8 [Rattus norvegicus]
deubiquitinase MYSM1 isoform X8 [Rattus norvegicus]
gi|2678947413|ref|XP_063144652.1|

Protein

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