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Select item 78411351.

Oxysterol-Binding Protein-Related Protein 8 Inhibits Gastric Cancer Growth Through Induction of ER Stress, Inhibition of Wnt Signaling, and Activation of Apoptosis

Xiaohe Guo, Lanfang Zhang, Yingying Fan, Dezhong Zhang, Lei Qin, Shuping Dong, Guangyan Li

Oncol Res. 2017; 25(5): 799–808. Published online 2017 May 24. doi: 10.3727/096504016X14783691306605

PMCID:: PMC7841135

Abstract Article PDF–15M

Select item 50363652.

Oxysterol binding protein-related protein 8 mediates the cytotoxicity of 25-hydroxycholesterol

Jiwei Li, Xiuting Zheng, Ning Lou, Wenbin Zhong, Daoguang Yan

J Lipid Res. 2016 Oct; 57(10): 1845–1853. doi: 10.1194/jlr.M069906

PMCID:: PMC5036365

Abstract Article PDF–1.3M

Select item 44236793.

Oxysterol-binding Protein-related Protein 8 (ORP8) Increases Sensitivity of Hepatocellular Carcinoma Cells to Fas-Mediated Apoptosis

Wenbin Zhong, Shengying Qin, Biying Zhu, Miaoshui Pu, Fupei Liu, Lin Wang, Guilin Ye, Qing Yi, Daoguang Yan

J Biol Chem. 2015 Apr 3; 290(14): 8876–8887. Published online 2015 Jan 16. doi: 10.1074/jbc.M114.610188

PMCID:: PMC4423679

Abstract Article PDF–3.0M

Select item 71080224.

ORP8 induces apoptosis by releasing cytochrome c from mitochondria in non-small cell lung cancer

Jiwei Li, Jieke Cui, Zhaoming Li, Xiaorui Fu, Jing Li, Hongwen Li, Shilei Wang, Mingzhi Zhang

Oncol Rep. 2020 May; 43(5): 1516–1524. Published online 2020 Feb 24. doi: 10.3892/or.2020.7517

PMCID:: PMC7108022

Abstract Article PDF–1.0M

Select item 56249645.

ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P₂) and regulate its level at the plasma membrane

Rajesh Ghai, Ximing Du, Huan Wang, Jiangqing Dong, Charles Ferguson, Andrew J. Brown, Robert G. Parton, Jia-Wei Wu, Hongyuan Yang

Nat Commun. 2017; 8: 757. Published online 2017 Oct 2. doi: 10.1038/s41467-017-00861-5

PMCID:: PMC5624964

Abstract Article PDF–5.5M

Select item 52786076.

ORP5/ORP8 localize to endoplasmic reticulum–mitochondria contacts and are involved in mitochondrial function

Romain Galmes, Audrey Houcine, Alexander R van Vliet, Patrizia Agostinis, Catherine L Jackson, Francesca Giordano

EMBO Rep. 2016 Jun; 17(6): 800–810. Published online 2016 Apr 13. doi: 10.15252/embr.201541108

PMCID:: PMC5278607

Abstract Article PDF–2.8M

Select item 31159897.

Tianhong Zhou, Shiqian Li, Wenbin Zhong, Terhi Vihervaara, Olivier Béaslas, Julia Perttilä, Wei Luo, Yingliang Jiang, Markku Lehto, Vesa M. Olkkonen, Daoguang Yan

PLoS One. 2011; 6(6): e21078. Published online 2011 Jun 15. doi: 10.1371/journal.pone.0021078

PMCID:: PMC3115989

Abstract Article PDF–800K

Select item 59403108.

PI(4,5)P₂ controls plasma membrane PI4P and PS levels via ORP5/8 recruitment to ER–PM contact sites

Mira Sohn, Marek Korzeniowski, James P. Zewe, Rachel C. Wills, Gerald R.V. Hammond, Jana Humpolickova, Lukas Vrzal, Dominika Chalupska, Vaclav Veverka, Gregory D. Fairn, Evzen Boura, Tamas Balla

J Cell Biol. 2018 May 7; 217(5): 1797–1813. doi: 10.1083/jcb.201710095

PMCID:: PMC5940310

Abstract Article PDF–2.8M

Select item 46382249.

