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Select item 87427301.

Dysregulation of the sensory and regulatory pathways controlling cellular iron metabolism in unilateral obstructive nephropathy

James A. Votava, Shannon R. Reese, Kathryn M. Deck, Christopher P. Nizzi, Sheila A. Anderson, Arjang Djamali, Richard S. Eisenstein

Am J Physiol Renal Physiol. 2022 Jan 1; 322(1): F89–F103. Published online 2021 Nov 30. doi: 10.1152/ajprenal.00537.2020

PMCID:: PMC8742730

Abstract Article

Select item 31617942.

Aconitase Regulation of Erythropoiesis Correlates with a Novel Licensing Function in Erythropoietin-Induced ERK Signaling

Anne-Laure Talbot, Grant C. Bullock, Lorrie L. Delehanty, Martin Sattler, Zhizhuang Joe Zhao, Adam N. Goldfarb

PLoS One. 2011; 6(8): e23850. Published online 2011 Aug 22. doi: 10.1371/journal.pone.0023850

PMCID:: PMC3161794

Abstract Article PDF–3.2M

Select item 3291533.

Sequence and expression of the murine iron-responsive element binding protein.

C C Philpott, T A Rouault, R D Klausner

Nucleic Acids Res. 1991 Nov 25; 19(22): 6333. doi: 10.1093/nar/19.22.6333

PMCID:: PMC329153

Summary Page Browse PDF–215K

Select item 111439294.

Iron regulatory proteins 1 and 2 have opposing roles in regulating inflammation in bacterial orchitis

Niraj Ghatpande, Aileen Harrer, Bar Azoulay-Botzer, Noga Guttmann-Raviv, Sudhanshu Bhushan, Andreas Meinhardt, Esther G. Meyron-Holtz

JCI Insight. 2024 Mar 8; 9(5): e175845. Published online 2024 Feb 1. doi: 10.1172/jci.insight.175845

PMCID:: PMC11143929

Abstract Article PDF–11M

Select item 111069635.

Diurnal control of iron responsive element containing mRNAs through iron regulatory proteins IRP1 and IRP2 is mediated by feeding rhythms

Hima Priyanka Nadimpalli, Georgia Katsioudi, Enes Salih Arpa, Lies Chikhaoui, Alaaddin Bulak Arpat, Angelica Liechti, Gaël Palais, Claudia Tessmer, Ilse Hofmann, Bruno Galy, David Gatfield

Genome Biol. 2024; 25: 128. Published online 2024 May 21. doi: 10.1186/s13059-024-03270-2

PMCID:: PMC11106963

Abstract Article PDF–7.1M

Select item 81090196.

Therapeutic inhibition of HIF-2α reverses polycythemia and pulmonary hypertension in murine models of human diseases

Manik C. Ghosh, De-Liang Zhang, Wade H. Ollivierre, Audrey Noguchi, Danielle A. Springer, W. Marston Linehan, Tracey A. Rouault

Blood. 2021 May 6; 137(18): 2509–2519. Prepublished online 2020 Dec 17. doi: 10.1182/blood.2020009138

PMCID:: PMC8109019

Abstract Article

Select item 45675237.

Iron misregulation and neurodegenerative disease in mouse models that lack iron regulatory proteins

Manik C. Ghosh, De-Liang Zhang, Tracey A. Rouault

Neurobiol Dis. Author manuscript; available in PMC 2016 Sep 1.

Published in final edited form as: Neurobiol Dis. 2015 Sep; 81: 66–75. Published online 2015 Mar 11. doi: 10.1016/j.nbd.2015.02.026

PMCID:: PMC4567523

Abstract Article PDF–1010K

Select item 35698568.

Deletion of Iron Regulatory Protein 1 Causes Polycythemia and Pulmonary Hypertension in Mice through Translational De-repression of HIF2α

Manik C. Ghosh, De-Liang Zhang, Suh Young Jeong, Gennadiy Kovtunovych, Hayden Ollivierre-Wilson, Audrey Noguchi, Tiffany Tu, Thomas Senecal, Gabrielle Robinson, Daniel R. Crooks, Wing-Hang Tong, Kavitha Ramaswamy, Anamika Singh, Brian B. Graham, Rubin M. Tuder, Zu-Xi Yu, Michael Eckhaus, Jaekwon Lee, Danielle A. Springer, Tracey A. Rouault

Cell Metab. Author manuscript; available in PMC 2014 Feb 5.

