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Select item 105893351.

Sympathetic activity regulates epithelial proliferation and wound healing via adrenergic receptor α_2A

Anne S. ten Hove, Shilpashree Mallesh, Konstantina Zafeiropoulou, Janna W. M. de Kleer, Patricia H. P. van Hamersveld, Olaf Welting, Theodorus B. M. Hakvoort, Sven Wehner, Jurgen Seppen, Wouter J. de Jonge

Sci Rep. 2023; 13: 17990. Published online 2023 Oct 20. doi: 10.1038/s41598-023-45160-w

PMCID:: PMC10589335

Abstract Article PDF–3.0M

Select item 86575012.

Dexmedetomidine Promotes Lipopolysaccharide-Induced Differentiation of Cardiac Fibroblasts and Collagen I/III Synthesis through α_2A Adrenoreceptor-Mediated Activation of the PKC-p38-Smad2/3 Signaling Pathway in Mice

Jia Liao, Kaiying Li, Xingyu Su, Yihua Chen, Yingwei Wang, Xiangxu Tang, Yun Xing, Yaqian Xu, Xiaomeng Dai, Jiashuo Teng, Hongmei Li, Huadong Wang, Xiuxiu Lv, Yiyang Wang

Int J Mol Sci. 2021 Dec; 22(23): 12749. Published online 2021 Nov 25. doi: 10.3390/ijms222312749

PMCID:: PMC8657501

Abstract Article PDF–3.6M

Select item 80727513.

Role of α2-Adrenoceptor Subtypes in Suppression of L-Type Ca²⁺ Current in Mouse Cardiac Myocytes

Edward V. Evdokimovskii, Ryounghoon Jeon, Sungjo Park, Oleg Y. Pimenov, Alexey E. Alekseev

Int J Mol Sci. 2021 Apr; 22(8): 4135. Published online 2021 Apr 16. doi: 10.3390/ijms22084135

PMCID:: PMC8072751

Abstract Article PDF–2.0M

Select item 67929324.

A Point Mutation (D79N) of the α2A Adrenergic Receptor Abolishes the Antiepileptogenic Action of Endogenous Norepinephrine

Sridevi Janumpalli, Linda S. Butler, Leigh B. MacMillan, Lee E. Limbird, James O. McNamara

J Neurosci. 1998 Mar 15; 18(6): 2004–2008. doi: 10.1523/JNEUROSCI.18-06-02004.1998

PMCID:: PMC6792932

Abstract Article PDF–107K

Select item 67623495.

The α_2A-Adrenergic Receptor Plays a Protective Role in Mouse Behavioral Models of Depression and Anxiety

Nicole L. Schramm, Michael P. McDonald, Lee E. Limbird

J Neurosci. 2001 Jul 1; 21(13): 4875–4882. doi: 10.1523/JNEUROSCI.21-13-04875.2001

PMCID:: PMC6762349

Abstract Article PDF–142K

Select item 67577816.

Mutation of the α_2A-Adrenoceptor Impairs Working Memory Performance and Annuls Cognitive Enhancement by Guanfacine

Jenna S. Franowicz, Lynn E. Kessler, Catherine M. Dailey Borja, Brian K. Kobilka, Lee E. Limbird, Amy F. T. Arnsten

J Neurosci. 2002 Oct 1; 22(19): 8771–8777. doi: 10.1523/JNEUROSCI.22-19-08771.2002

PMCID:: PMC6757781

Abstract Article PDF–132K

Select item 63686277.

The in vivo specificity of synaptic Gβ and Gγ subunits to the α_2a adrenergic receptor at CNS synapses

Yun Young Yim, Katherine M. Betke, W. Hayes McDonald, Ralf Gilsbach, Yunjia Chen, Karren Hyde, Qin Wang, Lutz Hein, Heidi Hamm

Sci Rep. 2019; 9: 1718. Published online 2019 Feb 8. doi: 10.1038/s41598-018-37222-1

Correction in:: Sci Rep. 2020; 10: 2966.

PMCID:: PMC6368627

Abstract Article PDF–2.4M

Select item 61915248.

Dorsal BNST α_2A-Adrenergic Receptors Produce HCN-Dependent Excitatory Actions That Initiate Anxiogenic Behaviors

Nicholas A. Harris, Austin T. Isaac, Anne Günther, Kevin Merkel, James Melchior, Michelle Xu, Eghosa Eguakun, Rafael Perez, Brett P. Nabit, Stephanie Flavin, Ralf Gilsbach, Brian Shonesy, Lutz Hein, Ted Abel, Arnd Baumann, Robert Matthews, Samuel W. Centanni, Danny G. Winder

J Neurosci. 2018 Oct 17; 38(42): 8922–8942. doi: 10.1523/JNEUROSCI.0963-18.2018

PMCID:: PMC6191524

Abstract Article PDF–7.0M

Select item 61276169.

Global Disruption of α2A Adrenoceptor Barely Affects Bone Tissue but Minimizes the Detrimental Effects of Thyrotoxicosis on Cortical Bone

Gisele M. Martins, Marília B. C. G. Teixeira, Marcos V. Silva, Bianca Neofiti-Papi, Manuela Miranda-Rodrigues, Patricia C. Brum, Cecilia H. A. Gouveia

Front Endocrinol (Lausanne) 2018; 9: 486. Published online 2018 Aug 28. doi: 10.3389/fendo.2018.00486

PMCID:: PMC6127616

Abstract Article PDF–6.6M

Select item 588279910.

α_2A-adrenergic blockade attenuates septic cardiomyopathy by increasing cardiac norepinephrine concentration and inhibiting cardiac endothelial activation

Xiaohui Yu, Yuan Wang, Duomeng Yang, Xiangxu Tang, Hongmei Li, Xiuxiu Lv, Renbin Qi, Chaofeng Hu, Daxiang Lu, Ben Lv, Huadong Wang

Sci Rep. 2018; 8: 5478. Published online 2018 Apr 3. doi: 10.1038/s41598-018-23304-7

PMCID:: PMC5882799

Abstract Article PDF–7.1M

Select item 425254911.

α2-Adrenergic Stimulation of the Ventrolateral Preoptic Nucleus Destabilizes the Anesthetic State

Hilary S. McCarren, Michael R. Chalifoux, Bo Han, Jason T. Moore, Qing Cheng Meng, Nina Baron-Hionis, Madineh Sedigh-Sarvestani, Diego Contreras, Sheryl G. Beck, Max B. Kelz

J Neurosci. 2014 Dec 3; 34(49): 16385–16396. doi: 10.1523/JNEUROSCI.1135-14.2014