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Select item 108458001.

The novel phosphatase NUDT5 is a critical regulator of triple-negative breast cancer growth

Jing Qian, Yanxia Ma, William M. Tahaney, Cassandra L. Moyer, Amanda Lanier, Jamal Hill, Darian Coleman, Negar Koupaei, Susan G. Hilsenbeck, Michelle I. Savage, Brent D. G. Page, Abhijit Mazumdar, Powel H. Brown

Breast Cancer Res. 2024; 26: 23. Published online 2024 Feb 5. doi: 10.1186/s13058-024-01778-w

Correction in:: Breast Cancer Res. 2024; 26: 53.

PMCID:: PMC10845800

Abstract Article PDF–5.6M

Select item 78775772.

The high expression of NUDT5 indicates poor prognosis of breast cancer by modulating AKT / Cyclin D signaling

He Zhang, Li-Qun Zhang, Cheng-Cheng Yang, Jin Li, Xin-Yuan Tian, Dan-Ni Li, Ju Cui, Jian-Ping Cai

PLoS One. 2021; 16(2): e0245876. Published online 2021 Feb 11. doi: 10.1371/journal.pone.0245876

PMCID:: PMC7877577

Abstract Article PDF–2.9M

Select item 57726483.

Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells

Brent D. G. Page, Nicholas C. K. Valerie, Roni H. G. Wright, Olov Wallner, Rebecka Isaksson, Megan Carter, Sean G. Rudd, Olga Loseva, Ann-Sofie Jemth, Ingrid Almlöf, Jofre Font-Mateu, Sabin Llona-Minguez, Pawel Baranczewski, Fredrik Jeppsson, Evert Homan, Helena Almqvist, Hanna Axelsson, Shruti Regmi, Anna-Lena Gustavsson, Thomas Lundbäck, Martin Scobie, Kia Strömberg, Pål Stenmark, Miguel Beato, Thomas Helleday

Nat Commun. 2018; 9: 250. Published online 2018 Jan 17. doi: 10.1038/s41467-017-02293-7

Correction in:: Nat Commun. 2019; 10: 5050.

PMCID:: PMC5772648

Abstract Article PDF–2.6M

Select item 33103904.

FUNCTION AND METABOLISM OF SIRTUIN METABOLITE O-ACETYL-ADP-RIBOSE

Lei Tong, John M. Denu

Biochim Biophys Acta. Author manuscript; available in PMC 2012 Mar 22.

Published in final edited form as: Biochim Biophys Acta. 2010 Aug; 1804(8): 1617–1625. Published online 2010 Feb 20. doi: 10.1016/j.bbapap.2010.02.007

PMCID:: PMC3310390

Abstract Article PDF–2.3M

Select item 32035875.

Diverse substrate recognition and hydrolysis mechanisms of human NUDT5

Takao Arimori, Haruhiko Tamaoki, Teruya Nakamura, Hiroyuki Kamiya, Shinji Ikemizu, Yasumitsu Takagi, Toru Ishibashi, Hideyoshi Harashima, Mutsuo Sekiguchi, Yuriko Yamagata

Nucleic Acids Res. 2011 Nov; 39(20): 8972–8983. Published online 2011 Jul 15. doi: 10.1093/nar/gkr575

PMCID:: PMC3203587

Abstract Article PDF–6.0M

Select item 11748966.

Mammalian enzymes for preventing transcriptional errors caused by oxidative damage

Toru Ishibashi, Hiroshi Hayakawa, Riyoko Ito, Masayuki Miyazawa, Yuriko Yamagata, Mutsuo Sekiguchi

Nucleic Acids Res. 2005; 33(12): 3779–3784. Published online 2005 Jul 7. doi: 10.1093/nar/gki682

PMCID:: PMC1174896

Abstract Article PDF–231K

Select item 12206487.

Cloning, expression and characterization of YSA1H, a human adenosine 5'-diphosphosugar pyrophosphatase possessing a MutT motif.

L Gasmi, J L Cartwright, A G McLennan

Biochem J. 1999 Dec 1; 344(Pt 2): 331–337.

PMCID:: PMC1220648

Summary PDF–267K

Select item 13191938.

A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides

Toru Ishibashi, Hiroshi Hayakawa, Mutsuo Sekiguchi

EMBO Rep. 2003 May; 4(5): 479–483. Published online 2003 Apr 25. doi: 10.1038/sj.embor.embor838

PMCID:: PMC1319193

Abstract Article PDF–110K

Select item 72894049.

Paradoxical mitotic exit induced by a small molecule inhibitor of APC/C^Cdc20

Katherine V. Richeson, Tatyana Bodrug, Katharine L. Sackton, Masaya Yamaguchi, Joao A. Paulo, Steven P. Gygi, Brenda A. Schulman, Nicholas G. Brown, Randall W. King

Nat Chem Biol. Author manuscript; available in PMC 2020 Sep 9.

Published in final edited form as: Nat Chem Biol. 2020 May; 16(5): 546–555. Published online 2020 Mar 9. doi: 10.1038/s41589-020-0495-z

PMCID:: PMC7289404

Abstract Article PDF–1.9M

Select item 1078754210.

Chromatin accessibility complex subunit 1 enhances tumor growth by regulating the oncogenic transcription of YAP in breast and cervical cancer

Shasha Li, Lulu Wang, Jing Shi, Yi Chen, Ang Xiao, Bingyue Huo, Wenjing Tian, Shilu Zhang, Gang Yang, Wensheng Gong, Huixia Zhang

PeerJ. 2024; 12: e16752. Published online 2024 Jan 10. doi: 10.7717/peerj.16752

PMCID:: PMC10787542

Abstract Article PDF–13M

Select item 758952411.