Published in final edited form as: Cell Metab. 2013 Feb 5; 17(2): 271–281. doi: 10.1016/j.cmet.2012.12.016

PMCID:: PMC3569856

Abstract Article PDF–4.9M

Select item 31230529.

Iron Regulatory Protein 1 Outcompetes Iron Regulatory Protein 2 in Regulating Cellular Iron Homeostasis in Response to Nitric Oxide

Agnieszka Styś, Bruno Galy, Rafal R. Starzyński, Ewa Smuda, Jean-Claude Drapier, Pawel Lipiński, Cécile Bouton

J Biol Chem. 2011 Jul 1; 286(26): 22846–22854. Published online 2011 May 12. doi: 10.1074/jbc.M111.231902

PMCID:: PMC3123052

Abstract Article PDF–1.4M

Select item 255657110.

Iron Regulatory Proteins Increase Neuronal Vulnerability to Hydrogen Peroxide

Raymond Regan, Zhi Li, Mai Chen, Xuefeng Zhang, Jing Chen-Roetling

Biochem Biophys Res Commun. Author manuscript; available in PMC 2009 Oct 10.

Published in final edited form as: Biochem Biophys Res Commun. 2008 Oct 10; 375(1): 6–10. Published online 2008 Jul 23. doi: 10.1016/j.bbrc.2008.07.061

PMCID:: PMC2556571

Abstract Article PDF–499K

Select item 169895811.

Electron tomography of degenerating neurons in mice with abnormal regulation of iron metabolism

Peijun Zhang, William Land, Stanton Lee, Jemma Juliani, Jonathan Lefman, Sophia R. Smith, David Germain, Martin Kessel, Richard Leapman, Tracey A. Rouault, Sriram Subramaniam

J Struct Biol. Author manuscript; available in PMC 2006 Dec 14.

Published in final edited form as: J Struct Biol. 2005 May; 150(2): 144–153. doi: 10.1016/j.jsb.2005.01.007

PMCID:: PMC1698958

Abstract Article PDF–2.6M

Select item 137059312.

Targeted mutagenesis of the murine IRP1 and IRP2 genes reveals context-dependent RNA processing differences in vivo

BRUNO GALY, DUNJA FERRING, MONIKA BENESOVA, VLADIMIR BENES, MATTHIAS W. HENTZE

RNA. 2004 Jul; 10(7): 1019–1025. doi: 10.1261/rna.7220704

PMCID:: PMC1370593

Abstract Article PDF–223K

Select item 953449613.

Iron regulatory protein (IRP)–mediated iron homeostasis is critical for neutrophil development and differentiation in the bone marrow

Michael Bonadonna, Sandro Altamura, Elisabeth Tybl, Gael Palais, Maria Qatato, Maria Polycarpou-Schwarz, Martin Schneider, Christina Kalk, Wibke Rüdiger, Alina Ertl, Natasha Anstee, Ruzhica Bogeska, Dominic Helm, Michael D. Milsom, Bruno Galy

Sci Adv. 2022 Oct; 8(40): eabq4469. Published online 2022 Oct 5. doi: 10.1126/sciadv.abq4469

PMCID:: PMC9534496

Abstract Article PDF–6.0M

Select item 587384914.

Translational repression of HIF2α expression in mice with Chuvash polycythemia reverses polycythemia

Manik C. Ghosh, De-Liang Zhang, Hayden Ollivierre, Michael A. Eckhaus, Tracey A. Rouault

J Clin Invest. 2018 Apr 2; 128(4): 1317–1325. Published online 2018 Feb 26. doi: 10.1172/JCI97684

PMCID:: PMC5873849

Abstract Article PDF–5.0M

Select item 543812315.