PI4P/phosphatidylserine countertransport at ORP5- and ORP8-mediated ER–plasma membrane contacts

Jeeyun Chung, Federico Torta, Kaori Masai, Louise Lucast, Heather Czapla, Lukas B. Tanner, Pradeep Narayanaswamy, Markus R. Wenk, Fubito Nakatsu, Pietro De Camilli

Science. Author manuscript; available in PMC 2015 Nov 9.

Published in final edited form as: Science. 2015 Jul 24; 349(6246): 428–432. doi: 10.1126/science.aab1370

PMCID:: PMC4638224

Abstract Article PDF–1.4M

Select item 344864810.

You Zhou, Marius R. Robciuc, Martin Wabitsch, Anne Juuti, Marja Leivonen, Christian Ehnholm, Hannele Yki-Järvinen, Vesa M. Olkkonen

PLoS One. 2012; 7(9): e45352. Published online 2012 Sep 21. doi: 10.1371/journal.pone.0045352

PMCID:: PMC3448648

Abstract Article PDF–2.0M

Select item 669139111.

Repurposing Brigatinib for the Treatment of Colorectal Cancer Based on Inhibition of ER-phagy

Zhe Zhang, Wei Gao, Li Zhou, Yan Chen, Siyuan Qin, Lu Zhang, Jiayang Liu, Yujia He, Yunlong Lei, Hai-Ning Chen, Junhong Han, Zong-Guang Zhou, Edouard C. Nice, Changlong Li, Canhua Huang, Xiawei Wei

Theranostics. 2019; 9(17): 4878–4892. Published online 2019 Jul 9. doi: 10.7150/thno.36254

PMCID:: PMC6691391

Abstract Article PDF–3.5M

Select item 718172012.

Non-proteolytic ubiquitination of OTULIN regulates NF-κB signaling pathway

Mengmeng Zhao, Kun Song, Wenzhuo Hao, Lingyan Wang, Girish Patil, Qingmei Li, Lingling Xu, Fang Hua, Bishi Fu, Jens C Schwamborn, Martin E Dorf, Shitao Li

J Mol Cell Biol. 2020 Mar; 12(3): 163–175. Published online 2019 Sep 3. doi: 10.1093/jmcb/mjz081

PMCID:: PMC7181720

Abstract Article PDF–1.3M

Select item 226729313.

The mammalian oxysterol-binding protein-related proteins (ORPs) bind 25-hydroxycholesterol in an evolutionarily conserved pocket

Monika Suchanek, Riikka Hynynen, Gerd Wohlfahrt, Markku Lehto, Marie Johansson, Hannu Saarinen, Anna Radzikowska, Christoph Thiele, Vesa M. Olkkonen

Biochem J. 2007 Aug 1; 405(Pt 3): 473–480. Prepublished online 2007 Apr 11. Published online 2007 Jul 13. doi: 10.1042/BJ20070176

PMCID:: PMC2267293

Abstract Article PDF–535K

Select item 790473414.

ORP/Osh mediate cross-talk between ER-plasma membrane contact site components and plasma membrane SNAREs

Marion Weber-Boyvat, Thorsten Trimbuch, Saundarya Shah, Jussi Jäntti, Vesa M. Olkkonen, Christian Rosenmund

Cell Mol Life Sci. 2021 Feb; 78(4): 1689–1708. Published online 2020 Jul 30. doi: 10.1007/s00018-020-03604-w

PMCID:: PMC7904734

Abstract Article PDF–3.9M

Select item 237498515.

Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns

Karol Szafranski, Stefanie Schindler, Stefan Taudien, Michael Hiller, Klaus Huse, Niels Jahn, Stefan Schreiber, Rolf Backofen, Matthias Platzer

Genome Biol. 2007; 8(8): R154. Published online 2007 Aug 1. doi: 10.1186/gb-2007-8-8-r154

PMCID:: PMC2374985

Abstract Article PDF–369K

Select item 856959316.

Neddylation modification of the U3 snoRNA-binding protein RRP9 by Smurf1 promotes tumorigenesis

Meng-ge Du, Fan Liu, Yan Chang, Shuai Tong, Wei Liu, Yu-jiao Chen, Ping Xie

J Biol Chem. 2021 Nov; 297(5): 101307. Published online 2021 Oct 15. doi: 10.1016/j.jbc.2021.101307

Correction in:: J Biol Chem. 2022 Nov; 298(11): 102567.

PMCID:: PMC8569593

Abstract Article PDF–4.2M

Select item 625176117.

Endogenous Cell Type-Specific DISC1 Interactomes Reveal Protein Networks Associated to Neurodevelopmental Disorders

Brent Wilkinson, Oleg Evgrafov, DongQing Zheng, Nicolas Hartel, James A. Knowles, Nicholas A. Graham, Justin Ichida, Marcelo P. Coba

Biol Psychiatry. Author manuscript; available in PMC 2020 Feb 15.

Published in final edited form as: Biol Psychiatry. 2019 Feb 15; 85(4): 305–316. Published online 2018 May 23. doi: 10.1016/j.biopsych.2018.05.009

PMCID:: PMC6251761

Abstract Article PDF–1.6M

Select item 492871618.

HIV–host interactome revealed directly from infected cells

Yang Luo, Erica Y. Jacobs, Todd M. Greco, Kevin D. Mohammed, Tommy Tong, Sarah Keegan, James M. Binley, Ileana M. Cristea, David Fenyö, Michael P. Rout, Brian T. Chait, Mark A. Muesing

Nat Microbiol. Author manuscript; available in PMC 2016 Jul 1.

Published in final edited form as: Nat Microbiol. 2016 Jul; 1(7): 16068. Published online 2016 May 23. doi: 10.1038/nmicrobiol.2016.68

PMCID:: PMC4928716

Abstract Article PDF–1.1M

Select item 325047919.

Defining human ERAD networks through an integrative mapping strategy

John C. Christianson, James A. Olzmann, Thomas A. Shaler, Mathew E. Sowa, Eric J. Bennett, Caleb M. Richter, Ryan E. Tyler, Ethan J. Greenblatt, J. Wade Harper, Ron R. Kopito

Nat Cell Biol. Author manuscript; available in PMC 2012 Jul 1.

Published in final edited form as: Nat Cell Biol. 2012 Jan; 14(1): 93–105. Published online 2011 Nov 27. doi: 10.1038/ncb2383

PMCID:: PMC3250479

Abstract Article PDF–2.7M

Select item 666388020.

Spatial proteomics reveal that the protein phosphatase PTP1B interacts with and may modify tyrosine phosphorylation of the rhomboid protease RHBDL4

Kyojiro N. Ikeda, Matthew Freeman

J Biol Chem. 2019 Jul 26; 294(30): 11486–11497. Published online 2019 Jun 7. doi: 10.1074/jbc.RA118.007074

PMCID:: PMC6663880

Abstract Article PDF–2.0M

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PMC Links for Gene (Select 114882) (85)
PMC
oxysterol-binding protein-related protein 8 isoform X5 [Homo sapiens]
oxysterol-binding protein-related protein 8 isoform X5 [Homo sapiens]
gi|2217287318|ref|XP_047284207.1|

Protein
PREDICTED: Homo sapiens oxysterol binding protein like 8 (OSBPL8), transcript va...
PREDICTED: Homo sapiens oxysterol binding protein like 8 (OSBPL8), transcript variant X7, mRNA
gi|2217287313|ref|XM_047428249.1|

Nucleotide

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