Targeting SKA3 suppresses the proliferation and chemoresistance of laryngeal squamous cell carcinoma via impairing PLK1–AKT axis-mediated glycolysis

Wei Gao, Yuliang Zhang, Hongjie Luo, Min Niu, Xiwang Zheng, Wanglai Hu, Jiajia Cui, Xuting Xue, Yunfeng Bo, Fengsheng Dai, Yan Lu, Dongli Yang, Yujia Guo, Huina Guo, Huizheng Li, Yu Zhang, Tao Yang, Li Li, Linshi Zhang, Rui Hou, Shuxin Wen, Changming An, Teng Ma, Lei Jin, Wei Xu, Yongyan Wu

Cell Death Dis. 2020 Oct; 11(10): 919. Published online 2020 Oct 26. doi: 10.1038/s41419-020-03104-6

PMCID:: PMC7589524

Abstract Article PDF–5.2M

Select item 856959312.

Neddylation modification of the U3 snoRNA-binding protein RRP9 by Smurf1 promotes tumorigenesis

Meng-ge Du, Fan Liu, Yan Chang, Shuai Tong, Wei Liu, Yu-jiao Chen, Ping Xie

J Biol Chem. 2021 Nov; 297(5): 101307. Published online 2021 Oct 15. doi: 10.1016/j.jbc.2021.101307

Correction in:: J Biol Chem. 2022 Nov; 298(11): 102567.

PMCID:: PMC8569593

Abstract Article PDF–4.2M

Select item 356152213.

Deubiquitinase FAM/USP9X Interacts with the E3 Ubiquitin Ligase SMURF1 Protein and Protects It from Ligase Activity-dependent Self-degradation

Yang Xie, Monika Avello, Markus Schirle, Elizabeth McWhinnie, Yan Feng, Eva Bric-Furlong, Christopher Wilson, Robin Nathans, Jing Zhang, Marc W. Kirschner, Shih-Min A. Huang, Feng Cong

J Biol Chem. 2013 Feb 1; 288(5): 2976–2985. Published online 2012 Nov 26. doi: 10.1074/jbc.M112.430066

PMCID:: PMC3561522

Abstract Article PDF–1.1M

Select item 31093414.

Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells

Qing-Hua Zhang, Min Ye, Xin-Yan Wu, Shuang-Xi Ren, Meng Zhao, Chun-Jun Zhao, Gang Fu, Yu Shen, Hui-Yong Fan, Gang Lu, Ming Zhong, Xiang-Ru Xu, Ze-Guang Han, Ji-Wang Zhang, Jiong Tao, Qiu-Hua Huang, Jun Zhou, Geng-Xi Hu, Jian Gu, Sai-Juan Chen, Zhu Chen

Genome Res. 2000 Oct; 10(10): 1546–1560. doi: 10.1101/gr.140200

PMCID:: PMC310934

Abstract Article PDF–1.3M

Select item 596587215.

Alterations in the brain interactome of the intrinsically disordered N-terminal domain of the cellular prion protein (PrP^C) in Alzheimer’s disease

Sarah Ulbrich, Petra Janning, Ralf Seidel, Jakob Matschke, Anika Gonsberg, Sebastian Jung, Markus Glatzel, Martin Engelhard, Konstanze F. Winklhofer, Jörg Tatzelt

PLoS One. 2018; 13(5): e0197659. Published online 2018 May 23. doi: 10.1371/journal.pone.0197659

PMCID:: PMC5965872

Abstract Article PDF–2.4M

Select item 435865916.

The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA

Benjamin A Diner, Tuo Li, Todd M Greco, Marni S Crow, John A Fuesler, Jennifer Wang, Ileana M Cristea

Mol Syst Biol. 2015 Feb; 11(2): 787. Published online 2015 Feb 9. doi: 10.15252/msb.20145808

PMCID:: PMC4358659

Abstract Article PDF–3.6M

Select item 412394417.

Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover

David J. Elzi, Meihua Song, Kevin Hakala, Susan T. Weintraub, Yuzuru Shiio

J Proteome Res. 2014 Aug 1; 13(8): 3783–3791. Published online 2014 Jul 7. doi: 10.1021/pr500387m

PMCID:: PMC4123944

Abstract Article PDF–3.8M

Select item 1076495818.

TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence

Jiang Ren, Shuai Wang, Zhi Zong, Ting Pan, Sijia Liu, Wei Mao, Huizhe Huang, Xiaohua Yan, Bing Yang, Xin He, Fangfang Zhou, Long Zhang

Nat Commun. 2024; 15: 244. Published online 2024 Jan 4. doi: 10.1038/s41467-023-44502-6

PMCID:: PMC10764958

Abstract Article PDF–4.4M

Select item 1064152419.

Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis

Robert S. Kiss, Jarred Chicoine, Youssef Khalil, Robert Sladek, He Chen, Alessandro Pisaturo, Cyril Martin, Jessica D. Dale, Tegan A. Brudenell, Archith Kamath, Jeffrey Kyei-Boahen, Anouar Hafiane, Girija Daliah, Célia Alecki, Tayah S. Hopes, Martin Heier, Irene A. Aligianis, Jean-Jacques Lebrun, Julie Aspden, Emanuele Paci, Anja Kerksiek, Dieter Lütjohann, Peter Clayton, Jimi C. Wills, Alex von Kriegsheim, Tommy Nilsson, Eamonn Sheridan, Mark T. Handley

J Biol Chem. 2023 Nov; 299(11): 105295. Published online 2023 Sep 28. doi: 10.1016/j.jbc.2023.105295

PMCID:: PMC10641524

Abstract Article PDF–3.8M

Select item 1114818420.

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek

Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x

PMCID:: PMC11148184

Abstract Article PDF–8.1M

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