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Select item 73438071.

PIM2 promotes hepatocellular carcinoma tumorigenesis and progression through activating NF-κB signaling pathway

Xuming Tang, Tingting Cao, Yun Zhu, Liyi Zhang, Jinna Chen, Tengfei Liu, Xiaoyan Ming, Shuo Fang, Yun-fei Yuan, Lingxi Jiang, Jian-Dong Huang, Xin-Yuan Guan

Cell Death Dis. 2020 Jul; 11(7): 510. Published online 2020 Jul 2. doi: 10.1038/s41419-020-2700-0

PMCID:: PMC7343807

Article PDF–5.6M

Select item 69594652.

Inhibition of PIM2 in liver cancer decreases tumor cell proliferation in vitro and in vivo primarily through the modulation of cell cycle progression

Pia Kronschnabl, Arnold Grünweller, Roland K. Hartmann, Achim Aigner, Ulrike Weirauch

Int J Oncol. 2020 Feb; 56(2): 448–459. Published online 2019 Dec 10. doi: 10.3892/ijo.2019.4936

PMCID:: PMC6959465

Article PDF–1.4M

Select item 58658833.

Role of PIM2 in allergic asthma

Wei Du, Tiantian Chen, Yingmeng Ni, Xiaoxia Hou, Youchao Yu, Qi Zhou, Fang Wu, Wei Tang, Guochao Shi

Mol Med Rep. 2017 Nov; 16(5): 7504–7512. Published online 2017 Sep 18. doi: 10.3892/mmr.2017.7499

PMCID:: PMC5865883

Article PDF–1.3M

Select item 50221834.

Pim2 is important for regulating DNA damage response in multiple myeloma cells

J Ramachandran, L Santo, K T Siu, C Panaroni, N Raje

Blood Cancer J. 2016 Aug; 6(8): e462. Published online 2016 Aug 26. doi: 10.1038/bcj.2016.73

PMCID:: PMC5022183

Article PDF–1.2M

Select item 46725125.

Loss of PIM2 enhances the anti-proliferative effect of the pan-PIM kinase inhibitor AZD1208 in non-Hodgkin lymphomas

S. Kreuz, K. B. Holmes, R. M. Tooze, P. F. Lefevre

Mol Cancer. 2015; 14: 205. Published online 2015 Dec 8. doi: 10.1186/s12943-015-0477-z

PMCID:: PMC4672512

Article PDF–2.6M

Select item 46723486.

Control of Pim2 kinase stability and expression in transformed human haematopoietic cells

Kévin Adam, Mireille Lambert, Elsa Lestang, Gabriel Champenois, Isabelle Dusanter-Fourt, Jérôme Tamburini, Didier Bouscary, Catherine Lacombe, Yael Zermati, Patrick Mayeux

Biosci Rep. 2015 Dec; 35(6): e00274. Prepublished online 2015 Oct 23. Published online 2015 Dec 8. doi: 10.1042/BSR20150217

PMCID:: PMC4672348

Article PDF–1.1M

Select item 44665137.

Pim-2 Modulates Aerobic Glycolysis and Energy Production during the Development of Colorectal Tumors

Xue-hui Zhang, Hong-liang Yu, Fu-jing Wang, Yong-long Han, Wei-liang Yang

Int J Med Sci. 2015; 12(6): 487–493. Published online 2015 Jun 8. doi: 10.7150/ijms.10982

PMCID:: PMC4466513

Article PDF–494K

Select item 44341768.

Pim-2/mTORC1 Pathway Shapes Inflammatory Capacity in Rheumatoid Arthritis Synovial Cells Exposed to Lipid Peroxidations

Geng Yin, Yan Li, Min Yang, Xiao-min Cen, Qi-bing Xie

Biomed Res Int. 2015; 2015: 240210. Published online 2015 May 4. doi: 10.1155/2015/240210

PMCID:: PMC4434176

Article PDF–2.0M

Select item 33235639.

Activation of Cell Cycle Arrest and Apoptosis by the Proto-Oncogene Pim-2

Daphna Levy, Ateret Davidovich, Shahar Zirkin, Yulia Frug, Amos M. Cohen, Sara Shalom, Jeremy Don

PLoS One. 2012; 7(4): e34736. Published online 2012 Apr 10. doi: 10.1371/journal.pone.0034736

PMCID:: PMC3323563

Article PDF–821K

Select item 289087710.

Ectopic Over-expression of Oncogene Pim-2 Induce Malignant Transformation of Nontumorous Human Liver Cell Line L02

Ke Ren, Wentao Duan, Yujun Shi, Bo Li, Zuojin Liu, Jiangping Gong

J Korean Med Sci. 2010 Jul; 25(7): 1017–1023. Published online 2010 Jun 17. doi: 10.3346/jkms.2010.25.7.1017

PMCID:: PMC2890877

Article PDF–1.5M

Select item 286279911.

Pim-2 phosphorylation of p21^Cip1/WAF1 enhances its stability and inhibits cell proliferation in HCT116 cells

Zeping Wang, Yandong Zhang, Juan Jenny Gu, Christine Davitt, Raymond Reeves, Nancy S. Magnuson

Int J Biochem Cell Biol. Author manuscript; available in PMC 2011 Jun 1.