A drastic superoxide-dependent oxidative stress is prerequisite for the down-regulation of IRP1: Insights from studies on SOD1-deficient mice and macrophages treated with paraquat

Anna Milczarek, Rafał R. Starzyński, Agnieszka Styś, Aneta Jończy, Robert Staroń, Agnieszka Grzelak, Paweł Lipiński

PLoS One. 2017; 12(5): e0176800. Published online 2017 May 19. doi: 10.1371/journal.pone.0176800

PMCID:: PMC5438123

Abstract Article PDF–14M

Select item 466694116.

IRON REGULATORY PROTEINS MEDIATE HOST RESISTANCE TO SALMONELLA INFECTION

Manfred Nairz, Dunja Ferring-Appel, Daniela Casarrubea, Thomas Sonnweber, Lydie Viatte, Andrea Schroll, David Haschka, Ferric C. Fang, Matthias W. Hentze, Guenter Weiss, Bruno Galy

Cell Host Microbe. Author manuscript; available in PMC 2016 Aug 12.

Published in final edited form as: Cell Host Microbe. 2015 Aug 12; 18(2): 254–261. Published online 2015 Jul 16. doi: 10.1016/j.chom.2015.06.017

PMCID:: PMC4666941

Abstract Article PDF–525K

Select item 369568817.

Abnormal body iron distribution and erythropoiesis in a novel mouse model with inducible gain of iron regulatory protein (IRP)-1 function

D. Casarrubea, L. Viatte, T. Hallas, A. Vasanthakumar, R. S. Eisenstein, K. Schümann, M. W. Hentze, B. Galy

J Mol Med (Berl) 2013; 91(7): 871–881. Published online 2013 Mar 1. doi: 10.1007/s00109-013-1008-2

PMCID:: PMC3695688

Abstract Article PDF–824K

Select item 361228918.

The IRP1-HIF-2α Axis Coordinates Iron and Oxygen Sensing with Erythropoiesis and Iron Absorption

Sheila A. Anderson, Christopher P. Nizzi, Yuan-I Chang, Kathryn M. Deck, Paul J. Schmidt, Bruno Galy, Alisa Damnernsawad, Aimee T. Broman, Christina Kendziorski, Matthias W. Hentze, Mark D. Fleming, Jing Zhang, Richard S. Eisenstein

Cell Metab. Author manuscript; available in PMC 2014 Feb 5.

Published in final edited form as: Cell Metab. 2013 Feb 5; 17(2): 282–290. doi: 10.1016/j.cmet.2013.01.007

PMCID:: PMC3612289

Abstract Article PDF–2.7M

Select item 318919819.

Iron Insufficiency Compromises Motor Neurons and Their Mitochondrial Function in Irp2-Null Mice

Suh Young Jeong, Daniel R. Crooks, Hayden Wilson-Ollivierre, Manik C. Ghosh, Rachid Sougrat, Jaekwon Lee, Sharon Cooperman, James B. Mitchell, Carole Beaumont, Tracey A. Rouault

PLoS One. 2011; 6(10): e25404. Published online 2011 Oct 7. doi: 10.1371/journal.pone.0025404

PMCID:: PMC3189198

Abstract Article PDF–8.7M

Select item 278029820.

Characterization of Detergent-Insoluble Proteins in ALS Indicates a Causal Link between Nitrative Stress and Aggregation in Pathogenesis

Manuela Basso, Giuseppina Samengo, Giovanni Nardo, Tania Massignan, Giuseppina D'Alessandro, Silvia Tartari, Lavinia Cantoni, Marianna Marino, Cristina Cheroni, Silvia De Biasi, Maria Teresa Giordana, Michael J. Strong, Alvaro G. Estevez, Mario Salmona, Caterina Bendotti, Valentina Bonetto

PLoS One. 2009; 4(12): e8130. Published online 2009 Dec 2. doi: 10.1371/journal.pone.0008130

PMCID:: PMC2780298

Abstract Article PDF–1.8M

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PMC Links for Gene (Select 11428) (51)
PMC
Mus musculus BAC clone RP24-74F2 from chromosome 9, complete sequence
Mus musculus BAC clone RP24-74F2 from chromosome 9, complete sequence
gi|62238138|gb|AC151729.6||gnl|wugs 4-74F2

Nucleotide
Larimichthys crocea
Larimichthys crocea

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