Published in final edited form as: Int J Biochem Cell Biol. 2010 Jun; 42(6): 1030–1038. Published online 2010 Mar 20. doi: 10.1016/j.biocel.2010.03.012

PMCID:: PMC2862799

Article PDF–3.8M

Select item 274328612.

Crystal Structure of the PIM2 Kinase in Complex with an Organoruthenium Inhibitor

Alex N. Bullock, Santina Russo, Ann Amos, Nicholas Pagano, Howard Bregman, Judit É. Debreczeni, Wen Hwa Lee, Frank von Delft, Eric Meggers, Stefan Knapp

PLoS One. 2009; 4(10): e7112. Published online 2009 Oct 20. doi: 10.1371/journal.pone.0007112

PMCID:: PMC2743286

Article PDF–732K

Select item 808794613.

Positive regulation of PFKFB3 by PIM2 promotes glycolysis and paclitaxel resistance in breast cancer

Chao Lu, Pengyun Qiao, Yonghong Sun, Chune Ren, Zhenhai Yu

Clin Transl Med. 2021 Apr; 11(4): e400. Published online 2021 May 1. doi: 10.1002/ctm2.400

PMCID:: PMC8087946

Article PDF–9.7M

Select item 622440214.

PIM2-mediated phosphorylation of hexokinase 2 is critical for tumor growth and paclitaxel resistance in breast cancer

Tingting Yang, Chune Ren, Pengyun Qiao, Xue Han, Li Wang, Shijun Lv, Yonghong Sun, Zhijun Liu, Yu Du, Zhenhai Yu

Oncogene. 2018; 37(45): 5997–6009. Published online 2018 Jul 9. doi: 10.1038/s41388-018-0386-x

Correction in:: Oncogene. 2020; 39(3): 720–721.

PMCID:: PMC6224402

Article PDF–3.6M

Select item 601070315.

Microenvironment‐induced PIM kinases promote CXCR4‐triggered mTOR pathway required for chronic lymphocytic leukaemia cell migration

Emilia Białopiotrowicz, Patryk Górniak, Monika Noyszewska‐Kania, Bartosz Puła, Hanna Makuch‐Łasica, Grażyna Nowak, Aleksandra Bluszcz, Maciej Szydłowski, Ewa Jabłonska, Karolina Piechna, Tomasz Sewastianik, Anna Polak, Ewa Lech‐Marańda, Bożena K. Budziszewska, Maja Wasylecka‐Juszczyńska, Katarzyna Borg, Krzysztof Warzocha, Wojciech Czardybon, Michał Gałęzowski, Renata Windak, Krzysztof Brzózka, Przemysław Juszczyński

J Cell Mol Med. 2018 Jul; 22(7): 3548–3559. Published online 2018 Apr 17. doi: 10.1111/jcmm.13632

PMCID:: PMC6010703

Article PDF–1.4M

Select item 592835716.

PIM2 interacts with tristetraprolin and promotes breast cancer tumorigenesis

Chune Ren, Tingting Yang, Pengyun Qiao, Li Wang, Xue Han, Shijun Lv, Yonghong Sun, Zhijun Liu, Yu Du, Zhenhai Yu

Mol Oncol. 2018 May; 12(5): 690–704. Published online 2018 Apr 14. doi: 10.1002/1878-0261.12192

PMCID:: PMC5928357

Article PDF–1.3M

Select item 512892317.

The role of PIM1/PIM2 kinases in tumors of the male reproductive system

Manuel Pedro Jiménez-García, Antonio Lucena-Cacace, María José Robles-Frías, Maja Narlik-Grassow, Carmen Blanco-Aparicio, Amancio Carnero

Sci Rep. 2016; 6: 38079. Published online 2016 Nov 30. doi: 10.1038/srep38079

PMCID:: PMC5128923

Article PDF–3.6M

Select item 447179818.

Persistent activation of STAT3 by PIM2-driven positive feedback loop for epithelial-mesenchymal transition in breast cancer

Nizam Uddin, Rae-Kwon Kim, Ki-Chun Yoo, Young-Heon Kim, Yan-Hong Cui, In-Gyu Kim, Yongjoon Suh, Su-Jae Lee

Cancer Sci. 2015 Jun; 106(6): 718–725. Published online 2015 May 8. doi: 10.1111/cas.12668

PMCID:: PMC4471798

Article PDF–2.2M

Select item 395301419.

Pim2 is required for maintaining multiple myeloma cell growth through modulating TSC2 phosphorylation

Jing Lu, Tatiana Zavorotinskaya, Yumin Dai, Xiao-Hong Niu, Joseph Castillo, Janet Sim, Jianjun Yu, Yingyun Wang, John L. Langowski, Jocelyn Holash, Kevin Shannon, Pablo D. Garcia

Blood. 2013 Aug 29; 122(9): 1610–1620. Prepublished online 2013 Jul 1. doi: 10.1182/blood-2013-01-481457

PMCID:: PMC3953014

Article

Select item 391497320.

A Regulatory Feedback Loop between HIF-1α and PIM2 in HepG2 Cells

Zhenhai Yu, Xiaoping Zhao, Yingying Ge, Teng Zhang, Liangqian Huang, Xiang Zhou, Lei Xie, Jianjun Liu, Gang Huang

PLoS One. 2014; 9(2): e88301. Published online 2014 Feb 5. doi: 10.1371/journal.pone.0088301

PMCID:: PMC3914973

Article PDF–1.2M

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